Medical and Biomedical Researches

Selection bias in evaluating of influenza vaccine effectiveness: A lesson from an observational stud

June 29th, 2008
Selection bias in evaluating of influenza vaccine effectiveness: A lesson from an observational study of elderly nursing home residents. Selection bias is of critical concern in the study of influenza vaccine effectiveness when using an observational study design. This bias is attributable to the inherently different ...

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Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associa

June 29th, 2008
Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit. Because of its production and use in Vietnam, the most widely used oral cholera vaccine consists of heat- or formalin-killed Vibrio cholerae whole cells (WC). An earlier version of this ...

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Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization

June 29th, 2008
Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model. This study examined the vaccine potential of the autotransporter protein BrkA of Bordetella pertussis in the sublethal intranasal murine respiratory challenge model of infection. Five different acellular pertussis (Pa) vaccines, containing different ...

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Analysis of the cellular immune response in patients with the digestive and indeterminate forms of C

June 29th, 2008
Analysis of the cellular immune response in patients with the digestive and indeterminate forms of Chagas\' disease. The commitment of the digestive organs observed in patients during the chronic phase of Chagas\' disease is mainly attributed to neuronal damage induced by immune and inflammatory processes elicited ...

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Characterization of the major histocompatibility complex class II DQB (MhcMamu-DQB1) alleles in a co

June 29th, 2008
Characterization of the major histocompatibility complex class II DQB (MhcMamu-DQB1) alleles in a cohort of Chinese rhesus macaques (Macaca mulatta). Rhesus macaques have long been used in animal models for various human diseases, the susceptibility and/or resistance to some of which have been associated with the ...

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Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord B

June 29th, 2008
Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank. Cord blood (CB) is considered an alternative resource to bone marrow and peripheral blood stem cells (PBSC) for allogeneic stem cell transplantation. In this study, human leukocyte ...

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Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate r

June 29th, 2008
Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Purified retina glial Müller cells can express the machinery for dopamine synthesis and release when maintained in culture. Dopamine is detected in cell extracts of cultures exposed to its precursor, l-DOPA. A large ...

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Role of antimicrobial peptides in host defense against mycobacterial infections.

June 29th, 2008
Role of antimicrobial peptides in host defense against mycobacterial infections. Worldwide, tuberculosis remains the most important infectious disease causing morbidity and death. Currently, at least one-third of the world\'s population is infected with Mycobacterium tuberculosis. In addition, the World Health Organization estimates that about 8-10 million ...

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Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain.

June 29th, 2008
Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain. The synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models. In this study, the effect of mS100A9p was investigated on neuropathic pain ...

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Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from k

June 29th, 2008
Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom. Snake venom Kunitz/BPTI members are good tools for understanding of structure-functional relationship between serine proteases and their inhibitors. A novel dual Kunitz/BPTI serine proteinase inhibitor named OH-TCI (trypsin- and chymotrypsin-dual ...

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Massive peptide sharing between viral and human proteomes.

June 29th, 2008
Massive peptide sharing between viral and human proteomes. Thirty viral proteomes were examined for amino acid sequence similarity to the human proteome, and, in parallel, a control of 30 sets of human proteins was analyzed for internal human overlapping. We find that all of the analyzed ...

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Influence of nutritional knowledge on perceived healthiness and willingness to try functional foods.

June 29th, 2008
Influence of nutritional knowledge on perceived healthiness and willingness to try functional foods. In order to assess the influence of nutritional knowledge on perceived healthiness and willingness to try functional foods, 104 consumers filled out a Nutritional Knowledge Questionnaire and answered a conjoint task. Participants had ...

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Functional food: Product development, marketing and consumer acceptance-A review.

June 29th, 2008
Functional food: Product development, marketing and consumer acceptance-A review. It was mainly the advances in understanding the relationship between nutrition and health that resulted in the development of the concept of functional foods, which means a practical and new approach to achieve optimal health status by ...

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Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system

June 29th, 2008
Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas. Ferrocenyl diphenol tamoxifen derivative (Fc-diOH) is one of the most active molecules of a new class of organometallic drugs, showing in vitro antiproliferative effects on both hormone-dependent and independent ...

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The temporal redistribution pattern of NK cells under acute stress based on CD62L adhesion molecule

June 29th, 2008
The temporal redistribution pattern of NK cells under acute stress based on CD62L adhesion molecule expression. Recent studies demonstrated that an acute psychological stressor elicited transient changes in lymphocyte redistribution. Earlier studies had established that CD3-CD16+CD56+ natural killer cells (NK cells) increased remarkably in peripheral blood ...

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Optimized generation of vectors for the construction of Haloferax volcanii deletion mutants.

June 29th, 2008
Optimized generation of vectors for the construction of Haloferax volcanii deletion mutants. A method for the construction of in frame deletions in chromosomal genes of the archaeon Haloferax volcanii has been described recently (Allers et al. (2004), Appl. Environ. Microbiol. 70:943-953). Two steps of the procedure ...

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The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets.

June 29th, 2008
The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets. A recently identified metastasis suppressor, N-myc downstream regulated gene-1 (Ndrg-1), has been shown to reduce the invasion and metastasis of breast, colon, prostate and pancreatic cancer. Among its many functions, Ndrg-1 is involved in modulating differentiation, ...

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High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fai

June 29th, 2008
High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour. Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) and one of its target structures, the ventromedial hypothalamus (VMH), produces a typical behaviour in rats consisting of vigorous running and jumping which ...

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Thomas Graham Brown (1882-1965), Anders Lundberg (1920-), and the neural control of stepping.

June 29th, 2008
Thomas Graham Brown (1882-1965), Anders Lundberg (1920-), and the neural control of stepping. Thomas Graham Brown (1882-1965) undertook experiments on the neural control of stepping in the University of Liverpool laboratory of Charles Sherrington (1857-1952) in 1910-13 and his own laboratory in 1913-15 at the University ...

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Chemical synthesis of fluorescent glycero- and sphingolipids.

June 29th, 2008
Chemical synthesis of fluorescent glycero- and sphingolipids. Glycero- and sphingolipids have been shown to be building blocks of membranes and lipoproteins, metabolites and important intermediaries in the signalling cascades involved in stress responses, proliferation of cells and also apoptosis. Investigations into the exact functions of these ...

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Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases.

June 29th, 2008
Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases. Synaptic dysfunction appears to be an early pathogenic event in Alzheimer\'s disease, amyotrophic lateral sclerosis and Parkinson\'s disease. Although the molecular mechanism of this synaptotoxicity is not known, evidence suggests that these diseases are characterized by a common pathophysiological ...

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The antimicrobial peptides piscidins are stored in the granules of professional phagocytic granulocy

June 29th, 2008
The antimicrobial peptides piscidins are stored in the granules of professional phagocytic granulocytes of fish and are delivered to the bacteria-containing phagosome upon phagocytosis. Antimicrobial peptides (AMPs) are increasingly recognized as a critical first line of defence against many pathogens. The genes encoding these peptides are ...

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Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiat

June 29th, 2008
Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor- and Toll-like receptor-induced activation of nuclear factor-kappaB (NF-kappaB). A novel isoform of chicken MyD88, designated chicken ...

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Photocrosslinkable starch-based polymers for ophthalmologic drug delivery.

June 29th, 2008
Photocrosslinkable starch-based polymers for ophthalmologic drug delivery. This study focused on the development and characterization of a starch-based polymer with urethane linkages to be used as a controlled drug delivery system for biomedical applications. Starch was modified with 2-isocyanatoethyl methacrylate in order to obtain a polymer ...

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Female gonadal hormones, mild restraint, and male preference.

June 29th, 2008
Female gonadal hormones, mild restraint, and male preference. The partner preference paradigm was used to test the hypothesis that mild restraint reduced sexual motivation of female rats. Ovariectomized rats were primed with 10 microg estradiol benzoate or estradiol benzoate and 500 microg progesterone. Additional rats were ...

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