Medical and Biomedical Researches

The new proximal femoral nail antirotation (PFNA((R))) in daily practice: Results of a multicentre c

June 29th, 2008
The new proximal femoral nail antirotation (PFNA((R))) in daily practice: Results of a multicentre clinical study. The treatment of unstable trochanteric femoral fractures is still challenging. The ideal implant should be easy to handle, allow for immediate full weight-bearing postoperatively and should have sufficient purchase in ...

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Is estimated peri-operative glomerular filtration rate associated with post-operative mortality in f

June 29th, 2008
Is estimated peri-operative glomerular filtration rate associated with post-operative mortality in fractured neck of femur patients? AIM: Comparison of renal function in patients who died within 30 days of surgery for hip fractures with surviving patients matched for age, type of surgery, type of anaesthesia and ...

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Social correlates of testosterone and ornamentation in male mandrills.

June 29th, 2008
Social correlates of testosterone and ornamentation in male mandrills. We investigated relationships between fecal androgen concentrations, facial coloration and behaviour in semi-free-ranging male mandrills. We found that fecal androgen levels were significantly positively related to dominance rank, independent of rank stability and the mating period, suggesting ...

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Endoscopic resection of minor papilla adenomas (with video).

June 29th, 2008
Endoscopic resection of minor papilla adenomas (with video). BACKGROUND: Although there are several large series on endoscopic resection of the major duodenal papilla, only commentary on individual cases has been presented on endoscopic minor papilla resection. OBJECTIVE: To evaluate the technical success and safety of endoscopy ...

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Safety of conventional and wireless capsule endoscopy in patients supported with nonpulsatile axial

June 29th, 2008
Safety of conventional and wireless capsule endoscopy in patients supported with nonpulsatile axial flow Heart-Mate II left ventricular assist device. BACKGROUND: Left ventricular assist devices (LVADs) are increasingly being used as a bridge for cardiac transplantation in patients with decompensated cardiac function. A known complication of ...

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Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subseq

June 29th, 2008
Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen-thawed cycles: potential paternal effects on pregnancy outcomes. OBJECTIVE: To evaluate objectively whether poor sperm quality affects sequential events from fertilization to delivery in fresh intracytoplasmic sperm injection (ICSI) and subsequent frozen-thawed ...

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Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase ge

June 29th, 2008
Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure. We found that four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF). All four polymorphisms were in strong linkage disequilibrium. The ...

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Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agoni

June 29th, 2008
Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). Relaxin-3 is a potent agonist for both G-protein coupled receptors (GPCR) RXFP3 (also known as GPCR135) and RXFP4 (also known as GPCR142) ...

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gamma-Radiation induces apoptosis via sarcoplasmatic reticulum in guinea pig ileum smooth muscle cel

June 29th, 2008
gamma-Radiation induces apoptosis via sarcoplasmatic reticulum in guinea pig ileum smooth muscle cells. We investigated the effects of gamma-radiation on cells isolated from the longitudinal smooth muscle layer of the guinea pig ileum, a relatively radioresistant tissue. Single doses (up to 50 Gy) reduced the amount ...

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The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells.

June 29th, 2008
The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. General anesthetic propofol (2,6-bis(isopropyl)-phenol) possess a chemical structure unrelated to other anesthetic drugs. It has been known to block a variety of ion currents. This study is designed to determine the effect of ...

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Cell adhesion modulates 5-HT(1D) and P2Y receptor signal trafficking differentially in LTK-8 cells.

June 29th, 2008
Cell adhesion modulates 5-HT(1D) and P2Y receptor signal trafficking differentially in LTK-8 cells. In this study, we investigated adhesion-induced changes in cellular responses to serotonin 5-HT(1D) and purinergic P2Y receptor stimulation. We demonstrated that detachment of LTK-8 cells increased 5-HT(1D) receptor-mediated intracellular Ca(2+) and extracellular signal ...

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Memantine prevents the cognitive impairment induced by 3,4-methylenedioxymethamphetamine in rats.

June 29th, 2008
Memantine prevents the cognitive impairment induced by 3,4-methylenedioxymethamphetamine in rats. Amphetamine abuse is an important risk factor for the development of cognitive impairment involving learning and memory. Since in previous studies we have demonstrated the effectiveness of alpha-7 nicotinic receptor antagonists in preventing the neurotoxicity induced ...

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5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin a

June 29th, 2008
5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats. 5-Hydroxytryptamine (5-HT), dopamine, oxytocin and melanocortin pathways are known to be involved in the induction of penile erections in rats. Although a dopamine-oxytocin-5-HT link in the central nervous system ...

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Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endo

June 29th, 2008
Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing. Tricarbonyldichlororuthenium (II) dimer (CORM2) has been developed as carbon monoxide (CO) donor. We found that CORM2 activated a type of specific current which was distinct from the big-conductance Ca(2+)-activated ...

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ASP4000, a novel, selective, dipeptidyl peptidase 4 inhibitor with antihyperglycemic activity.

June 29th, 2008
ASP4000, a novel, selective, dipeptidyl peptidase 4 inhibitor with antihyperglycemic activity. ASP4000, (2S)-1-{[(1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]hept-3-yl]carbonyl}-2-pyrrolidinecar bonitrile hydrochloride, is a novel dipeptidyl peptidase (DPP) 4 inhibitor. In the present study, we characterized the compound as an oral antidiabetic agent both in vitro and in vivo. ASP4000 inhibited human recombinant ...

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The receptor phosphatase HmLAR2 collaborates with focal adhesion proteins in filopodial tips to cont

June 29th, 2008
The receptor phosphatase HmLAR2 collaborates with focal adhesion proteins in filopodial tips to control growth cone morphology. Receptor protein tyrosine phosphatases (RPTPs) have been shown to play key roles in regulating axon guidance and synaptogenesis. HmLAR2, one of two closely related LAR-like RPTPs in the embryonic ...

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Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epitheli

June 29th, 2008
Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. The development of extraocular orbital structures, in particular the choroid and sclera, is regulated by a complex series of interactions between neuroectoderm, neural crest and mesoderm derivatives, ...

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Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation.

June 29th, 2008
Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation. Nodal is a key player in the process regulating oral-aboral axis formation in the sea urchin embryo. Expressed early within an oral organizing centre, it is required to specify both the ...

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Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extensi

June 29th, 2008
Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. The zyxin-related LPP protein is localized at focal adhesions and cell-cell contacts and is involved in the regulation of smooth muscle cell migration. A known interaction ...

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The large functional spectrum of the heparin-binding cytokines MK and HB-GAM in continuously growing

June 29th, 2008
The large functional spectrum of the heparin-binding cytokines MK and HB-GAM in continuously growing organs: The rodent incisor as a model. The heparin binding molecules MK and HB-GAM are involved in the regulation of growth and differentiation of many tissues and organs. Here we analyzed the ...

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Perception of speech reflects optimal use of probabilistic speech cues.

June 29th, 2008
Perception of speech reflects optimal use of probabilistic speech cues. Listeners are exquisitely sensitive to fine-grained acoustic detail within phonetic categories for sounds and words. Here we show that this sensitivity is optimal given the probabilistic nature of speech cues. We manipulated the probability distribution of ...

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Stereoselective inhibition of human, mouse, and horse cholinesterases by bambuterol enantiomers.

June 29th, 2008
Stereoselective inhibition of human, mouse, and horse cholinesterases by bambuterol enantiomers. Bambuterol is a chiral carbamate and a selective inhibitor of butyrylcholinesterase (BChE, EC 3.1.1.8). In order to relate bambuterol selectivity and stereoselectivity of BChE and acetylcholinesterase (AChE, EC 3.1.1.7) of different species, we studied the ...

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Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles-T

June 29th, 2008
Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles-The role of calcineurin signaling. There are two main differences regarding acetylcholinesterase (AChE) expression in the extrajunctional regions of fast and slow rat muscles: (1) the activity of AChE catalytic subunits (G1 form) is much ...

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Reactivation of model cholinesterases by oximes and intermediate phosphyloximes: A computational stu

June 29th, 2008
Reactivation of model cholinesterases by oximes and intermediate phosphyloximes: A computational study. Phosphyloximes (POX) are generated upon the reactivation of organophosphorus (OP)-inhibited cholinesterases (ChEs) by pyridinium oximes. These POXs are known to be potent inhibitors of the ChEs following reactivation. However, they can also decompose to ...

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Heteroaromatic N-base ligands in 1,10-phenanthroline- and 2,2′-bipyridyl-assisted chromic acid oxid

June 29th, 2008
Heteroaromatic N-base ligands in 1,10-phenanthroline- and 2,2\'-bipyridyl-assisted chromic acid oxidation of (-)-l-sorbose in aqueous micellar acid media: a kinetic study. In aqueous sulfuric acid media, Cr(VI) oxidation of (-)-l-sorbose in the presence and absence of catalysts like 1,10-phenanthroline (phen), 2,2\'-bipyridyl (bipy) have been carried out under ...

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