Medical and Biomedical Researches

Caveolinopathy - New mutations and additional symptoms.

June 29th, 2008
Caveolinopathy - New mutations and additional symptoms. Mutations in the caveolin-3 gene (CAV3) can lead to a broad spectrum of clinical phenotypes. Phenotypes that have so far been associated with primary caveolin-3 deficiency include limb girdle muscular dystrophy, rippling muscle disease, distal myopathy and hyperCKaemia. This ...

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A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT(6) ligands.

June 29th, 2008
A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT(6) ligands. A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands is reported. Liu KG, Lo JR, Comery TA, Zhang GM, Zhang JY, Kowal DM, Smith DL, Di L, Kerns EH, Schechter ...

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Synthesis and cytotoxicity of aurilide analogs.

June 29th, 2008
Synthesis and cytotoxicity of aurilide analogs. The artificial analogs of aurilide (1), a potent cytotoxic cyclodepsipeptide of marine origin, were synthesized, and the structure-activity relationships were investigated. Suenaga K, Kajiwara S, Kuribayashi S, Handa T, Kigoshi H. Department of Chemistry, Faculty of Science and Technology, ...

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Isosteric exchange of the acylsulfonamide moiety in Abbott’s Bcl-X(L) protein interaction antagonis

June 29th, 2008
Isosteric exchange of the acylsulfonamide moiety in Abbott\'s Bcl-X(L) protein interaction antagonist. A multi-component reaction strategy was used for the fast and efficient synthesis of amide isosteres of known Bcl-2 inhibitors capable of disrupting protein-protein interactions. Ugi reaction and a subsequent nucleophilic aromatic substitution reaction provide ...

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Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1

June 29th, 2008
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). PXR, pregnane X receptor, in its activated state, is a validated target for controlling certain drug-drug interactions in humans. In this context, there is a paucity of ...

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Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism.

June 29th, 2008
Vitamin D receptor levels in colorectal cancer Possible role of BsmI polymorphism. A high expression of vitamin D receptor (VDR) in colorectal cancer (CRC) tumoral tissue has been related to a good prognosis and it has been proposed that it could be a good biological marker ...

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Mathematical modeling to predict residential solid waste generation.

June 29th, 2008
Mathematical modeling to predict residential solid waste generation. One of the challenges faced by waste management authorities is determining the amount of waste generated by households in order to establish waste management systems, as well as trying to charge rates compatible with the principle applied worldwide, ...

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Cell adhesion receptors in mechanotransduction.

June 29th, 2008
Cell adhesion receptors in mechanotransduction. Integrins and cadherins are tri-functional: they bind ligands on other cells or in the extracellular matrix, connect to the cytoskeleton inside the cell, and regulate intracellular signaling pathways. These adhesion receptors therefore transmit mechanical stresses and are well positioned to mediate ...

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Regulation of hemidesmosome disassembly by growth factor receptors.

June 29th, 2008
Regulation of hemidesmosome disassembly by growth factor receptors. Hemidesmosomes (HDs) promote the stable adhesion of basal epithelial cells to the underlying basement membrane (BM). Critical for the mechanical stability of the HD is the interaction between integrin alpha6beta4 and plectin, which is destabilized when HD disassembly ...

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Donor heart preservation with iloprost supplemented St. Thomas Hospital cardioplegic solution in iso

June 29th, 2008
Donor heart preservation with iloprost supplemented St. Thomas Hospital cardioplegic solution in isolated rat hearts. This study was designed to assess the influence of St. Thomas Hospital cardioplegic solution (St. Th.) on heart preservation in rat hearts subjected to 6h ischemia when supplemented with iloprost. In ...

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Pharmacokinetics and immunomodulatory effects of phytotherapeutic lozenges (bonbons) with Echinacea

June 29th, 2008
Pharmacokinetics and immunomodulatory effects of phytotherapeutic lozenges (bonbons) with Echinacea purpurea extract. The relative bioavailability of the major alkamides, dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides, from Echinacea purpurea phytotherapeutic lozenges at three different dose levels (0.07, 0.21 and 0.9mg) was evaluated in a pharmacokinetic study in humans and the ...

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Phytotherapy and psychiatry: Bibliometric study of the scientific literature from the last 20 years.

June 29th, 2008
Phytotherapy and psychiatry: Bibliometric study of the scientific literature from the last 20 years. In diverse areas of therapy, including psychiatry, increasing interest in herbal medicine has been shown in recent years. Plants have a wide range of traditional uses, but only a few have been ...

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Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydr

June 29th, 2008
Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes. From our screening program, we identified the anti-inflammatory effects of the extracts of Heliotropium ovalifolium in its ability to inhibit specific cytokines. The H. ovalifolium ...

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Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxida

June 29th, 2008
Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Artichoke is a plant with antioxidant properties. In this study, we investigated the effect of artichoke extract pretreatment on carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity. Rats were given artichoke leaf extract ...

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Protective effects of beta-glucan extracted from barley against benzo[a]pyrene-induced DNA damage in

June 29th, 2008
Protective effects of beta-glucan extracted from barley against benzo[a]pyrene-induced DNA damage in hepatic cell HepG2. The aim of the present study was to assess the genotoxic and antigenotoxic effect of beta-glucan (BG) extracted from barley. The genotoxicity of BG was tested in the single-cell gel electrophoresis ...

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Oral l-arginine protects against cyclosporine-induced hepatotoxicity in rats.

June 29th, 2008
Oral l-arginine protects against cyclosporine-induced hepatotoxicity in rats. Cyclosporine A (CyA) leads to liver injury, probably by causing the production of free radicals and resulting in nitric oxide (NO) deficiency. We evaluated CyA-mediated liver damage histopathologically to determine the possible beneficial effects of l-arginine (l-Arg). In ...

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Basic butylated methacrylate copolymer/kappa-carrageenan interpolyelectrolyte complex: Preparation,

June 29th, 2008
Basic butylated methacrylate copolymer/kappa-carrageenan interpolyelectrolyte complex: Preparation, characterization and drug release behaviour. The formation of a novel interpolyelectrolyte complex (IPEC) between basic butylated methacrylate copolymer and kappa-carrageenan was investigated and the product formed was characterized. Turbidity measurements and elemental analyses pointed to a 1:1 interaction of ...

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Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drug

June 29th, 2008
Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: Improved drug solubilization and enhanced in vitro cytotoxicity. Two poorly soluble, potent anti-cancer drugs, paclitaxel and camptothecin, were successfully solubilized by mixed micelles of polyethylene glycol-phosphatidyl ethanolamine (PEG-PE) and vitamin E. Drug-containing micelles were ...

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Glycation during storage and administration of monoclonal antibody formulations.

June 29th, 2008
Glycation during storage and administration of monoclonal antibody formulations. Covalent modifications of therapeutic proteins are of interest for the biotech industry as they potentially impact the quality of the material. This study focuses on covalent protein modifications by the reducing monosaccharide glucose via the glycation reaction. ...

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Reovirus: Viral Therapy for Cancer ‘as Nature Intended’

June 29th, 2008
Reovirus: Viral Therapy for Cancer \'as Nature Intended\' Oncolytic viruses are tumour selective and able to lyse cancer cells after infection. Reovirus is an example of a wild-type oncolytic virus and is currently being investigated as a potential novel therapy for cancer. This overview gives a ...

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Controlled complexation of plasmid DNA with cationic polymers: Effect of surfactant on the complexat

June 29th, 2008
Controlled complexation of plasmid DNA with cationic polymers: Effect of surfactant on the complexation and stability of the complexes. The aggregation of the cationic polymer-plasmid DNA complexes of two commonly used polymers, polyethyleneimine (PEI) and poly-l-lysine (PLL) were systematically compared. The complexation was studied in 5% ...

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The synthesis of biodegradable graft copolymer cellulose-graft-poly(l-lactide) and the study of its

June 29th, 2008
The synthesis of biodegradable graft copolymer cellulose-graft-poly(l-lactide) and the study of its controlled drug release. According to the concept of green chemistry and sustainable development, a new biodegradable copolymer comprised of hydrophobic poly(l-lactide) (PLLA) segments and hydrophilic cellulose segment (cellulose-g-PLLA) was designed and synthesized. The structure ...

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Zeta potential measurement as a diagnostic tool in enzyme immobilisation.

June 29th, 2008
Zeta potential measurement as a diagnostic tool in enzyme immobilisation. The efficiency of binding during enzyme immobilisation does not only depend on the chemical properties of the enzyme and the matrix particle, but also on their surface potential. Zeta potential quantifies the electrostatic interactions between enzyme ...

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Differences in the surface composition of seemingly similar F75 cobalt-chromium micron-sized particu

June 29th, 2008
Differences in the surface composition of seemingly similar F75 cobalt-chromium micron-sized particulates can affect synovial fibroblast viability. We present data and analyses concerning the cytotoxicity and bioreactivity associated with the surface composition of fine metal particulates that are similar to those commonly released in the body ...

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A roadmap to disentangle the molecular etiology of schizophrenia.

June 29th, 2008
A roadmap to disentangle the molecular etiology of schizophrenia. Schizophrenia is a severe mental disorder striking mainly young adults and leading to life-long disability in a substantial portion of the sufferers. On the other hand, substantial knowledge about its etiology and pathogenesis is still lacking. Therefore ...

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