Medical and Biomedical Researches

Distribution and phylogenetic relationships of Australian glow-worms Arachnocampa (Diptera, Keroplat

June 29th, 2008
Distribution and phylogenetic relationships of Australian glow-worms Arachnocampa (Diptera, Keroplatidae). Glow-worms are bioluminescent fly larvae (Order Diptera, genus Arachnocampa) found only in Australia and New Zealand. Their core habitat is rainforest gullies and wet caves. Eight species are present in Australia; five of them have been ...

Posted in researches 5 | No Comments »

Combining sparsity and rotational invariance in EEG/MEG source reconstruction.

June 29th, 2008
Combining sparsity and rotational invariance in EEG/MEG source reconstruction. We introduce Focal Vector Field Reconstruction (FVR), a novel technique for the inverse imaging of vector fields. The method was designed to simultaneously achieve two goals: a) invariance with respect to the orientation of the coordinate system, ...

Posted in researches 5 | No Comments »

Correlation between serotonin synthesis and 5-HT(1A) receptor binding in the living human brain: A c

June 29th, 2008
Correlation between serotonin synthesis and 5-HT(1A) receptor binding in the living human brain: A combined alpha-[(11)C]MT and [(18)F]MPPF positron emission tomography study. Serotonin (5-HT) is one of the major neurotransmitters and has been implicated in a wide variety of cerebral functions. Several lines of evidence indicate ...

Posted in researches 5 | No Comments »

Integration of motion correction and physiological noise regression in fMRI.

June 29th, 2008
Integration of motion correction and physiological noise regression in fMRI. Physiological fluctuations resulting from the heart beat and respiration are a dominant source of noise in fMRI, particularly at high field strengths. Commonly used physiological noise correction techniques, such as RETROspective Image CORrection (RETROICOR), rely critically ...

Posted in researches 5 | No Comments »

Mode level cognitive subtraction (MLCS) quantifies spatiotemporal reorganization in large-scale brai

June 29th, 2008
Mode level cognitive subtraction (MLCS) quantifies spatiotemporal reorganization in large-scale brain topographies. Contemporary brain theories of cognitive function posit spatial, temporal and spatiotemporal reorganization as mechanisms for neural information processing. Corresponding brain imaging results underwrite this perspective of large-scale reorganization. As we show here, a suitable ...

Posted in researches 5 | No Comments »

Resolving crossing fibres using constrained spherical deconvolution: Validation using diffusion-weig

June 29th, 2008
Resolving crossing fibres using constrained spherical deconvolution: Validation using diffusion-weighted imaging phantom data. Diffusion-weighted imaging can potentially be used to infer the connectivity of the human brain in vivo using fibre-tracking techniques, and is therefore of great interest to neuroscientists and clinicians. A key requirement for ...

Posted in researches 5 | No Comments »

The tuning-fork model of human social cognition: A critique.

June 29th, 2008
The tuning-fork model of human social cognition: A critique. The tuning-fork model of human social cognition, based on the discovery of mirror neurons (MNs) in the ventral premotor cortex of monkeys, involves the four following assumptions: (1) mirroring processes are processes of resonance or simulation. (2) ...

Posted in researches 5 | No Comments »

Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is

June 29th, 2008
Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer\'s disease. In order to understand the gene-mediated processes underlying sporadic Alzheimer\'s disease (AD), we carried out a subtractive cloning screen for novel AD candidate genes. We identified ...

Posted in researches 5 | No Comments »

Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration.

June 29th, 2008
Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration. A decline in developing neuronal cAMP levels appears to render mammalian axons susceptible to growth inhibitory factors in the damaged CNS. cAMP elevation enhances axon regeneration, but the cellular mechanisms involved have yet to be fully elucidated. ...

Posted in researches 5 | No Comments »

Endothelial cell-derived bone morphogenetic proteins control proliferation of neural stem/progenitor

June 29th, 2008
Endothelial cell-derived bone morphogenetic proteins control proliferation of neural stem/progenitor cells. Neurogenesis persists in the adult brain subventricular zone where neural stem/progenitor cells (NSPCs) lie close to brain endothelial cells (BECs). We show in mouse that BECs produce bone morphogenetic proteins (BMPs). Coculture of embryonic and ...

Posted in researches 5 | No Comments »

T and B lymphocyte differentiation from hematopoietic stem cell.

June 29th, 2008
T and B lymphocyte differentiation from hematopoietic stem cell. Until the past few years, it has been thought that lymphoid and myeloid lineage segregation represents the first step of lineage restriction during hematopoiesis from hematopoietic stem cell. Recent investigation of the cell populations within multipotent progenitors ...

Posted in researches 5 | No Comments »

Polyunsaturated fatty acids as antioxidants.

June 29th, 2008
Polyunsaturated fatty acids as antioxidants. The susceptibility of fatty acids to oxidation is thought to be directly dependent on their degree of unsaturation. However, some in vitro and in vivo studies suggest that the relation between chemical structure and susceptibility to oxidation is not as straightforward ...

Posted in researches 5 | No Comments »

Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats.

June 29th, 2008
Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats. Objectives: The effect of low dose of cyclophosphamide (CP) protecting cardiac function from ischemia-reperfusion injury was studied on rats. The premise is that CP inhibits immune and inflammatory process, thereby limits I/R injury and improves myocardial ...

Posted in researches 5 | No Comments »

The early and late results of combined off-pump coronary artery bypass grafting and pulmonary resect

June 29th, 2008
The early and late results of combined off-pump coronary artery bypass grafting and pulmonary resection in patients with concomitant lung cancer and unstable coronary heart disease. Objective: The aim of this study was to analyze the early and long-term results of simultaneous surgical treatment of both ...

Posted in researches 5 | No Comments »

Additional pulmonary resections after pneumonectomy: actual long-term survival and functional result

June 29th, 2008
Additional pulmonary resections after pneumonectomy: actual long-term survival and functional results. Objective: Pulmonary resections after pneumonectomy due to metastases or metachronous non-small cell lung cancer (NSCLC) are rare because of the high potential risk of the second procedure and uncertain long-term results. On the basis of ...

Posted in researches 5 | No Comments »

Verification of dose delivery for a prostate sIMRT treatment using a SLIC-EPID.

June 29th, 2008
Verification of dose delivery for a prostate sIMRT treatment using a SLIC-EPID. The current work focuses on the verification of transmitted dose maps, measured using a scanning liquid ionization chamber-electronic portal imaging device (SLIC-EPID) for a typical step-and-shoot prostate IMRT treatment using an anthropomorphic phantom at ...

Posted in researches 5 | No Comments »

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.

June 29th, 2008
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Human enterovirus (EV) belongs to the picornavirus family, which consists of over 200 medically relevant viruses. A peptidomimetic inhibitor AG7088 was developed to inhibit the 3C protease of rhinovirus (a member of the family), ...

Posted in researches 5 | No Comments »

Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine mono

June 29th, 2008
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase. Synthesis of novel inhibitors of human IMP dehydrogenase is described. These inhibitors are isosteric methylenebis(sulfonamide) analogues 5-8 of earlier reported mycophenolic adenine methylenebis(phosphonate)s 1-3. The parent bis(phosphonate) 1 and its bis(sulfonamide) analogue 5 showed ...

Posted in researches 5 | No Comments »

Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3′,4′,5′-trime

June 29th, 2008
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3\',4\',5\'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents. 6-Methoxy-3-(3\',4\',5\'-trimethoxybenzoyl)-1H-indole (BPR0L075) (1) is a potent inhibitor of tubulin polymerization which exhibits both in vitro and in vivo activities against a broad spectrum of solid tumors. This compound was designed as ...

Posted in researches 5 | No Comments »

Transtibial versus anteromedial portal of the femoral tunnel in ACL reconstruction: A cadaveric stud

June 29th, 2008
Transtibial versus anteromedial portal of the femoral tunnel in ACL reconstruction: A cadaveric study. The aim of this cadaveric study was to compare the transtibial versus the anteromedial portal with respect to the anatomic femoral positioning of the ACL attachment. Ten fresh frozen cadaveric knees were ...

Posted in researches 5 | No Comments »

Injury to the infrapatellar branch of the saphenous nerve in ACL reconstruction with the hamstrings

June 29th, 2008
Injury to the infrapatellar branch of the saphenous nerve in ACL reconstruction with the hamstrings technique: Clinical and electrophysiological study. The incidence of IBSN injury to the infrapatellar branch of the saphenous nerve (IBSN) in ACL surgery using the hamstrings technique has been reported to be ...

Posted in researches 5 | No Comments »

CMV infection is associated with the depletion but lack of activation of peripheral blood natural ki

June 29th, 2008
CMV infection is associated with the depletion but lack of activation of peripheral blood natural killer cells in a lung transplant cohort. INTRODUCTION: Following lung transplantation, cytomegalovirus (CMV) has both direct and indirect adverse effects on the allograft. Natural killer cells mediate immune responses to CMV. ...

Posted in researches 5 | No Comments »

Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors.

June 29th, 2008
Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors. Learning and memory are essential processes of both vertebrate and invertebrate nervous systems that allow animals to survive and reproduce. The neurotransmitter glutamate signals via ionotropic glutamate receptors (iGluRs) that have been linked to learning ...

Posted in researches 5 | No Comments »

FGF Signaling Regulates Cytoskeletal Remodeling during Epithelial Morphogenesis.

June 29th, 2008
FGF Signaling Regulates Cytoskeletal Remodeling during Epithelial Morphogenesis. Changes in the cytoskeletal architecture underpin the dynamic changes in tissue shape that occur during development [1-4]. It is clear that such changes must be coordinated so that individual cell behaviors are synchronized; however, the mechanisms by which ...

Posted in researches 5 | No Comments »

The Functional Impact of Mental Imagery on Conscious Perception.

June 29th, 2008
The Functional Impact of Mental Imagery on Conscious Perception. Mental imagery has been proposed to contribute to a variety of high-level cognitive functions, including memory encoding and retrieval, navigation, spatial planning, and even social communication and language comprehension [1-5]. However, it is debated whether mental imagery ...

Posted in researches 5 | No Comments »