Medical and Biomedical Researches

Distinct Functions of Autoreactive Memory and Effector CD4+ T Cells in Experimental Autoimmune Encep

June 29th, 2008
Distinct Functions of Autoreactive Memory and Effector CD4+ T Cells in Experimental Autoimmune Encephalomyelitis. The persistence of human autoimmune diseases is thought to be mediated predominantly by memory T cells. We investigated the phenotype and migration of memory versus effector T cells in vivo in experimental ...

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An Experimental Model of Acute Humoral Rejection of Renal Allografts Associated with Concomitant Cel

June 29th, 2008
An Experimental Model of Acute Humoral Rejection of Renal Allografts Associated with Concomitant Cellular Rejection. Acute humoral rejection (AHR), which occurs in up to 8% of kidney transplant recipients, is a significant cause of renal allograft dysfunction and loss. More efficacious treatment modalities are needed to ...

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Transforming Growth Factor-{beta} Stimulates Intestinal Epithelial Focal Adhesion Kinase Synthesis v

June 29th, 2008
Transforming Growth Factor-{beta} Stimulates Intestinal Epithelial Focal Adhesion Kinase Synthesis via Smad- and p38-Dependent Mechanisms. Focal adhesion kinase (FAK) regulates cell migration, proliferation, and apoptosis. FAK protein is reduced at the edge of migrating gut epithelial sheets in vitro, but it has not been characterized in ...

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Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Hum

June 29th, 2008
Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction. Unexplained intrauterine growth restriction of the fetus (IUGR) results from impaired placental development, frequently associated with maternal malperfusion. Some cases are complicated further by preeclampsia (PE+IUGR). Here, we provide ...

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Interplay between liquid crystalline and isotropic gels in self-assembled neurofilament networks.

June 29th, 2008
Interplay between liquid crystalline and isotropic gels in self-assembled neurofilament networks. Neurofilaments (NFs) are a major constituent of nerve cell axons that assemble from three subunit proteins of low (NF-L), medium (NF-M), and high (NF-H) molecular weight into a 10 nm diameter rod with radiating sidearms ...

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Using the Case Mix of Pressure Ulcer Healing to Evaluate Nursing Home Performance.

June 29th, 2008
Using the Case Mix of Pressure Ulcer Healing to Evaluate Nursing Home Performance. Pressure ulcer healing is an important quality measure for nursing homes, but the factors that predict healing have not been well studied. Using the Minimum Data Set, the authors identified candidate variables for ...

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Longitudinal Outcomes After Endovascular Repair of Abdominal Aortic Aneurysms.

June 29th, 2008
Longitudinal Outcomes After Endovascular Repair of Abdominal Aortic Aneurysms. Objective: Endovascular abdominal aneurysm repair (EVAR) is increasingly used, but there is insufficient evaluation of long-term outcomes. Method: Retrospective cohort study using the linked Washington State hospital discharge database. Result: 3,350 patients underwent elective repair of AAA ...

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Endovascular Covered Stenting for Visceral Artery Pseudoaneurysm Rupture: Report of 2 Cases and a Su

June 29th, 2008
Endovascular Covered Stenting for Visceral Artery Pseudoaneurysm Rupture: Report of 2 Cases and a Summary of the Disease Process and Treatment Options. We present 2 cases of hemorrhage from a visceral artery pseudoaneurysm, managed successfully with endovascular covered stent placement. The first case was a 59-year-old ...

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Delayed Treatment of a Traumatic Left Subclavian Artery Pseudoaneurysm.

June 29th, 2008
Delayed Treatment of a Traumatic Left Subclavian Artery Pseudoaneurysm. A 22-year-old man sustained 4 gunshot wounds to the upper torso resulting in left pneumothorax, an expanding right neck hematoma, left humerus fracture, a traumatic arteriovenous fistula from the right subclavian artery to the right brachiocephalic vein, ...

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Descending Thoracic Aortic Dissection: Evaluation and Management in the Era of Endovascular Technolo

June 29th, 2008
Descending Thoracic Aortic Dissection: Evaluation and Management in the Era of Endovascular Technology. Acute aortic dissection is a relatively uncommon but highly lethal condition. Without proper treatment, devastating consequences can occur due to aortic rupture, cardiac tamponade, or irreversible ischemia involving the spinal cord or the ...

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Integration of Patient Safety Technologies Into Sclerotherapy for Varicose Veins.

June 29th, 2008
Integration of Patient Safety Technologies Into Sclerotherapy for Varicose Veins. The American College of Surgeons, the Joint Commission, the Needlestick Safety and Prevention Act, and the Occupational Safety and Health Administration all direct surgical departments, including vascular surgeons who supply sclerotherapy services, to develop formal mechanisms ...

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Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts.

June 29th, 2008
Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts. Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers ...

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Long-term Results of Femoro-Femoral Crossover Bypass After Endovascular Aortouniiliac Repair of Abdo

June 29th, 2008
Long-term Results of Femoro-Femoral Crossover Bypass After Endovascular Aortouniiliac Repair of Abdominal Aortic and Aortoiliac Aneurysms. Aortouniiliac stent grafts allow the endovascular treatment of complex anatomy aortoiliac aneurysms. The main drawback is the need for femoro-femoral crossover bypass, with its complications and its patency limitations. However, ...

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Safety and Efficacy of Carotid Angioplasty/Stenting in 100 Consecutive High Surgical Risk Patients:

June 29th, 2008
Safety and Efficacy of Carotid Angioplasty/Stenting in 100 Consecutive High Surgical Risk Patients: Immediate and Long-Term Follow-up. Background/purpose. This study analyzes the safety and efficacy of carotid angioplasty/stenting (CAS) with embolic protection devices in high surgical risk (HSR) patients. Patient population/methods. This study includes 100 consecutive ...

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Intraoperative Fluid Restriction Predicts Improved Outcomes in Major Vascular Surgery.

June 29th, 2008
Intraoperative Fluid Restriction Predicts Improved Outcomes in Major Vascular Surgery. Background: Traditional fluid resuscitation during general anesthesia has been questioned in recent studies. One study of patients undergoing abdominal surgery showed decreased postoperative weight gain, earlier return of bowel function, and shorter intensive care unit (ICU) ...

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Implementing RFID technology in a novel triage system during a simulated mass casualty situation.

June 29th, 2008
Implementing RFID technology in a novel triage system during a simulated mass casualty situation. The purpose of this study is to determine the applicability of Radio Frequency Identification (RFID) technology and commercial cellular networks to provide an online triage system for handling mass casualty situations. This ...

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Electronic health records approaches and challenges: a comparison between Malaysia and four East Asi

June 29th, 2008
Electronic health records approaches and challenges: a comparison between Malaysia and four East Asian countries. An integrated Lifetime Health Record (LHR) is fundamental for achieving seamless and continuous access to patient medical information and for the continuum of care. However, the aim has not yet been ...

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Personal health records: key adoption issues and implications for management.

June 29th, 2008
Personal health records: key adoption issues and implications for management. Electronic Personal Health Records (PHRs) has been perceived as the tool to empower consumers to become active decision-makers of their healthcare instead of leaving the decision to providers. However, there has been the lack of enthusiasm ...

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Biometrics-based service marketing issues: exploring acceptability and risk factors of iris scans as

June 29th, 2008
Biometrics-based service marketing issues: exploring acceptability and risk factors of iris scans associated with registered travel programmes. The marketability and viability of biometric technologies by companies marketing their own versions of pre-approved registered travel programmes have generated a number of controversies. Data were collected and analysed ...

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Developing a Web 2.0 Telemedical Education System: the AJAX-Cocoon Portal.

June 29th, 2008
Developing a Web 2.0 Telemedical Education System: the AJAX-Cocoon Portal. Web 2.0 technologies such as wikis, podcasts/vodcasting, blogs and semantic portals could be quite effective tools in e-learning for health professionals. If effectively deployed, such tools can offer a way to enhance students\', clinicians\' and patients\' ...

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A study of RFID application impacts on medical safety.

June 29th, 2008
A study of RFID application impacts on medical safety. With the international reform in medical management systems gaining ground worldwide, hospital management has gradually begun to shift its focus from providing expensive medical treatment to improving medical service quality and patient safety. In this study, we ...

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Safety of Unilateral Antegrade Cerebral Perfusion at 22 degrees C Systemic Hypothermia.

June 29th, 2008
Safety of Unilateral Antegrade Cerebral Perfusion at 22 degrees C Systemic Hypothermia. Background. The superiority of antegrade cerebral perfusion (ACP) in aortic surgery is widely accepted, but the sufficiency of unilateral cerebral perfusion and the optimal systemic temperature during the operation are still controversial.Methods. Thirty patients ...

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Minimally invasive sternotomy for aortic valve replacement followed by a minilaparotomy for abdomina

June 29th, 2008
Minimally invasive sternotomy for aortic valve replacement followed by a minilaparotomy for abdominal aneurysm repair. Abdominal aortic aneurysms (AAAs) are commonly associated with severe coronary artery disease, but the incidence of associated aortic valve disease and AAAs in the general population is not known. The standard ...

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Seven-year experience with ablation of permanent atrial fibrillation concomitant to mitral valve sur

June 29th, 2008
Seven-year experience with ablation of permanent atrial fibrillation concomitant to mitral valve surgery in 152 patients. Background. This study analyzed 7 years of results for monopolar endocardial radiofrequency (RF) ablation of permanent atrial fibrillation (pAF) concomitant to mitral valve (MV) surgery.Methods. Between 2001 and 2007, 152 ...

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Iatrogenic Aortic Dissection during Right Coronary Artery Stenting.

June 29th, 2008
Iatrogenic Aortic Dissection during Right Coronary Artery Stenting. Aortic dissection limited to one sinus of Valsalva has been observed as an iatrogenic complication during coronary intervention. We report on a 65-year-old female patient who had a diagnosis of acute inferior myocardial infarction and experienced type A ...

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