Medical and Biomedical Researches

Germline mutations in the von Hippel-Lindau disease (VHL) gene in mainland Chinese families.

May 1st, 2008
Germline mutations in the von Hippel-Lindau disease (VHL) gene in mainland Chinese families. BACKGROUND: von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations in the VHL gene. To date, more than 500 VHL families have been reported worldwide. However, few information is ...

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The use of prostate specific antigen (PSA) density in detecting prostate cancer in Chinese men with

May 1st, 2008
The use of prostate specific antigen (PSA) density in detecting prostate cancer in Chinese men with PSA levels of 4-10 ng/mL. AIM: To investigate the utility of prostate specific antigen density for detecting prostate cancer in men with serum PSA levels of 4-10 ng/mL. METHODS: Between ...

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Drug utilisation profile in the Italian paediatric population.

May 1st, 2008
Drug utilisation profile in the Italian paediatric population. OBJECTIVE: In order to evaluate the prescribing pattern in the Italian paediatric population, prescriptions involving 923,353 children under 14 years old and dispensed during 2006 by the retail pharmacies of 22 Italian local health units were analysed. MATERIALS ...

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Pulse methylprednisolone with gammaglobulin as an initial treatment for acute Kawasaki disease.

May 1st, 2008
Pulse methylprednisolone with gammaglobulin as an initial treatment for acute Kawasaki disease. Approximately 15-20% of patients with Kawasaki disease (KD) are not responsive to high-dose intravenous gammaglobulin (IVIG). We have previously reported a predictive method for identifying IVIG-non-responsive patients (high-risk KD patients). We determined the safety ...

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Dissociating restart cost and mixing cost in task switching.

May 1st, 2008
Dissociating restart cost and mixing cost in task switching. Three experiments investigated the cognitive mechanisms underlying the restart cost and mixing cost in task switching. To this aim, the predictability of task order was varied (unpredictable in Experiment 1 and predictable in Experiments 2 and 3) ...

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Expressing a gene encoding wheat oxalate oxidase enhances resistance to Sclerotinia sclerotiorum in

May 1st, 2008
Expressing a gene encoding wheat oxalate oxidase enhances resistance to Sclerotinia sclerotiorum in oilseed rape (Brassica napus). Sclerotinia sclerotiorum causes a highly destructive disease in oilseed rape (Brassica napus). Oxalic acid (OA) secreted by the pathogen is a key pathogenicity factor. Oxalate oxidase (OXO) can oxidize ...

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Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calc

May 1st, 2008
Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels. Calcium, as an integral part of a large number of cellular regulatory pathways, is selective in the control of specific cell functions like the start of G1 phase in cell cycle. ...

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Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat caro

May 1st, 2008
Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body. The structure and function of the carotid body are greatly altered during chronic hypoxia. Recent studies showed the expression of interleukin (IL)-1 receptor and IL-6 receptor in the carotid body, suggesting ...

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Evaluation of different types of lamellar keratoplasty for treatment of peripheral corneal perforati

May 1st, 2008
Evaluation of different types of lamellar keratoplasty for treatment of peripheral corneal perforation. BACKGROUND: To discuss the efficacy and visual outcomes of different types of lamellar keratoplasty (LK) for the treatment of peripheral corneal perforation. METHODS: Sixty patients (67 eyes) with peripheral corneal perforation underwent semilunar ...

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Structure of intracorneal femtosecond laser pulse effects in conical incision profiles.

May 1st, 2008
Structure of intracorneal femtosecond laser pulse effects in conical incision profiles. PURPOSE: As the applicative potential of femtosecond lasers is to be extended from LASIK-flap creation into intrastromal ablation uses, the interdependency of influencing factors has to be understood. We therefore evaluated the relationship between focus ...

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Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female inf

May 1st, 2008
Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant. A case of sudden infant death with histiocytoid cardiomyopathy and ventricular non-compaction was investigated with immunohistochemical methods. Histiocytoid cardiomyopathy is thought to be a developmental defect of the cardiomyocytes of the ...

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Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF r

May 1st, 2008
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase. The family of human epidermal growth factor receptors (EGFR, HER2-4) exerts key functions in normal and malignant epithelial cells. Both EGFR and HER2 are valuable targets for anti-cancer drugs ...

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Increased frequency of pulmonary hypertension in psoriasis patients.

May 1st, 2008
Increased frequency of pulmonary hypertension in psoriasis patients. Several reports have demonstrated an association between psoriasis and cardiovascular diseases such as hypertension, valvular disease and arrhythmia. However, the data is scarce. Forty-seven psoriasis patients and 20 healthy people underwent transthoracic echocardiographic examination including pulse- and tissue ...

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Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer’s disease with amygda

May 1st, 2008
Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer\'s disease with amygdala Lewy bodies. We recently reported that Alzheimer\'s disease (AD) with amygdala Lewy bodies (ALB) is a distinct form of alpha-synucleinopathy that occurs in advanced AD. In AD/ALB the alpha-synuclein pathology correlated with ...

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Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites insta

May 1st, 2008
Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines. PURPOSE: The Bethesda guidelines suggest to perform microsatellite instability (MSI) test in early onset rectal cancer and not in patients >50 years with ...

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Swim pacemakers in box jellyfish are modulated by the visual input.

May 1st, 2008
Swim pacemakers in box jellyfish are modulated by the visual input. A major part of the cubozoan central nervous system is situated in the eye-bearing rhopalia. One of the neuronal output channels from the rhopalia carries a swim pacemaker signal, which has a one-to-one relation with ...

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Prospective comparison of high- and low-spatial-resolution dynamic MR imaging with sensitivity encod

May 1st, 2008
Prospective comparison of high- and low-spatial-resolution dynamic MR imaging with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinoma. The purpose of this study was to prospectively evaluate the efficacy of high-spatial-resolution dynamic MRI using sensitivity encoding (SENSE) in detection of hypervascular hepatocellular carcinoma (HCC). Thirty-five patients were ...

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Reference values for quantitative left ventricular and left atrial measurements in cardiac computed

May 1st, 2008
Reference values for quantitative left ventricular and left atrial measurements in cardiac computed tomography. To assess reference values for left ventricular (LV) and left atrial (LA) dimensions, global LV function, and LV-myocardial mass for cardiac CT. We examined 120 subjects undergoing a coronary angiography using 64-slice ...

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Nonmalignant papillary lesions of the breast at US-guided directional vacuum-assisted removal: a pre

May 1st, 2008
Nonmalignant papillary lesions of the breast at US-guided directional vacuum-assisted removal: a preliminary report. This study was conducted to assess the accuracy of US-guided directional vacuum-assisted removal (US-DVAR) in evaluating nonmalignant papillary breast lesions. This retrospective study was approved by the institutional review board at our ...

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Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and

May 1st, 2008
Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology. Diffusion-weighted magnetic resonance imaging (DWI) provides functional information and can be used for the detection and characterization of pathologic processes, including malignant tumors. The recently introduced concept of \"diffusion-weighted whole-body imaging ...

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In vivo Gd-DTPA concentration for MR lung perfusion measurements: Assessment with computed tomograph

May 1st, 2008
In vivo Gd-DTPA concentration for MR lung perfusion measurements: Assessment with computed tomography in a porcine model. A linear relationship between MR signal and contrast-agent concentration (CAC) of the arterial-input function (AIF) is crucial for MR lung-perfusion quantification. The aim was to determine the in-vivo real ...

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Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle qua

May 1st, 2008
Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle quantitative measurements, inter- and intra-observer agreement. Our purpose was to determine the repeatability of squamous cell cancer in head and neck (SCCHN) and muscle tissue vascularity measurements as well as ...

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Cutaneous application of local anaesthetic-a useful help in galactography.

May 1st, 2008
Cutaneous application of local anaesthetic-a useful help in galactography. Galactography is an important step in the diagnostic workup of abnormal nipple discharge. At times it is impossible to insert the cannula in the secreting duct and galactography cannot be performed. In such cases we tried applying ...

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Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid art

May 1st, 2008
Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis. The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual ...

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Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced

May 1st, 2008
Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced solid tumors who have failed standard therapy. PURPOSE: To establish the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), safety and recommended Phase II dose of ixabepilone, administered weekly as an intravenous ...

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