Medical and Biomedical Researches

Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vi

May 1st, 2008
Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation. The purpose of this study was to prepare lipospheres containing aceclofenac intended for topical skin delivery with the aim of exploiting the favorable properties of this carrier system and developing a sustained ...

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Amorphization Alone Does Not Account for the Enhancement of Solubility of Drug Co-ground with Silica

May 1st, 2008
Amorphization Alone Does Not Account for the Enhancement of Solubility of Drug Co-ground with Silicate: The Case of Indomethacin. The solubility advantage of indomethacin amorphized by co-grinding with Neusilin US2 in various media was investigated. Physical mixtures of gamma-indomethacin and Neusilin US2 (in the ratios 1:1, ...

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Design and evaluation of microemulsions for improved parenteral delivery of propofol.

May 1st, 2008
Design and evaluation of microemulsions for improved parenteral delivery of propofol. The objective of this investigation was to evaluate the potential of the microemulsions to improve the parenteral delivery of propofol. Pseudo-ternary phase diagrams were plotted to identify microemulsification region of propofol. The propofol microemulsions were ...

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Preparation, characterization and evaluation of marsupsin-phospholipid complex.

May 1st, 2008
Preparation, characterization and evaluation of marsupsin-phospholipid complex. The aim of this research was to formulate Marsupsin-phospholipid complex (M-P Complex) in attempt to increase the bioavailability of marsupsin and to characterize this new formulation along with its evaluation. Marsupsin-phospholipid complex was formulated by mechanical dispersion method. In ...

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Formulation and evaluation of microemulsion based delivery system for amphotericin B.

May 1st, 2008
Formulation and evaluation of microemulsion based delivery system for amphotericin B. The present studies were designed to develop a formulation of amphotericin B in a lipid-based preparation as a microemulsion and to compare its toxicity with the commercial formulation Fungizone(R). The final product developed is a ...

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Estimating the Number of Droplets and Drug Particles Emitted from MDIs.

May 1st, 2008
Estimating the Number of Droplets and Drug Particles Emitted from MDIs. The objective of this paper is to assess the number of drug particles or droplets contained in metered dose inhaler (MDI) aerosols. Equations were developed to estimate this. The number of drug particles was estimated ...

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Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers.

May 1st, 2008
Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers. The purpose of the present study was to investigate the potential use of two PEGylated derivatives of rosin (PD) as sustained release film forming materials. The derivatives differed chemically by their acid numbers-PD-1 with 120.93 ...

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Modified polysaccharides as fast disintegrating excipients for orodispersible tablets of roxithromyc

May 1st, 2008
Modified polysaccharides as fast disintegrating excipients for orodispersible tablets of roxithromycin. The purpose of this study was to develop a dosage form that was easy to administer and provides rapid release of the drug roxithromycin, using modified polysaccharides as rapidly disintegrating excipients. Modified polysaccharides co grinded ...

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Effect of Eudragit((R)) RS 30D and Talc Powder on Verapamil Hydrochloride Release from Beads Coated

May 1st, 2008
Effect of Eudragit((R)) RS 30D and Talc Powder on Verapamil Hydrochloride Release from Beads Coated with Drug Layered Matrices. The aim of this study was to investigate the effect of Eudragit(R) RS 30D, talc, and verapamil hydrochloride on dissolution and mechanical properties of beads coated with ...

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Development and characterization of pectinate micro/nanoparticles for gene delivery.

May 1st, 2008
Development and characterization of pectinate micro/nanoparticles for gene delivery. The aim of this study was to investigate the possibility of using pectinate micro/nanoparticles as gene delivery systems. Pectinate micro/nanoparticles were produced by ionotropic gelation. Various factors were studied for their effects on the preparation of pectinate ...

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Optimization studies on design and evaluation of orodispersible pediatric formulation of indomethaci

May 1st, 2008
Optimization studies on design and evaluation of orodispersible pediatric formulation of indomethacin. In the present study, the aim was to optimize an orodispersible formulation of indomethacin using a combined approach of subliming agent and superdisintegrant. The tablets were made by non-aqueous wet granulation technique with superdisintegrant ...

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Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet

May 1st, 2008
Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique. The purpose of this research was to obtain directly compressible agglomerates of naproxen containing disintegrant by spherical crystallization technique. Acetone-water containing hydroxypropyl celloluse (HPC) and disintegrant was used as ...

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Development of spray dried liposomal dry powder inhaler of dapsone.

May 1st, 2008
Development of spray dried liposomal dry powder inhaler of dapsone. This investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated Dapsone (DS) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of Pneumocystis carinii ...

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Study of the RESS Process for Producing Beclomethasone-17,21-Dipropionate Particles Suitable for Pul

May 1st, 2008
Study of the RESS Process for Producing Beclomethasone-17,21-Dipropionate Particles Suitable for Pulmonary Delivery. The purpose of this research was to micronize beclomethasone-17,21-dipropionate (BDP), an anti-inflammatory inhaled corticosteroid commonly used to treat asthma, using the rapid expansion of supercritical solution (RESS) technique. The RESS technique was chosen ...

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Granulation by roller compaction and enteric coated tablet formulation of the extract of the seeds o

May 1st, 2008
Granulation by roller compaction and enteric coated tablet formulation of the extract of the seeds of glinus lotoides loaded on aeroperl(r) 300 pharma. The purpose of this research was to improve the hygrpscopicity and poor flow properties of the crude dry extract of the seeds of ...

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Selected Physical and Chemical Properties of Feverfew (Tanacetum parthenium) Extracts Important for

May 1st, 2008
Selected Physical and Chemical Properties of Feverfew (Tanacetum parthenium) Extracts Important for Formulated Product Quality and Performance. The objectives of this research are: (1) to assess selected formulation-relevant physical properties of several commercial Feverfew extracts, including flowability, hygroscopicity, compressibility and compactibility (2) to develop and validate ...

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Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus.

May 1st, 2008
Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus. The objective of present investigation was to formulate self-microemulsifying drug delivery systems (SMEDDS) of tacrolimus (FK 506), a poorly water soluble immunosuppressant that exhibits low and erratic bioavailability. Solubility of FK 506 in various oils, ...

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Effect of drying methods on swelling, erosion and drug release from chitosan-naproxen sodium complex

May 1st, 2008
Effect of drying methods on swelling, erosion and drug release from chitosan-naproxen sodium complexes. The purpose of this research was to explore theapplication of ionic interactions between naproxen sodium (NS) and chitosan (CH) in complexes (NSC) prepared by tray drying (TD) and spray drying (SD) methods. ...

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Genes related to chromate resistance by Pseudomonas aeruginosa PAO1.

May 1st, 2008
Genes related to chromate resistance by Pseudomonas aeruginosa PAO1. Chromate-hypersensitive mutants of the Pseudomonas aeruginosa PAO1 strain were isolated using transposon-insertion mutagenesis. Comparison of the nucleotide sequences of the regions interrupted in the mutants with the PAO1 genome revealed that the genes affected in three mutant ...

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Resistin is expressed in human hepatocytes and induces insulin resistance.

May 1st, 2008
Resistin is expressed in human hepatocytes and induces insulin resistance. Resistin, known as an adipocyte-specific secretory factor (ADSF), is implicated to modulate insulin resistance in rodents. However, the precise role of this factor for human insulin resistance has remained elusive. Here, we investigate the relationship between ...

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Signaling for Vesicle Mobilization and Synaptic Plasticity.

May 1st, 2008
Signaling for Vesicle Mobilization and Synaptic Plasticity. The hypothesis that release of classical neurotransmitters and neuropeptides is facilitated by increasing the mobility of small synaptic vesicles (SSVs) and dense core vesicles (DCVs) could not be tested until the advent of methods for visualizing these secretory vesicles ...

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Metastatic Small Cell Carcinoma to the Thyroid Gland: a Pathologic and Molecular Study Demonstrating

May 1st, 2008
Metastatic Small Cell Carcinoma to the Thyroid Gland: a Pathologic and Molecular Study Demonstrating the Origin in the Urinary Bladder. Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the ...

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True Adrenal Mesothelial Cyst in a Patient with Flank Pain and Hematuria : A Case Report.

May 1st, 2008
True Adrenal Mesothelial Cyst in a Patient with Flank Pain and Hematuria : A Case Report. True mesothelial (epithelial) cysts in the adrenal gland are rare lesions. They represent 9% of adrenal cysts and are much less common than vascular adrenal cysts. We report a case ...

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Lysergic Acid Amide-Induced Posterior Reversible Encephalopathy Syndrome with Status Epilepticus.

May 1st, 2008
Lysergic Acid Amide-Induced Posterior Reversible Encephalopathy Syndrome with Status Epilepticus. INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is known to occur in association with several substances. However, lysergic acid amide (LSA) is not among the previously reported causes of PRES. METHODS: We report on a patient with ...

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Cardiac-Targeted Transgenic Mutant Mitochondrial Enzymes: mtDNA Defects, Antiretroviral Toxicity and

May 1st, 2008
Cardiac-Targeted Transgenic Mutant Mitochondrial Enzymes: mtDNA Defects, Antiretroviral Toxicity and Cardiomyopathy. Mitochondrial (mt) DNA biogenesis is critical to cardiac contractility. DNA polymerase gamma (Pol gamma) replicates mtDNA, whereas thymidine kinase 2 (TK2) monophosphorylates pyrimidines intramitochondrially. Point mutations in POLG and TK2 result in clinical diseases associated ...

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