Medical and Biomedical Researches

Non-genomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in ch

June 29th, 2008
Non-genomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in chromaffin cells. Adrenal medulla chromaffin cells are neuroendocrine and modified sympathetic ganglion cells. Catecholamines released from chromaffin cells mediate the \"fight-or-flight\" response, or alert reaction against dangerous conditions. Here we report that short-term treatment with glucocorticoids, ...

Posted in researches 5 | No Comments »

Molecular and morphological changes in placenta and embryo development associated to the inhibition

June 29th, 2008
Molecular and morphological changes in placenta and embryo development associated to the inhibition of polyamine synthesis during midpregnancy in mice. Polyamines play an essential role in murine development, as demonstrated by both gene ablation in ornithine decarboxylase (ODC)-deficient embryos and pharmacological treatments of pregnant mice. However, ...

Posted in researches 5 | No Comments »

Age affects spontaneous activity and depolarizing afterpotentials in isolated gonadotropin releasing

June 29th, 2008
Age affects spontaneous activity and depolarizing afterpotentials in isolated gonadotropin releasing hormone neurons. Neuronal activity underlying the pulsatile secretion of gonadotropin releasing hormone (GnRH) remains poorly understood, as does the endogenous generation of such activity. It is clear that changes at the level of the hypothalamus ...

Posted in researches 5 | No Comments »

ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in anti-h

June 29th, 2008
ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in anti-hormone resistant breast cancer cells. Anti-oestrogens such as Tamoxifen are the mainstay of treatment for oestrogen receptor positive breast cancer. However, their effectiveness is limited by the development of endocrine resistance, allowing tumour re-growth and ...

Posted in researches 5 | No Comments »

Leptin Acts in the Periphery to Protect Thymocytes from Glucocorticoid-mediated Apoptosis in the Abs

June 29th, 2008
Leptin Acts in the Periphery to Protect Thymocytes from Glucocorticoid-mediated Apoptosis in the Absence of Weight Loss. Leptin is a member of the IL-6 cytokine family and is primarily produced by adipose tissue. At high enough concentration, leptin engages leptin receptors expressed in the hypothalamus that ...

Posted in researches 5 | No Comments »

Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial

June 29th, 2008
Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers. We studied gene expression profiles in two mouse models of human thyroid carcinoma: the Tg-RET/PTC3 (RP3) and Tg-E7 mice. RP3 fusion gene ...

Posted in researches 5 | No Comments »

Rosiglitazone Treatment Reduces Diabetic Neuropathy in STZ Treated DBA/2J Mice.

June 29th, 2008
Rosiglitazone Treatment Reduces Diabetic Neuropathy in STZ Treated DBA/2J Mice. Diabetic Neuropathy (DN) is a common complication of diabetes. Currently, there is no drug treatment to prevent or slow the development of DN. Rosiglitazone (Rosi) is a potent insulin sensitizer and may also slow the development ...

Posted in researches 5 | No Comments »

Modulation of caveolin-1 expression can effect signalling through the PI-3K/Akt pathway and cellular

June 29th, 2008
Modulation of caveolin-1 expression can effect signalling through the PI-3K/Akt pathway and cellular proliferation in response to IGF-I. The insulin-like growth factors (IGFs) mediate their effects on cell function through the type 1 IGF receptor (IGFIR) and numerous intracellular signalling molecules including the PI-3K/Akt pathway. The ...

Posted in researches 5 | No Comments »

Unique Form and Osmoregulatory Function of a Neurohypophysial Hormone in a Urochordate.

June 29th, 2008
Unique Form and Osmoregulatory Function of a Neurohypophysial Hormone in a Urochordate. The cyclic nonapeptides, oxytocin and vasopressin, are neurohypophysial hormones that regulate many significant physiological processes related especially to reproduction and osmoregulation. In this study, we characterized an oxytocin-related peptide cDNA from a urochordate, Styela ...

Posted in researches 5 | No Comments »

MR Imaging Findings in Hepatic Encephalopathy.

June 29th, 2008
MR Imaging Findings in Hepatic Encephalopathy. SUMMARY: The term hepatic encephalopathy (HE) includes a spectrum of neuropsychiatric abnormalities occurring in patients with liver dysfunction. Most cases are associated with cirrhosis and portal hypertension or portal-systemic shunts, but the condition can also be seen in patients with ...

Posted in researches 5 | No Comments »

LEO Stent Monotherapy for the Endovascular Reconstruction of Fusiform Aneurysms of the Middle Cerebr

June 29th, 2008
LEO Stent Monotherapy for the Endovascular Reconstruction of Fusiform Aneurysms of the Middle Cerebral Artery. SUMMARY: We present the case of a patient with a fusiform aneurysm of the M1 segment of the middle cerebral artery (MCA) in which endovascular stent placement without coiling was performed. ...

Posted in researches 5 | No Comments »

Emergent Image-Guided Treatment of a Large CSF Leak to Reverse “In-Extremis” Signs of Intracranial

June 29th, 2008
Emergent Image-Guided Treatment of a Large CSF Leak to Reverse \"In-Extremis\" Signs of Intracranial Hypotension. SUMMARY: We report the use of an emergent, targeted fibrin spinal epidural blood patch with subarachnoid saline infusion to rapidly reverse \"in-extremis\" clinical and imaging signs of posterior-fossa coning brought about ...

Posted in researches 5 | No Comments »

Systematic Review of CT and MR Perfusion Imaging for Assessment of Acute Cerebrovascular Disease.

June 29th, 2008
Systematic Review of CT and MR Perfusion Imaging for Assessment of Acute Cerebrovascular Disease. BACKGROUND AND PURPOSE: Perfusion imaging sequences are an important part of imaging studies designed to provide information to guide therapy for treatment of cerebrovascular disease. The purpose of this study was to ...

Posted in researches 5 | No Comments »

Differentiation Between Classic and Atypical Meningiomas with Use of Diffusion Tensor Imaging.

June 29th, 2008
Differentiation Between Classic and Atypical Meningiomas with Use of Diffusion Tensor Imaging. BACKGROUND AND PURPOSE: The differentiation between classic and atypical meningiomas may have implications in preoperative planning but may not be possible on the basis of conventional MR imaging. Our hypothesis was that classic and ...

Posted in researches 5 | No Comments »

Brain Single-Photon Emission Computed Tomography Physics Principles.

June 29th, 2008
Brain Single-Photon Emission Computed Tomography Physics Principles. SUMMARY: The basic principles of scintigraphy are reviewed and extended to 3D imaging. Single-photon emission computed tomography (SPECT) is a sensitive and specific 3D technique to monitor in vivo functional processes in both clinical and preclinical studies. SPECT/CT systems ...

Posted in researches 5 | No Comments »

Stability of Intracranial Aneurysms Adequately Occluded 6 Months after Coiling: A 3T MR Angiography

June 29th, 2008
Stability of Intracranial Aneurysms Adequately Occluded 6 Months after Coiling: A 3T MR Angiography Multicenter Long-Term Follow-Up Study. BACKGROUND AND PURPOSE: The long-term fate of coiled intracranial aneurysms is largely unknown, and prolonged imaging follow-up has been advocated. The yield of follow-up imaging in coiled aneurysms ...

Posted in researches 5 | No Comments »

Histogram Analysis of MR Imaging-Derived Cerebral Blood Volume Maps: Combined Glioma Grading and Ide

June 29th, 2008
Histogram Analysis of MR Imaging-Derived Cerebral Blood Volume Maps: Combined Glioma Grading and Identification of Low-Grade Oligodendroglial Subtypes. BACKGROUND AND PURPOSE: Inclusion of oligodendroglial tumors may confound the utility of MR based glioma grading. Our aim was, first, to assess retrospectively whether a histogram-analysis method of ...

Posted in researches 5 | No Comments »

Susceptibility-Weighted Imaging Findings of Cortical Laminar Necrosis in Pediatric Patients.

June 29th, 2008
Susceptibility-Weighted Imaging Findings of Cortical Laminar Necrosis in Pediatric Patients. BACKGROUND AND PURPOSE: MR susceptibility-weighted imaging (SWI) is a highly sensitive technique for detection of hemorrhage, but its utility in the evaluation of children with laminar necrosis is not yet known. We assessed whether cortical laminar ...

Posted in researches 5 | No Comments »

Pain Relief Following Vertebroplasty in Patients with and without Localizing Tenderness on Palpation

June 29th, 2008
Pain Relief Following Vertebroplasty in Patients with and without Localizing Tenderness on Palpation. BACKGROUND AND PURPOSE: Focal point tenderness over the fractured level is believed to be a necessary criterion for performing vertebroplasty. The purpose of this study was to explore whether the presence of focal-point ...

Posted in researches 5 | No Comments »

Assessment of Dural Arteriovenous Fistulas of the Cavernous Sinuses on 3D Dynamic MR Angiography.

June 29th, 2008
Assessment of Dural Arteriovenous Fistulas of the Cavernous Sinuses on 3D Dynamic MR Angiography. BACKGROUND AND PURPOSE: Flow voids within the cavernous sinuses and/or certain venous drainage on spin-echo MR imaging and time-of-flight (TOF) flow enhancement on MR angiography (MRA) have indicated high-velocity shunt flow and ...

Posted in researches 5 | No Comments »

The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determi

June 29th, 2008
The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. Serum calcium and phosphate concentrations and experimental chronic kidney failure control parathyroid hormone (PTH) gene expression post-transcriptionally through regulated binding of the trans-acting proteins AUF1 and upstream of N-ras (Unr) to ...

Posted in researches 5 | No Comments »

Is a two-week steroid trial after initial negative workup for malignancy useful in differentiating a

June 29th, 2008
Is a two-week steroid trial after initial negative workup for malignancy useful in differentiating autoimmune pancreatitis from pancreatic cancer? : A prospective outcome study. BACKGROUND: Autoimmune pancreatitis (AIP) is a peculiar type of chronic pancreatitis that responds dramatically to steroid therapy. To date, there are no ...

Posted in researches 5 | No Comments »

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC{alpha}-/PKA-dependent

June 29th, 2008
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC{alpha}-/PKA-dependent mechanism in rat liver. OBJECTIVE: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by PKC-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCalpha agonist. We tested whether PKA might contribute to the anticholestatic action of TUDCA via ...

Posted in researches 5 | No Comments »

Budd-Chiari Syndrome and Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome.

June 29th, 2008
Budd-Chiari Syndrome and Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome. Budd-Chiari syndrome (BCS) . Many patients with BCS harbour several prothrombotic disorders. . Liver disease blurs the diagnostic features of most prothrombotic disorders. . Myeloproliferative disease account for 50% of BCS patients. Their recognition largely relies on the assessment ...

Posted in researches 5 | No Comments »

Left ventricular strain and strain rate in a general population.

June 29th, 2008
Left ventricular strain and strain rate in a general population. Aims Strain and strain rate (SR) are measures of deformation that reflect left ventricular (LV) function. To our knowledge, no previous study described these indexes in a general population. We therefore described peak-systolic strain and SR ...

Posted in researches 5 | No Comments »