Medical and Biomedical Researches

Parental stress and childhood wheeze in a prospective cohort study.

May 1st, 2008
Parental stress and childhood wheeze in a prospective cohort study. Background. Although studies indicate that psychological stress is linked with asthma morbidity, it is unknown whether stress is associated with the incidence of asthma symptoms. Method. In a cohort of 5-to 6-year-old school children participating in ...

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Characterizing community-based asthma knowledge in chicago and its high risk neighborhoods.

May 1st, 2008
Characterizing community-based asthma knowledge in chicago and its high risk neighborhoods. The goal of this study was to characterize asthma knowledge in high risk neighborhoods compared to a random sample of residents in the Chicago area. The Chicago Community Asthma Survey-32 (CCAS-32) was administered to 1006 ...

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Birth-related exposures and asthma and allergy in adulthood: a population-based cross-sectional stud

May 1st, 2008
Birth-related exposures and asthma and allergy in adulthood: a population-based cross-sectional study of young adults in north staffordshire. The rise in the prevalence of asthma and other allergic disorders over the past two decades has been well documented, yet this increase has still to be fully ...

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Early respiratory infections and asthma among new york city head start children.

May 1st, 2008
Early respiratory infections and asthma among new york city head start children. Background. Respiratory infections in neonates have been found to predict wheeze among young children. We hypothesized that among preschool children from low-income minority communities in New York City, current asthma would be associated with ...

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Costs and resource use of mild persistent asthma patients initiated on controller therapy.

May 1st, 2008
Costs and resource use of mild persistent asthma patients initiated on controller therapy. Background. The treatment of mild persistent asthma is controversial. Objectives. A retrospective database approach was used to evaluate different alternatives to treating mild persistent asthma. We hypothesized that treatment with inhaled corticosteroids (ICS) ...

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Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis.

May 1st, 2008
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. We sought a genotype-phenotype association: between single-nucleotide polymorphisms (SNPs) in olfactory receptor (OR) genes from the two largest OR gene clusters and odor-triggered nonallergic vasomotor rhinitis (nVMR). In the initial pedigree screen, using transmission disequilibrium test (TDT) analysis, ...

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Improving Care for Urban Children with Asthma: Design and Methods of the School-Based Asthma Therapy

May 1st, 2008
Improving Care for Urban Children with Asthma: Design and Methods of the School-Based Asthma Therapy (SBAT) Trial. The School Based Asthma Therapy (SBAT) trial builds on a pilot study in which we found that school-based administration of preventive asthma medications for inner-city children reduced asthma symptoms. ...

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Normal Variation of Bronchial Reactivity in Nonasthmatics is Associated with the Level of Mite-Speci

May 1st, 2008
Normal Variation of Bronchial Reactivity in Nonasthmatics is Associated with the Level of Mite-Specific IgE. Objective. To investigate association between non-specific bronchial reactivity (NBR) and level of mite specific IgE amongst mite-sensitized non-asthmatic subjects. Methods. Subjects attending occupational check-up were assessed for: respiratory symptoms, atopic status ...

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Early Bronchodilatory Effects of Budesonide/Formoterol pMDI Compared with Fluticasone/Salmeterol DPI

May 1st, 2008
Early Bronchodilatory Effects of Budesonide/Formoterol pMDI Compared with Fluticasone/Salmeterol DPI and Albuterol pMDI: 2 Randomized Controlled Trials in Adults with Persistent Asthma Previously Treated with Inhaled Corticosteroids. Two identically designed, randomized, multicenter, single-dose, crossover studies were conducted in patients aged >/=18 years with mild to moderate ...

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Asthma genetics: personalizing medicine.

May 1st, 2008
Asthma genetics: personalizing medicine. Asthma is a chronic inflammatory lung disease that leads to significant morbidity, mortality, and economic burden. The clinical symptoms, which are a result of airway inflammation and reversible airway obstruction, have led to the mainstay of therapies for asthma: anti-inflammatory medications and ...

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Early maternal separation and chronic variable stress as adults differentially affect fos expression

May 1st, 2008
Early maternal separation and chronic variable stress as adults differentially affect fos expression in the anterodorsal thalami nuclei. The present study examined the participation of the anterodorsal thalamic nuclei (ADTN) in mediating the long-term effects of early maternal separation on the stress/hypothalamic-pituitary-adrenal axis response of adult ...

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Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites.

May 1st, 2008
Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites. Results from several studies have shown that a series of chemically distinct insecticide compounds (picrotoxin, BIDN, TBPS, fipronil, lindane, EBOB, and alpha-endosulfan) affect GABA(A) receptor function. In this investigation, docking of this set of insecticides ...

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Effects of nestin-antisense treatment in mice on memory-related performance.

May 1st, 2008
Effects of nestin-antisense treatment in mice on memory-related performance. Nestin is a neuronal stem cell marker. It has been reported that newly generated adult neurons play a role in murine memory. The purpose of this study was to determine whether nestin itself plays a role in ...

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Reduced Energy Utilization in the Brain is a Feature of an Animal Model of Fatigue.

May 1st, 2008
Reduced Energy Utilization in the Brain is a Feature of an Animal Model of Fatigue. Recently, the authors established an animal model of fatigue. The fatigued animals showed reduced 2-[(18)F]fluoro-2-deoxy-D-glucose uptake in their brain, although their blood glucose level did not differ from that of the ...

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The effects of antidepressants in Parkinson’s disease: a meta-analysis.

May 1st, 2008
The effects of antidepressants in Parkinson\'s disease: a meta-analysis. This study explored the therapeutic effect of antidepressants in Parkinson\'s disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin ...

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Near-infrared spectroscopy study of language activated hyper- and hypo-oxygenation in human prefront

May 1st, 2008
Near-infrared spectroscopy study of language activated hyper- and hypo-oxygenation in human prefrontal cortex. Oxygenation changes in the left prefrontal cortex during language processing were assessed with near-infrared spectroscopy (NIRS). Oxyhemoglobin and deoxyhemoglobin concentrations at the Fp1 site during 5 min of resting with eyes closed (control), ...

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Increased Tunel Positive Cells in CA1, CA2, and CA3 Subfields of Rat Hippocampus Due to Copper and E

May 1st, 2008
Increased Tunel Positive Cells in CA1, CA2, and CA3 Subfields of Rat Hippocampus Due to Copper and Ethanol Co-Exposure. Copper (Cu) is an essential element for life. However, it is toxic at excessive doses, whereas exposure to ethanol (EtOH) has known to cause morphological changes, degeneration, ...

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Angiotensinogen gene polymorphism predicts hypertension, and iridological constitutional classificat

May 1st, 2008
Angiotensinogen gene polymorphism predicts hypertension, and iridological constitutional classification enhances the risk for hypertension in koreans. This study investigated the relationship between iridological constitution and angiotensinogen (AGN) gene polymorphism in hypertensives. In addition to angiotensin converting enzyme gene, AGN genotype is also one of the most ...

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Spontaneous incomplete recovery of peroneal palsy after a sealbite.

May 1st, 2008
Spontaneous incomplete recovery of peroneal palsy after a sealbite. Incomplete recovery of peroneal palsy, after a sealbite during swimming has not been reported. A 58-year-old woman was bitten into the right knee by a seal during swimming, resulting in incomplete division of the right profound branch ...

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Bilateral and Unilateral Hippocampal Inactivation Did not Differ in their Effect on Consolidation Pr

May 1st, 2008
Bilateral and Unilateral Hippocampal Inactivation Did not Differ in their Effect on Consolidation Processes in the Morris Water Maze. Consolidation processes were studied in the rat by using functional inactivation techniques. Previous results showed that unilateral hippocampal inactivation alters consolidation. It is not clear if bilateral ...

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Analysis of altered mental status in Turkey.

May 1st, 2008
Analysis of altered mental status in Turkey. The aim of this study was to determine the frequency and etiology of altered mental status in adults at an Emergency Department. Medical records of 790 patients with altered mental status were reviewed. Out of 790 patients, 414 (52.3%) ...

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Grammaticality judgements in adolescents with and without language impairment.

May 1st, 2008
Grammaticality judgements in adolescents with and without language impairment. Background: Existing evidence suggests that young children with specific language impairment have unusual difficulty in detecting omissions of obligatory tense-marking morphemes, but little is known about adolescents\' sensitivity to such violations. Aims: The study investigated whether limitations ...

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Investigating factors related to the effects of time-out on stuttering in adults.

May 1st, 2008
Investigating factors related to the effects of time-out on stuttering in adults. Background: Response-contingent time-out has been shown to be an effective technique for enhancing fluency in people who stutter. However, the factors that determine individual responsiveness to time-out are not well understood. Aims: The study ...

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Economic aspects of a therapy and support service for people with long-term stroke and aphasia.

May 1st, 2008
Economic aspects of a therapy and support service for people with long-term stroke and aphasia. Backgound: This paper considers some economic aspects of a therapy and support service for people with stroke and aphasia. This material was part of a broader evaluation of the service, which ...

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Development of Controlled Release Sildenafil Formulations for Vaginal Administration.

May 1st, 2008
Development of Controlled Release Sildenafil Formulations for Vaginal Administration. Sildenafil is an active substance that has already been approved by FDA for human use. It is known to be an active compound for the treatment of sexual dysfunction in men. Some encouraging results have been published ...

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