Medical and Biomedical Researches

Sarcoma and look-alikes: the important role of ultrastructural evaluation.

May 1st, 2008
Sarcoma and look-alikes: the important role of ultrastructural evaluation. Due to the variable light microscopic appearance of sarcomas, a large number of neoplasms may need to be considered in the differential diagnosis in some situations. In difficult cases, the surgical pathologist must approach the differential diagnosis ...

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Molecular profiling in the diagnosis and treatment of high grade sarcomas.

May 1st, 2008
Molecular profiling in the diagnosis and treatment of high grade sarcomas. High-density microarrays are used to measure in a comprehensive manner large-scale (\"profile\") gene expression patterns (when tumor RNA is tested) or gene copy number changes (when tumor genomic DNA is tested). Microarray-based studies are increasingly ...

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Complete hydatidiform mole with co-existing healthy fetus: A case report.

May 1st, 2008
Complete hydatidiform mole with co-existing healthy fetus: A case report. A twin pregnancy is described consisting of a complete hydatiform mole (CHM) with coexisting healthy fetus. Pregnancy occurred after IVF-ICSI. The couple wished to continue the pregnancy and a decision to accept was taken after having ...

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The incidence of birth trauma among live born term neonates at a referral hospital in Rafsanjan, Ira

May 1st, 2008
The incidence of birth trauma among live born term neonates at a referral hospital in Rafsanjan, Iran. Background. Some special problems of neonates are related to the adverse effects of delivery such as birth trauma with high mortality and morbidity. The aim of this study was ...

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Idiopathic bleeding during the second half of pregnancy as a risk factor for adverse perinatal outco

May 1st, 2008
Idiopathic bleeding during the second half of pregnancy as a risk factor for adverse perinatal outcome. Objective. To investigate pregnancy outcome in women suffering from idiopathic vaginal bleeding (IVB) during the second half of pregnancy. Methods. A comparison between patients admitted to the hospital due to ...

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Comparative study on the outcome of obstetric cholestasis.

May 1st, 2008
Comparative study on the outcome of obstetric cholestasis. Objectives. The aim of this study was to determine the characteristics and outcomes of obstetric cholestasis (OC) and the significance of measuring total bile acid (TBA) to aid diagnosis. Methods. This study was conducted over a 27-month period ...

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Screening for postpartum depression with the Edinburgh Postnatal Depression Scale in an indigent pop

May 1st, 2008
Screening for postpartum depression with the Edinburgh Postnatal Depression Scale in an indigent population: Does a directed interview improve detection rates compared with the standard self-completed questionnaire? Background. The Edinburgh Postnatal Depression Scale (EPDS) is a well-validated screening tool for the detection of patients at risk ...

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Obstetric outcomes with a false-positive one-hour glucose challenge test by the Carpenter-Coustan cr

May 1st, 2008
Obstetric outcomes with a false-positive one-hour glucose challenge test by the Carpenter-Coustan criteria. Objective. Pregnancies complicated by a false-positive one-hour glucose challenge test (GCT), as determined by the National Diabetes Data Group (NDDG) criteria, have higher rates of adverse maternal and neonatal outcomes. This study was ...

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A comparison of lispro and regular insulin for the management of type 1 and type 2 diabetes in pregn

May 1st, 2008
A comparison of lispro and regular insulin for the management of type 1 and type 2 diabetes in pregnancy. Objective. To describe perinatal outcomes of women with pregestational diabetes treated with short-acting, regular insulin and the short-acting insulin analogue, lispro. Study design. This was a prospective ...

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Comparison of three neonatal pain scales during minor painful procedures.

May 1st, 2008
Comparison of three neonatal pain scales during minor painful procedures. Objective. There is no single or widely accepted method to define pain in neonates. The aim of this study was to compare three different neonatal pain scales in the estimation of the pain response to minor ...

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The role of continuous fetal monitoring in the management of preterm premature rupture of membranes.

May 1st, 2008
The role of continuous fetal monitoring in the management of preterm premature rupture of membranes. Objective. Continuous fetal monitoring (CFM) is often used in the management of preterm premature rupture of membranes (PPROM) but there is little evidence to support this approach. The objective of this ...

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Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of pret

May 1st, 2008
Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery. Objective. The objective of this study was to investigate the level of insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions and Bishop score as predictors of preterm delivery in asymptomatic pregnant women. ...

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Recurrence of preterm birth in twin pregnancies in the presence of a prior singleton preterm birth.

May 1st, 2008
Recurrence of preterm birth in twin pregnancies in the presence of a prior singleton preterm birth. Objective. We examined recurrence of preterm birth in twin pregnancy in the presence of a previous singleton preterm pregnancy, and assessed if these recurrence risks differed for medically indicated and ...

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The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between th

May 1st, 2008
The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age. Introduction. An imbalance between angiogenic and anti-angiogenic factors has been proposed as central to the pathophysiology ...

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The KLAB Toolbox: A Suite of In-house Software Applications for Epigenetic Analysis.

May 1st, 2008
The KLAB Toolbox: A Suite of In-house Software Applications for Epigenetic Analysis. Systems biology presents a new paradigm for elucidating the processes required to organize and sustain life. We now have access to whole genome sequences, gene expression data for multiple cell types, and databases for ...

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Evaluation of effects of methamphetamine repeated dosing on proliferation and apoptosis of rat germ

May 1st, 2008
Evaluation of effects of methamphetamine repeated dosing on proliferation and apoptosis of rat germ cells. Methamphetamine (MAMP) is a central nervous system stimulant that is increasingly abused especially by teenagers and young adults, a group in its reproductive age. MAMP effects on the male reproductive system ...

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Lipid peroxidation in human spermatozoa from men with genitourinary infections.

May 1st, 2008
Lipid peroxidation in human spermatozoa from men with genitourinary infections. A fluorescent assay was used to reveal the presence of lipid peroxidation (LPO) in spermatozoa from individuals with genitourinary infections (GI). The incidence of LPO was compared with sperm pathologies (apoptosis, immaturity, necrosis) evaluated by transmission ...

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Proteins involved in meiotic recombination: a role in male infertility?

May 1st, 2008
Proteins involved in meiotic recombination: a role in male infertility? Meiotic recombination results in the formation of crossovers, by which genetic information is exchanged between homologous chromosomes during prophase I of meiosis. Recombination is a complex process involving many proteins. Alterations in the genes involved in ...

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Partial and severe factor XI deficiency in South Australia and the usefulness of factor XI mutation

May 1st, 2008
Partial and severe factor XI deficiency in South Australia and the usefulness of factor XI mutation analysis for diagnosis. Aims: To correlate the presence or absence of a factor XI gene mutation with factor XI activity in patients with severe or partial reduction in factor XI. ...

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Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell.

May 1st, 2008
Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Aims: Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumour occurring almost exclusively in young adult males. Although histologically benign, it can be locally aggressive with a significant recurrence rate. The finding of activating beta-catenin gene mutations ...

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Clonal status of fibrous dysplasia.

May 1st, 2008
Clonal status of fibrous dysplasia. Aim: The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. Materials and methods: ...

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Peripheral vascular disease: who gets it and why? A histomorphological analysis of 261 arterial segm

May 1st, 2008
Peripheral vascular disease: who gets it and why? A histomorphological analysis of 261 arterial segments from 58 cases. Aims: This retrospective study aimed to document and illustrate the histomorphological changes underlying peripheral vascular disease (PVD). More specifically, it aimed to analyse and quantify those changes that ...

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Pathological findings in explanted prosthetic heart valves from ventricular assist devices.

May 1st, 2008
Pathological findings in explanted prosthetic heart valves from ventricular assist devices. Aims: Ventricular assist devices (VADs) are now a mainstay in the management of patients with end-stage heart failure. An important consideration in the long-term durability of these devices is the structural integrity of the prosthetic ...

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Histological characteristics of singleton placentas delivered before the 28th week of gestation.

May 1st, 2008
Histological characteristics of singleton placentas delivered before the 28th week of gestation. Aims: The placenta is a record of the fetal environment and its examination may provide information about the baby\'s subsequent growth and development. We describe the histological characteristics of 947 singleton placentas from infants ...

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Use of reticulin stain in the diagnosis of intra-uterine gestation.

May 1st, 2008
Use of reticulin stain in the diagnosis of intra-uterine gestation. Aims: The diagnosis of intra-uterine gestation may be problematic when specimens from clinically suspected products of conception lack chorionic villi and/or fetal somatic tissues, since the distinction of intermediate trophoblast from decidual or myometrial elements can ...

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