Medical and Biomedical Researches

Better understanding of ADPKD results in potential new treatment options: ready for the cure?

May 1st, 2008
Better understanding of ADPKD results in potential new treatment options: ready for the cure? Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary disorders. It accounts for 6% of the incidence of end-stage renal disease in Europe. Over the last decade, knowledge ...

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[Can telemedicine re-establish geographic equity in the treatment of acute stroke?]

May 1st, 2008
[Can telemedicine re-establish geographic equity in the treatment of acute stroke?] INTRODUCTION. In acute stroke patients, urgent expert neurologic evaluation and thrombolytic treatment within the first hours alter onset are the only proven effective therapeutic measures. Patients living far from large hospitals do not have access ...

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[Advances in the diagnosis and treatment of narcolepsy-cataplexy syndrome.]

May 1st, 2008
[Advances in the diagnosis and treatment of narcolepsy-cataplexy syndrome.] INTRODUCTION. Narcolepsy is a disabling sleep disorder that is characterised by excessive daytime sleepiness and abnormal manifestations in REM (rapid eye movement) sleep that include, among other symptoms, cataplexy (the sudden loss of muscle tone triggered by ...

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[Learning and implicit memory: mechanisms and neuroplasticity.]

May 1st, 2008
[Learning and implicit memory: mechanisms and neuroplasticity.] INTRODUCTION. Learning and memory are complex processes that researchers have been attempting to unravel for over a century in order to gain a clear view of the underlying mechanisms. AIMS. To review the basic cellular and molecular mechanisms involved ...

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[Idiopathic spinal epidural hematoma in patients with sudden paraplegia: a case report.]

May 1st, 2008
[Idiopathic spinal epidural hematoma in patients with sudden paraplegia: a case report.] INTRODUCTION. Spontaneous spinal epidural hematoma (SEH) represents 0.3-0.9% of spinal epidural space-occupying lesions, and most surgeons advocate aggressive and early surgical intervention. In this paper we describe a patient with SEH with sudden paraplegia. ...

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[Hyperammonaemic encephalopathy due to valproic acid.]

May 1st, 2008
[Hyperammonaemic encephalopathy due to valproic acid.] INTRODUCTION. One of the less frequent idiosyncratic side effects of valproic acid (VPA) is encephalopathy. Here we report one case. CASE REPORT. An 83-year-old female with no relevant past history, who received treatment with VPA following a post-traumatic subarachnoid haemorrhage ...

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[Neurofibromatosis type 1 and optic pathway gliomas. A series of 80 patients.]

May 1st, 2008
[Neurofibromatosis type 1 and optic pathway gliomas. A series of 80 patients.] PATIENTS AND METHODS. From a series of 530 patients with neurofibromatosis type 1 (NF1), we performed a retrospective assessment of the long-term neurologic, visual, neuroimaging and evolution of 80 patients (15%) with optic pathway ...

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[Abnormalities in the central nervous system and alterations in the upper limbs in patients with mye

May 1st, 2008
[Abnormalities in the central nervous system and alterations in the upper limbs in patients with myelomeningocele.] INTRODUCTION. Myelomeningocele is a neural tube defect resulting in motor and sensory deficit below the level of the lesion, bowel and neurogenic bladder, sexual dysfunction, cognitive dysfunction, neurodevelopment delay and ...

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[A comparative study of the effectiveness and tolerability of a procedure involving slow dose-escala

May 1st, 2008
[A comparative study of the effectiveness and tolerability of a procedure involving slow dose-escalation of rivastigmine in patients with mild or moderate Alzheimer-type dementia: the SCALEX study.] AIMS. To determine and to compare the tolerability and effectiveness of a slow escalation of the dose of rivastigmine ...

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[Characteristics of falls of neurological cause in the elderly.]

May 1st, 2008
[Characteristics of falls of neurological cause in the elderly.] INTRODUCTION. Falls are a cause of disability and death in geriatric population. Third part of the elderly suffer at least one fall per year. Neurological illness are a very important risk factor in developing falls. AIM. To ...

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Properties of the amniotic membrane for potential use in tissue engineering.

May 1st, 2008
Properties of the amniotic membrane for potential use in tissue engineering. An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue and provide an excellent environment for ...

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Circulating Pro- and Anti-inflammatory Cytokines in Polish Women with Gestational Diabetes.

May 1st, 2008
Circulating Pro- and Anti-inflammatory Cytokines in Polish Women with Gestational Diabetes. In this study we measured serum concentrations of proinflammatory interleukin-6, interleukin-8, and interleukin-18 as well as anti-inflammatory interleukin-10 in 30 pregnant women with normal glucose tolerance, in 32 women with abnormal results of a 50-g ...

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Adrenocortical Dysfunction in Obesity and the Metabolic Syndrome.

May 1st, 2008
Adrenocortical Dysfunction in Obesity and the Metabolic Syndrome. Recently, it has become evident that the adrenals play a key role in obesity as well as in the metabolic syndrome and their complications. On the one hand, adrenal steroids are involved in physiological regulation of adipose tissue ...

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The Vascular Pedicle of the Anterolateral Thigh Flap as an Alternative Recipient Site for Thigh Free

May 1st, 2008
The Vascular Pedicle of the Anterolateral Thigh Flap as an Alternative Recipient Site for Thigh Free Flaps. The indications for a free flap for thigh defects are relatively uncommon. Regardless, a reasonable recipient site will always be of paramount importance. The major femoral vessels, usually accessed ...

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A Single-Stage Reconstruction of a Complex Achilles Wound with Modified Free Composite Lateral Arm F

May 1st, 2008
A Single-Stage Reconstruction of a Complex Achilles Wound with Modified Free Composite Lateral Arm Flap. Composite defect of the posterior aspect of the heel, including the Achilles tendon, usually is very difficult to reconstruct as we face the problems of controlling infection, resurfacing the deficient skin ...

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Use of Flap Based on Anterior Tibial Artery for Free Transfer.

May 1st, 2008
Use of Flap Based on Anterior Tibial Artery for Free Transfer. Free flap transfer can be a challenge because of the risk of anastomotic failure, especially in microvascular tissue transfers. Free lateral crural flap based on the anterior tibial artery has good vascular condition that results ...

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[Treatment of adult men with congenital adrenal hyperplasia due to 21-hydroxylase deficiency]

May 1st, 2008
[Treatment of adult men with congenital adrenal hyperplasia due to 21-hydroxylase deficiency] Information about the treatment of males with congenital adrenal hyperplasia (CAH) is scarce and there are no therapeutical guidelines. The aim of this review is to provide a survey of the current data. An ...

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[Factitious disorder–fever and delayed wound healing]

May 1st, 2008
[Factitious disorder--fever and delayed wound healing] HISTORY AND ADMISSION FINDINGS: A 23-year-old woman was admitted to the department of rheumatology for detailed diagnostic tests for a suspected immune deficiency. Over the past 3 years, she has had repeated unexplained febrile episodes and impaired wound healing, which ...

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[Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in patients in long-term care in h

May 1st, 2008
[Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in patients in long-term care in hospitals, rehabilitation centers and nursing homes of a rural district in Germany] BACKGROUND: In recent years multi-resistant pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA) have been causing increasing problems in hospitals and nursing homes. In ...

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Resveratrol from Red Grapes - Pedestrian Polyphenol or Useful Anticancer Agent?

May 1st, 2008
Resveratrol from Red Grapes - Pedestrian Polyphenol or Useful Anticancer Agent? Resveratrol is a phytoalexin with cancer chemopreventive properties in preclinical models of carcinogenesis. The mechanisms via which resveratrol is thought to exert chemopreventive efficacy are inhibition of cyclooxygenase enzymes, inhibition of angiogenesis, modulation of drug ...

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Phytochemicals for Bacterial Resistance - Strengths, Weaknesses and Opportunities.

May 1st, 2008
Phytochemicals for Bacterial Resistance - Strengths, Weaknesses and Opportunities. This review covers some of the opportunities which currently exist to exploit plants for their natural products as templates for new antibacterial substances. This is a timely exercise given the continuing and developing problems of bacterial resistance, ...

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Radioprotective Effects of Gentianella austriaca Fractions and Polyphenolic Constituents in Human Ly

May 1st, 2008
Radioprotective Effects of Gentianella austriaca Fractions and Polyphenolic Constituents in Human Lymphocytes. The aim of this study was to identify active principles of GENTIANELLA AUSTRIACA responsible for the reduction of the incidence of micronuclei in irradiated lymphocytes IN VITRO. The radioprotective effects of ether (EF) and ...

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Constituents from Hoya parasitica and their Cell Growth Inhibitory Activity.

May 1st, 2008
Constituents from Hoya parasitica and their Cell Growth Inhibitory Activity. An androstanoid, hoyasterone ( 1), a sesquiterpene, 15-bulnesolic acid ( 2), and a phenolic compound, 1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol ( 3), together with a known triterpene, dihydrocanaric acid, were isolated from HOYA PARASITICA. Structures were elucidated by 1 D ...

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Contribution of cytogenetics to the management of poorly differentiated sarcomas.

May 1st, 2008
Contribution of cytogenetics to the management of poorly differentiated sarcomas. Sarcomas constitute a heterogeneous group of rare tumors that in recent years have been shown by cytogenetic analysis to have a remarkably high incidence of specific and primary alterations. These genetic alterations not only have guided ...

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Recognizing hidden phenotypes in sarcomas through the electron microscope.

May 1st, 2008
Recognizing hidden phenotypes in sarcomas through the electron microscope. Differentiation along a distinct cell lineage can be identified either morphologically or with the adjunct of different ancillary techniques. While immunohistochemistry has progressively supplanted electron microscopy as the method of choice to characterize the phenotype of neoplastic ...

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