Medical and Biomedical Researches

Integration of devices into long-term condition management: a synthesis of qualitative studies.

June 29th, 2008
Integration of devices into long-term condition management: a synthesis of qualitative studies. BACKGROUND: Understanding peoples\' responses to and ability to incorporate technology for managing long-term conditions into their everyday lives is relevant for informing the development and implementation of new technologies as part of future long-term ...

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Teledermatology for chronic disease management: coherence and normalization.

June 29th, 2008
Teledermatology for chronic disease management: coherence and normalization. OBJECTIVE: To explore the importance of ;coherence\' in the normalization of treatment interventions by examining teledermatology for skin disease management from the perspectives of patients and their advocates. METHODS: Twelve teledermatology services were studied using semi-structured interviews. Participants ...

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Making connections through online asthma monitoring.

June 29th, 2008
Making connections through online asthma monitoring. OBJECTIVES: This was an observational study of an online asthma monitoring system in Danish primary care practices aimed at exploring the reasons why information and communication technologies (ICTs) intended to connect chronic patients with their care provider fail to become ...

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Understanding factors that inhibit or promote the utilization of telecare in chronic lung disease.

June 29th, 2008
Understanding factors that inhibit or promote the utilization of telecare in chronic lung disease. OBJECTIVES: To perform a process evaluation of a randomized controlled trial (RCT) of home telecare for the management of acute exacerbations of chronic obstructive pulmonary disease (COPD), using the normalization process model ...

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Continuous positive airway pressure machines and the work of coordinating technologies at home.

June 29th, 2008
Continuous positive airway pressure machines and the work of coordinating technologies at home. OBJECTIVES: Research on the use of health technology at home has consistently reported that it is underpinned by users\' evaluations of the technology in relation to their illness trajectory, their social network, and ...

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The duality of health technology in chronic illness: how designers envision our future.

June 29th, 2008
The duality of health technology in chronic illness: how designers envision our future. This essay critically explores the role of technological innovation in the constitution of chronic states and illness. Drawing on the co-construction of technology and society perspective, it focuses more specifically on the way ...

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Remission in schizophrenia: the relationship to baseline symptoms and changes in symptom domains dur

June 29th, 2008
Remission in schizophrenia: the relationship to baseline symptoms and changes in symptom domains during a one-year study. Abstract The concepts of partial recovery and remission have become increasingly important for the evaluation of the effectiveness of schizophrenia therapeutics. The relationship of baseline symptoms and changes in ...

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Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorti

June 29th, 2008
Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series. Abstract The psychopathologies underlying affective disorders are thought to involve persistent changes in the expression and function of both mineralocorticoid receptors and glucocorticoid receptors in the hippocampus. In addition, exposure to ...

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Duloxetine for major depressive episodes in the course of psychotic disorders: an observational clin

June 29th, 2008
Duloxetine for major depressive episodes in the course of psychotic disorders: an observational clinical trial. Abstract Patients with psychotic disorders often suffer from intercurrent major depressive episodes (MDE). Case reports suggested successful antidepressive treatment with duloxetine, a selective dual reuptake inhibitor of serotonin and norepinephrine. We ...

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A 60-year-old woman with agitation and psychosis following ingestion of dextromethorphan and opioid

June 29th, 2008
A 60-year-old woman with agitation and psychosis following ingestion of dextromethorphan and opioid analgesics. Abstract A patient presented with agitation, paranoia, and psychosis following ingestion of dextromethorphan, propoxyphene, and hydrocodone, a previously unreported combination. Symptoms resolved with antipsychotics and cessation of offending drugs. The pharmacodynamics of ...

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Depot and oral antipsychotics: patient preferences and attitudes are not the same thing.

June 29th, 2008
Depot and oral antipsychotics: patient preferences and attitudes are not the same thing. Abstract Some clinicians believe that antipsychotic depot injections are unacceptable to patients. This cross-sectional study investigated patients\' attitudes regarding antipsychotics, and included within-participant comparisons. Two hundred and twenty-two out-patients with schizophrenia/schizoaffective disorder completed ...

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Reduced cooperativeness and reward-dependence in depression with above-normal plasma vasopressin con

June 29th, 2008
Reduced cooperativeness and reward-dependence in depression with above-normal plasma vasopressin concentration. Abstract The neuropeptide vasopressin is centrally involved in the regulation of social behaviour and response to stress. We previously found support for a subcategory of depression defined by above-normal plasma vasopressin (AVP) concentration. This subcategory ...

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Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers.

June 29th, 2008
Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers. Abstract Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation may be beneficial in the treatment of several psychiatric disorders, including depression. A small number of studies have suggested that there may also be cognitive and mood effects ...

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Should ethanol be scheduled as a drug of high risk to public health?

June 29th, 2008
Should ethanol be scheduled as a drug of high risk to public health? Abstract Six criteria described in the New Zealand Misuse of Drugs Act and used by the Expert Advisory Committee on Drugs (EACD) for determining the risk of a drug to public health were ...

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Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a ra

June 29th, 2008
Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial. Abstract The objective of this study was to identify mechanisms through which valproic acid (VPA) causes weight gain. Healthy participants (N = 52) were randomized to VPA ...

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Modelling of the concentration-effect relationship of THC on central nervous system parameters and h

June 29th, 2008
Modelling of the concentration-effect relationship of THC on central nervous system parameters and heart rate - insight into its mechanisms of action and a tool for clinical research and development of cannabinoids. Abstract Pharmacokinetics after pulmonary administration of delta-9-tetrahydrocannabinol (THC) and its major metabolites 11-OH-THC and ...

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Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in th

June 29th, 2008
Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests. Abstract Current literature suggests involvement of nicotinic acetylcholine receptors (nAChRs) in major depression. However, it is controversial whether the antidepressant-like effect of nAChR modulation is induced ...

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Models of mania and antimanic drug actions: progressing the endophenotype approach.

June 29th, 2008
Models of mania and antimanic drug actions: progressing the endophenotype approach. Abstract Mania is a multifaceted manifestation of bipolar disorder, and a constellation of clinical features is required for its diagnosis in patients. Despite showing face validity, animal models of mania based on \'facets\' of the ...

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Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers wit

June 29th, 2008
Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity. Abstract Pathological gambling (PG) is a serious psychiatric disorder afflicting 1-3% of the general population. Experimental evidence indicates shared neurochemical substrates for PG and psychostimulant addiction. Impulsivity ...

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Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex ch

June 29th, 2008
Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with nonobstructive azoospermia. Both aberrant meiotic recombination and an increased frequency of sperm aneuploidy have been observed in infertile men. However, this association has not been demonstrated ...

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Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) Induces Decidualization of Human Endometrial

June 29th, 2008
Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) Induces Decidualization of Human Endometrial Stromal Cells via {alpha}5{beta}1 Integrin. Progesterone is known to induce decidualization of human endometrial stromal cells in vitro. Decidualized stromal cells produce insulin-like growth factor binding protein-1 (IGFBP-1) as well as prolactin (PRL). In this ...

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Changes in Functional Walking Distance and Health-Related Quality of Life After Gastric Bypass Surge

June 29th, 2008
Changes in Functional Walking Distance and Health-Related Quality of Life After Gastric Bypass Surgery. BACKGROUND AND PURPOSE:/b> Early physical functional changes after gastric bypass surgery (GBS) are unclear, and the relationship between these changes and health-related quality of life (HR-QOL) has not been reported. We measured ...

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Effects of vasopressin V1b receptor deficiency on ACTH release from anterior pituitary cells in resp

June 29th, 2008
Effects of vasopressin V1b receptor deficiency on ACTH release from anterior pituitary cells in response to oxytocin stimulation. Oxytocin (OT) is one of the secretagogues for stress-induced adrenocorticotropoic hormone (ACTH) release. OT-induced ACTH release is reported to be mediated by the vasopressin V1b receptor in the ...

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Regulation of AgRP mRNA transcription and peptide secretion by acute and chronic inflammation.

June 29th, 2008
Regulation of AgRP mRNA transcription and peptide secretion by acute and chronic inflammation. Agouti-related protein (AgRP) is an orexigenic neuropeptide produced by neurons in the hypothalamic arcuate nucleus (ARC) that is a key component of central neural circuits that control food intake and energy expenditure. Disorders ...

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REGULATION OF ANGIOTENSIN TYPE 2 RECEPTOR IN BOVINE GRANULOSA CELLS.

June 29th, 2008
REGULATION OF ANGIOTENSIN TYPE 2 RECEPTOR IN BOVINE GRANULOSA CELLS. Angiotensin II (AngII) is best known for its role in blood pressure regulation, but it also has documented actions in the reproductive system. There are two AngII receptors, type 1 (AGTR1) and type 2 (AGTR2). AGTR2 ...

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