Medical and Biomedical Researches

Seasonal variations in the composition of urine in relation to calcium stone-formation.

June 23rd, 2008
Seasonal variations in the composition of urine in relation to calcium stone-formation. 1. A retrospective cross-sectional study was carried out on data derived from single 24 h urine collections from 246 male idiopathic calcium stone-formers. 2. The daily urine volume and pH and the exretions of ...

Posted in researches 6 | No Comments »

The renal elimination of procainamide.

June 23rd, 2008
The renal elimination of procainamide. The question of pH or flow dependence for the renal elimination of procainamide (PCA) was studied under 4 conditions in each of 4 subjects. Each subject received 500 mg of PCA intravenously at weekly intervals while in a state of (1) ...

Posted in researches 6 | No Comments »

Evaluation of lorazepam and pentobarbital as surgical premedicants.

June 23rd, 2008
Evaluation of lorazepam and pentobarbital as surgical premedicants. Lorazepam, a new benzodiazepine, was compared with a standard surgical premedicant, pentobarbital. In a double-blind study in 128 patients, lorazepam, 2 and 4 mg, and pentobarbital, 50 and 100 mg, were given intravenously in a randomized sequence. Significant ...

Posted in researches 6 | No Comments »

Plasma concentrations and the time-course of beta blockade due to propranolol.

June 23rd, 2008
Plasma concentrations and the time-course of beta blockade due to propranolol. The effectiveness of intravenously administered propranolol in antagonizing the chronotropic effect of isoproterenol and exercise has been investigated, and has been found at all times to be a predictable function of its plasma concentrations according ...

Posted in researches 6 | No Comments »

Fluroxene toxicity induced by phenobarbital.

June 23rd, 2008
Fluroxene toxicity induced by phenobarbital. Because of reports of fluroxene toxicity in man, the effect of phenobarbital treatment on the toxicity and metabolism of fluroxene was studied in 9 rhesus monkeys. Six monkeys that were exposed to a mean calculated alveolar fluroxene concentration of 5.8% for ...

Posted in researches 6 | No Comments »

Rosette formation by mouse lymphocytes. IV. Fc and C3 receptors occurring together and separately on

June 23rd, 2008
Rosette formation by mouse lymphocytes. IV. Fc and C3 receptors occurring together and separately on T cells and other leucocytes. A method is described for detecting the simultaneous presence of Fc and C3 receptors on mouse spleen cells. A proportion of both T cells and non-T ...

Posted in researches 6 | No Comments »

Glucose-phosphate isomerase deficiency due to a new variant (GP I Barcelona) and to a silent gene: b

June 23rd, 2008
Glucose-phosphate isomerase deficiency due to a new variant (GP I Barcelona) and to a silent gene: biochemical, immunological and genetic studies. A 12-year-old girl of Spanish origin was found to be double heterozygote for a deficient GP I variant (GP I Barcelona) and for a silent ...

Posted in researches 6 | No Comments »

Properties of beta-glucuronidase activity in human synovial fluid.

June 23rd, 2008
Properties of beta-glucuronidase activity in human synovial fluid. The purpose of the present study was to evaluate the properties of beta-glucuronidase (EC 3.2.1.31) in human synovial fluid. It was shown to have a pH requirement of 5.0 and a KM value of about 8.0 - 10(-3) ...

Posted in researches 6 | No Comments »

A stabilising factor for gamma-glutamyl transpeptidase in urine.

June 23rd, 2008
A stabilising factor for gamma-glutamyl transpeptidase in urine. Urinary gamma-glutamyl transpeptidase (gamma-GT) has been found to be stable when stored at room temperature and 4 degrees C. Activity is lost rapidly when urine is frozen but prior dialysis will prevent this loss. Urea is the major ...

Posted in researches 6 | No Comments »

The dependence of tryptamine excretion on urinary pH.

June 23rd, 2008
The dependence of tryptamine excretion on urinary pH. It is demonstrated that urinary tryptamine decreases significantly with increasing urinary pH. This effect becomes important at a urinary pH of 6.5 and over. Price J.

Posted in researches 6 | No Comments »

Improved separation of creatine kinase cardiac isoenzyme in serum by batch fractionation.

June 23rd, 2008
Improved separation of creatine kinase cardiac isoenzyme in serum by batch fractionation. I describe a simple, single-tube batch fractionation procedure for separating MM and MB isoenzymes of creatine kinase on a macroporous strong anion exchanger (AG MP-1, Bio-Rad Laboratories). The isoenzymes can be separated in less ...

Posted in researches 6 | No Comments »

Spectrophotometric end-point method for assay of serum cystyl-aminopeptidase in pregnancy.

June 23rd, 2008
Spectrophotometric end-point method for assay of serum cystyl-aminopeptidase in pregnancy. An optimized end-point method that requires little sophisticated equipment is described for estimating serum cystyl-aminopeptidase during pregnancy. S-Benzyl-L-cysteine-4-nitroanilide is used as the substrate. Durham BH.

Posted in researches 6 | No Comments »

Quantitative fractionation of alkaline phosphatase isoenzymes according to their thermostability.

June 23rd, 2008
Quantitative fractionation of alkaline phosphatase isoenzymes according to their thermostability. Continuous monitoring of heat denaturation of a mixture of alkaline phosphatase isoenzymes at 60 degrees C and pH 7.5 permits the simultaneous direct identification and quantitation of three isoenzymes: the placental isoenzyme, the L-phenylalanine-sensitive intestinal isoenzyme, ...

Posted in researches 6 | No Comments »

Effects of storage in the cold on activity of gamma-glutamyltransferase in serum.

June 23rd, 2008
Effects of storage in the cold on activity of gamma-glutamyltransferase in serum. Sera from patients with hepatobiliary disorders were selected to represent a wide range of activity of gamma-glutamyltransferase (EC 2.3.2.2). Samples were stored at 4 degrees C and periodically tested for as long as nine ...

Posted in researches 6 | No Comments »

Evidence for a physiological role of renal sympathetic nerves in adrenergic stimulation of renin rel

June 23rd, 2008
Evidence for a physiological role of renal sympathetic nerves in adrenergic stimulation of renin release in the rat. Previous studies on renin release by an in vitro system of rat kidney slices, which is devoid of hemodynamic influences, have provided evidence that renin release is stimulated ...

Posted in researches 6 | No Comments »

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relat

June 23rd, 2008
Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. The antitumor and immunosuppressive activities of the lankacidin-group antibiotics were studied in mice. Seventeen of 29 newly prepared lankacidin-group antibiotics, including 14-derivatives of lankacidin C, lankacidinol, isolankacidinol, and lankacidinol 14-acetate, possessed considerable antitumor activity against ascites 6C3HED/OG ...

Posted in researches 6 | No Comments »

L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino aci

June 23rd, 2008
L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine. L-[alphaS,5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501), an antibiotic elaborated by Streptomyces sviceus, has been shown to be a powerful inhibitor of many mammalian and bacterial reactions involving the transfer of nitrogen from ...

Posted in researches 6 | No Comments »

Immunotherapy for cancer: an overview.

June 23rd, 2008
Immunotherapy for cancer: an overview. Immunotherapy of cancer is of interest to oncologists because it is specifically directed to cancer cells, sparing normal cells. While it is ineffective in most patients, especially those with widespread metastatic disease, it occasionally produces good results. Each of the available ...

Posted in researches 6 | No Comments »

Properties of a free and a solubilized form of bound alpha,alpha-trehalase purified from honey bee t

June 23rd, 2008
Properties of a free and a solubilized form of bound alpha,alpha-trehalase purified from honey bee thorax. The free and bound forms of alpha,alpha-trehalase (EC 3.2.1.28) of the honey bee thorax were separated and the bound enzyme was solubilized by raising the pH to 8.0 for 10 ...

Posted in researches 6 | No Comments »

Porcine chymotrypsin A-pi, a more acidic chymotrypsin.

June 23rd, 2008
Porcine chymotrypsin A-pi, a more acidic chymotrypsin. A kinetic study of procine chymotrypsin A-pi revealed two characteristic properties of this type of chymotrypsin: 1. Porcine chymotrypsin A-pi, like bovine chymotrypsin B-pi does not bind proflavin, which is a competitive inhibitor of bovine trypsin and chymotrypsin A-alpha. ...

Posted in researches 6 | No Comments »

Mechanism of action of Mg2+ and Zn2+ on rat placental alkaline phosphatase. I. Studies on the solubl

June 23rd, 2008
Mechanism of action of Mg2+ and Zn2+ on rat placental alkaline phosphatase. I. Studies on the soluble Zn2+ and Mg2+ alkaline phosphatases. Rat placental alkaline phosphatase (EC 3.1.3.1), a dimer of 135,000 daltons, is strongly activated by Mg2+. However, Zn2+ has to be present on the ...

Posted in researches 6 | No Comments »

Trans-synaptic regulation of the development of end organ innervation by sympathetic neurons.

June 23rd, 2008
Trans-synaptic regulation of the development of end organ innervation by sympathetic neurons. To examine the regulation of development of end organ innervation the superior cervical ganglion (SCG), and two of its target organs, the iris and pineal gland, were studied using biochemical and histofluorescent approaches. During ...

Posted in researches 6 | No Comments »

Neurochemical studies in a mouse teratoma with neuroepithelial differentiation. Presence of cyclic A

June 23rd, 2008
Neurochemical studies in a mouse teratoma with neuroepithelial differentiation. Presence of cyclic AMP, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems. A transplantable mouse testicular teratoma (OTT 6050) which displays a spectrum of neuroepithelial differentiation was evaluated biochemically for concentrations of cyclic AMP (cAMP), ...

Posted in researches 6 | No Comments »

Impact of psychosocial factors on the conduct of combined drug and psychotherapy research.

June 23rd, 2008
Impact of psychosocial factors on the conduct of combined drug and psychotherapy research. The effect of attitudes of therapists, patients and researchers on the conduct and outcome of combined drug and psychotherapy research was examined in a brief crisis-oriented psychotherapy clinic. Seventy-seven consecutive patients were given ...

Posted in researches 6 | No Comments »

The use of radioactive microspheres to compare the effects of hydralazine, guanethidine and SK &

June 23rd, 2008
The use of radioactive microspheres to compare the effects of hydralazine, guanethidine and SK & F 24260 on the redistribution of cardiac output in anaesthetized rabbits. 1 The use of radioactive microspheres is described for the measurement of cardiac output in anaesthetized rabbits and its redistribution ...

Posted in researches 6 | No Comments »