Medical and Biomedical Researches

Three-Dimensional Culture Environments Enhance Osteoblast Differentiation.

June 25th, 2008
Three-Dimensional Culture Environments Enhance Osteoblast Differentiation. Purpose: In previous work from our laboratory, we demonstrated that the three-dimensional (3D) cell cultures developed in simulated microgravity environments enhanced osseous-like aggregate formation and accelerated preosteoblast cell differentiation. Thus, as described here, we hypothesize that aggregate formation and mineralization ...

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PerioGlas((R)) Regulates Osteoblast RNA Interfering.

June 25th, 2008
PerioGlas((R)) Regulates Osteoblast RNA Interfering. Purpose: PerioGlas((R)) (PG) is an alloplastic material that has been used for grafting periodontal osseous defects since the 1990s. In animal models, it has been proven that PG achieves histologically good repairs of surgically created defects. In clinical trials, PG is ...

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Dual Path: A Concept to Improve the Esthetic Replacement of Missing Anterior Teeth with a Removable

June 25th, 2008
Dual Path: A Concept to Improve the Esthetic Replacement of Missing Anterior Teeth with a Removable Partial Denture. The dual path of insertion concept for removable partial denture (RPD) design may be used in esthetically demanding situations. When compared to conventional RPDs, the main advantage of ...

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The Effect of Etching Technique on the Retention of Adhesively Cemented Prefabricated Dowels.

June 25th, 2008
The Effect of Etching Technique on the Retention of Adhesively Cemented Prefabricated Dowels. Purpose: To determine if etching technique influences the bond strength of resin cement to root canal dentin. Materials and Methods: Fifty-five extracted teeth were endodontically treated, dowel space prepared, and divided into five ...

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Mineral Status of COPD Patients under Long-Term Inhaled Corticosteroid Therapy.

June 25th, 2008
Mineral Status of COPD Patients under Long-Term Inhaled Corticosteroid Therapy. Purpose: The aim of this study was to determine the mineral status of mandibles, femurs, and spines in chronic obstructive pulmonary disease (COPD) patients under long-term inhaled corticosteroid therapy. Materials and Methods: Pulmanory function tests were ...

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Fabricating a Hollow Obturator with Visible Light-Cured Resin System.

June 25th, 2008
Fabricating a Hollow Obturator with Visible Light-Cured Resin System. Obturators are routinely used in the rehabilitation of maxillectomy defects. Ideally, obturators should be easily constructed to produce a comfortable and stable prosthesis. This article describes a technique that provides an easy method for the construction of ...

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Change in psychopathology in referred children: the role of life events and perceived stress.

June 25th, 2008
Change in psychopathology in referred children: the role of life events and perceived stress. Background: This study examined the relation between stress and change in emotional and behavioural problems in children and adolescents referred for mental health services. Method: At three waves across four years, children ...

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Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters,

June 25th, 2008
Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls. Background: This study examined neuropsychological functioning in a longitudinal sample of adolescents/young adults with attention deficit/hyperactivity disorder (ADHD) and controls as a function of the persistence of ADHD. We hypothesized that measures ...

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Practitioner Review: How can epidemiology help us plan and deliver effective child and adolescent me

June 25th, 2008
Practitioner Review: How can epidemiology help us plan and deliver effective child and adolescent mental health services? This review focuses on ways in which epidemiological research can inform mental health service development and clinical practice. Data from epidemiological studies can provide cross-sectional and secular estimates of ...

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Analysing body condition: mass, volume or density?

June 25th, 2008
Analysing body condition: mass, volume or density? 1. Body condition (defined as the relative amount of energy reserves in the body) is an animal trait with strong ecological implications. In some animal taxa (e.g. arthropods), the external volume of the body part in which most nutrients ...

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Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation.

June 25th, 2008
Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. The transplant acceptance-inducing cell (TAIC) is a type of immunoregulatory macrophage with the capacity to specifically dampen allogeneic rejection responses to a degree allowing safe minimization of conventional immunosuppressive therapy. In the first part of this ...

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A cell-based approach to the minimization of immunosuppression in renal transplantation.

June 25th, 2008
A cell-based approach to the minimization of immunosuppression in renal transplantation. Five renal transplant recipients were preoperatively treated with transplant acceptance-inducing cells (TAICs) in a Phase-I safety study of TAICs as an adjunct immune-conditioning therapy in living-donor kidney transplantation. Initially, patients received anti-thymocyte globulin induction therapy ...

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Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant

June 25th, 2008
Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells. This report describes the case of patient FR, a 31-year-old recipient of a living-related kidney transplant from a donor against whom he was presensitized. Seventeen days prior to transplantation, a central venous infusion ...

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Management of Refractory Ascites Using Nocturnal Home Hemodialysis.

June 25th, 2008
Management of Refractory Ascites Using Nocturnal Home Hemodialysis. Ascites in patients with end-stage renal disease (ESRD) poses a challenging management scenario for nephrologists. We present two patients with ascites refractory to treatment with standard outpatient hemodialysis which resolved upon the initiation of nocturnal home hemodialysis (NHD). ...

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Nonphosphate-Binding Effects of Sevelamer-Are They of Clinical Relevance?

June 25th, 2008
Nonphosphate-Binding Effects of Sevelamer-Are They of Clinical Relevance? Sevelamer is an ion-exchanging resin that binds phosphate in the gut. Because it does so without increasing the calcium load, treatment with sevelamer may lead to less vascular calcification and better survival in chronic kidney disease patients. However, ...

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Beyond Anemia: The Clinical Impact of the Physiologic Effects of Erythropoietin.

June 25th, 2008
Beyond Anemia: The Clinical Impact of the Physiologic Effects of Erythropoietin. Although we have known that oxygen tension affects erythrocyte production since the 19th century, we have only recently begun to understand many subtleties of erythropoietin (EPO) physiology. EPO administration has allowed hundreds of thousands of ...

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Hemodialysis Central Venous Catheters as a Source of Inflammation and Its Implications.

June 25th, 2008
Hemodialysis Central Venous Catheters as a Source of Inflammation and Its Implications. The mortality rate for end-stage renal disease patients is six times higher than in the general population. Hemodialysis central venous catheter (CVC) utilization has increased by 50% between 1998 and 2004 and data from ...

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Diet, Inflammation, and Chronic Kidney Disease: Getting to the Heart of the Matter.

June 25th, 2008
Diet, Inflammation, and Chronic Kidney Disease: Getting to the Heart of the Matter. Cardiovascular disease (CVD) remains a leading cause of death in patients with chronic kidney disease (CKD). CVD is now thought to result from the interplay of several factors including inflammation, oxidative stress and ...

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Regularized Estimation for the Accelerated Failure Time Model.

June 25th, 2008
Regularized Estimation for the Accelerated Failure Time Model. In the presence of high-dimensional predictors, it is challenging to develop reliable regression models that can be used to accurately predict future outcomes. Further complications arise when the outcome of interest is an event time, which is often ...

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Marginal Mark Regression Analysis of Recurrent Marked Point Process Data.

June 25th, 2008
Marginal Mark Regression Analysis of Recurrent Marked Point Process Data. Longitudinal studies typically collect information on the timing of key clinical events and on specific characteristics that describe those events. Random variables that measure qualitative or quantitative aspects associated with the occurrence of an event are ...

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High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobu

June 25th, 2008
High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobulin synthesis in cerebrospinal fluid. Background - So far, an inflammation of the central nervous system (CNS) is diagnosed by immunoglobulin measurement in cerebrospinal fluid (CSF) and serum as well as by ...

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The Role of Invariant NKT Cells in Pre-Eclampsia.

June 25th, 2008
The Role of Invariant NKT Cells in Pre-Eclampsia. Problem Recent data suggest a dominant role of the innate, rather than the adaptive immune system in pregnancy-related immunoregulation. Invariant NKT (iNKT) cells represent a link between the innate and the acquired immune systems; however, little is known ...

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High Expression of l-Selectin Ligand in Secretory Endometrium is Associated with Better Endometrial

June 25th, 2008
High Expression of l-Selectin Ligand in Secretory Endometrium is Associated with Better Endometrial Receptivity and Facilitates Embryo Implantation in Human Being. Problem l-selectin ligand has displayed mediating adhesion at the maternal-fetal interface. Therefore, we investigated the impact of l-selectin ligand on establishing pregnancy in women undergoing ...

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Genetic Predisposition to Idiopathic Recurrent Spontaneous Abortion: Contribution of Genetic Variati

June 25th, 2008
Genetic Predisposition to Idiopathic Recurrent Spontaneous Abortion: Contribution of Genetic Variations in IGF-2 and H19 Imprinted Genes. Problem Recurrent spontaneous abortion (RSA) is a common clinical problem with a complex etiology of genetic and non-genetic causes, which remains to be fully determined. IGF-2 stimulates trophoblast invasion, ...

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Cytokine Gene Polymorphisms in Recurrent Spontaneous Abortions: A Comprehensive Review.

June 25th, 2008
Cytokine Gene Polymorphisms in Recurrent Spontaneous Abortions: A Comprehensive Review. Problem Cytokine gene polymorphism studies in women with recurrent spontaneous abortion (RSA) are reviewed to provide comprehensive understanding and a direction for the future investigation. Method of study A search of PubMed was made to identify ...

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