Medical and Biomedical Researches

Caveolae are an essential component of the pathway for endothelial cell signaling associated with ab

June 27th, 2008
Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. Abrupt cessation of flow representing the acute loss of shear stress (simulated ischemia) to flow-adapted pulmonary microvascular endothelial cells (PMVEC) leads to reactive oxygen species (ROS) generation ...

Posted in for377cat | No Comments »

Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cell

June 27th, 2008
Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cells. Trafficking of the TrkA receptor after stimulation by NGF is of emerging importance in structural cells in the context of airway inflammatory diseases. We have recently reported the expression of functional TrkA receptors ...

Posted in for377cat | No Comments »

IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines.

June 27th, 2008
IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. The gastric mucosal levels of the pro-inflammatory cytokine Interleukin 6 (IL-6) have been reported to be increased in Helicobacter pylori-infected subjects and, in gastric adenocarcinomas, the up-regulation of intestinal mucin genes (MUC2 and MUC4) ...

Posted in for377cat | No Comments »

Supramolecular organization of protein complexes in the mitochondrial inner membrane.

June 27th, 2008
Supramolecular organization of protein complexes in the mitochondrial inner membrane. The liquid state model that envisions respiratory chain complexes diffusing freely in the membrane is increasingly challenged by reports of supramolecular organization of the complexes in the mitochondrial inner membrane. Supercomplexes of complex III with complex ...

Posted in for377cat | No Comments »

Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolesce

June 27th, 2008
Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolescent C57BL/6 mice. We have previously demonstrated that anxiety-like behavior assessed in the elevated plus maze does not predict subsequent nicotine consumption in naïve adolescent mice. However, an association between anxiety and relapse to drug use ...

Posted in for377cat | No Comments »

Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 infl

June 27th, 2008
Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice. The replication efficiency and multi-organ dissemination of some influenza A (H5N1) viruses requires a rapid (re)evaluation of the available antiviral strategies. We assessed five regimens of the neuraminidase (NA) inhibitor peramivir in ...

Posted in for377cat | No Comments »

Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HS

June 27th, 2008
Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs. These studies were performed to determine the effect of AD-472, an attenuated human herpes simplex virus (HSV) type 2 ...

Posted in for377cat | No Comments »

CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells.

June 27th, 2008
CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells. A subset of CD4(+) T cells, the CD4(+) CD25(+) regulatory T (T(reg)) cells in the lymphoid organs and peripheral blood are known to possess suppressive function. Previous in vitro and in ...

Posted in for377cat | No Comments »

Spatial analysis of the etiology of amyotrophic lateral sclerosis among 1991 Gulf War veterans.

June 27th, 2008
Spatial analysis of the etiology of amyotrophic lateral sclerosis among 1991 Gulf War veterans. BACKGROUND: Veterans of the 1991 Gulf War have an increased risk of amyotrophic lateral sclerosis (ALS), but the etiology is unknown. OBJECTIVES: This study sought to identify geographic areas with elevated risk ...

Posted in for377cat | No Comments »

Central 5-HT receptors in cardiovascular control during stress.

June 27th, 2008
Central 5-HT receptors in cardiovascular control during stress. Our aim is to consolidate recent data on relationship between central serotonergic neurotransmission and stress-elicited cardiovascular changes. Activation of central of 5-HT1A receptors attenuates tachycardic and pressor changes elicited by a wide range of stressors (airjet, restraint, open ...

Posted in for377cat | No Comments »

Modafinil decreases food intake in humans subjected to simulated shift work.

June 27th, 2008
Modafinil decreases food intake in humans subjected to simulated shift work. In a limited number of studies modafinil has been shown to decrease food intake by laboratory animals and humans. The present study represents a secondary data analysis, in which the effects of modafinil on several ...

Posted in for377cat | No Comments »

Toxin-screening and identification of bacteria isolated from highly toxic marine gastropod Nassarius

June 27th, 2008
Toxin-screening and identification of bacteria isolated from highly toxic marine gastropod Nassarius semiplicatus. Bacteria isolated from a highly toxic sample of gastropod Nassarius semiplicatus in Lianyungang, Jiangsu Province in July 2007, were studied to probe into the relationship between bacteria and toxicity of nassariid gastropod. The ...

Posted in for377cat | No Comments »

First report on azaspiracid and yessotoxin groups detection in French shellfish.

June 27th, 2008
First report on azaspiracid and yessotoxin groups detection in French shellfish. The French Phytoplankton and Phycotoxins monitoring network (REPHY) recently found positive or dubious negative shellfish samples using lipophilic toxins mouse bioassay. These samples were analyzed by liquid chromatography (LC) in combination with mass spectrometry (MS) ...

Posted in for377cat | No Comments »

Proteomic analysis of the honey bee worker venom gland focusing on the mechanisms of protection agai

June 27th, 2008
Proteomic analysis of the honey bee worker venom gland focusing on the mechanisms of protection against tissue damage. Honey bee workers use venom for the defence of the colony and themselves when they are exposed to dangers and predators. It is produced by a long thin, ...

Posted in for377cat | No Comments »

Aged-related toxic effects and recovery from okadaic acid treatment in Enchytraeus crypticus (Anneli

June 27th, 2008
Aged-related toxic effects and recovery from okadaic acid treatment in Enchytraeus crypticus (Annelida: Oligochaeta). The effects of 48h okadaic acid (OA) treatment and the ability to recover the induced toxicological injuries were examined in Enchytraeus crypticus of different ages (25 days and 3 months). The results ...

Posted in for377cat | No Comments »

Bacterial degradation of paralytic shellfish toxins.

June 27th, 2008
Bacterial degradation of paralytic shellfish toxins. Bacteria isolated from the digestive tracts of blue mussels (Mytilus edulis) contaminated with paralytic shellfish toxins (PSTs) were screened for the ability to reduce the toxicity of a PST mixture in vitro. Bacteria were isolated on marine agar and grown ...

Posted in for377cat | No Comments »

Radicicol improves regeneration of skeletal muscle previously damaged by crotoxin in mice.

June 27th, 2008
Radicicol improves regeneration of skeletal muscle previously damaged by crotoxin in mice. This work investigates the influence of heat shock proteins (HSPs) on necrosis and subsequent skeletal muscle regeneration induced by crotoxin (CTX), the major component of Crotalus durissus terrificus venom. Mice were treated with radicicol, ...

Posted in for377cat | No Comments »

Developmental neurotoxicity of Propylthiouracil (PTU) in rats: Relationship between transient hypoth

June 27th, 2008
Developmental neurotoxicity of Propylthiouracil (PTU) in rats: Relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes. Markedly lowered thyroid hormone levels during development may influence a child\'s behaviour, intellect, and auditory function. Recent studies, indicating that even small changes in the mother\'s thyroid ...

Posted in for377cat | No Comments »

Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothe

June 27th, 2008
Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells. Vascular tissue expresses two isoforms of the enzyme 11beta-Hydroxysteroid dehydrogenase, 11beta-HSD1 and 11beta-HSD2. These enzymes are responsible for the local metabolism of endogenous glucocorticoids (GCs). 11beta-HSD1 deactivates GCs to their 11keto metabolites or transforms ...

Posted in for377cat | No Comments »

Who caused the pain? An fMRI investigation of empathy and intentionality in children.

June 27th, 2008
Who caused the pain? An fMRI investigation of empathy and intentionality in children. When we perceive other people in pain, the neural circuits underpinning the processing of first-hand experience of pain are activated in the observer. This basic somatic sensorimotor resonance plays a critical role in ...

Posted in for377cat | No Comments »

A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate)

June 27th, 2008
A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate) is a candidate therapeutic agent for Alzheimer\'s disease that inhibits oxidative stress and nitric oxide-induced neurotoxicity and acts as a neurotrophic factor. The present study examines the effect of T-817MA on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine ...

Posted in for377cat | No Comments »

Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus

June 27th, 2008
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. It is known that N-methyl-d-aspartate (NMDA) receptor in the basolateral nucleus of amygdala (BLA) is essential for fear memory formation. NMDA NR2B and NR2A subtype receptors ...

Posted in for377cat | No Comments »

The cost of cerebral ischaemia.

June 27th, 2008
The cost of cerebral ischaemia. Cerebral ischaemia is a major cause of disability and death globally and has a profoundly negative impact on the individuals it affects, those that care for them and society as a whole. The most common and familiar manifestation is stroke, 85% ...

Posted in for377cat | No Comments »

Lethal pathogens, non-lethal synergists and the evolutionary ecology of resistance.

June 27th, 2008
Lethal pathogens, non-lethal synergists and the evolutionary ecology of resistance. Mixed pathogenic infections are known to have profound effects on the ecological and evolutionary diversity of both hosts and parasites. Although a variety of mechanisms have been proposed by which hosts can withstand parasitic infections, the ...

Posted in for377cat | No Comments »

The effects of distributed life cycles on the dynamics of viral infections.

June 27th, 2008
The effects of distributed life cycles on the dynamics of viral infections. We explore the role of cellular life cycles for viruses and host cells in an infection process. For this purpose, we derive a generalized version of the basic model of virus dynamics (Nowak, M.A., ...

Posted in for377cat | No Comments »