Medical and Biomedical Researches

Novel Twinkle (PEO1) gene mutations in mendelian progressive external ophthalmoplegia.

June 27th, 2008
Novel Twinkle (PEO1) gene mutations in mendelian progressive external ophthalmoplegia. Multiple deletions of mitochondrial DNA (mtDNA) are associated with different mitochondrial disorders inherited as autosomal dominant and recessive traits. Causative mutations have been found in five genes, mainly involved in mtDNA replication and stability. They include ...

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Shunt-responsive parkinsonism and reversible white matter lesions in patients with idiopathic NPH.

June 27th, 2008
Shunt-responsive parkinsonism and reversible white matter lesions in patients with idiopathic NPH. BACKGROUND : Idiopathic normal pressure hydrocephalus (iNPH) is a potentially treatable dementia and gait disorder with abnormal CSF dynamics. OBJECTIVE : To investigate and characterize the changes in motor symptoms and CT and MRI ...

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A natural history study of late onset spinal muscular atrophy types 3b and 4.

June 27th, 2008
A natural history study of late onset spinal muscular atrophy types 3b and 4. BACKGROUND : Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron (SMN)1 gene. The nearly identical SMN2 gene plays a disease modifying role. SMA is classified ...

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An evaluation of cognitive disorders after anterior choroidal artery infarction.

June 27th, 2008
An evaluation of cognitive disorders after anterior choroidal artery infarction. Anterior choroidal artery infarction (AChAI) can be the source of aphasia and spatial neglect, but we have no idea of the other possible cognitive disorders. Here, we investigated these disorders in a relatively large cohort of ...

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Creutzfeldt-Jakob disease: Which diffusion-weighted imaging abnormality is associated with periodic

June 27th, 2008
Creutzfeldt-Jakob disease: Which diffusion-weighted imaging abnormality is associated with periodic EEG complexes? BACKGROUND : Clinical diagnosis of CJD remains important due to lack of access to a genetic or histopathological diagnosis. Using current WHO criteria, diagnostic certainty can be increased from \"possible\" to \"probable\" CJD if ...

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Familiality of major depressive disorder and patterns of lifetime comorbidity. The NEMESIS and GenMo

June 27th, 2008
Familiality of major depressive disorder and patterns of lifetime comorbidity. The NEMESIS and GenMood studies : A comparison of three samples. BACKGROUND: Major depressive disorder (MDD) aggregates in families and is associated with high rates of lifetime axis-I comorbidity. This study examined whether familiality of MDD ...

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The generalized anxiety spectrum: prevalence, onset, course and outcome.

June 27th, 2008
The generalized anxiety spectrum: prevalence, onset, course and outcome. BACKGROUND: Generalized anxiety disorder (GAD) is generally considered to be a chronic condition, waxing and waning in severity; however prospective investigation of the course of GAD in community samples is lacking. This study seeks to fill that ...

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Reduced calcium responsiveness characterizes contractile dysfunction following coronary microemboliz

June 27th, 2008
Reduced calcium responsiveness characterizes contractile dysfunction following coronary microembolization. AIMS: We addressed calcium responsiveness in microembolized myocardium at 6 h after coronary microembolization (ME). METHODS AND RESULTS: In anesthetized pigs calcium responsiveness was determined as the increase of a myocardial work index (WI; LV pressure development ...

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A process and criteria for the evaluation of software frameworks in the domain of computer assisted

June 27th, 2008
A process and criteria for the evaluation of software frameworks in the domain of computer assisted surgery. Software application frameworks provide a modular and reusable context for the development of custom applications, e.g. in the domain of medical image processing and computer assisted surgery (CAS). The ...

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The zebrafish embryo model in environmental risk assessment-applications beyond acute toxicity testi

June 27th, 2008
The zebrafish embryo model in environmental risk assessment-applications beyond acute toxicity testing. BACKGROUND, AIM, AND SCOPE: The use of fish embryos is not regulated by current legislations on animal welfare and is therefore considered as a refinement, if not replacement of animal experiments. Fish embryos represent ...

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Signal decay due to susceptibility-induced intravoxel dephasing on multiple air-filled cylinders: MR

June 27th, 2008
Signal decay due to susceptibility-induced intravoxel dephasing on multiple air-filled cylinders: MRI simulations and experiments. OBJECTIVE: Characterization of magnetic susceptibility artefacts with assessment of the gradient-echo signal decay function of echo time, pixel size, and object geometry in the case of air-filled cylinders embedded in water. ...

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The natural history of acute non-traumatic aortic diseases.

June 27th, 2008
The natural history of acute non-traumatic aortic diseases. Acute non-traumatic aortic vascular disease is a significant cause of mortality although remains poorly understood in clinical practice. In this pictorial essay, the natural history of three entities will be considered: penetrating aortic ulcer, aortic dissection, and aortic ...

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Yersinia enterocolitica infection in diarrheal patients.

June 27th, 2008
Yersinia enterocolitica infection in diarrheal patients. In this study, we hoped to provide valuable clinical information on yersiniosis for clinicians. Two thousand six hundred stool samples were collected from in- and outpatients with diarrhea, which were tested with both culture method and real-time polymerase chain reaction ...

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Inappropriate initial antimicrobial therapy as a risk factor for mortality in patients with communit

June 27th, 2008
Inappropriate initial antimicrobial therapy as a risk factor for mortality in patients with community-onset Pseudomonas aeruginosa bacteraemia. This study was performed to identify the risk factors for mortality and evaluate the effect of inappropriate initial antimicrobial therapy on the outcomes of patients with community-onset Pseudomonas aeruginosa ...

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Lateralization for visual processes: eye preference in Campbell’s monkeys (Cercopithecus c. campbel

June 27th, 2008
Lateralization for visual processes: eye preference in Campbell\'s monkeys (Cercopithecus c. campbelli). Brain lateralization has been the matter of extensive research over the last centuries, but it remains an unsolved issue. While hand preferences have been extensively studied, very few studies have investigated laterality of eye ...

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Learning generalization in problem solving by a blue-fronted parrot (Amazona aestiva).

June 27th, 2008
Learning generalization in problem solving by a blue-fronted parrot (Amazona aestiva). Pepperberg (The Alex studies: cognitive and communicative abilities of gray parrots. Harvard University Press, Cambridge;1999) showed that some of the complex cognitive capabilities found in primates are also present in psittacine birds. Through the replication ...

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Free flap transfer in cranio-maxillofacial surgery: a review of the current data.

June 27th, 2008
Free flap transfer in cranio-maxillofacial surgery: a review of the current data. BACKGROUND: The advances of cranio-maxillofacilal surgery are considerably driven by the evolution of microsurgical techniques. At present, these methods continue to provide new therapeutic options to the field. Especially, free flap transfer has evolved ...

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Microanchor mediated upper molar intrusion in deep posterior bite after long-term edentulousness for

June 27th, 2008
Microanchor mediated upper molar intrusion in deep posterior bite after long-term edentulousness for prosthetic reconstruction with dental implants. INTRODUCTION: Long-term edentulousness can lead to elongation of antagonistic teeth, making prosthetic rehabilitation impossible. An interdisciplinary case is presented where elongated teeth were successfully intruded by micoranchor-mediated orthodontic ...

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Diabetes mellitus and odontogenic infections-an exaggerated risk?

June 27th, 2008
Diabetes mellitus and odontogenic infections-an exaggerated risk? INTRODUCTION: The diabetic host is considered to be at an increased risk for the development of odontogenic infections due to his medically compromised state. This perceived risk of higher infections often results in dentists delaying much-needed surgical treatment in ...

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DFT and GA Studies on the QSAR of 2-aryl-5-nitro-1H-indole derivatives as NorA Efflux Pump Inhibitor

June 27th, 2008
DFT and GA Studies on the QSAR of 2-aryl-5-nitro-1H-indole derivatives as NorA Efflux Pump Inhibitors. The structures of 2-aryl-5-nitro-1H-indole derivatives were optimized with PM3 and DFT at b3lyp/6-31 g* level successively. Some structural and electric descriptors were obtained from the single point energy calculation and natural ...

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Electrochemical interrogations of the Mtr cytochromes from Shewanella: opening a potential window.

June 27th, 2008
Electrochemical interrogations of the Mtr cytochromes from Shewanella: opening a potential window. The multi-heme cytochromes from Shewanella oneidensis associated with the dissimilatory metal reduction (DMR) pathway have been investigated using the technique of protein film voltammetry (PFV). Using PFV, we have interrogated each of the multi-heme ...

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Anterior instrumentation for the treatment of pyogenic vertebral osteomyelitis of thoracic and lumba

June 27th, 2008
Anterior instrumentation for the treatment of pyogenic vertebral osteomyelitis of thoracic and lumbar spine. Anterior radical debridement and bone grafting is popular in the treatment of pyogenic infection of the spine, but there remains great concern of placing instrumentation in the presence of infection because of ...

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Long-term investigation of nonsurgical treatment for thoracolumbar and lumbar burst fractures: an ou

June 27th, 2008
Long-term investigation of nonsurgical treatment for thoracolumbar and lumbar burst fractures: an outcome analysis in sight of spinopelvic balance. The nonsurgical treatment of thoracolumbar (TLB) and lumbar burst (LB) fractures remains to be of interest, though it is not costly and avoids surgical risks. However, a ...

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A prospective cohort study comparing the VAS spine score and Roland-Morris disability questionnaire

June 27th, 2008
A prospective cohort study comparing the VAS spine score and Roland-Morris disability questionnaire in patients with a type A traumatic thoracolumbar spinal fracture. The Roland Morris Disability Questionnaire (RMDQ-24) and the VAS spine score have been regularly used to measure functional outcome in patients with back ...

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Vitamin D insufficiency and hyperparathyroidism in children with chronic kidney disease.

June 27th, 2008
Vitamin D insufficiency and hyperparathyroidism in children with chronic kidney disease. Chronic kidney disease (CKD) is associated with altered calcium-phosphate homeostasis and hyperparathyroidism due to decreased activity of 1alpha-hydroxylase and impaired activation of 25-hydroxyvitamin D3 [25(OH)D3]. In some patients these problems start earlier because of vitamin ...

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