Medical and Biomedical Researches

BOLD correlates of continuously fluctuating epileptic activity isolated by independent component ana

July 3rd, 2008
BOLD correlates of continuously fluctuating epileptic activity isolated by independent component analysis. Combined EEG/fMRI recordings offer a promising opportunity to detect brain areas with altered BOLD signal during interictal epileptic discharges (IEDs). These areas are likely to represent the irritative zone, which is itself a reflection ...

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Evoked magnetic fields following noxious laser stimulation of the thigh in humans.

July 3rd, 2008
Evoked magnetic fields following noxious laser stimulation of the thigh in humans. Primary somatosensory cortex (SI) and posterior parietal cortex (PPC) are activated by noxious stimulation. In neurophysiological studies using magnetoencephalography (MEG), however, it has been difficult to separate the activity in SI from that in ...

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Evaluation of denoising algorithms for biological electron tomography.

July 3rd, 2008
Evaluation of denoising algorithms for biological electron tomography. Tomograms of biological specimens derived using transmission electron microscopy can be intrinsically noisy due to the use of low electron doses, the presence of a \"missing wedge\" in most data collection schemes, and inaccuracies arising during 3D volume ...

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Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture.

July 3rd, 2008
Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Ascl1 (previously Mash1) is a bHLH transcription factor essential for neuronal differentiation and specification in the nervous system. Although it has been studied for its role in several neural lineages, the full complement of ...

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p42/44 MAPK is an essential effector for purine nucleoside-mediated neuroprotection of hypoxic PC12

July 3rd, 2008
p42/44 MAPK is an essential effector for purine nucleoside-mediated neuroprotection of hypoxic PC12 cells and primary cerebellar granule neurons. Purine nucleosides protect neurons against hypoxic insult, but the signaling mechanisms have not yet been fully elucidated. We studied the role of the p42/44 MAPK pathway in ...

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Critical roles for c-Myb in hematopoietic progenitor cells.

July 3rd, 2008
Critical roles for c-Myb in hematopoietic progenitor cells. While it has long been known that the transcription factor c-Myb is an essential regulator of hematopoiesis, its precise molecular targets have remained elusive. Cell line studies suggest that c-Myb promotes proliferation and at the same time inhibits ...

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The Effect of Phosphorylation on the Electron Capture Dissociation of Peptide Ions.

July 3rd, 2008
The Effect of Phosphorylation on the Electron Capture Dissociation of Peptide Ions. The effect of site and frequency of phosphorylation on the electron capture dissociation of peptide ions has been investigated. The ECD of a suite of synthetic peptides (APLSFRGSLPKSYVK; one unmodified, three singly-phosphorylated, three-doubly phosphorylated, ...

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Optimum Waveforms for Differential Ion Mobility Spectrometry (FAIMS).

July 3rd, 2008
Optimum Waveforms for Differential Ion Mobility Spectrometry (FAIMS). Differential mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) is a new tool for separation and identification of gas-phase ions, particularly in conjunction with mass spectrometry. In FAIMS, ions are filtered by the difference between mobilities ...

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Topical application of autologous blood products during surgical closure following a coronary artery

July 3rd, 2008
Topical application of autologous blood products during surgical closure following a coronary artery bypass graft. Objective: Surgical site wound complications are associated with increased cost, morbidity, and mortality following cardiothoracic surgery. Recent publications have advocated the application of autologous blood components as an adjunctive tool to ...

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The utility of a reusable bipolar sealing instrument, BiClamp((R)), for pulmonary resection.

July 3rd, 2008
The utility of a reusable bipolar sealing instrument, BiClamp((R)), for pulmonary resection. Objective: To assess the use of a combination of bipolar sealing and electrosurgical coagulation for pulmonary resection. Methods: The procedure was used in both dogs and humans. Initially, lung wedge resections were performed on ...

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Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, lo

July 3rd, 2008
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Secreted amyloid precursor protein-alpha (sAPPalpha) levels are reduced during the pathogenesis of Alzheimer\'s disease, but the significance of this for neural function is not well understood. Here, we show that intrahippocampal ...

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QSAR prediction of inhibition of aldose reductase for flavonoids.

July 3rd, 2008
QSAR prediction of inhibition of aldose reductase for flavonoids. We performed a predictive analysis based on quantitative structure-activity relationships (QSAR) of an important property of flavonoids, which is the inhibition (IC(50)) of aldose reductase (AR). The importance of AR inhibition is that it prevents cataract formation ...

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A novel Syk family kinase inhibitor: Design, synthesis, and structure-activity relationship of 1,2,4

July 3rd, 2008
A novel Syk family kinase inhibitor: Design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives. Splenic tyrosine kinase (Syk) family kinases, which are members of the protein tyrosine kinase family, play crucial roles in immune responses, with Syk participating in B-cell activation and the zeta-associated ...

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Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE i

July 3rd, 2008
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. A number of mono- and bis-quaternary ammonium salts, containing edrophonium-like and coumarin moieties tethered by an appropriate linker, proved to be highly potent and selective dual binding site acetylcholinesterase inhibitors with good ...

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Regional bone density changes in anterior cruciate ligament deficient knees: A DEXA study.

July 3rd, 2008
Regional bone density changes in anterior cruciate ligament deficient knees: A DEXA study. Bone mineral density (BMD) loss is one of the secondary problems occurring in knee joint after injury of anterior cruciate ligament (ACL). The effect of this injury on BMDs of specific regions is ...

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Akt signaling: a damaging interaction makes good.

July 3rd, 2008
Akt signaling: a damaging interaction makes good. Phosphorylation of the protein kinase Akt at Ser473 is a key regulatory event in the induction of cellular survival mechanisms. A new study provides a novel mechanism for Akt activation. In cells and mice exposed to DNA-damaging insults, Ser473 ...

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A gait analysis of simulated knee flexion contracture to elucidate knee-spine syndrome.

July 3rd, 2008
A gait analysis of simulated knee flexion contracture to elucidate knee-spine syndrome. Knee flexion contracture influences the physiological movements in lower extremities and may cause the kinematic changes of the trunk. Our purpose was to investigate static and dynamic changes in trunk kinematics with simulated knee ...

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The in vivo three-dimensional motion of the human lumbar spine during gait.

July 3rd, 2008
The in vivo three-dimensional motion of the human lumbar spine during gait. Lumbar spine pathology accounts for billions of dollars in societal costs each year. Although the symptomatology of these conditions is relatively well understood, the mechanical changes in the spine are not. Previous direct measurements ...

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Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition.

July 3rd, 2008
Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition. Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family ...

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Integration of Bimodal Looming Signals through Neuronal Coherence in the Temporal Lobe.

July 3rd, 2008
Integration of Bimodal Looming Signals through Neuronal Coherence in the Temporal Lobe. The ability to integrate information across multiple sensory systems offers several behavioral advantages, from quicker reaction times and more accurate responses to better detection and more robust learning [1]. At the neural level, multisensory ...

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Calcium-Activated Myosin V Closes the Drosophila Pupil.

July 3rd, 2008
Calcium-Activated Myosin V Closes the Drosophila Pupil. Approximately 40 years ago, an elegant automatic-gain control was revealed in compound eye photoreceptors: In bright light, an assembly of small pigment granules migrates to the cytoplasmic face of the photosensitive membrane organelle, the rhabdomere, where they attenuate waveguide ...

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Natural products in parallel synthesis: Triazole libraries of nonactic acid.

July 3rd, 2008
Natural products in parallel synthesis: Triazole libraries of nonactic acid. The synthesis of a library of nonactic acid-derived triazoloamide derivatives and their evaluation as antimicrobial agents is described. Luesse SB, Wells G, Nayek A, Smith AE, Kusche BR, Bergmeier SC, McMills MC, Priestley ND, Wright DL. ...

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Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines.

July 3rd, 2008
Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. We synthesized several novel 2-O- or 11-O-substituted N-alkylnoraporphines and assessed their affinities at dopamine D(1) and D(2), and serotonin 5-HT(1A) receptors in rat forebrain tissue. Tested compounds displayed moderate to high affinities to D(2) receptors but low ...

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T-type Ca(2+) channel blockers suppress the growth of human cancer cells.

July 3rd, 2008
T-type Ca(2+) channel blockers suppress the growth of human cancer cells. In order to further clarify the role of T-type Ca(2+) channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca(2+) channel blockers. As a result, ...

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Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

July 3rd, 2008
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. The importance of cysteine proteases in parasites, compounded with the lack of redundancy compared to their mammalian hosts makes proteases attractive targets for the development of new therapeutic agents. The binding mode of K11002 to cruzain, the major cysteine ...

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