Medical and Biomedical Researches

Synthesis and Antimicrobial Study of Novel 1-Aryl-2-oxo-indano[3,2-d]pyrido/pyrimido[1,2-b]pyrimidin

June 27th, 2008
Synthesis and Antimicrobial Study of Novel 1-Aryl-2-oxo-indano[3,2-d]pyrido/pyrimido[1,2-b]pyrimidines. A series of 2-(arylidene)-indan-1, 3-diones 1 were prepared by Knoevenagel reaction between indane-1,3-dione and the appropriate araldehydes. The alpha,beta-enones 1 have been used as a component of Michael addition with equimolar amounts of 2-aminopyridine/2-aminopyrimidine to give novel heterocyclic systems ...

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Clinical and cost effectiveness of sacral nerve stimulation for faecal incontinence.

June 27th, 2008
Clinical and cost effectiveness of sacral nerve stimulation for faecal incontinence. BACKGROUND:: Sacral nerve stimulation (SNS) has better results and safety than other surgical procedures for faecal incontinence. This prospective study assessed the clinical effectiveness and costs of SNS at a single centre. METHODS:: Patients who ...

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Impact of preoperative thyroid ultrasonography on the surgical management of primary hyperparathyroi

June 27th, 2008
Impact of preoperative thyroid ultrasonography on the surgical management of primary hyperparathyroidism. BACKGROUND:: Primary hyperparathyroidism (PHPT) with coexisting thyroid disease has been considered a contraindication to minimally invasive parathyroidectomy (MIP). This study assessed the impact of thyroid ultrasonography and guided fine-needle aspiration (FNA) biopsy with cytological ...

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Central bisectionectomy for centrally located hepatocellular carcinoma.

June 27th, 2008
Central bisectionectomy for centrally located hepatocellular carcinoma. BACKGROUND:: Central bisectionectomy, which involves the removal of the central hepatic segments (IVA, IVB, V, VIII) for hepatocellular carcinoma (HCC), is performed to reduce the volume of resected liver and to overcome the problem of insufficient future residual volume. ...

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Highly Accurate CCSD(T) and DFT-SAPT Stabilization Energies of H-Bonded and Stacked Structures of th

June 27th, 2008
Highly Accurate CCSD(T) and DFT-SAPT Stabilization Energies of H-Bonded and Stacked Structures of the Uracil Dimer. The CCSD(T) interaction energies for the H-bonded and stacked structures of the uracil dimer are determined at the aug-cc-pVDZ and aug-cc-pVTZ levels. On the basis of these calculations we can ...

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Ambipolar Transport in the Smectic E Phase of 2-Propyl-5”-Hexynylterthiophene Derivative over a W

June 27th, 2008
Ambipolar Transport in the Smectic E Phase of 2-Propyl-5\'\'-Hexynylterthiophene Derivative over a Wide Temperature Range. 5-Hexyl-5\'\'-hexynyl-2,2\':5\',2\'\'-terthiophene exhibits the smectic E phase below 200 degrees C and does not crystallize when it is cooled to -100 degrees C. Between 200 and -100 degrees C, non-dispersive transport is ...

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Rhizobium rubi(T): A Gram-Negative Phytopathogenic Bacterium Expressing the Lewis B Epitope on the O

June 27th, 2008
Rhizobium rubi(T): A Gram-Negative Phytopathogenic Bacterium Expressing the Lewis B Epitope on the Outer Core of its Lipooligosaccharide Fraction. The structure of the core oligosaccharide from the phytopathogenic bacterium Rhizobium rubi was deduced by combining information from complementary chemical approaches (alkaline and acid hydrolysis), similar to ...

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Benzene Polyphosphates as Tools for Cell Signalling: Inhibition of Inositol 1,4,5-Trisphosphate 5-Ph

June 27th, 2008
Benzene Polyphosphates as Tools for Cell Signalling: Inhibition of Inositol 1,4,5-Trisphosphate 5-Phosphatase and Interaction with the PH Domain of Protein Kinase Balpha. Novel benzene polyphosphates were synthesised as inositol polyphosphate mimics and evaluated against type-I inositol 1,4,5-trisphosphate 5-phosphatase, which only binds soluble inositol polyphosphates, and against ...

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Zn(2+) Complexes of Di- and Tri-nucleating Azacrown Ligands as Base-Moiety-Selective Cleaving Agents

June 27th, 2008
Zn(2+) Complexes of Di- and Tri-nucleating Azacrown Ligands as Base-Moiety-Selective Cleaving Agents of RNA 3\',5\'-Phosphodiester Bonds: Binding to Guanine Base. The ability of the dinuclear Zn(2+) complex of 1,4-bis[(1,5,9-triazacyclododecan-3-yloxy)methyl]benzene (L(1)) to promote the cleavage of the phosphodiester bond of dinucleoside-3\',5\'-monophosphates that contain a guanine base has ...

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Ethanol fermentation in a yeast immobilized tubular fermentor.

June 27th, 2008
Ethanol fermentation in a yeast immobilized tubular fermentor. In this article, a mathematical model describing the kinetics of ethanol fermentation in a whole cell immobilized tubular fermentor is proposed. Experimental results show reasonable agreement with the proposed model. A procedure for treating the fermentation data for ...

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Immobilization of Escherichia coli cells with penicillin-amidohydrolase activity on solid polymeric

June 27th, 2008
Immobilization of Escherichia coli cells with penicillin-amidohydrolase activity on solid polymeric carriers. Whole cells of Escherichia coli containing the enzyme penicillinamidohydrolase EC 3.5.1.11 were immobilized on the surface of modified macroporous copolymers of glycidylmethacrylate with ethylenedimethacrylate and of copolymers of methacrylaldehyde (MA) with divinylbenzene (DVB) by ...

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On the role of reversible denaturation (unfolding) in the irreversible thermal inactivation of enzym

June 27th, 2008
On the role of reversible denaturation (unfolding) in the irreversible thermal inactivation of enzymes. The contribution of the reversible thermal unfolding of an enzyme toward the overall irreversible thermoinactivation process has been examined both theoretically and experimentally. Using bovine pancreatic ribonuclease as a model, we have ...

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Enzyme immobilization by the coulomb force.

June 27th, 2008
Enzyme immobilization by the coulomb force. A new immobilization technique has been developed. It involves immobilizing enzymes on a porous polytetrafluoroethylene membrane with a nonporous polyurethane coat by the use of an electrostatic force, i.e. the Coulomb force. The immobilized enzyme can be recovered by supplying ...

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Application of macroscopic balances to the identification of gross measurement errors.

June 27th, 2008
Application of macroscopic balances to the identification of gross measurement errors. A systematic method is presented which is capable of both detecting the presence of grossly biased measurement errors and locating the source of these errors in a bioreactor through statistical hypothesis testing. Equality constraints derived ...

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Activated sludge treatment of synthetic wastewater containing pentachlorophenol.

June 27th, 2008
Activated sludge treatment of synthetic wastewater containing pentachlorophenol. Activated sludge treatment of a pentachlorophenol (PCP)-containing synthetic waste was examined. With a waste containing some sugars, and 40-120 mg/L PCP, laboratory activated sludge required about seven days for acclimation. However, the prior addition of a quasipure culture ...

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Statistical mechanical estimation of the free energy of formation of E. coli biomass for use with ma

June 27th, 2008
Statistical mechanical estimation of the free energy of formation of E. coli biomass for use with macroscopic bioreactor balances. The need for the determination of the free energy of formation of biomass in bioreactor second law balances is well established. A statistical mechanical method for the ...

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Fuel ethanol and high protein feed from corn and corn-whey mixtures in a farm-scale plant.

June 27th, 2008
Fuel ethanol and high protein feed from corn and corn-whey mixtures in a farm-scale plant. Distiller\'s wet grain (DWG) and 95% ethanol were produced from corn in a farm-scale process involving batch cooking-fermentation and continuous distillation-centrifugation. The energy balance was 2.26 and the cost was $1.86/gal ...

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Competition between two microbial populations in a nonmixed environment: Effect of cell random motil

June 27th, 2008
Competition between two microbial populations in a nonmixed environment: Effect of cell random motility. In a nonmixed environment, bacterial population growth can be influenced significantly by cell motility properties as well as by growth kinetic properties. Therefore, in a situation of competition between two bacterial populations ...

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Proton imaging of siloxanes to map tissue oxygenation levels (PISTOL): a tool for quantitative tissu

June 27th, 2008
Proton imaging of siloxanes to map tissue oxygenation levels (PISTOL): a tool for quantitative tissue oximetry. Hexamethyldisiloxane (HMDSO) has been identified as a sensitive proton NMR indicator of tissue oxygenation (pO(2)) based on spectroscopic spin-lattice relaxometry. A rapid MRI approach has now been designed, implemented, and ...

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Chemical design of nanoparticle probes for high-performance magnetic resonance imaging.

June 27th, 2008
Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Synthetic magnetic nanoparticles (MNPs) are emerging as versatile probes in biomedical applications, especially in the area of magnetic resonance imaging (MRI). Their size, which is comparable to biological functional units, and their unique magnetic properties allow ...

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The Role of Aromaticity and the pi-Conjugated Framework in Multiporphyrinic Systems as Single-Molecu

June 27th, 2008
The Role of Aromaticity and the pi-Conjugated Framework in Multiporphyrinic Systems as Single-Molecule Switches. A systematic analysis of electron-transport characteristics for monomer, dimer, and tetramer multiporphyrinic systems is presented, to provide a thorough understanding of the structural dependence of electron transport related to the aromatic nature ...

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Tumor-Inhibitory Effect and Immunomodulatory Activity of Fullerol C(60)(OH)(x).

June 27th, 2008
Tumor-Inhibitory Effect and Immunomodulatory Activity of Fullerol C(60)(OH)(x). The tumor-inhibitory effect of C(60)(OH)(x) was tested on the murine H22 hepatocarcinoma model. Doses of 0.2 and 1.0 mg kg(-1) body weight both showed significant antitumor activity with tumor inhibition rates of 31.9 and 38.4%, respectively, when mice ...

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Complete NMR data assignments for novel pterocarpans from Harpalyce brasiliana.

June 27th, 2008
Complete NMR data assignments for novel pterocarpans from Harpalyce brasiliana. A NMR study of two new pterocarpans isolated from the roots of Harpalyce brasiliana is described. In addition to 1D NMR, 2D shift-correlated NMR pulse sequences ((1)H--(1)H-COSY, HSQC and HMBC) were used to establish the structures, ...

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Human catalytic antibody Se-scFv-B3 with high glutathione peroxidase activity.

June 27th, 2008
Human catalytic antibody Se-scFv-B3 with high glutathione peroxidase activity. In order to generate catalytic antibodies with glutathione peroxidase (GPX) activity, we prepared GSH-S-2,4-dinitrophenyl t-butyl ester (GSH-S-DNPBu) as target antigen. Three clones (A11, B3, and D5) that bound specifically to the antigen were selected from the phage ...

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Validation of fast MR thermometry at 1.5 T with gradient-echo echo planar imaging sequences: phantom

June 27th, 2008
Validation of fast MR thermometry at 1.5 T with gradient-echo echo planar imaging sequences: phantom and clinical feasibility studies. The purpose of this work was to validate in phantom studies and demonstrate the clinical feasibility of MR proton resonance frequency thermometry at 1.5 T with segmented ...

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