Medical and Biomedical Researches

Guidelines for visual-sensitive EEG testing.

June 27th, 2008
Guidelines for visual-sensitive EEG testing. A high level of evidence does not exist for many aspects of testing for visual sensitivity. Evidenced-based studies are needed in several areas, including (i) reliability of LED-based stimulators, (ii) the most appropriate montages for displaying responses, (iii) testing during pregnancy, ...

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[Curriculum for additional advanced specialist training in psychotherapy–concept and initial experi

June 27th, 2008
[Curriculum for additional advanced specialist training in psychotherapy--concept and initial experience in practice] The regulations for advanced specialist training passed by the German Medical Council in May 2003 make it possible for any clinical physician to complete advanced training for \"specialty-related psychotherapy\". Critics see this as ...

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[Multiple nuclear pseudogenes of mitochondrial cytochrome oxidase I gene in Scylla paramamosain (Dec

June 27th, 2008
[Multiple nuclear pseudogenes of mitochondrial cytochrome oxidase I gene in Scylla paramamosain (Decapoda : Portunidae)] Nuclear mitochondrial pseudogenes (Numts), widely existing in nuclear genomes of many organisms, are those nuclear DNA sequences which have high similarity with mtDNAs. In this study, we identified 14 different multiple ...

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[Treatment of urethral fistulas in children with application of allogenic fibroblasts]

June 27th, 2008
[Treatment of urethral fistulas in children with application of allogenic fibroblasts] The study was aimed at upgrading the results of conservative treatment of children with urethral fistulas using methods of tissue engineering. A total of 126 operations for closure of urethral fistulas (UF) were made from ...

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[Ipsilateral adrenalectomy is not obligatory in nephrectomy for renal cell carcinoma]

June 27th, 2008
[Ipsilateral adrenalectomy is not obligatory in nephrectomy for renal cell carcinoma] To analyse the necessity of obligatory ipsilateral adrenalectomy (IA) for renal cell carcinoma (RCC), we made a study of 329 RCC patients operated from 2002 to 2007. Nephrectomy was conducted in 208 (63.2%) patients, renal ...

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[Laparoscopic nephropexy with polypropilen graft implantation: a clinico-experimental study]

June 27th, 2008
[Laparoscopic nephropexy with polypropilen graft implantation: a clinico-experimental study] The article presents experimental data on interaction of the polypropilen implant with the kidney and adjacent tissues, on comparative evaluation of reliability of mechanical methods of polypropilen net fixation to different human tissues (the kidney, muscles and ...

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Sensibility loss after ACL reconstruction with hamstring graft.

June 27th, 2008
Sensibility loss after ACL reconstruction with hamstring graft. Injury to the infrapatellar branch of the saphenous nerve (IPBSN), is known to cause regional hypoesthesia of the lower leg after anterior cruciate ligament (ACL) reconstruction. The aim of this study was to determine if the orientation of ...

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Better genechip microarray layouts by combining probe placement and embedding.

June 27th, 2008
Better genechip microarray layouts by combining probe placement and embedding. The microarray layout problem is a generalization of the border length minimization problem, and asks to distribute oligonucleotide probes on a microarray and to determine their embeddings in the deposition sequence in such a way that ...

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Deconvoluting bac-gene relationships using a physical map.

June 27th, 2008
Deconvoluting bac-gene relationships using a physical map. Deconvolution of relationships between bacterial artificial chromosome (BAC) clones and genes is a crucial step in the selective sequencing of regions of interest in a genome. It often includes combinatorial pooling of unique probes obtained from the genes (unigenes), ...

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Improving the performance of protein threading using insertion/deletion frequency arrays.

June 27th, 2008
Improving the performance of protein threading using insertion/deletion frequency arrays. As a protein evolves, not every part of the amino acid sequence has an equal probability of being deleted or for allowing insertions, because not every amino acid plays an equally important role in maintaining the ...

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Clustering of main orthologs for multiple genomes.

June 27th, 2008
Clustering of main orthologs for multiple genomes. The identification of orthologous genes shared by multiple genomes is critical for both functional and evolutionary studies in comparative genomics. While it is usually done by sequence similarity search and reconciled tree construction in practice, recently a new combinatorial ...

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Gene regulatory network reconstruction by bayesian integration of prior knowledge and/or different e

June 27th, 2008
Gene regulatory network reconstruction by bayesian integration of prior knowledge and/or different experimental conditions. There have been various attempts to improve the reconstruction of gene regulatory networks from microarray data by the systematic integration of biological prior knowledge. Our approach is based on pioneering work by ...

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Mango: multiple alignment with N gapped oligos.

June 27th, 2008
Mango: multiple alignment with N gapped oligos. Multiple sequence alignment is a classical and challenging task. The problem is NP-hard. The full dynamic programming takes too much time. The progressive alignment heuristics adopted by most state-of-the-art works suffer from the \"once a gap, always a gap\" ...

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Using directed information to build biologically relevant influence networks.

June 27th, 2008
Using directed information to build biologically relevant influence networks. The systematic inference of biologically relevant influence networks remains a challenging problem in computational biology. Even though the availability of high-throughput data has enabled the use of probabilistic models to infer the plausible structure of such networks, ...

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On preprocessing and antisymmetry in de novo Peptide sequencing: improving efficiency and accuracy.

June 27th, 2008
On preprocessing and antisymmetry in de novo Peptide sequencing: improving efficiency and accuracy. Peptide sequencing plays a fundamental role in proteomics. Tandem mass spectrometry, being sensitive and efficient, is one of the most commonly used techniques in peptide sequencing. Many computational models and algorithms have been ...

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Using indirect protein-protein interactions for protein complex prediction.

June 27th, 2008
Using indirect protein-protein interactions for protein complex prediction. Protein complexes are fundamental for understanding principles of cellular organizations. As the sizes of protein-protein interaction (PPI) networks are increasing, accurate and fast protein complex prediction from these PPI networks can serve as a guide for biological experiments ...

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PPiClust: EFFICIENT CLUSTERING OF 3D PROTEIN-PROTEIN INTERACTION INTERFACES.

June 27th, 2008
PPiClust: EFFICIENT CLUSTERING OF 3D PROTEIN-PROTEIN INTERACTION INTERFACES. The biological mechanisms through which proteins interact with one another are best revealed by studying the structural interfaces between interacting proteins. Protein-protein interfaces can be extracted from three-dimensional (3D) structural data of protein complexes and then clustered to ...

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Three-dimensional water diffusion in impermeable cylindrical tubes: theory versus experiments.

June 27th, 2008
Three-dimensional water diffusion in impermeable cylindrical tubes: theory versus experiments. Characterizing diffusion of gases and liquids within pores is important in understanding numerous transport processes and affects a wide range of practical applications. Previous measurements of the pulsed gradient stimulated echo (PGSTE) signal attenuation, E(q), of ...

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Short-scan-time multi-slice diffusion MRI of the mouse cervical spinal cord using echo planar imagin

June 27th, 2008
Short-scan-time multi-slice diffusion MRI of the mouse cervical spinal cord using echo planar imaging. Mouse spinal cord (SC) diffusion-weighted imaging (DWI) provides important information on tissue morphology and structural changes that may occur during pathologies such as multiple sclerosis or SC injury. The acquisition scheme of ...

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Effect of paramagnetic manganese cations on (1)H MRS of the brain.

June 27th, 2008
Effect of paramagnetic manganese cations on (1)H MRS of the brain. Manganese cations (Mn(2+)) can be used as an intracellular contrast agent for structural, functional and neural pathway imaging applications. However, at high concentrations, Mn(2+) is neurotoxic and may influence the concentration of (1)H MR-detectable metabolites. ...

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Synthesis and Anti-HBV Activities Evaluation of New Ethyl 8-Imidazolylmethyl-7-hydroxyquinoline-3-ca

June 27th, 2008
Synthesis and Anti-HBV Activities Evaluation of New Ethyl 8-Imidazolylmethyl-7-hydroxyquinoline-3-carboxylate Derivatives in vitro. Some new ethyl 8-imidazolylmethyl-7-hydroxyquinoline-3-carboxylate derivatives have been synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in HepG2.2.15 cells stable transfection with HBV. Compounds 13a, 11b, 11c, 12c, 13c, 11g, and ...

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Syntheses and Cytotoxic Properties of the Curcumin Analogs 2,6-Bis(benzylidene)-4-phenylcyclohexanon

June 27th, 2008
Syntheses and Cytotoxic Properties of the Curcumin Analogs 2,6-Bis(benzylidene)-4-phenylcyclohexanones. Fifteen curcumin analogs were synthesized and tested for in-vitro cytotoxicity towards B16 and L1210 murine cancer cell lines using an MTT assay. Significant activity was discovered for two analogs: 8 (B16 IC(50) = 1.6 muM; L1210 IC(50) ...

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Facile One-Pot Synthesis and Antimycobacterial Evaluation of Pyrazolo[3,4-d]pyrimidines.

June 27th, 2008
Facile One-Pot Synthesis and Antimycobacterial Evaluation of Pyrazolo[3,4-d]pyrimidines. The present article describes a facile one-pot synthesis of a series of eight pyrazolo[3,4-d]pyrimidines 4a-h which were evaluated for their in-vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar-Blue susceptibility test and the activity expressed as the ...

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Synthesis and Biological Evaluation of Some 2,4,5-Trisubstituted Thiazole Derivatives as Potential A

June 27th, 2008
Synthesis and Biological Evaluation of Some 2,4,5-Trisubstituted Thiazole Derivatives as Potential Antimicrobial and Anticancer Agents. We report on the synthesis and biological evaluation of two series of 2,4,5-polysubstituted thiazoles comprising the acid hydrazide functionality and some derived pharmacophores known to contribute to various chemotherapeutic activities. All ...

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The Discovery of Taranabant, a Selective Cannabinoid-1 Receptor Inverse Agonist for the Treatment of

June 27th, 2008
The Discovery of Taranabant, a Selective Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity. The cannabinoid-1 receptor (CB1R) has emerged as one of the most important targets for the treatment of obesity. Pioneering studies with rimonabant helped to validate animal models of food intake reduction ...

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