Medical and Biomedical Researches

Enhancement of arsenic trioxide-induced apoptosis in HeLa cells by diethyldithiocarbamate or buthion

June 27th, 2008
Enhancement of arsenic trioxide-induced apoptosis in HeLa cells by diethyldithiocarbamate or buthionine sulfoximine. Arsenic trioxide (ATO) affects many biological functions such as cell proliferation, apoptosis, differentiation and angiogenesis in various cells. We investigated the in vitro effects of ATO as a reactive oxygen species (ROS) generator ...

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Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and H

June 27th, 2008
Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumors. The epidermal growth factor receptors, HER1, HER2, HER3 and HER4 play a key role in the growth of malignant tumors. The receptors of the ...

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Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic m

June 27th, 2008
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Cdc42, a member of Rho GTPases family, is involved in the regulation of several cellular functions, such as rearrangement of actin cytoskeleton, membrane trafficking, cell-cycle progression, and transcriptional regulation. Aberrant expression or ...

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siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth.

June 27th, 2008
siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth. Interferon regulatory factor (IRF) 1 and its functional antagonist IRF2 were originally discovered as transcription factors that regulate the interferon-beta gene. Control of cell growth has led to the definition of IRF1 as a tumour suppressor ...

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CD31 density is a novel risk factor for patients with B-cell chronic lymphocytic leukaemia.

June 27th, 2008
CD31 density is a novel risk factor for patients with B-cell chronic lymphocytic leukaemia. CD31 is the physiological ligand for CD38. CD38 expression in a high percentage of malignant cells is a risk factor for patients with B-cell chronic lymphocytic leukaemia (B-CLL). A previous investigation demonstrated ...

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Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gas

June 27th, 2008
Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models. Overexpression of the transcription factor Sp1 may play a critical role in human gastric cancer angiogenesis. In the present studies, we determined whether targeting Sp1 has a therapeutic ...

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MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells.

June 27th, 2008
MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells. The MUC1 oncoprotein is aberrantly expressed in human multiple myeloma cells by mechanisms that are not understood. Moreover, the functional role of MUC1 in multiple myeloma is not known. The present studies demonstrate that the ...

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Poor outcome in adolescents with high-risk Hodgkin lymphoma.

June 27th, 2008
Poor outcome in adolescents with high-risk Hodgkin lymphoma. This retrospective study looks at the differences between adolescents (15-19 years) and young adults (20-25 years), diagnosed with Hodgkin lymphoma and treated at the same adult institution. Outcome according to risk category was evaluated, and although there were ...

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Differential expression of GHRH receptor and its splice variant 1 in human normal and malignant muco

June 27th, 2008
Differential expression of GHRH receptor and its splice variant 1 in human normal and malignant mucosa of the oesophagus and colon. Recent evidence indicates that growth hormone-releasing hormone (GHRH) functions as a growth factor for gastrointestinal (GI) tumours. The tumourigenic effects of GHRH appear to be ...

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Osteoprogenitor differentiation is not affected by immunomodulatory thalidomide analogs but is promo

June 27th, 2008
Osteoprogenitor differentiation is not affected by immunomodulatory thalidomide analogs but is promoted by low bortezomib concentration, while both agents suppress osteoclast differentiation. We investigated the effects of bortezomib (PS-341) and immunomodulatory thalidomide analogs (immunomodulatory compounds; CC-4047, CC-6032, and CC-5013, or lenalidomide) on osteoblast and osteoclast differentiation ...

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Combined therapy using suicide gef gene and paclitaxel enhances growth inhibition of multicellular t

June 27th, 2008
Combined therapy using suicide gef gene and paclitaxel enhances growth inhibition of multicellular tumour spheroids of A-549 human lung cancer cells. The low efficiency of conventional therapies in achieving long-term survival of lung cancer patients calls for development of novel options. The potential use of combined ...

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Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable progn

June 27th, 2008
Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis. Chemokines play an important role in the pathogenesis of non-small cell lung cancer (NSCLC). However, aberrant methylation of CXCL12 has not been examined in NSCLC. CXCL12 mRNA expression and methylation were ...

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Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a

June 27th, 2008
Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel. Paclitaxel, a natural product originally isolated from Taxus brevifolia, belongs to the most successful anticancer drugs. Nevertheless, its poor water solubility represents a considerable disadvantage in ...

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Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against

June 27th, 2008
Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein. Therapeutic DNA vaccines against oncogenic infection with human papillomavirus type 16 (HPV16) are mostly targeted against viral oncoproteins E7 and E6. To adapt the E7 oncoprotein for DNA immunization, we have ...

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ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells.

June 27th, 2008
ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells. Resveratrol (RSVL), a phytoalexin found in abundance in grapes and other grape-related products, has been shown to be antiproliferative and protective against various types of cancers, including breast cancer. However, the precise underlying mechanisms are not ...

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Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metast

June 27th, 2008
Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas. Tumor metastasis depends on cell adhesiveness, motility and deformability, resulting from quantitative alterations and rearrangement of various actin-binding cytoskeletal components, such as cortactin and fascin. To clarify the ...

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Functional domains of CCN1 (Cyr61) regulate breast cancer progression.

June 27th, 2008
Functional domains of CCN1 (Cyr61) regulate breast cancer progression. CCN1 plays diverse roles in cellular proliferation, survival, migration and angiogenesis. We determined the relationship between CCN1 protein expression and clinical factors that are important for the classification of breast cancer. CCN1 contains four functional domains; the ...

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Establishment of combined immuno-chemotherapy with systemically administered gemcitabine and intra-p

June 27th, 2008
Establishment of combined immuno-chemotherapy with systemically administered gemcitabine and intra-portal administration of interleukin-2 in murine models of liver metastases of pancreatic cancer. Despite attempts to use multiple drug combinations that include gemcitabine (GEM), there is very little evidence that these combination regimens are superior to the ...

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Inverse relationship between E-cadherin and p27Kip1 expression in renal cell carcinoma.

June 27th, 2008
Inverse relationship between E-cadherin and p27Kip1 expression in renal cell carcinoma. The cell-cell adhesion system plays a pivotal role in the maintenance of tissue structure and cell-cell communication. E-cadherin is a major adhesion protein of the epithelial cells, and E-cadherin expression may be involved in the ...

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Tum-1, a tumstatin fragment, gene delivery into hepatocellular carcinoma suppresses tumor growth thr

June 27th, 2008
Tum-1, a tumstatin fragment, gene delivery into hepatocellular carcinoma suppresses tumor growth through inhibiting angiogenesis. Since hepatocellular carcinoma (HCC) is a hypervascular cancer, anti-angiogenic therapy is a promising approach to treat HCC. In the present study, we investigated the antiangiogenic and antitumor effects of tum-1, a ...

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Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event

June 27th, 2008
Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer. Previously we found that levels of LRRC49 (leucine rich repeat containing 49; FLJ20156) transcripts were elevated in ER-positive breast tumors compared with ER-negative breast tumors. The LRRC49 gene is ...

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Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colo

June 27th, 2008
Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. Cell adhesion molecules have been implicated in the selective colonization of cancer in distant organs. Breast cancer has a strong predilection for spreading to bone. Cadherin-11, which is one of ...

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Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulat

June 27th, 2008
Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Focal necrosis is a key pathologic feature that distinguishes glioblastoma from lower grade glioma. The presence of necrosis in a glioblastoma could promote its rapid growth ...

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The anti-tumor immune response induced by a combination of MAGE-3/MAGE-n-derived peptides.

June 27th, 2008
The anti-tumor immune response induced by a combination of MAGE-3/MAGE-n-derived peptides. Tumor antigen-derived peptides have been widely used to elicit tumor-specific cytotoxic T lymphocytes (CTLs). MAGE gene products are of particular interest owing to their wide expression in many tumors and their potential to induce tumor-specific ...

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In vitro cytotoxic activity of anthrapyrazole analogues in human prostate DU-145 and testicular NTER

June 27th, 2008
In vitro cytotoxic activity of anthrapyrazole analogues in human prostate DU-145 and testicular NTERA-2 carcinoma cells. Anthrapyrazoles are potent cytotoxic agents that intercalate into DNA, causing DNA strand breaks, inhibition of DNA synthesis and topoisomerase II. In this study, we investigated the in vitro cytotoxic activity ...

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