Medical and Biomedical Researches

Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: Heat shock prot

June 27th, 2008
Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: Heat shock protein 70 levels are modulated in microglial cells. Functional loss after spinal cord injuries is originated by primary and secondary injury phases whose underlying mechanisms include massive release of excitatory amino acids ...

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Abnormal tactile discrimination and somatosensory plasticity in familial primary hyperhidrosis.

June 27th, 2008
Abnormal tactile discrimination and somatosensory plasticity in familial primary hyperhidrosis. Abnormal sensory processing seems to be involved in hyperhidrosis. To test this hypothesis, we investigated tactile acuity and cortical plastic changes in patients with primary hyperhidrosis (PH) and their asymptomatic relatives. We studied thirteen subjects belonging ...

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Expression of the neuron-specific potassium chloride cotransporter KCC2 in adult rat cochlear.

June 27th, 2008
Expression of the neuron-specific potassium chloride cotransporter KCC2 in adult rat cochlear. Auditory transduction in the cochlear is subject to modulate higher auditory centers in the brain via the efferent systems, which provide protection against damage caused by excessive excitation during auditory over stimulation. GABA is ...

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Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neurona

June 27th, 2008
Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice. We evaluated the potential neuroprotective effects of combination treatment with normobaric hyperoxia (NBO) and edaravone, a potent scavenger of hydroxyl radicals, on acute brain injuries after stroke. Mice subjected to 2-h ...

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The spectral power coherence of the EEG under different EMF conditions.

June 27th, 2008
The spectral power coherence of the EEG under different EMF conditions. The present study introduces the concept of spectral power coherence (SPC), which reflects the pattern of coordination of the four basic EEG bands (delta, theta, alpha, and beta) at a specific location of the brain. ...

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Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1-14-3-3

June 27th, 2008
Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1-14-3-3 dissociation. The mechanism by which a brief episode of sublethal ischemia followed by reperfusion (ischemic preconditioning, IPC) prevents the lethal effects of subsequent periods of prolonged ischemia, are poorly understood. A completely randomized, controlled study ...

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Antiepileptic effect of electroacupuncture vs. vagus nerve stimulation in the rat thalamus.

June 27th, 2008
Antiepileptic effect of electroacupuncture vs. vagus nerve stimulation in the rat thalamus. Our previous study has shown that both electroacupuncture (EA) and vagus nerve stimulation (VNS) can inhibit cortical epileptiform activities induced by pentylenetetrazole (PTZ). The current study compared the effects of EA and VNS on ...

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A modified single-prolonged stress model for post-traumatic stress disorder.

June 27th, 2008
A modified single-prolonged stress model for post-traumatic stress disorder. In the rat, single-prolonged stress (SPS) model produces a core symptom of post-traumatic stress disorder (PTSD), the enhanced fear response to the traumatic cue (conditioned fear response). This investigative tool is typically used for PTSD studies. However, ...

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The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats.

June 27th, 2008
The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats. The antiepileptic activity of hydrophilic extract of Vitex agnus castus fruit (Vitex) was evaluated by the kindling model of epilepsy. Intact male rats (250-300g) were stereotaxically implanted with a tripolar and ...

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Effects of different-concentration oxygen-ozone of on rats’ astrocytes in vitro.

June 27th, 2008
Effects of different-concentration oxygen-ozone of on rats\' astrocytes in vitro. Although the widespread use of the oxygen-ozone in pain management, there is currently no consensus on its mechanisms of action and nearly no report for its action on nervous cells. Accordingly, the present study was designed ...

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The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene ex

June 27th, 2008
The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression. The differential recruitment of coregulatory proteins to the DNA-bound estrogen receptor alpha (ERalpha) plays a critical role in mediating estrogen-responsive gene expression. We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) ...

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Manganese chloride-induced G0/G1 and S phase arrest in A549 cells.

June 27th, 2008
Manganese chloride-induced G0/G1 and S phase arrest in A549 cells. In the present study, we investigated the effects of manganese chloride (MnCl(2)) on cell cycle progression in A549 cells used as a model of Mn-induced lung toxicity. Cells were treated with various concentrations of MnCl(2) (0, ...

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The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: E

June 27th, 2008
The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: Evidence from a large chemical survey. Acetaldehyde is a volatile compound naturally found in alcoholic beverages, and it is regarded as possibly being carcinogenic to humans (IARC Group 2B). Acetaldehyde formed during ethanol ...

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Studies on cytotoxic, hydroxyl radical scavenging and topoisomerase inhibitory activities of extract

June 27th, 2008
Studies on cytotoxic, hydroxyl radical scavenging and topoisomerase inhibitory activities of extracts of Tabernaemontana divaricata (L.) R.Br. ex Roem. and Schult. In the present investigation, the cytotoxic, hydroxyl radical scavenging and topoisomerase inhibition activities of Tabernaemontana divaricata (Apocynaceae) were evaluated. The extracts from leaves of the ...

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Combined physico-chemical treatments based on enterocin AS-48 for inactivation of Gram-negative bact

June 27th, 2008
Combined physico-chemical treatments based on enterocin AS-48 for inactivation of Gram-negative bacteria in soybean sprouts. Enterocin AS-48 was tested for decontamination of soybean sprouts against Gram-negative bacteria. Although treatment with bacteriocin alone had no effect on Salmonella enterica, a synergistic antimicrobial effect was detected at pH ...

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School-based influenza immunization.

June 27th, 2008
School-based influenza immunization. Annual influenza vaccination of schoolchildren will protect individual vaccines and, with high coverage, may protect entire communities. Because schoolchildren are more difficult to reach than preschoolers, school-based immunization programs may be needed to reach a high percentage of children. We offered free live, ...

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A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibo

June 27th, 2008
A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibody response to Haemophilus influenzae type b CRM(197) conjugate vaccine. CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, ...

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Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus.

June 27th, 2008
Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus. Allergic rhinitis (AR) is characterized by an inflammatory reaction sustained by Th2 polarization, whereas systemic lupus erythematosus (SLE) is a typical autoimmune disorder. Vascular endothelial growth factor (VEGF) is a critical mediator of inflammation. ...

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Identification of novel human leukocyte antigen G alleles in an East African population by high-reso

June 27th, 2008
Identification of novel human leukocyte antigen G alleles in an East African population by high-resolution sequence-based typing. We report two novel human leukocyte antigen G (HLA-G) alleles identified in an East African population during sequence-based typing of HLA-G. The novel alleles were confirmed by sequencing multiple ...

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Hyperphagia and obesity produced by arcuate injection of NPY-saporin does not require upregulation o

June 27th, 2008
Hyperphagia and obesity produced by arcuate injection of NPY-saporin does not require upregulation of lateral hypothalamic orexigenic peptide genes. Neuropeptide Y (NPY) conjugated with a ribosomal inactivating toxin, saporin (SAP), is a toxin that targets NPY receptor-expressing cells. Injection of NPY-SAP into the rat arcuate nucleus ...

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Serine/threonine kinase (pk-1) is a component of Autographa californica multiple nucleopolyhedroviru

June 27th, 2008
Serine/threonine kinase (pk-1) is a component of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) very late gene transcription complex and it phosphorylates a 102kDa polypeptide of the complex. The baculovirus gene, protein kinase-I (pk-1) encodes a serine/threonine kinase that is essential for very late gene expression. Late and ...

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Electrophysiological correlates of the disrupted processing of anger in alcoholism.

June 27th, 2008
Electrophysiological correlates of the disrupted processing of anger in alcoholism. OBJECTIVE: Recent studies have shown that alcoholism is characterized by a deficit in the processing of emotional facial expressions (EFE), and that this deficit could be \"emotion specific\". The present study explored the hypothesis that there ...

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Determination of volatile metabolites originating from mould growth on wall paper and synthetic medi

June 27th, 2008
Determination of volatile metabolites originating from mould growth on wall paper and synthetic media. Microbial volatile organic compounds (MVOCs) emitted from the mould species Penicillium expansum, P. chrysogenum, Aspergillus versicolor, A. fumigatus, A. niger and Cladosporium cladosporoides were analyzed by means of solid phase microextraction (SPME) ...

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CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury.

June 27th, 2008
CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury. Following peripheral nerve injury repair, improved behavioural outcome may be the most important evidence of functionality of axon regeneration after any repair strategy. A range of behavioural testing paradigms have been developed for peripheral ...

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An improved method for the estimation of firing rate dynamics using an optimal digital filter.

June 27th, 2008
An improved method for the estimation of firing rate dynamics using an optimal digital filter. In most neural systems, neurons communicate by means of sequences of action potentials or \'spikes\'. Information encoded by spike trains is often quantified in terms of the firing rate which emphasizes ...

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