Medical and Biomedical Researches

LUSH shapes up for a starring role in olfaction.

July 3rd, 2008
LUSH shapes up for a starring role in olfaction. In the fruit fly Drosophila, odorant-binding proteins are secreted into the fluid that bathes olfactory neurons. Laughlin et al. (2008) now challenge the assumption that the odorant-binding protein LUSH passively transports its pheromone to a specific olfactory ...

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Forging new ties between E. coli genes.

July 3rd, 2008
Forging new ties between E. coli genes. A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some ...

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A lexicon for homeodomain-DNA recognition.

July 3rd, 2008
A lexicon for homeodomain-DNA recognition. Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work (Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in ...

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Molecular movies… coming to a lecture near you.

July 3rd, 2008
Molecular movies... coming to a lecture near you. Scientific visualizations are powerful tools for communicating the intricacies of cellular and molecular structures and dynamics. There is a disconnect, however, between the research data sets we seek to represent and the kinds of animation that allow us ...

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Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coa

July 3rd, 2008
Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection. A new material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane}(PMDFPS) sensitive to toxic organophosphate vapor was synthesized with 2,3-difluorophenol, allyl bromide and poly (methyl hydrosiloxane) as raw materials, via O-alkylation, Claisen rearrange reaction and hydrosilylation reaction. This novel material was ...

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Simultaneous determination of monoamine and amino acid neurotransmitters in rat endbrain tissues by

July 3rd, 2008
Simultaneous determination of monoamine and amino acid neurotransmitters in rat endbrain tissues by pre-column derivatization with high-performance liquid chromatographic fluorescence detection and mass spectrometric identification. A sensitive and efficient method for simultaneous determination of glutamic acid (Glu), gamma-amino-butyric acid (GABA), dopamine (DA), 5-hydroxytryptamine (5-HT) and 5-hydroxyindole ...

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Simultaneous square-wave voltammetric determination of aspartame and cyclamate using a boron-doped d

July 3rd, 2008
Simultaneous square-wave voltammetric determination of aspartame and cyclamate using a boron-doped diamond electrode. A simple and highly selective electrochemical method was developed for the simultaneous determination of aspartame and cyclamate in dietary products at a boron-doped diamond (BDD) electrode. In square-wave voltammetric (SWV) measurements, the BDD ...

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Simultaneous determination of eight pesticide residues in coconut using MSPD and GC/MS.

July 3rd, 2008
Simultaneous determination of eight pesticide residues in coconut using MSPD and GC/MS. A simple and effective extraction method based on matrix solid-phase dispersion (MSPD) was developed to determine dimethoate, malathion, lufenuron, carbofuran, 3-hydroxycarbofuran, thiabendazole, difenoconazole and trichlorfon in coconut pulp using gas chromatography-mass spectrometry with selected ...

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A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescen

July 3rd, 2008
A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection. A sequential injection analysis procedure with dual-reagent chemiluminescence detection was applied to the screening of street drug seizure samples for the presence of heroin. The chemiluminescence reagents (acidic potassium permanganate and tris(2,2\'-bipyridine)ruthenium(III)) ...

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Cloud point extraction for cobalt preconcentration with on-line phase separation in a knotted reacto

July 3rd, 2008
Cloud point extraction for cobalt preconcentration with on-line phase separation in a knotted reactor followed by ETAAS determination in drinking waters. A novel method for cobalt preconcentration by cloud point extraction with on-line phase separation in a PTFE knotted reactor and further determination by electrothermal atomic ...

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Simultaneous determination of adenosine and inosine using single-wall carbon nanotubes modified pyro

July 3rd, 2008
Simultaneous determination of adenosine and inosine using single-wall carbon nanotubes modified pyrolytic graphite electrode. Voltammetric determination of adenosine and inosine has been carried out at single-wall carbon nanotubes (SWNTs) modified pyrolytic graphite electrode (PGE) at pH 7.2 using Osteryoung square wave voltammetry (OSWV). The modified electrode ...

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Separation of chromium(III) and chromium(VI) by ion chromatography and an inductively coupled plasma

July 3rd, 2008
Separation of chromium(III) and chromium(VI) by ion chromatography and an inductively coupled plasma mass spectrometer as element-selective detector. Due to its extensive use in industrial processes, large quantities of chromium compounds are discharged into the environment. Common approaches for the speciation of Cr employ the determination ...

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Monitoring the synthetic procedures of commercial drugs by 2H NMR spectroscopy: the case of ibuprofe

July 3rd, 2008
Monitoring the synthetic procedures of commercial drugs by 2H NMR spectroscopy: the case of ibuprofen and naproxen. We determined the D/H isotope ratios of some ibuprofen and naproxen samples by (2)H NMR spectroscopy. Some of these values were found to be useful for collecting hints on ...

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Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste

July 3rd, 2008
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry. This paper reports a derivatization, mass fragmentation study relating to the most common, non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, ketoprofen and diclofenac, identified ...

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On the re-assessment of the optimum conditions for the determination of platinum, palladium and rhod

July 3rd, 2008
On the re-assessment of the optimum conditions for the determination of platinum, palladium and rhodium in environmental samples by electrothermal atomic absorption spectrometry and microwave digestion. The experimental conditions for the determination of platinum, palladium and rhodium by graphite furnace atomic absorption spectrometry (GFAAS) are re-assessed. ...

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Direct sample introduction of wines in graphite furnace atomic absorption spectrometry for the simul

July 3rd, 2008
Direct sample introduction of wines in graphite furnace atomic absorption spectrometry for the simultaneous determination of arsenic, cadmium, copper and lead content. A multi-element graphite furnace atomic absorption spectrometry (GFAAS) method was elaborated for the simultaneous determination of As, Cd, Cu, and Pb in wine samples ...

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Problems in the application of the three-step BCR sequential extraction to low amounts of sediments:

July 3rd, 2008
Problems in the application of the three-step BCR sequential extraction to low amounts of sediments: an alternative validated route. Poor recoveries are obtained if the BCR three-step sequential extraction is applied to 100 mg specimens rather than to 1 g. It is observed that analytes are ...

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Use of a capacitance measurement device for surrogate noncontact conductance measurement.

July 3rd, 2008
Use of a capacitance measurement device for surrogate noncontact conductance measurement. A capacitance to digital converter (AD7746) is used in the same mode as noncontact conductance detectors. The detector output is linearly proportional to specific conductance (sigma) at low sigma values but becomes nonlinear and reaches ...

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Nanocrystalline In2O3-based H2S sensors operable at low temperatures.

July 3rd, 2008
Nanocrystalline In2O3-based H2S sensors operable at low temperatures. Nanocrystalline In(2)O(3)-based solid solutions, with different concentration of Co, with cubic structure were successfully prepared by a simple route. The as-prepared materials were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The indirect heating structure sensors ...

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Classification of data with missing elements and outliers.

July 3rd, 2008
Classification of data with missing elements and outliers. Missing elements and outliers can often occur in experimental data. The presence of outliers makes the evaluation of any least squares model parameters difficult, while the missing values influence the adequate identification of outliers. Therefore, approaches that can ...

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Advantages of pentafluorophenylpropyl stationary phase over conventional C18 stationary phase–appli

July 3rd, 2008
Advantages of pentafluorophenylpropyl stationary phase over conventional C18 stationary phase--application to analysis of triamcinolone acetonide. A pentafluorophenylpropyl (PFPP) stationary phase was for the first time tested for the simultaneous determination of triamcinolone acetonide, its degradation product triamcinolone and two preservatives, methylparaben, and propylparaben. A new simple ...

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Ion mobility spectrometry of volatile compounds from Iberian pig fat for fast feeding regime authent

July 3rd, 2008
Ion mobility spectrometry of volatile compounds from Iberian pig fat for fast feeding regime authentication. Characteristic ion mobility spectra for volatile compounds present in fat were used to authenticate the feeding regime of Iberian pigs. Volatile compounds were obtained by heating the solid samples at 150 ...

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First interlaboratory exercise on non-steroidal anti-inflammatory drugs analysis in environmental sa

July 3rd, 2008
First interlaboratory exercise on non-steroidal anti-inflammatory drugs analysis in environmental samples. Comparability of monitoring data are essential for any meaningful assessment and for the management of environmental risks of emerging pollutants. The reliability and comparability of data at European level is often limited, because analytical methods ...

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Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasm

July 3rd, 2008
Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasma mass spectrometry (ICP-MS) after tetramethylammonium hydroxide solubilization at room temperature: comparison with ETAAS. A simple method is described for the determination of Cd, Cu, Mn, Ni, Pb and Zn ...

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Classification of genomic data: some aspects of feature selection.

July 3rd, 2008
Classification of genomic data: some aspects of feature selection. Feature selection, while working with genomic data sets, is of particular interest, not only for classification (diagnostics) improvement, but also for the data interpretability. Application of the multivariate feature selection approaches allows an efficient reduction of data ...

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