Medical and Biomedical Researches

Patterns of admission to acute psychiatric in-patient facilities: a national survey in Italy.

June 28th, 2008
Patterns of admission to acute psychiatric in-patient facilities: a national survey in Italy. BACKGROUND: A proper understanding of patterns of care represents a crucial step in improving clinical decision making and enhancing service provision. Only a few studies, however, have explored global patterns of psychiatric admissions ...

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Molecular cloning and expression analysis of the STAT1 gene from olive flounder, Paralichthys olivac

June 28th, 2008
Molecular cloning and expression analysis of the STAT1 gene from olive flounder, Paralichthys olivaceus. ABSTRACT: BACKGROUND: Signal transducer and activator of transcription 1 (STAT1) is a critical component of interferon (IFN)-alpha/beta and IFN-gamma signaling. Although seven isoforms of STAT proteins have been reported from mammals, limited ...

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A weighted average difference method for detecting differentially expressed genes from microarray da

June 28th, 2008
A weighted average difference method for detecting differentially expressed genes from microarray data. ABSTRACT: BACKGROUND: Identification of differentially expressed genes (DEGs) under different experimental conditions is an important task in many microarray studies. However, choosing which method to use for a particular application is problematic because ...

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A physical map of human Alu repeats cleavage by restriction endonucleases.

June 28th, 2008
A physical map of human Alu repeats cleavage by restriction endonucleases. ABSTRACT: BACKGROUND: Alu repetitive elements are the abundant sequences in human genome. Diversity of DNA sequences of these elements makes difficult the construction of theoretical patterns of Alu repeats cleavage by restriction endonucleases. We have ...

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An Examination of Cancer Epidemiology Studies Among Populations Living Close to Toxic Waste Sites.

June 28th, 2008
An Examination of Cancer Epidemiology Studies Among Populations Living Close to Toxic Waste Sites. ABSTRACT: BACKGROUND: Toxic waste sites contain a broad range of suspected or confirmed human carcinogens, and remain a source of concern to many people, particularly those living in the vicinity of a ...

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SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonic

June 28th, 2008
SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum. ABSTRACT: BACKGROUND: Schistosoma japonicum is one of the three major blood fluke species, the etiological agents of schistosomiasis which remains a serious public health problem with an estimated 200 million people infected in 76 ...

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Systems biology driven software design for the research enterprise.

June 28th, 2008
Systems biology driven software design for the research enterprise. ABSTRACT: BACKGROUND: In systems biology, and many other areas of research, there is a need for the interoperability of tools and data sources that were not originally designed to be integrated. Due to the interdisciplinary nature of ...

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Induction of beta Defensin 2 by NTHi requires TLR2 Mediated MyD88 and IRAK-TRAF6-p38MAPK Signaling P

June 28th, 2008
Induction of beta Defensin 2 by NTHi requires TLR2 Mediated MyD88 and IRAK-TRAF6-p38MAPK Signaling Pathway in Human Middle Ear Epithelial Cells. ABSTRACT: BACKGROUND: All mucosal epithelia, including those of the tubotympanium, are secreting a variety of antimicrobial innate immune molecules (AIIMs). In our previous study, we ...

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Characterization of early and terminal complement proteins associated with polymorphonuclear leukocy

June 28th, 2008
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury. ABSTRACT: BACKGROUND: The complement system has been suggested to affect injury or disease of the central nervous system (CNS) by regulating numerous physiological events and pathways. ...

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Relating Gene Expression Data on Two-Component Systems to Functional Annotations in Escherichia coli

June 28th, 2008
Relating Gene Expression Data on Two-Component Systems to Functional Annotations in Escherichia coli. ABSTRACT: BACKGROUND: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionally, this has been done in two consecutive steps. The first step identifies important ...

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Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for s

June 28th, 2008
Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. ABSTRACT: BACKGROUND: Dengue virus pathogenesis is not yet fully understood and the identification of patients at high risk for developing severe disease forms is still a great challenge in dengue patient care. ...

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Indel PDB: a database of structural insertions and deletions derived from sequence alignments of clo

June 28th, 2008
Indel PDB: a database of structural insertions and deletions derived from sequence alignments of closely related proteins. ABSTRACT: BACKGROUND: Insertions and deletions (indels) represent a common type of sequence variations, which are less studied and pose many important biological questions. Recent research has shown that the ...

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Contributions to Early HIV Diagnosis Among Patients Linked to Care Vary by Testing Venue.

June 28th, 2008
Contributions to Early HIV Diagnosis Among Patients Linked to Care Vary by Testing Venue. ABSTRACT: OBJECTIVE: Early HIV diagnosis reduces transmission and improves health outcomes; screening in non-traditional settings is increasingly advocated. We compared test venues by the number of new diagnoses successfully linked to the ...

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Decision-making in percutaneous coronary intervention: a survey.

June 28th, 2008
Decision-making in percutaneous coronary intervention: a survey. ABSTRACT: BACKGROUND: Few researchers have examined the perceptions of physicians referring cases for angiography regarding the degree to which collaboration occurs during percutaneous coronary intervention (PCI) decision-making. We sought to determine perceptions of physicians concerning their involvement in PCI ...

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Genetic characterization of Hawaiian isolates of Plasmodium relictum reveals mixed-genotype infectio

June 28th, 2008
Genetic characterization of Hawaiian isolates of Plasmodium relictum reveals mixed-genotype infections. ABSTRACT: BACKGROUND: The relatively recent introduction of a highly efficient mosquito vector and an avian pathogen (Plasmodium relictum) to an isolated island ecosystem with naive, highly susceptible avian hosts provides a unique opportunity to investigate ...

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Health services research in the public healthcare system in Hong Kong: An analysis of over 1 million

June 28th, 2008
Health services research in the public healthcare system in Hong Kong: An analysis of over 1 million antihypertensive prescriptions between 2004-2007 as an example of the potential and pitfalls of using routinely collected electronic patient data. ABSTRACT: Objectives Increasing use is being made of routinely collected ...

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Determination of metal ion content of beverages and estimation of target hazard quotients: a compara

June 28th, 2008
Determination of metal ion content of beverages and estimation of target hazard quotients: a comparative study. ABSTRACT: BACKGROUND: Considerable research has been directed towards the roles of metal ions in nutrition with metal ion toxicity attracting particular attention. The aim of this study is to measure ...

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On the nature of fur evolution: a phylogenetic approach in Actinobacteria.

June 28th, 2008
On the nature of fur evolution: a phylogenetic approach in Actinobacteria. ABSTRACT: BACKGROUND: An understanding of the evolution of global transcription regulators is essential for comprehending the complex networks of cellular metabolism that have developed among related organisms. The fur gene encodes one of those regulators ...

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The design, implementation and acceptability of an integrated intervention to address multiple behav

June 28th, 2008
The design, implementation and acceptability of an integrated intervention to address multiple behavioral and psychosocial risk factors among pregnant African American women. ABSTRACT: BACKGROUND: African American women are at increased risk for poor pregnancy outcomes compared to other racial-ethnic groups. Single or multiple psychosocial and behavioral ...

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Proteomic Profile of Dormant Trichophyton Rubrum Conidia.

June 28th, 2008
Proteomic Profile of Dormant Trichophyton Rubrum Conidia. ABSTRACT: BACKGROUND: Trichophyton rubrum is the most common dermatophyte causing fungal skin infections in humans. Asexual sporulation is an important means of propagation for T. rubrum, and conidia produced by this way are thought to be the primary cause ...

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Legal themes concerning obesity regulation in the United States: Theory and practice.

June 28th, 2008
Legal themes concerning obesity regulation in the United States: Theory and practice. ABSTRACT: Despite national health objectives to reduce the incidence of obesity to 15% of the population by 2010, public health data suggest that the incidence of obesity in the United States is actually increasing. ...

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Performance comparison of two microarray platforms to assess differential gene expression in human m

June 28th, 2008
Performance comparison of two microarray platforms to assess differential gene expression in human monocyte and macrophage cells. ABSTRACT: BACKGROUND: In this study we assessed the respective ability of Affymetrix and Illumina microarray methodologies to answer a relevant biological question, namely the change in gene expression between ...

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Mucinous cystadenoma of the appendix misdiagnosed as cystic hydatid disease of the liver: a case rep

June 28th, 2008
Mucinous cystadenoma of the appendix misdiagnosed as cystic hydatid disease of the liver: a case report. ABSTRACT: INTRODUCTION: Primary neoplastic lesions presenting with a mucocele of the appendix are very rare and can be divided into benign variants of mucinous adenomas or cystadenomas, mucinous tumours of ...

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Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP an

June 28th, 2008
Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog. ABSTRACT: BACKGROUND: A novel, fluorescent cAMP analog, 8- [Pharos-575]- adenosine- 3\', 5\'- cyclic monophosphate was characterized in its spectral, biochemical and cellular properties. The ability of the analog to interact and activate different ...

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Automated Discovery and Phylogenetic Analysis of New Toxin-Antitoxin Systems.

June 28th, 2008
Automated Discovery and Phylogenetic Analysis of New Toxin-Antitoxin Systems. ABSTRACT: BACKGROUND: Although often viewed as elements \"at the service of\" bacteria, plasmids exhibit replication and maintenance mechanisms that make them purely \"selfish DNA\" candidates. Toxin-antitoxin (TA) systems are a spectacular example of such mechanisms: a gene ...

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