Medical and Biomedical Researches

Nano ES GEMMA and PDMA, New Tools for the Analysis of Nanobioparticles-Protein Complexes, Lipopartic

July 3rd, 2008
Nano ES GEMMA and PDMA, New Tools for the Analysis of Nanobioparticles-Protein Complexes, Lipoparticles, and Viruses. Differential mobility analysis (DMA) is a technique suited for size analysis as well as preparative collection of airborne nanosized airborne particles. In the recent decade, the analysis of intact viruses, ...

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Boys, girls and shuttling of SRY and SOX9.

July 3rd, 2008
Boys, girls and shuttling of SRY and SOX9. In the mammalian embryo, SRY and SOX9 are key Sertoli cell proteins that drive the development of the bipotential gonad into a testes rather than an ovary, leading ultimately to the male phenotype. Clinical SRY and SOX9 mutations ...

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Distinct cell proliferation events during abstinence after alcohol dependence: Microglia proliferati

July 3rd, 2008
Distinct cell proliferation events during abstinence after alcohol dependence: Microglia proliferation precedes neurogenesis. Excessive alcohol intake characteristic of Alcohol Use Disorders (AUDs) produces neurodegeneration that may recover with abstinence. The mechanism of regeneration is unclear, however neurogenesis from neural stem/progenitor cells is a feasible mechanism of ...

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Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17.

July 3rd, 2008
Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. Seipin, which is encoded by the BSCL2 gene, is a glycoprotein of unknown biochemical function that is associated with dominant hereditary motor neuron diseases. Mutations in the N-glycosylation site of seipin are associated with the disease ...

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Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disor

July 3rd, 2008
Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders. Environmental stimulation throughout development adjusts the neurobehavioral systems involved in learning, memory and defensive responses. Environment-mediated phenotypic plasticity can be considered from two different, yet complementary, viewpoints. On one hand, the possibility that ...

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Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.

July 3rd, 2008
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. G1-phase cyclin D1 (cD1) expression has been documented in post-mitotic neurons undergoing apoptosis, leading others to propose that attempted cell cycle re-entry may induce cell death. Here, cD1 immunoreactivity was found in a subpopulation ...

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Novel N(1)-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcrip

July 3rd, 2008
Novel N(1)-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. Several N(1)-substituted 1,3-dihydro-2H-benzimidazol-2-ones were synthesized and evaluated as anti-HIV agents. Some of them proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentration as potent non-nucleoside HIV-1 RT inhibitors (NNRTIs) with low cytotoxicity. SAR studies ...

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Phenyl phosphotriester derivatives of AZT: Variations upon the SATE moiety.

July 3rd, 2008
Phenyl phosphotriester derivatives of AZT: Variations upon the SATE moiety. Synthesis, in vitro anti-HIV activity, stability studies as well as potential for oral absorption of some novel phenyl S-acyl-2-thioethyl (SATE) phosphotriester derivatives of AZT (zidovudine; 3\'-azido-2\',3\'-dideoxythymidine) are described herein. These pronucleotides are characterized by the presence ...

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A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code.

July 3rd, 2008
A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code. Most nuclear factor-kappaB (NF-kappaB) inducers converge to activate the IkappaB kinase (IKK) complex, leading to NF-kappaB nuclear accumulation. However, depending on the inducer and the cell line, the subset of NF-kappaB-induced genes is different, ...

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The role of virulence determinants in community-associated MRSA pathogenesis.

July 3rd, 2008
The role of virulence determinants in community-associated MRSA pathogenesis. The recent emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) marked a quantum change in the biology and epidemiology of a major human pathogen. Various virulence determinants unique to CA-MRSA have been uncovered recently, which shed light on ...

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Sensory ataxic neuropathy with ophthalmoparesis caused by POLG mutations.

July 3rd, 2008
Sensory ataxic neuropathy with ophthalmoparesis caused by POLG mutations. Mutations in POLG gene are responsible for a wide spectrum of clinical disorders with altered mitochondrial DNA (mtDNA) integrity, including mtDNA multiple deletions and depletion. Sensory ataxic neuropathy with ophthalmoparesis (SANDO) caused by mutations in POLG gene, ...

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Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1

July 3rd, 2008
Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist. Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716, 1) and an investigation of the effect of replacement of the -CO group in ...

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Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone rece

July 3rd, 2008
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands. Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has ...

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Production, purification and chemical characterization of the catecholate siderophore from potent pr

July 3rd, 2008
Production, purification and chemical characterization of the catecholate siderophore from potent probiotic strains of Bacillus spp. The aim of the present study was to characterize the probiotic qualities of Bacillus isolates and study their siderophore prior to possible siderophoregenic probiotic application for iron nutrition in animals ...

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Improved degradation of organophosphate dichlorvos by Trichoderma atroviride transformants generated

July 3rd, 2008
Improved degradation of organophosphate dichlorvos by Trichoderma atroviride transformants generated by restriction enzyme-mediated integration (REMI). A simple technique, REMI (restriction enzyme-mediated integration), was used to construct transformants of Trichoderma atroviride with improved capability of degrading organophosphate pesticide dichlorvos. Linearized DNA of plasmid pV2 bearing the hygromycin ...

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Pyrolysis kinetics behavior of solid tire wastes available in Bangladesh.

July 3rd, 2008
Pyrolysis kinetics behavior of solid tire wastes available in Bangladesh. Pyrolysis kinetics of available bicycle/rickshaw, motorcycle and truck tire wastes in Bangladesh have been investigated thermogravimetrically in a nitrogen atmosphere at heating rates of 10 and 60 degrees C/min over a temperature range of 30-800 degrees ...

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Double-blind, placebo-controlled evaluation of grass pollen specific immunotherapy with oral drops a

July 3rd, 2008
Double-blind, placebo-controlled evaluation of grass pollen specific immunotherapy with oral drops administered sublingually or supralingually. Forty-one patients suffering from grass pollen allergy underwent specific immunotherapy with standardized allergen extract consisting of six grass pollens (H-Al per os) administered either sublingually or supralingually for one year. In ...

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Study on the relationship between cadmium chloride-induced adrenocortical cell of guinea pig apoptos

July 3rd, 2008
Study on the relationship between cadmium chloride-induced adrenocortical cell of guinea pig apoptosis and stress-activated protein kinase activity. Heavy metals are important environmental pollutants that affect many cellular functions. The signaling pathways that lead to apoptosis of adrenocortical cells following exposure to cadmium chloride (CdCl(2)) have ...

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Supramolecular organization and release properties of phospholipid-hyaluronan microparticles encapsu

July 3rd, 2008
Supramolecular organization and release properties of phospholipid-hyaluronan microparticles encapsulating dexamethasone. We describe the supramolecular organization of hybrid microparticles encapsulating dexamethasone (DXM) prepared by spray drying 1,2-Dipalmitoyl-sn-Glycero-3-Phosphocholine (DPPC) and hyaluronic acid (HA). The effect of DXM concentration on size distribution and encapsulation efficacy was evaluated as a ...

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Support vector machine-based arrhythmia classification using reduced features of heart rate variabil

July 3rd, 2008
Support vector machine-based arrhythmia classification using reduced features of heart rate variability signal. OBJECTIVE: This paper presents an effective cardiac arrhythmia classification algorithm using the heart rate variability (HRV) signal. The proposed algorithm is based on the generalized discriminant analysis (GDA) feature reduction scheme and the ...

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Bariatric surgery for extreme adolescent obesity: Indications, outcomes, and physiologic effects on

July 3rd, 2008
Bariatric surgery for extreme adolescent obesity: Indications, outcomes, and physiologic effects on the gut-brain axis. OBJECTIVE: This review will summarize current indications, limitations and outcomes of bariatric surgery in adolescents, as well as provide an overview of the physiologic effects of bariatric surgery on enteric hormones ...

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Effect of polyethylene glycol on preparation of rifampicin-loaded PLGA microspheres with membrane em

July 3rd, 2008
Effect of polyethylene glycol on preparation of rifampicin-loaded PLGA microspheres with membrane emulsification technique. Monodisperse poly(lactide-co-glycolide) (PLGA) microspheres containing rifampicin (RFP), anti-tubercle drug, as hydrophobic model drug were prepared by solvent evaporation method with a membrane emulsification technique using Shirasu Porous Glass (SPG) membranes. Five kinds ...

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Deuteron spin-lattice relaxation in partly and fully deuterated (NH(4))(2)PdCl(6).

July 3rd, 2008
Deuteron spin-lattice relaxation in partly and fully deuterated (NH(4))(2)PdCl(6). Deuteron spin-lattice relaxation and spectra were studied in partially and fully deuterated (NH(4))(2)PdCl(6) in the temperature range 5-300K. The relaxation rate maximum was observed at 45K in (ND(4))(2)PdCl(6). Its value is reduced due to limited jumps by ...

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Tumor necrosis factor alpha small interfering RNA decreases herpes simplex virus-induced inflammatio

July 3rd, 2008
Tumor necrosis factor alpha small interfering RNA decreases herpes simplex virus-induced inflammation in a mouse model. BACKGROUND: Anti-TNFalpha antibodies have been used for treating inflammation in patients. But, more effective and safer drugs need to be developed for improved future therapeutic use. OBJECTIVES: To inhibit the ...

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Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in fronta

July 3rd, 2008
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats. Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. ...

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