Medical and Biomedical Researches

Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or with

June 28th, 2008
Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuse. OBJECTIVE: Decreased dopamine transporters (DAT) in the basal ganglia were shown in patients with human immunodeficiency virus (HIV) associated dementia. Therefore, we assessed the relationship between striatal DAT and ...

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Three-dimensional brain current source reconstruction from intra-cranial ECoG recordings.

June 28th, 2008
Three-dimensional brain current source reconstruction from intra-cranial ECoG recordings. We have investigated 3-dimensional brain current density reconstruction (CDR) from intracranial electrocorticogram (ECoG) recordings by means of finite element method (FEM). The brain electrical sources are modeled by a current density distribution and estimated from the ECoG ...

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Reproducibility of fMRI in the clinical setting: Implications for trial designs.

June 28th, 2008
Reproducibility of fMRI in the clinical setting: Implications for trial designs. With expanding potential clinical applications of functional magnetic resonance imaging (fMRI) it is important to test how reliable different measures of fMRI activation are between subjects and sessions and between centres. This study compared variability ...

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Expression of Chlamydophila psittaci MOMP heat-labile toxin B subunit fusion gene in transgenic rice

June 28th, 2008
Expression of Chlamydophila psittaci MOMP heat-labile toxin B subunit fusion gene in transgenic rice. A DNA fragment encoding the MOMP gene of Chlamydophila psittaci was fused to the heat-labile toxin B subunit gene (LTB-MOMP) and transferred into rice callus by Agrobacterium tumefaciens-mediated transformation. The LTB-MOMP fusion ...

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How transcription factors program chromatin-Lessons from studies of the regulation of myeloid-specif

June 28th, 2008
How transcription factors program chromatin-Lessons from studies of the regulation of myeloid-specific genes. Hematopoietic stem cells exhibit a multi-lineage gene expression program, and this expression program is either maintained when these cells self-renew, or re-programmed when they differentiate. Both processes require the regulated expression of sequence-specific ...

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The role of the chemokines MCP-1, GRO-alpha, IL-8 and their receptors in the adhesion of monocytic c

June 28th, 2008
The role of the chemokines MCP-1, GRO-alpha, IL-8 and their receptors in the adhesion of monocytic cells to human atherosclerotic plaques. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. Previous experimental models have shown ...

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Biological responses to the simulated Martian UV radiation of bacteriophages and isolated DNA.

June 28th, 2008
Biological responses to the simulated Martian UV radiation of bacteriophages and isolated DNA. Mars is considered as a main target for astrobiologically relevant exploration programmes. In this work the effect of simulated Martian solar UV radiation was examined on bacteriophage T7 and on isolated T7 DNA. ...

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Photoreactions of 1,4-naphthoquinone with lysozyme studied by laser flash photolysis and steady-stat

June 28th, 2008
Photoreactions of 1,4-naphthoquinone with lysozyme studied by laser flash photolysis and steady-state analysis. Photoprocesses of 1,4-naphthoquinone (NQ) and its photoreactions with lysozyme in acetonitrile/water (3:1, v/v) solution were studied using 355nm laser flash photolysis technique combined with electrophoresis and turbidimetric assay. The transient spectra of NQ ...

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Ascending aortic cannulation in acute aortic dissection type A: the Hannover experience.

June 28th, 2008
Ascending aortic cannulation in acute aortic dissection type A: the Hannover experience. Objective: The incidence of embolic events and of cerebral malperfusion in aortic dissection type A (AADA) must be viewed in the context of the existence of a number of possible cannulation techniques. Since femoral ...

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Postrecurrence survival in patients with stage I non-small cell lung cancer.

June 28th, 2008
Postrecurrence survival in patients with stage I non-small cell lung cancer. Objective: Postoperative recurrence is a major obstacle to achieving a cure and long-term survival in patients with non-small lung cancer. However, prognostic factors and the efficacy of therapy after recurrence remain controversial. We evaluated the ...

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Tricuspid valve surgery: a thirty-year assessment of early and late outcome.

June 28th, 2008
Tricuspid valve surgery: a thirty-year assessment of early and late outcome. Objective: Tricuspid valve (TV) surgery is usually performed as a concomitant reconstruction procedure in addition to the correction of other cardiac pathologies. Isolated tricuspid procedures are exceptionally rare. Prosthetic valve replacement is also seldom required. ...

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Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygen

June 28th, 2008
Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation. Bleeding remains a potential complication for patients requiring extracorporeal life support systems. Recombinant activated factor VII (rFVIIa) is one of the drugs used in controlling bleeding. Its use is generally found to ...

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Heparin-induced thrombocytopenia and cardiopulmonary bypass: anticoagulation with unfractionated hep

June 28th, 2008
Heparin-induced thrombocytopenia and cardiopulmonary bypass: anticoagulation with unfractionated heparin and the GPIIb/IIIa inhibitor tirofiban and successful use of rFVIIa for post-protamine bleeding due to persistent platelet blockade. Heparin-induced thrombocytopenia was diagnosed in a 50-year-old man on day 5 after cardiac surgery (aorto-coronary bypass and mitral valve ...

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Recognition of diastolic heart failure in the postoperative heart.

June 28th, 2008
Recognition of diastolic heart failure in the postoperative heart. Diastolic dysfunction is assuming more importance as it is increasingly evident that it can be solely responsible for heart failure. Although many comprehensive studies pertinent to diastolic dysfunction and diastolic heart failure have been recently published, there ...

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A quarter of a century experience with sleeve lobectomy for non-small cell lung cancer.

June 28th, 2008
A quarter of a century experience with sleeve lobectomy for non-small cell lung cancer. Objective: Sleeve lobectomy represents an effective and widely accepted surgical therapy for non-small cell lung carcinoma (NSCLC). We sought to review our experience in terms of mortality, early and late morbidity, and ...

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Using reagent-supported thromboelastometry (ROTEM((R))) to monitor haemostatic changes in congenital

June 28th, 2008
Using reagent-supported thromboelastometry (ROTEM((R))) to monitor haemostatic changes in congenital heart surgery employing deep hypothermic circulatory arrest. Objective: Cardiac surgery employing cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) can induce coagulation disturbances and bleeding complications that may be especially severe in infants. A better ...

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Technical advances improved outcome in patients undergoing surgery of the ascending aorta and/or aor

June 28th, 2008
Technical advances improved outcome in patients undergoing surgery of the ascending aorta and/or aortic arch: ten years experience. Background: Several technical advances in thoracic aortic surgery, such as the use of antegrade cerebral perfusion, avoidance of cross-clamping and the application of glue, have beneficially influenced postoperative ...

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Surgical therapy in patients with active infective endocarditis: seven-year single centre experience

June 28th, 2008
Surgical therapy in patients with active infective endocarditis: seven-year single centre experience in a subgroup of 255 patients treated with the Shelhigh((R)) stentless bioprosthesis. Objective: We investigated outcomes after surgical therapy in patients with active infective endocarditis (AIE) with regard to survival in relation to surgical ...

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Treatment of mediastinitis using video-assisted thoracoscopic surgery.

June 28th, 2008
Treatment of mediastinitis using video-assisted thoracoscopic surgery. Background: Mediastinitis remains a life-threatening disease that is difficult to manage and has a poor prognosis. This is especially true of descending necrotizing mediastinitis, which before the 1990s era had a mortality of approximately 40% despite the use of ...

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Radical resection of a pulmonary blastoma involving the pulmonary artery.

June 28th, 2008
Radical resection of a pulmonary blastoma involving the pulmonary artery. Pulmonary blastoma is a rare malignant lesion with a poor prognosis. We described a case of a 47-year-old woman with a large biphasic pulmonary blastoma, involving the left pulmonary artery. Under cardiopulmonary bypass, it was treated ...

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Left ventricular-right atrial communication following tricuspid annuloplasty.

June 28th, 2008
Left ventricular-right atrial communication following tricuspid annuloplasty. A 71-year-old woman was admitted for examination of a heart murmur and anemia. She had a history of mitral valve replacement and tricuspid ring annuloplasty 8 months prior to admission. A new systolic murmur was heard, and echocardiography showed ...

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Frequency and pattern of de-novo three-vessel and left main coronary artery disease; insights from s

June 28th, 2008
Frequency and pattern of de-novo three-vessel and left main coronary artery disease; insights from single center enrolment in the SYNTAX study. Objectives: To characterize the current patient population regarding extent and pattern of coronary artery disease (CAD) in a routine cardiac catheterization practice with special focus ...

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Dimensional error in selective laser sintering and 3D-printing of models for craniomaxillary anatomy

June 28th, 2008
Dimensional error in selective laser sintering and 3D-printing of models for craniomaxillary anatomy reconstruction. BACKGROUND: Selective laser sintering (SLS) and three-dimensional printing (3DPtrade mark) are rapid prototyping (RP) techniques to fabricate prototypes from biomedical images. To be used in maxillofacial surgery, these models must accurately reproduce ...

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Contribution of the Malpighian tubules for the maintenance of symbiotic microorganisms in cephalotes

June 28th, 2008
Contribution of the Malpighian tubules for the maintenance of symbiotic microorganisms in cephalotes ants. Given the physiological importance of the Malpighian tubules to homeostasis in ants, this study aimed to characterize the enzymology, histology, histochemistry, and ultramorphology of the Malpighian tubules of Cephalotes atratus, C. clypeatus, ...

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Synthesis of 3′-deoxy-3′-C-methyl nucleoside derivatives.

June 28th, 2008
Synthesis of 3\'-deoxy-3\'-C-methyl nucleoside derivatives. 2\',3\'-Dideoxy-3\'-C-methyl nucleosides bearing the five naturally occurring nucleic acid bases were synthesized. Additionally, the 3\'-deoxy-3\'-C-methyl nucleoside analogues bearing 5-aminoimidazole-4-carboxamide as well as 1,2,4-triazole-3-carboxamide moieties were prepared. The synthesis of the corresponding 2\',3\'-dideoxy-3\'-C-methyl triazole derivative was also accomplished. The dideoxynucleoside derivatives were ...

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