Medical and Biomedical Researches

Telephone clinic follow-up following carpal tunnel decompression.

June 28th, 2008
Telephone clinic follow-up following carpal tunnel decompression. This paper investigates the feasibility of a telephone clinic follow-up service for patients undergoing carpal tunnel decompression. Six hundred and thirty patients were recruited over a 2-year period and we assessed their outcome and satisfaction level in the service, ...

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Clinical consequences of different exsanguination methods in hand surgery. A double-blind randomised

June 28th, 2008
Clinical consequences of different exsanguination methods in hand surgery. A double-blind randomised study. A randomised trial was performed in 100 patients in order to evaluate the effectiveness of three commonly used methods of exsanguination (simple elevation, squeeze method and Esmarch bandage) in a clinical setting. The ...

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The osteogenic potential of pseudoarthrosis tissue and bone from human scaphoid non-unions.

June 28th, 2008
The osteogenic potential of pseudoarthrosis tissue and bone from human scaphoid non-unions. Scaphoid fractures have the highest prevalence of non-union in the human body, but little is known about the osteogenic potential of cells at the pseudoarthrosis. It was our goal to determine whether cells isolated ...

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Closed reduction and percutaneous K-wires versus open reduction and interosseous loop wires for disp

June 28th, 2008
Closed reduction and percutaneous K-wires versus open reduction and interosseous loop wires for displaced unstable transverse fractures of the shaft of the proximal phalanx of the fingers in industrial workers. Seventy-eight male industrial workers with displaced unstable transverse fractures of the shaft of the proximal phalanx ...

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Genetic networks for the functional study of genomes.

June 28th, 2008
Genetic networks for the functional study of genomes. The high-throughput analytical techniques used in genome, proteome and metabolome studies produce large sets of data that must be studied using appropriate tools. The construction of networks linking different genetic elements and/or functions makes it possible to obtain ...

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Systems biology at the Institute for Systems Biology.

June 28th, 2008
Systems biology at the Institute for Systems Biology. Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different ...

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Label-free mass spectrometry-based protein quantification technologies in proteomic analysis.

June 28th, 2008
Label-free mass spectrometry-based protein quantification technologies in proteomic analysis. Major technological advances have made proteomics an extremely active field for biomarker discovery and validation in recent years. These improvements have lead to an increased emphasis on larger scale, faster and more efficient methods for protein biomarker ...

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Proteomics: from hypothesis to quantitative assay on a single platform. Guidelines for developing MR

June 28th, 2008
Proteomics: from hypothesis to quantitative assay on a single platform. Guidelines for developing MRM assays using ion trap mass spectrometers. High-throughput HPLC-mass spectrometry (HPLC-MS) is routinely used to profile biological samples for potential protein markers of disease, drug efficacy and toxicity. The discovery technology has advanced ...

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RADIOLOGICAL SIGNIFICANCE OF BEACH SAND USED FOR CLIMATOTHERAPY FROM SAFAGA, EGYPT.

June 28th, 2008
RADIOLOGICAL SIGNIFICANCE OF BEACH SAND USED FOR CLIMATOTHERAPY FROM SAFAGA, EGYPT. As a part of national survey to evaluate natural radioactivity in the environment, concentration levels of radioactivity were analysed for sand samples from Safaga, Egypt, which is an ideal area for climatotherapy of psoriasis. Gamma ...

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Changes in p19Arf Localization Accompany Crisis During Pre-B Cell Transformation by Abelson Murine L

June 28th, 2008
Changes in p19Arf Localization Accompany Crisis During Pre-B Cell Transformation by Abelson Murine Leukemia Virus. Transformation by Abelson virus is a multi-step process in which growth stimulatory signals from the v-Abl oncoprotein and growth suppressive signals from the p19(Arf) - p53 tumor suppressor pathway oppose each ...

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LINKER HISTONES ARE MOBILIZED DURING INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1 (HSV-1).

June 28th, 2008
LINKER HISTONES ARE MOBILIZED DURING INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1 (HSV-1). Histones interact with HSV-1 genomes and localize to replication compartments early during infections. However, HSV-1 genomes do not interact with histones in virions and are deposited in nuclear domains devoid of histones. Moreover, ...

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Vectorial entry and release of hepatitis A virus in polarized human hepatocytes.

June 28th, 2008
Vectorial entry and release of hepatitis A virus in polarized human hepatocytes. Hepatitis A virus (HAV) is an enterically transmitted virus that replicates predominantly in hepatocytes within the liver before excretion via bile through feces. Hepatocytes are polarized epithelial cells, and it has been assumed that ...

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CD4 Binding Affinity Determines HIV-1 Induced Plasmacytoid Dendritic Cell Interferon Alpha Productio

June 28th, 2008
CD4 Binding Affinity Determines HIV-1 Induced Plasmacytoid Dendritic Cell Interferon Alpha Production. Plasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to HIV-1 infection. To better define the underlying mechanisms, we studied the magnitude of IFN-alpha induction by recombinant viruses containing ...

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Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of HIV-1-infected Elite Suppressor

June 28th, 2008
Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of HIV-1-infected Elite Suppressors Correlates with Low CD4+ T-cell Activation. Elite suppressors (ES) are untreated human immunodeficiency virus type 1 (HIV-1)-infected individuals who maintain normal CD4(+) T cell counts and control viremia to levels that are ...

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Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-deriv

June 28th, 2008
Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus. Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and ...

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CD81 is a central regulator of cellular events required for HCV infection of human hepatocytes.

June 28th, 2008
CD81 is a central regulator of cellular events required for HCV infection of human hepatocytes. Infection with hepatitis C virus (HCV) is still a major public health problem, and the events leading to hepatocyte infection are not yet fully understood. Combining confocal microscopy with biochemical analysis ...

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Anomalies in the Influenza Genome Database: New Biology or Lab Errors?

June 28th, 2008
Anomalies in the Influenza Genome Database: New Biology or Lab Errors? A search of the influenza genome database reveals anomalies associated with a non-negligible number of submitted sequences. There are many pairs of viral segments that are very close to each other in nucleotide sequence but ...

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Pathways of Cross Species Transmission of Synthetically Reconstructed Zoonotic SARS-CoV.

June 28th, 2008
Pathways of Cross Species Transmission of Synthetically Reconstructed Zoonotic SARS-CoV. Zoonotic SARS Coronavirus (SARS-CoV) likely evolved to infect humans by a series of transmission events between humans and animals in markets in China. Virus sequence data suggests the palm civet served as an amplification host where ...

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Temporary depletion of CD11c+ dendritic cells delays lymphoinvasion after intraperitonal scrapie inf

June 28th, 2008
Temporary depletion of CD11c+ dendritic cells delays lymphoinvasion after intraperitonal scrapie infection. The involvement of immune cells in prion capture and transport to lymphoid tissues still remains unclear. To investigate the role of dendritic cells (DC), we used DTR(+/+)mice, a transgenic model designed to trigger short-term ...

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Influenza virus protecting RNA: an effective prophylactic and therapeutic antiviral.

June 28th, 2008
Influenza virus protecting RNA: an effective prophylactic and therapeutic antiviral. Another influenza pandemic is inevitable, and new measures to combat this and seasonal influenza are urgently needed. Here we describe a new concept in antivirals based on a defined, naturally occurring defective influenza RNA that has ...

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Translational termination re-initiation between ORF1 and ORF2 enables capsid expression in a bovine

June 28th, 2008
Translational termination re-initiation between ORF1 and ORF2 enables capsid expression in a bovine norovirus without the need for production of viral sub-genomic RNA. A generally accepted view of norovirus replication is that capsid expression requires production of a sub-genomic transcript, the presence of capsid often being ...

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Loss of the N-linked Glycan at Residue 173 on Human Parainfluenza Virus Type 1 Hemagglutinin-Neurami

June 28th, 2008
Loss of the N-linked Glycan at Residue 173 on Human Parainfluenza Virus Type 1 Hemagglutinin-Neuraminidase Exposes a Second Receptor-Binding Site. BCX 2798 effectively inhibited the activities of the hemagglutinin-neuraminidase (HN) of human parainfluenza viruses (hPIV) in vitro, and protected mice from lethal infection with a recombinant ...

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Structural Domains Within the 3′ UTR of Turnip Crinkle Virus.

June 28th, 2008
Structural Domains Within the 3\' UTR of Turnip Crinkle Virus. The genomes of positive strand RNA viruses undergo conformational shifts that complicate efforts to equate structures with function. We have initiated a detailed analysis of secondary and tertiary elements within the 3\' end of Turnip crinkle ...

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Capsid Proteins from Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus SIVmac ca

June 28th, 2008
Capsid Proteins from Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus SIVmac can Coassemble into Mature Cores of Infectious Viruses. We have recently shown that the Gag polyproteins from human immunodeficiency virus type 1 (HIV-1) and HIV-2 can coassemble and functionally complement each other. During ...

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Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sid

June 28th, 2008
Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain. Changes in the envelope protein of retroviruses can alter the ability of these viruses to infect the CNS and induce neurological disease. In the current ...

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