Medical and Biomedical Researches

Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis.

June 28th, 2008
Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. PURPOSE: To report an 81-year-old woman with corneal neovascularization secondary to herpetic stromal keratitis treated with subconjunctival bevacizumab and to discuss the role of this novel antiangiogenic treatment. METHODS: Case report and review of medical literature. RESULTS: ...

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Juvenile xanthogranuloma of the corneal limbus: report of two cases and review of the literature.

June 28th, 2008
Juvenile xanthogranuloma of the corneal limbus: report of two cases and review of the literature. PURPOSE: To report the clinical and histopathologic findings of limbal juvenile xanthogranuloma lesions in 2 pediatric cases. METHODS: Case report and literature review. RESULTS: Two cases (a 7-month-old girl and a ...

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Corneal pathology in microphthalmia with linear skin defects syndrome.

June 28th, 2008
Corneal pathology in microphthalmia with linear skin defects syndrome. PURPOSE: To describe the histopathology of the cornea in microphthalmia with linear streaks (MLS) syndrome. METHODS: Two patients with MLS syndrome underwent penetrating keratoplasty. This study describes the histopathology and investigates immunophenotype of the corneal extracellular matrix ...

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Minimal conjunctival limbal autograft for total limbal stem cell deficiency.

June 28th, 2008
Minimal conjunctival limbal autograft for total limbal stem cell deficiency. PURPOSE: To report the results of one 60 degrees conjunctival limbal autograft (CLAU) combined with amniotic membrane (AM) transplantation for an eye with total limbal stem cell deficiency (LSCD). METHODS: One eye of a patient with ...

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Epithelial ingrowth after Descemet-stripping automated endothelial keratoplasty.

June 28th, 2008
Epithelial ingrowth after Descemet-stripping automated endothelial keratoplasty. PURPOSE: To report the diagnosis and treatment of a patient who developed epithelial ingrowth after Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS: We describe the case of an 80-year-old woman who underwent DSAEK for pseudophakic bullous keratopathy. After surgery, the ...

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Primary graft failure after Descemet-stripping automated endothelial keratoplasty: clinico-pathologi

June 28th, 2008
Primary graft failure after Descemet-stripping automated endothelial keratoplasty: clinico-pathological study. PURPOSE: Descemet-stripping automated endothelial keratoplasty (DSAEK) is a selective tissue corneal transplantation procedure in which only the diseased endothelium and the Descemet membrane is replaced. Refractive and visual results have been encouraging with this procedure, but ...

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Surgically induced necrotizing scleritis after pterygium surgery with conjunctival autograft.

June 28th, 2008
Surgically induced necrotizing scleritis after pterygium surgery with conjunctival autograft. PURPOSE: To report a case of surgically induced necrotizing scleritis (SINS) as a complication of conjunctival autograft after pterygium excision. METHODS: A 52-year-old man had undergone nasal pterygium excision with conjunctival autograft in the right eye ...

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Efficacy of contact lens systems against recent clinical and tap water Acanthamoeba isolates.

June 28th, 2008
Efficacy of contact lens systems against recent clinical and tap water Acanthamoeba isolates. PURPOSE: A recent increase in Acanthamoeba keratitis (AK) cases has been associated with Complete MoisturePlus, although many cases used other solutions. Complete MoisturePlus contains taurine and hydroxypropyl methylcellulose, unlike other multipurpose solutions (MPSs). ...

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Femtosecond laser-assisted endothelial keratoplasty: a laboratory model.

June 28th, 2008
Femtosecond laser-assisted endothelial keratoplasty: a laboratory model. PURPOSE: To evaluate the ability of a 40-kHz femtosecond laser in performing posterior stromal ablation for endothelial keratoplasty. METHODS: Human corneoscleral rims were mounted on an artificial anterior chamber. After corneal pachymetry, the femtosecond laser was used to create ...

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A mouse model of allogeneic corneal endothelial cell transplantation.

June 28th, 2008
A mouse model of allogeneic corneal endothelial cell transplantation. PURPOSE: Corneal endothelial cell (CEC) transplantation should become clinically applicable in the near future. However, the immunologic changes after allo-CEC transplantation are poorly understood at present. We tried to establish a mouse model of allogeneic CEC transplantation ...

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Phospholipase D in the human ocular surface and in pterygium.

June 28th, 2008
Phospholipase D in the human ocular surface and in pterygium. PURPOSE: Pterygium is a fibro-vascular disease of unknown etiology characterized by proliferation and advancement of tissue onto the cornea. Phospholipase Ds (PLDs) are members of an important class of enzymes involved in inflammation and differentiation. In ...

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Mitomycin C potentiates ultraviolet-related cytotoxicity in corneal fibroblasts.

June 28th, 2008
Mitomycin C potentiates ultraviolet-related cytotoxicity in corneal fibroblasts. PURPOSE: To study the morphologic changes and cytotoxicity in corneal fibroblasts after mitomycin C (MMC) treatment, ultraviolet B (UVB) irradiation, or in combination. METHODS: Primary porcine corneal fibroblasts, passages 3-5, were treated with MMC (0.1 or 0.2 mg/mL, ...

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Femtosecond laser-assisted inverted mushroom keratoplasty.

June 28th, 2008
Femtosecond laser-assisted inverted mushroom keratoplasty. PURPOSE: To evaluate best-corrected visual acuity (BCVA), refractive outcome, corneal topography, optical coherence tomography, and endothelial cell density 12 months after femtosecond laser-assisted inverted mushroom keratoplasty. METHODS: We performed a prospective study of a surgical case series of 5 patients undergoing ...

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Posterior mushroom keratoplasty in patients with Fuchs endothelial dystrophy and pseudophakic bullou

June 28th, 2008
Posterior mushroom keratoplasty in patients with Fuchs endothelial dystrophy and pseudophakic bullous keratopathy: transplant outcome. PURPOSE: To report the outcome of posterior mushroom or top-hat-shaped keratoplasty for patients with Fuchs endothelial dystrophy (FED) or pseudophakic bullous keratopathy (PBK), concerning postoperative astigmatism, visual improvement, and endothelial cell ...

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Femtosecond laser-assisted lamellar keratoplasty: early results.

June 28th, 2008
Femtosecond laser-assisted lamellar keratoplasty: early results. PURPOSE: To evaluate the outcomes and safety of lamellar keratoplasty (LK) assisted by a femtosecond laser. METHODS: Twenty-one eyes of 21 patients affected by different corneal pathologies (5 posttraumatic corneal scar, 3 postkeratitis corneal leucoma, and 13 keratoconus) underwent LK ...

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Results of pterygium surgery using a biologic adhesive.

June 28th, 2008
Results of pterygium surgery using a biologic adhesive. PURPOSE: To evaluate the recurrence rate after pterygium surgery using a biologic adhesive (Tiseel Duo Quick). METHODS: Eighty-eight patients with primary pterygium were included. This was a prospective nonrandomized trial. Primary endpoints were recurrence rate and operation time, ...

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Current patterns in the use of diagnostic tests in dry eye evaluation.

June 28th, 2008
Current patterns in the use of diagnostic tests in dry eye evaluation. PURPOSE: To clarify the roles of objective signs and subjective symptoms in the diagnosis and management of dry eye by describing their use by a group of expert practitioners. Dry eye signs and symptoms ...

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Manual trephination of mushroom keratoplasty in advanced keratoconus.

June 28th, 2008
Manual trephination of mushroom keratoplasty in advanced keratoconus. PURPOSE: To evaluate the technique of mushroom keratoplasty for patients with advanced keratoconus, with respect to postoperative astigmatism, visual improvement and stability, and endothelial cell count. METHODS: Sixteen eyes of 15 patients with advanced keratoconus received a mushroom ...

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Effect of ocular surface reconstruction by using amniotic membrane transplant for symptomatic conjun

June 28th, 2008
Effect of ocular surface reconstruction by using amniotic membrane transplant for symptomatic conjunctivochalasis on fluorescein clearance test results. PURPOSE: To evaluate the hypothesis that the therapeutic effect of amniotic membrane transplantation (AMT) ocular surface reconstruction in the setting of symptomatic temporal conjunctivochalasis is through improved tear ...

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Does endothelial cell density correlate with corneal diameter in a group of young adults?

June 28th, 2008
Does endothelial cell density correlate with corneal diameter in a group of young adults? PURPOSE: In children, but not in the elderly, an association exists between corneal diameter and endothelial cell density (ECD). We tested whether such an association also held true in young adults. METHODS: ...

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Eye bank survey of surgeons using precut donor tissue for descemet stripping automated endothelial k

June 28th, 2008
Eye bank survey of surgeons using precut donor tissue for descemet stripping automated endothelial keratoplasty. PURPOSE: To assess surgeon satisfaction with precut corneal tissue from 1 eye bank for Descemet stripping automated endothelial keratoplasty (DSAEK). Surgical techniques and predictors of procedural success were also examined. METHODS: ...

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Scintigraphic demonstration of transplant perfusion compromise with calyceal reflux.

June 28th, 2008
Scintigraphic demonstration of transplant perfusion compromise with calyceal reflux. Nuclear medicine provides a great clinical impact in the assessment and follow-up of kidney transplantation. In addition to the direct evaluation of transplant perfusion and function, indirect scintigraphic features may enhance the detection of potential transplant complications. ...

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Paget disease of the humerus mimicking metastatic disease in a patient with metastatic malignant mes

June 28th, 2008
Paget disease of the humerus mimicking metastatic disease in a patient with metastatic malignant mesothelioma on whole body F-18 FDG PET/CT. A 71-year-old man with newly diagnosed malignant mesothelioma was referred for an F-18 FDG PET/CT study to evaluate the extent of disease. PET showed mild ...

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Myxoid liposarcoma involving the liver, subcutaneous tissue, and epidural space in a polycystic dise

June 28th, 2008
Myxoid liposarcoma involving the liver, subcutaneous tissue, and epidural space in a polycystic disease patient. We present a case of a myxoid liposarcoma involving the liver, subcutaneous tissue, and epidural space in a polycystic disease patient with minimally increased F-18 FDG activity and review the image ...

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Demonstration of thyroidal metastasis from lung cancer by F-18 FDG PET scan.

June 28th, 2008
Demonstration of thyroidal metastasis from lung cancer by F-18 FDG PET scan. A case is presented of detection of a secondary thyroid cancer arising from a pulmonary adenocarcinoma by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET). The need to investigate thyroidal hypermetabolic foci detected incidentally on PET ...

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