Medical and Biomedical Researches

Confidentiality, privacy, and security of genetic and genomic test information in electronic health

June 28th, 2008
Confidentiality, privacy, and security of genetic and genomic test information in electronic health records: points to consider. As clinical genetics evolves, and we embark down the path toward more personalized and effective health care, the amount, detail, and complexity of genetic/genomic test information within the electronic ...

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A model for offering carrier screening for fragile X syndrome to nonpregnant women: results from a p

June 28th, 2008
A model for offering carrier screening for fragile X syndrome to nonpregnant women: results from a pilot study. PURPOSE:: To develop a model of offering population carrier screening for fragile X syndrome to nonpregnant women in primary care, using a program evaluation framework. METHODS:: A three-phase ...

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A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community

June 28th, 2008
A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact. PURPOSE:: Hereditary long QT syndrome is named for a prolonged QT interval reflecting predisposition to ventricular arrhythmias ...

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Ocular Adnexal Lymphoma Associated With IgG4+ Chronic Sclerosing Dacryoadenitis: A Previously Undesc

June 28th, 2008
Ocular Adnexal Lymphoma Associated With IgG4+ Chronic Sclerosing Dacryoadenitis: A Previously Undescribed Complication of IgG4-related Sclerosing Disease. IgG4-related sclerosing disease is a recently recognized inflammatory lesion frequently involving pancreas, submandibular gland, lacrimal gland, and lymph node. We report 3 cases of ocular adnexal lymphoma arising in ...

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SMARCB1/INI1 Protein Expression in Round Cell Soft Tissue Sarcomas Associated With Chromosomal Trans

June 28th, 2008
SMARCB1/INI1 Protein Expression in Round Cell Soft Tissue Sarcomas Associated With Chromosomal Translocations Involving EWS: A Special REFERENCE to SMARCB1/INI1 Negative Variant Extraskeletal Myxoid Chondrosarcoma. Several previous studies have demonstrated the lack of SMARCB1/INI1 protein expression in only the malignant rhabdoid tumor (MRT). Several sarcoma groups ...

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Seminoma With Conspicuous Signet Ring Cells: A Rare, Previously Uncharacterized Morphologic Variant.

June 28th, 2008
Seminoma With Conspicuous Signet Ring Cells: A Rare, Previously Uncharacterized Morphologic Variant. We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years of age, who presented with testicular masses; 1 seminoma was a component of a ...

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Immunohistochemical Staining of Reg IV and Claudin-18 is Useful in the Diagnosis of Gastrointestinal

June 28th, 2008
Immunohistochemical Staining of Reg IV and Claudin-18 is Useful in the Diagnosis of Gastrointestinal Signet Ring Cell Carcinoma. Signet-ring cell carcinoma (SRCC) is a unique subtype of adenocarcinoma that is characterized by abundant intracellular mucin accumulation and a crescent-shaped nucleus displaced toward one end of the ...

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Expression of the Interferon Regulatory Factor 8/ICSBP-1 in Human Reactive Lymphoid Tissues and B-ce

June 28th, 2008
Expression of the Interferon Regulatory Factor 8/ICSBP-1 in Human Reactive Lymphoid Tissues and B-cell Lymphomas: A Novel Germinal Center Marker. To assess the role of interferon regulatory factor (IRF) 8 in B-cell development and lymphomagenesis, we studied its expression in reactive lymphoid tissues, its relationship to ...

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Cardiovascular challenge.

June 28th, 2008
Cardiovascular challenge. Test your knowledge by taking this quick quiz.

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Nimodipine: Test your drug IQ.

June 28th, 2008
Nimodipine: Test your drug IQ. Find out how this calcium channel blocker treats cerebral vasospasm after subarachnoid hemorrhage. Devlin MM. Melissa M. Devlin is a clinical consulting pharmacist for Hospice Pharmacia, a division of excelleRx in Philadelphia, Pa.

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Third-spacing: When body fluid shifts.

June 28th, 2008
Third-spacing: When body fluid shifts. Left untreated, third-spacing can lead to serious complications. Here\'s what you need to know to get your patient back in balance. Holcomb SS. Susan Simmons Holcomb is a nurse practitioner at Olathe (Kan.) Medical Services, Inc., and a consultant in ...

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Responding to 4 gastrointestinal complications in cancer patients.

June 28th, 2008
Responding to 4 gastrointestinal complications in cancer patients. If your patient has cancer, be prepared to help her manage such serious GI complications as bowel obstruction, peritonitis, fistula formation, and intestinal perforation. Held-Warmkessel J, Schiech L. Jeanne Held-Warmkessel and Linda Schiech are clinical nurse specialists ...

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Nursing2008 Nurse/physician relationships survey report.

June 28th, 2008
Nursing2008 Nurse/physician relationships survey report. Are physicians and nurses pulling together more now than when we reported our last survey in 1991? Compare your experiences with those of readers responding to this nationwide survey. Sirota T. Theodora Sirota is an associate professor of nursing at ...

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Jack.

June 28th, 2008
Jack. As nurses work longer hours with less staff to care for sicker patients, our profession has become more stressful than ever. Sometimes we leave work with hearts as achy as our feet. This nurse\'s story reminds us of what makes it all worthwhile: our patients ...

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Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy.

June 28th, 2008
Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy. We report a case of the nucleoside reverse transcriptase inhibitors, stavudine and lamivudine inducing Fanconi syndrome in a patient. The presence of simultaneous lactic acidosis suggests mitochondrial toxicity within the proximal renal tubular cells as ...

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Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients foll

June 28th, 2008
Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years. Suppression of HIV replication using highly active antiretroviral therapy (HAART) might influence chemokine (C-C motif) receptor 5 expression on infected cells and therefore modulate the activity of ...

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Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patient

June 28th, 2008
Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients. Both low and high ankle-brachial index are considered as indicators of systemic atherosclerosis in older HIV-negative adults. Whether those ankle-brachial index values are predictors of atherosclerosis in HIV-positive subjects remains unknown. We measured ankle-brachial index ...

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Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women.

June 28th, 2008
Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women. BACKGROUND: Longitudinal associations between patterns of crack cocaine use and progression of HIV-1 disease are poorly understood, especially among women. This study explores relationships between crack use and HIV-1 disease outcomes in ...

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Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in th

June 28th, 2008
Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in the United States, 1994-2005. OBJECTIVES: To assess temporal trends in the rates of hospitalizations and associated diagnoses among HIV-infected patients before and during the era of highly active antiretroviral therapy. DESIGN: ...

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Early virological suppression with three-class antiretroviral therapy in HIV-infected African infant

June 28th, 2008
Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants. OBJECTIVES: Infants infected with HIV-1 perinatally despite single-dose nevirapine progress rapidly. Data on treatment outcome in sub-Saharan African infants exposed to single-dose nevirapine are urgently required. This feasibility study addresses efficacy of infant antiretroviral therapy ...

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Clinical features and etiology of pneumonia in acid-fast bacillus sputum smear-negative HIV-infected

June 28th, 2008
Clinical features and etiology of pneumonia in acid-fast bacillus sputum smear-negative HIV-infected patients hospitalized in Asia and Africa. OBJECTIVES: To determine the main causes of acid-fast bacillus sputum smear-negative pneumonia in Asian and African HIV-infected patients DESIGN AND SETTING: A prospective multicenter study (ANRS 1260) of ...

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Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunizati

June 28th, 2008
Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452). OBJECTIVE: Evaluate immunogenicity and clinical efficacy of two immunization strategies with the ALVAC-HIV-recombinant canarypox vaccine (vCP1452) in treated HIV-infected patients. DESIGN: Randomized, double-blind, placebo-controlled, phase II study of ...

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Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Fr

June 28th, 2008
Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières. OBJECTIVES: To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associated with survival. DESIGN/METHODS: We used patient data from 62 Médecins ...

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Humans with chimpanzee-like major histocompatibility complex-specificities control HIV-1 infection.

June 28th, 2008
Humans with chimpanzee-like major histocompatibility complex-specificities control HIV-1 infection. BACKGROUND: Major histocompatibility complex (MHC) class I molecules allow immune surveillance by presenting a snapshot of the intracellular state of a cell to circulating cytotoxic T lymphocytes. The MHC class I alleles of an HIV-1 infected individual ...

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Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutane

June 28th, 2008
Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. BACKGROUND: Treatment of HIV with some protease inhibitors has been associated with dyslipidemia, insulin resistance and fat redistribution. It has been hypothesized that some protease inhibitors may alter the ...

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