Archive for May, 2008
Thursday, May 1st, 2008
Screening for postpartum depression with the Edinburgh Postnatal Depression Scale in an indigent population: Does a directed interview improve detection rates compared with the standard self-completed questionnaire?
Background. The Edinburgh Postnatal Depression Scale (EPDS) is a well-validated screening tool for the detection of patients at risk ...
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Thursday, May 1st, 2008
Obstetric outcomes with a false-positive one-hour glucose challenge test by the Carpenter-Coustan criteria.
Objective. Pregnancies complicated by a false-positive one-hour glucose challenge test (GCT), as determined by the National Diabetes Data Group (NDDG) criteria, have higher rates of adverse maternal and neonatal outcomes. This study was ...
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Thursday, May 1st, 2008
A comparison of lispro and regular insulin for the management of type 1 and type 2 diabetes in pregnancy.
Objective. To describe perinatal outcomes of women with pregestational diabetes treated with short-acting, regular insulin and the short-acting insulin analogue, lispro. Study design. This was a prospective ...
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Thursday, May 1st, 2008
Comparison of three neonatal pain scales during minor painful procedures.
Objective. There is no single or widely accepted method to define pain in neonates. The aim of this study was to compare three different neonatal pain scales in the estimation of the pain response to minor ...
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Thursday, May 1st, 2008
The role of continuous fetal monitoring in the management of preterm premature rupture of membranes.
Objective. Continuous fetal monitoring (CFM) is often used in the management of preterm premature rupture of membranes (PPROM) but there is little evidence to support this approach. The objective of this ...
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Thursday, May 1st, 2008
Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery.
Objective. The objective of this study was to investigate the level of insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions and Bishop score as predictors of preterm delivery in asymptomatic pregnant women. ...
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Thursday, May 1st, 2008
Recurrence of preterm birth in twin pregnancies in the presence of a prior singleton preterm birth.
Objective. We examined recurrence of preterm birth in twin pregnancy in the presence of a previous singleton preterm pregnancy, and assessed if these recurrence risks differed for medically indicated and ...
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Thursday, May 1st, 2008
The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age.
Introduction. An imbalance between angiogenic and anti-angiogenic factors has been proposed as central to the pathophysiology ...
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Thursday, May 1st, 2008
The KLAB Toolbox: A Suite of In-house Software Applications for Epigenetic Analysis.
Systems biology presents a new paradigm for elucidating the processes required to organize and sustain life. We now have access to whole genome sequences, gene expression data for multiple cell types, and databases for ...
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Thursday, May 1st, 2008
Evaluation of effects of methamphetamine repeated dosing on proliferation and apoptosis of rat germ cells.
Methamphetamine (MAMP) is a central nervous system stimulant that is increasingly abused especially by teenagers and young adults, a group in its reproductive age. MAMP effects on the male reproductive system ...
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Thursday, May 1st, 2008
Lipid peroxidation in human spermatozoa from men with genitourinary infections.
A fluorescent assay was used to reveal the presence of lipid peroxidation (LPO) in spermatozoa from individuals with genitourinary infections (GI). The incidence of LPO was compared with sperm pathologies (apoptosis, immaturity, necrosis) evaluated by transmission ...
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Thursday, May 1st, 2008
Proteins involved in meiotic recombination: a role in male infertility?
Meiotic recombination results in the formation of crossovers, by which genetic information is exchanged between homologous chromosomes during prophase I of meiosis. Recombination is a complex process involving many proteins. Alterations in the genes involved in ...
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Thursday, May 1st, 2008
Partial and severe factor XI deficiency in South Australia and the usefulness of factor XI mutation analysis for diagnosis.
Aims: To correlate the presence or absence of a factor XI gene mutation with factor XI activity in patients with severe or partial reduction in factor XI. ...
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Thursday, May 1st, 2008
Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell.
Aims: Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumour occurring almost exclusively in young adult males. Although histologically benign, it can be locally aggressive with a significant recurrence rate. The finding of activating beta-catenin gene mutations ...
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Thursday, May 1st, 2008
Clonal status of fibrous dysplasia.
Aim: The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. Materials and methods: ...
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Thursday, May 1st, 2008
Peripheral vascular disease: who gets it and why? A histomorphological analysis of 261 arterial segments from 58 cases.
Aims: This retrospective study aimed to document and illustrate the histomorphological changes underlying peripheral vascular disease (PVD). More specifically, it aimed to analyse and quantify those changes that ...
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Thursday, May 1st, 2008
Pathological findings in explanted prosthetic heart valves from ventricular assist devices.
Aims: Ventricular assist devices (VADs) are now a mainstay in the management of patients with end-stage heart failure. An important consideration in the long-term durability of these devices is the structural integrity of the prosthetic ...
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Thursday, May 1st, 2008
Histological characteristics of singleton placentas delivered before the 28th week of gestation.
Aims: The placenta is a record of the fetal environment and its examination may provide information about the baby\'s subsequent growth and development. We describe the histological characteristics of 947 singleton placentas from infants ...
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Thursday, May 1st, 2008
Use of reticulin stain in the diagnosis of intra-uterine gestation.
Aims: The diagnosis of intra-uterine gestation may be problematic when specimens from clinically suspected products of conception lack chorionic villi and/or fetal somatic tissues, since the distinction of intermediate trophoblast from decidual or myometrial elements can ...
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Thursday, May 1st, 2008
Fine needle aspiration cytology in young women with breast cancer: diagnostic difficulties.
Background: Breast carcinoma is the most common malignancy in women worldwide. Though fine needle aspiration cytology (FNAC) plays an important role in preoperative diagnosis, there may be diagnostic delays in affected young women due ...
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Thursday, May 1st, 2008
Histopathological features of \'BRCAX\' familial breast cancers in the kConFab resource.
Aims: In recent years histopathology has made an important contribution to the study of familial breast cancer, largely on the basis of the distinctive cancer phenotype commonly identified in BRCA1-mutation carriers. The aim of this ...
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Thursday, May 1st, 2008
Diagnosis of extramammary malignancy metastatic to the breast by fine needle biopsy.
Aims: To review and illustrate the findings in fine needle biopsy (FNB) of extramammary malignancies presenting with breast metastases (MMB). Methods: We reviewed 32 cases of MMB diagnosed on breast FNB. The clinical data, ...
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Thursday, May 1st, 2008
Diagnostic utility of p16(INK4a): a reappraisal of its use in cervical biopsies.
p16(INK4a), an indirect marker of cell cycle dysregulation, is commonly expressed in cervical dysplasias and carcinomas associated with high risk human papillomavirus (HR-HPV) infections. Although p16(INK4a) immunohistology is routinely used as a cost effective ...
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Thursday, May 1st, 2008
The role of transmembrane AMPA receptor regulatory proteins (TARPs) in neurotransmission and receptor trafficking (Review).
AMPA receptors (AMPAR) mediate the majority of fast excitatory neurotransmission in the central nervous system (CNS). Transmembrane AMPAR regulatory proteins (TARPs) have been identified as a novel family of proteins which ...
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Thursday, May 1st, 2008
Measurement and characteristics of neurotransmitter receptor surface trafficking (Review).
Neurotransmitter receptor trafficking in and out synapses has emerged as a key process to regulate synaptic transmission during synaptic development and plasticity both at excitatory and inhibitory synapses. Lateral diffusion of surface neurotransmitter receptors has recently emerged ...
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