Archive for May, 2008
Thursday, May 1st, 2008
A comparative molecular force spectroscopy study of homophilic JAM-A interactions and JAM-A interactions with reovirus attachment protein sigma1.
JAM-A belongs to a family of immunoglobulin-like proteins called junctional adhesion molecules (JAMs) that localize at epithelial and endothelial intercellular tight junctions. JAM-A is also expressed on dendritic ...
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Thursday, May 1st, 2008
Immunization of rabbits with DNase I produces polyclonal antibodies with DNase and RNase activities.
Immunization of rabbits with DNase I leads to the production of antiidiotypic Abs with DNase activity. It is not known at present whether antiidiotypic Abs against DNA-hydrolyzing enzymes can possess RNase activity. ...
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Thursday, May 1st, 2008
The six-minute walk test in outpatients with obesity: reproducibility and known group validity.
Background and Purpose. To assess the reproducibility and validity of the six-minute walk test (6MWT) in men and women with obesity in order to facilitate evaluation of treatment outcome. Method. A test-retest design ...
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Thursday, May 1st, 2008
Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase.
This study presents an approach that can be used to search for lead peptide candidates, including unconstrained structures in a recognized sequence. This approach was performed using the design of ...
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Thursday, May 1st, 2008
Klinische Toxikologie der Trizyklischen Antidepressiva. Moderne Antidepressiva verringern Suizidgefahr.
Die TZA haben aufgrund alpha(1)-adrenerger, antihistaminerger und anticholinerger Nebenwirkungen unerwünschte Begleiteffekte, die moderne Antidepressiva, insbesondere SSRI, nicht haben. Darüber hinaus haben TZA relevante kardiotoxische Wirkung durch eine chinidinartige Blockade der schnellen Natrium-Kanäle in der Herzmuskelzelle. Das Toxidrom ...
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Thursday, May 1st, 2008
Pharmazeutische Betreuung depressiver Patienten. Compliance im Focus.
Die Depression ist eine ernst zu nehmende Krankheit, die immer noch zu sehr tabuisiert, zu selten diagnostiziert und adäquat behandelt wird. Im Rahmen der antidepressiven Pharmakotherapie werden zum Teil aus gesundheitsökonomischen Gründen immer noch sehr häufig die älteren trizyklischen ...
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Thursday, May 1st, 2008
High levels of stable phytase accumulate in the culture medium of transgenic Medicago truncatula cell suspension cultures.
The use of plants for production of recombinant proteins is becoming widely accepted. More recently, plant cell cultures have been proposed as valuable systems for producing a wide range ...
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Thursday, May 1st, 2008
Mitochondrial protein quality control: Implications in ageing.
Mitochondria represent both a major source for reactive oxygen species (ROS) production and a target for oxidative macromolecular damage. Increased production of ROS and accumulation of oxidized proteins have been associated with cellular ageing. Protein quality control, also referred ...
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Thursday, May 1st, 2008
Native-DIGE: A new look at the mitochondrial membrane proteome.
Respiratory chain proteins play a pivotal role in mitochondrial metabolism and thereby in the aging process. Differential display of the mitochondrial proteome reveals the abundance changes occurring in proteins as response to complex events such as senescence ...
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Thursday, May 1st, 2008
Mitochondria and ageing in Drosophila.
Studies in different organisms have revealed that ageing is a complex process involving a tight regulation of gene expression. Among other features, ageing organisms generally display an increased oxidative stress and a decreased mitochondrial function. The increase in oxidative stress can ...
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Thursday, May 1st, 2008
Mitochondrial pAL2-1 plasmid homologs are senescence factors in Podospora anserina independent of intrinsic senescence.
Since the first description of a linear mitochondrial plasmid in Podospora anserina, pAL2-1, and homologous plasmids have gone from being considered beneficial longevity plasmids, via neutral genetic elements, toward mutator plasmids causing ...
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Thursday, May 1st, 2008
Sonographic appearances of the normal ulnar nerve in the cubital tunnel.
PURPOSE.: To investigate the sonographic characteristics of the normal ulnar nerve in the cubital tunnel, as well as any differences related to age, sex, and dominant arm. METHOD.: Two hundred twelve elbows in healthy volunteers ...
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Thursday, May 1st, 2008
An unusual case of a glomus tumor developing in a subcutaneous vein of the wrist.
Glomus tumors are benign tumors that originate in a neuromyoarterial glomus body and most commonly occur in the subungual regions. We present an unusual case of a glomus tumor in a ...
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Thursday, May 1st, 2008
Sonographic diagnosis of fibromatosis.
PURPOSE.: To investigate the value of sonography in the diagnosis of fibromatosis. METHOD.: We retrospectively reviewed the sonographic findings, pathologic results, and other medical records of 42 patients with pathologically proven fibromatosis. The tumor\'s size and location were recorded. Echogenicity, margins, vascularity, ...
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Thursday, May 1st, 2008
The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome.
Studies on the structure of the methylenetetrahydrofolate reductase (MTHFR) gene and the mechanisms by which folate may reduce homocysteine levels in bacteria ...
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Thursday, May 1st, 2008
Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13.
Mental retardation (MR) occurs in approximately 3% of the population and therefore significantly impacts public health. Despite this relatively high prevalence, the specific causes of MR remain unknown in most cases, although both genetic ...
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Thursday, May 1st, 2008
Sonographic findings of healthy volunteers infected with dengue virus.
PURPOSE.: Sonography has historically been used in developing countries to help diagnose dengue infection during epidemics of dengue hemorrhagic fever in endemic areas and to predict the clinical course. In this article, we describe the sonographic findings ...
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Thursday, May 1st, 2008
Postnephrectomy fistula between the renal artery stump and inferior vena cava treated with Amplatzer vascular plug: Gray-scale and Doppler sonographic findings.
Fistulous communication between the renal artery stump and the inferior vena cava is a rare complication of nephrectomy. We report a case of an adult ...
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Thursday, May 1st, 2008
Cockayne syndrome type II in a Druze isolate in Northern Israel in association with an insertion mutation in ERCC6.
Cockayne syndrome (CS) (OMIM #133540) is a rare autosomal recessive disease characterized by severe growth and developmental retardation, progressive neurological dysfunction and symptoms of premature aging. The ...
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Thursday, May 1st, 2008
Predictors of reproductive success in female white-faced capuchins (Cebus capucinus).
Early investigations into variable reproductive success in nonhuman primates tended to focus on the benefits conferred by high dominance rank. However, the effect of high rank on individual reproductive success has been found to vary both ...
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Thursday, May 1st, 2008
Brief communication: Locomotor limb preferences in captive chimpanzees (Pan troglodytes): Implications for morphological asymmetries in limb bones.
Understanding the evolutionary origins of hemispheric specialization remains a topic of considerable interest in a variety of scientific disciplines. Whether nonhuman primates exhibit population-level limb preferences continues to be ...
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Thursday, May 1st, 2008
Hair color measurement and variation.
Pigmentation of hair in humans has been investigated by medical scientists, anthropologists and, more recently, by forensic scientists. In every investigation, hair color must first be defined by the researchers. Subjective color assessment inhibits the reproducibility of experiments and the direct ...
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Thursday, May 1st, 2008
Epidemiologic transition in an isolated indigenous community in the Valley of Oaxaca, Mexico.
The objective of the present study is to analyze age-specific mortality in a rural indigenous community in the throes of a secular increase in size in the Valley of Oaxaca, southern Mexico, over ...
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Thursday, May 1st, 2008
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations.
Capillary malformation-arteriovenous malformation (CM-AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1 mutations ...
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Thursday, May 1st, 2008
Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits.
Intake of Korean red ginseng (KRG, ginseng Radix rubra), rich in glycosylated saponins (ginsenosides), has been known to inhibit platelet aggregation in the normocholesterolemic condition. However, it is unclear whether KRG ...
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