Archive for May, 2008
Thursday, May 1st, 2008
Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels.
Calcium, as an integral part of a large number of cellular regulatory pathways, is selective in the control of specific cell functions like the start of G1 phase in cell cycle. ...
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Thursday, May 1st, 2008
Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body.
The structure and function of the carotid body are greatly altered during chronic hypoxia. Recent studies showed the expression of interleukin (IL)-1 receptor and IL-6 receptor in the carotid body, suggesting ...
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Thursday, May 1st, 2008
Evaluation of different types of lamellar keratoplasty for treatment of peripheral corneal perforation.
BACKGROUND: To discuss the efficacy and visual outcomes of different types of lamellar keratoplasty (LK) for the treatment of peripheral corneal perforation. METHODS: Sixty patients (67 eyes) with peripheral corneal perforation underwent semilunar ...
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Thursday, May 1st, 2008
Structure of intracorneal femtosecond laser pulse effects in conical incision profiles.
PURPOSE: As the applicative potential of femtosecond lasers is to be extended from LASIK-flap creation into intrastromal ablation uses, the interdependency of influencing factors has to be understood. We therefore evaluated the relationship between focus ...
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Thursday, May 1st, 2008
Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant.
A case of sudden infant death with histiocytoid cardiomyopathy and ventricular non-compaction was investigated with immunohistochemical methods. Histiocytoid cardiomyopathy is thought to be a developmental defect of the cardiomyocytes of the ...
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Thursday, May 1st, 2008
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase.
The family of human epidermal growth factor receptors (EGFR, HER2-4) exerts key functions in normal and malignant epithelial cells. Both EGFR and HER2 are valuable targets for anti-cancer drugs ...
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Thursday, May 1st, 2008
Increased frequency of pulmonary hypertension in psoriasis patients.
Several reports have demonstrated an association between psoriasis and cardiovascular diseases such as hypertension, valvular disease and arrhythmia. However, the data is scarce. Forty-seven psoriasis patients and 20 healthy people underwent transthoracic echocardiographic examination including pulse- and tissue ...
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Thursday, May 1st, 2008
Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer\'s disease with amygdala Lewy bodies.
We recently reported that Alzheimer\'s disease (AD) with amygdala Lewy bodies (ALB) is a distinct form of alpha-synucleinopathy that occurs in advanced AD. In AD/ALB the alpha-synuclein pathology correlated with ...
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Thursday, May 1st, 2008
Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines.
PURPOSE: The Bethesda guidelines suggest to perform microsatellite instability (MSI) test in early onset rectal cancer and not in patients >50 years with ...
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Thursday, May 1st, 2008
Swim pacemakers in box jellyfish are modulated by the visual input.
A major part of the cubozoan central nervous system is situated in the eye-bearing rhopalia. One of the neuronal output channels from the rhopalia carries a swim pacemaker signal, which has a one-to-one relation with ...
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Thursday, May 1st, 2008
Prospective comparison of high- and low-spatial-resolution dynamic MR imaging with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinoma.
The purpose of this study was to prospectively evaluate the efficacy of high-spatial-resolution dynamic MRI using sensitivity encoding (SENSE) in detection of hypervascular hepatocellular carcinoma (HCC). Thirty-five patients were ...
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Thursday, May 1st, 2008
Reference values for quantitative left ventricular and left atrial measurements in cardiac computed tomography.
To assess reference values for left ventricular (LV) and left atrial (LA) dimensions, global LV function, and LV-myocardial mass for cardiac CT. We examined 120 subjects undergoing a coronary angiography using 64-slice ...
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Thursday, May 1st, 2008
Nonmalignant papillary lesions of the breast at US-guided directional vacuum-assisted removal: a preliminary report.
This study was conducted to assess the accuracy of US-guided directional vacuum-assisted removal (US-DVAR) in evaluating nonmalignant papillary breast lesions. This retrospective study was approved by the institutional review board at our ...
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Thursday, May 1st, 2008
Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology.
Diffusion-weighted magnetic resonance imaging (DWI) provides functional information and can be used for the detection and characterization of pathologic processes, including malignant tumors. The recently introduced concept of \"diffusion-weighted whole-body imaging ...
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Thursday, May 1st, 2008
In vivo Gd-DTPA concentration for MR lung perfusion measurements: Assessment with computed tomography in a porcine model.
A linear relationship between MR signal and contrast-agent concentration (CAC) of the arterial-input function (AIF) is crucial for MR lung-perfusion quantification. The aim was to determine the in-vivo real ...
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Thursday, May 1st, 2008
Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle quantitative measurements, inter- and intra-observer agreement.
Our purpose was to determine the repeatability of squamous cell cancer in head and neck (SCCHN) and muscle tissue vascularity measurements as well as ...
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Thursday, May 1st, 2008
Cutaneous application of local anaesthetic-a useful help in galactography.
Galactography is an important step in the diagnostic workup of abnormal nipple discharge. At times it is impossible to insert the cannula in the secreting duct and galactography cannot be performed. In such cases we tried applying ...
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Thursday, May 1st, 2008
Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis.
The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual ...
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Thursday, May 1st, 2008
Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced solid tumors who have failed standard therapy.
PURPOSE: To establish the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), safety and recommended Phase II dose of ixabepilone, administered weekly as an intravenous ...
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Thursday, May 1st, 2008
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy.
Abnormal accumulation of myeloid-derived suppressor cells (MDSC) is an important mechanism of tumor immune evasion. Cyclophosphamide (CTX) has also been shown in non-tumor bearing animals to cause transient surges in ...
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Thursday, May 1st, 2008
A novel CD4 T-cell epitope described from one of the cervical cancer patients vaccinated with HPV 16 or 18 E7-pulsed dendritic cells.
Previously, safety and immunogenicity of human papillomavirus type 16 (HPV16) or 18 E7-pulsed dendritic cells (DC) vaccinations were demonstrated in a dose-escalation Phase I ...
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Thursday, May 1st, 2008
Pediatric neurodegenerative white matter processes: leukodystrophies and beyond.
Pediatric neurodegenerative white matter processes are complex, numerous and result from a vast array of causes ranging from white matter injury or inflammation to congenital metabolic disorders. When faced with a neurodegenerative white matter process on neuroimaging, the ...
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Thursday, May 1st, 2008
Multimodality imaging in the diagnosis of deep vein thrombosis and popliteal pseudoaneurysm complicating a sessile osteochondroma.
Synergistic use of ultrasonography, radiography, multidetector CT (MDCT) and MRI enabled a prompt and accurate diagnosis of a nonocclusive popliteal vein thrombus (deep venous thrombosis, DVT) and a pseudoaneurysm complicating ...
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Thursday, May 1st, 2008
Craniofacial and temporal bone CT findings in cleidocranial dysplasia.
Cleidocranial dysplasia (CCD) is a multistructural polyostotic genetic disorder that results from mutation of the CBFA1 gene. Hearing loss is a frequent finding in CCD. We describe the CT craniofacial findings in CCD and provide a comprehensive ...
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Thursday, May 1st, 2008
The haptic perception of spatial orientations.
This review examines the isotropy of the perception of spatial orientations in the haptic system. It shows the existence of an oblique effect (i.e., a better perception of vertical and horizontal orientations than oblique orientations) in a spatial plane intrinsic ...
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