Archive for May, 2008
Thursday, May 1st, 2008
Long-range charge transport through double-stranded DNA mediated by manganese or iron porphyrins.
Guanine oxidation by electron transfer results in the formation of a guanine radical cation, which is at the origin of long-range charge transport through double-stranded DNA. It is possible to observe guanine lesions at ...
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Thursday, May 1st, 2008
\"Iron priming\" guides folding of denatured aporubredoxins.
The relationship between iron uptake by aporubredoxins (apoRds) and formation of native holorubredoxins (holoRd), including their Fe(SCys)(4) sites, was studied. In the absence of denaturants, apoRds exhibited spectroscopic features consistent with structures very similar to those of the folded ...
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Thursday, May 1st, 2008
The international spine registry SPINE TANGO: status quo and first results.
With an official life time of over 5 years, Spine Tango can meanwhile be considered the first international spine registry. In this paper we present an overview of frequency statistics of Spine Tango for demonstrating ...
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Thursday, May 1st, 2008
Revision strategies for complications and failure of vertebroplasties.
Percutaneous vertebroplasty is widely discussed in the management of osteoporotic spinal compression fracture, but few reports are available concerning salvage procedures after failure of this technique. We studied 22 percutaneous vertebroplasty patients who required revision surgery upon presentation ...
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Thursday, May 1st, 2008
Cerebral glucose metabolic abnormality in patients with congenital scoliosis.
A possible association between congenital scoliosis and low mental status has been recognized, but there are no reports describing the mental status or cerebral metabolism in patients with congenital scoliosis in detail. We investigated the mental status ...
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Thursday, May 1st, 2008
Study of the effect of donor source on graft and patient survival in pediatric renal transplant recipients.
Evaluation of the impact of live unrelated kidney donor (LURD) source on the outcome of renal transplantation is not adequately studied. We aimed to compare the long-term outcome of ...
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Thursday, May 1st, 2008
Genetic causes of hypercalciuric nephrolithiasis.
Renal stone disease (nephrolithiasis) affects 3-5% of the population and is often associated with hypercalciuria. Hypercalciuric nephrolithiasis is a familial disorder in over 35% of patients and may occur as a monogenic disorder that is more likely to manifest itself in ...
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Thursday, May 1st, 2008
The kidney in leptospirosis.
Leptospirosis is a worldwide zoonosis. Typically, patients are young men, although children can be affected. In children, this disease causes mainly alterations of sensorium. Acute renal failure and jaundice (Weil\'s syndrome) are less common in children than in adults. The main renal ...
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Thursday, May 1st, 2008
Saccharomyces boulardii prevents oral-poliovirus vaccine-induced IgA nephropathy in mice.
Immunoglobulin A nephropathy (IgAN) is associated with mucosal IgA defect. Probiotics regulate specific and innate immunity. We evaluated the effect of Saccharomyces boulardii on experimental IgAN in mice. Four groups of BALB/c mice (eight for each) were ...
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Thursday, May 1st, 2008
Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease.
Bone morphogenic protein-7 (BMP7) is a morphogen that is important for kidney development and which is also an integral part of the kidney\'s physiological response to repair of acute ...
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Thursday, May 1st, 2008
Glomerular tip changes in childhood minimal change nephropathy.
Segmental glomerular lesions at the tubular opening, or tip changes, are found in the renal biopsies of adults in many disorders, including some initially considered to show minimal change nephropathy. The hypothesis was that similar tip changes occurred ...
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Thursday, May 1st, 2008
Oral-ibuprofen-induced acute renal failure in a preterm infant.
The side effects of indomethacin for ductal closure in preterm neonates (e.g. increased incidence of necrotizing enterocolitis, decreased cerebral blood volume and transient renal failure) have led clinicians to seek a safer alternative. Intravenous indomethacin and ibuprofen appear ...
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Thursday, May 1st, 2008
Virgins in the wild: mating status affects the behavior of a parasitoid foraging in the field.
In haplodiploid organisms, virgin females can produce offspring, albeit only sons. They may therefore face a trade-off between either: (1) searching for hosts and producing sons immediately; or (2) searching ...
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Thursday, May 1st, 2008
Beyond the reaction progress variable: the meaning and significance of isotopic incorporation data.
Ecologists conduct isotopic incorporation experiments to determine the residence time of various stable isotopes in animal tissues. These experiments permit determining the time window through which isotopic ecologists perceive the course of diet ...
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Thursday, May 1st, 2008
Diversification of the barley and wheat blt101/wpi6 promoters by the Xumet element without affecting stress responsiveness.
BLT101-family plasma membrane proteins are found in a wide range of organisms from bacteria to nematodes and are involved in the regulation of cellular cation concentration under stress conditions. A ...
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Thursday, May 1st, 2008
Global consequences of phosphatidylcholine reduction in Bradyrhizobium japonicum.
Phosphatidylcholine (PC) is the major phospholipid in eukaryotic membranes. In contrast, it is found in only a limited number of bacteria including members of the Rhizobiales. Here, PC is required for pathogenic and symbiotic plant-microbe interactions, as shown ...
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Thursday, May 1st, 2008
Modification of a human monoclonal antibody Fab fragment specific for Plasmodium falciparum 19-kDa C-terminal merozoite surface protein 1 by site-directed mutagenesis.
We recently produced human monoclonal antibody Fab fragments specific for the 19-kDa C-terminal merozoite surface protein 1 of Plasmodium falciparum in a bacterial expression system. ...
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Thursday, May 1st, 2008
Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2.
PURPOSE: Bone morphogenetic proteins (BMPs) are multifunctional regulators of various cell functions. The BMP-signalling network plays a pivotal role during embryogenesis and tumorigenesis. BMPs, e.g. BMP-2 exert their biological function in ...
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Thursday, May 1st, 2008
Identification of transgelin as a potential novel biomarker for gastric adenocarcinoma based on proteomics technology.
PURPOSE: To find a biomarker for gastric adenocarcinomas (GA). METHODS: Ten protein expression profiles of GA and paired non-neoplastic mucosa tissues were analyzed by two-dimensional gel electrophoresis. Forty-two protein spots that ...
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Thursday, May 1st, 2008
Germline mutations in the von Hippel-Lindau disease (VHL) gene in mainland Chinese families.
BACKGROUND: von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations in the VHL gene. To date, more than 500 VHL families have been reported worldwide. However, few information is ...
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Thursday, May 1st, 2008
The use of prostate specific antigen (PSA) density in detecting prostate cancer in Chinese men with PSA levels of 4-10 ng/mL.
AIM: To investigate the utility of prostate specific antigen density for detecting prostate cancer in men with serum PSA levels of 4-10 ng/mL. METHODS: Between ...
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Thursday, May 1st, 2008
Drug utilisation profile in the Italian paediatric population.
OBJECTIVE: In order to evaluate the prescribing pattern in the Italian paediatric population, prescriptions involving 923,353 children under 14 years old and dispensed during 2006 by the retail pharmacies of 22 Italian local health units were analysed. MATERIALS ...
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Thursday, May 1st, 2008
Pulse methylprednisolone with gammaglobulin as an initial treatment for acute Kawasaki disease.
Approximately 15-20% of patients with Kawasaki disease (KD) are not responsive to high-dose intravenous gammaglobulin (IVIG). We have previously reported a predictive method for identifying IVIG-non-responsive patients (high-risk KD patients). We determined the safety ...
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Thursday, May 1st, 2008
Dissociating restart cost and mixing cost in task switching.
Three experiments investigated the cognitive mechanisms underlying the restart cost and mixing cost in task switching. To this aim, the predictability of task order was varied (unpredictable in Experiment 1 and predictable in Experiments 2 and 3) ...
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Thursday, May 1st, 2008
Expressing a gene encoding wheat oxalate oxidase enhances resistance to Sclerotinia sclerotiorum in oilseed rape (Brassica napus).
Sclerotinia sclerotiorum causes a highly destructive disease in oilseed rape (Brassica napus). Oxalic acid (OA) secreted by the pathogen is a key pathogenicity factor. Oxalate oxidase (OXO) can oxidize ...
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