Archive for May, 2008
Thursday, May 1st, 2008
Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers.
The purpose of the present study was to investigate the potential use of two PEGylated derivatives of rosin (PD) as sustained release film forming materials. The derivatives differed chemically by their acid numbers-PD-1 with 120.93 ...
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Thursday, May 1st, 2008
Modified polysaccharides as fast disintegrating excipients for orodispersible tablets of roxithromycin.
The purpose of this study was to develop a dosage form that was easy to administer and provides rapid release of the drug roxithromycin, using modified polysaccharides as rapidly disintegrating excipients. Modified polysaccharides co grinded ...
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Thursday, May 1st, 2008
Effect of Eudragit((R)) RS 30D and Talc Powder on Verapamil Hydrochloride Release from Beads Coated with Drug Layered Matrices.
The aim of this study was to investigate the effect of Eudragit(R) RS 30D, talc, and verapamil hydrochloride on dissolution and mechanical properties of beads coated with ...
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Thursday, May 1st, 2008
Development and characterization of pectinate micro/nanoparticles for gene delivery.
The aim of this study was to investigate the possibility of using pectinate micro/nanoparticles as gene delivery systems. Pectinate micro/nanoparticles were produced by ionotropic gelation. Various factors were studied for their effects on the preparation of pectinate ...
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Thursday, May 1st, 2008
Optimization studies on design and evaluation of orodispersible pediatric formulation of indomethacin.
In the present study, the aim was to optimize an orodispersible formulation of indomethacin using a combined approach of subliming agent and superdisintegrant. The tablets were made by non-aqueous wet granulation technique with superdisintegrant ...
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Thursday, May 1st, 2008
Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique.
The purpose of this research was to obtain directly compressible agglomerates of naproxen containing disintegrant by spherical crystallization technique. Acetone-water containing hydroxypropyl celloluse (HPC) and disintegrant was used as ...
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Thursday, May 1st, 2008
Development of spray dried liposomal dry powder inhaler of dapsone.
This investigation was undertaken to evaluate practical feasibility of site specific pulmonary delivery of liposomal encapsulated Dapsone (DS) dry powder inhaler for prolonged drug retention in lungs as an effective alternative in prevention of Pneumocystis carinii ...
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Thursday, May 1st, 2008
Study of the RESS Process for Producing Beclomethasone-17,21-Dipropionate Particles Suitable for Pulmonary Delivery.
The purpose of this research was to micronize beclomethasone-17,21-dipropionate (BDP), an anti-inflammatory inhaled corticosteroid commonly used to treat asthma, using the rapid expansion of supercritical solution (RESS) technique. The RESS technique was chosen ...
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Thursday, May 1st, 2008
Granulation by roller compaction and enteric coated tablet formulation of the extract of the seeds of glinus lotoides loaded on aeroperl(r) 300 pharma.
The purpose of this research was to improve the hygrpscopicity and poor flow properties of the crude dry extract of the seeds of ...
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Thursday, May 1st, 2008
Selected Physical and Chemical Properties of Feverfew (Tanacetum parthenium) Extracts Important for Formulated Product Quality and Performance.
The objectives of this research are: (1) to assess selected formulation-relevant physical properties of several commercial Feverfew extracts, including flowability, hygroscopicity, compressibility and compactibility (2) to develop and validate ...
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Thursday, May 1st, 2008
Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus.
The objective of present investigation was to formulate self-microemulsifying drug delivery systems (SMEDDS) of tacrolimus (FK 506), a poorly water soluble immunosuppressant that exhibits low and erratic bioavailability. Solubility of FK 506 in various oils, ...
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Thursday, May 1st, 2008
Effect of drying methods on swelling, erosion and drug release from chitosan-naproxen sodium complexes.
The purpose of this research was to explore theapplication of ionic interactions between naproxen sodium (NS) and chitosan (CH) in complexes (NSC) prepared by tray drying (TD) and spray drying (SD) methods. ...
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Thursday, May 1st, 2008
Genes related to chromate resistance by Pseudomonas aeruginosa PAO1.
Chromate-hypersensitive mutants of the Pseudomonas aeruginosa PAO1 strain were isolated using transposon-insertion mutagenesis. Comparison of the nucleotide sequences of the regions interrupted in the mutants with the PAO1 genome revealed that the genes affected in three mutant ...
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Thursday, May 1st, 2008
Resistin is expressed in human hepatocytes and induces insulin resistance.
Resistin, known as an adipocyte-specific secretory factor (ADSF), is implicated to modulate insulin resistance in rodents. However, the precise role of this factor for human insulin resistance has remained elusive. Here, we investigate the relationship between ...
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Thursday, May 1st, 2008
Signaling for Vesicle Mobilization and Synaptic Plasticity.
The hypothesis that release of classical neurotransmitters and neuropeptides is facilitated by increasing the mobility of small synaptic vesicles (SSVs) and dense core vesicles (DCVs) could not be tested until the advent of methods for visualizing these secretory vesicles ...
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Thursday, May 1st, 2008
Metastatic Small Cell Carcinoma to the Thyroid Gland: a Pathologic and Molecular Study Demonstrating the Origin in the Urinary Bladder.
Small cell carcinomas may occur in the thyroid gland. Infrequently, they are primary tumors, and have been interpreted as variants of medullary thyroid carcinoma. However, the ...
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Thursday, May 1st, 2008
True Adrenal Mesothelial Cyst in a Patient with Flank Pain and Hematuria : A Case Report.
True mesothelial (epithelial) cysts in the adrenal gland are rare lesions. They represent 9% of adrenal cysts and are much less common than vascular adrenal cysts. We report a case ...
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Thursday, May 1st, 2008
Lysergic Acid Amide-Induced Posterior Reversible Encephalopathy Syndrome with Status Epilepticus.
INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is known to occur in association with several substances. However, lysergic acid amide (LSA) is not among the previously reported causes of PRES. METHODS: We report on a patient with ...
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Thursday, May 1st, 2008
Cardiac-Targeted Transgenic Mutant Mitochondrial Enzymes: mtDNA Defects, Antiretroviral Toxicity and Cardiomyopathy.
Mitochondrial (mt) DNA biogenesis is critical to cardiac contractility. DNA polymerase gamma (Pol gamma) replicates mtDNA, whereas thymidine kinase 2 (TK2) monophosphorylates pyrimidines intramitochondrially. Point mutations in POLG and TK2 result in clinical diseases associated ...
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Thursday, May 1st, 2008
A Critique of Positive Responsibility in Computing.
It has been claimed that (1) computer professionals should be held responsible for an undisclosed list of \"undesirable events\" associated with their work and (2) most if not all computer disasters can be avoided by truly understanding responsibility. Programmers, ...
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Thursday, May 1st, 2008
The novel 5bp deletion polymorphism in the promoter region of bovine ACRP30 gene.
ACRP30 gene was located nearby the QTL affecting the marbling, ribeye muscle area and fat thickness on the BAT1 in Angus. In this study, a 5bp deletion mutation within the bovine ACRP30 gene ...
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Thursday, May 1st, 2008
Comparative study of interspecific genetic divergence and phylogenic analysis of genus Jatropha by RAPD and AFLP : Genetic divergence and phylogenic analysis of genus Jatropha.
Genus Jatropha with 172 species having significant economic importance belongs to the family Euphorbiaceae. There are no reports on molecular characterization ...
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Thursday, May 1st, 2008
Identification of the cyclin D1b mRNA variant in mouse.
Cyclin D1 plays a key regulatory role during the G1 phase of the cell cycle and its gene is amplified and over-expressed in many cancers. The cyclin D1b mRNA variant was established in human cells and recent ...
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Thursday, May 1st, 2008
Village chicken production in Turkey: Tokat province example.
The aim of this work was to reveal the current form of village chicken production in Tokat province of Turkey. A survey was applied to 153 randomly selected farmers of 5 subdistricts in Tokat province. The ratios of ...
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Thursday, May 1st, 2008
Mixing behavior of the rhombic micromixers over a wide Reynolds number range using Taguchi method and 3D numerical simulations.
A planar micromixer with rhombic microchannels and a converging-diverging element has been systematically investigated by the Taguchi method, CFD-ACE simulations and experiments. To reduce the footprint and ...
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