Archive for May, 2008
Thursday, May 1st, 2008
An overview of patent law as applied to the field of veterinary medicine.
This article analyzes some of the challenges that can arise when patent law is applied to the field of veterinary medicine. Topics covered in this article include an overview of the different kinds ...
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Thursday, May 1st, 2008
Process optimization, characterization and pharmacokinetic evaluation in rats of ursodeoxycholic Acid-phospholipid complex.
The purpose of this research was to study whether the bioavailability of ursodeoxycholic acid could be improved by administering ursodeoxycholic acid-phospholipid complex (UDCA-PLC) orally to rats. A central composite design approach was used for ...
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Thursday, May 1st, 2008
Physicochemical Properties and Dissolution Studies of Dexamethasone Acetate-beta-Cyclodextrin Inclusion Complexes Produced by Different Methods.
Inclusion complexes between dexamethasone acetate (DMA), a poorly water soluble drug, and beta-cyclodextrin (betaCD) were obtained to improve the solubility and dissolution rate of this drug. Phase-solubility profile indicated that the solubility ...
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Thursday, May 1st, 2008
Controlled release matrix tablets of Zidovudine: effect of formulation variables on the in vitro drug release kinetics.
The purpose of this research was to design oral controlled release (CR) matrix tablets of zidovudine (AZT) using hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC) and carbopol-971P (CP) and to ...
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Thursday, May 1st, 2008
Preliminary investigation on the development of diltiazem resin complex loaded carboxymethyl xanthan beads.
The objective of this study was to develop a multiunit sustained release dosage form of diltiazem using a natural polymer from a completely aqueous environment. Diltiazem was complexed with resin and the resinate-loaded ...
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Thursday, May 1st, 2008
Development of Novel Biodegradable Polymeric Nanoparticles-in-Microsphere Formulation for Local Plasmid DNA Delivery in the Gastrointestinal Tract.
There is a critical need for development of novel delivery systems to facilitate the translation of nucleic acid-based macromolecules into clinically-viable therapies. The aim of this investigation was to develop ...
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Thursday, May 1st, 2008
A new rapid on-line imaging method to determine particle size distribution of granules.
The purpose of this research was to study the feasibility of the new image analysis method in the particle size determination of the granules. The method is capable of forming a three-dimensional topographic ...
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Thursday, May 1st, 2008
Influence of compression force on the behavior of mucoadhesive buccal tablets.
The purpose of this research was to study the compression force influence on polymers, tablet behavior and drug release rate. Several tablet batches were produced by varying the compression force and by using hydroxyethyl cellulose ...
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Thursday, May 1st, 2008
Ultrasound transmission technique as a potential tool for physical evaluation of monolithic matrix tablets.
The aim of this study was to investigate the effects of tablet porosity and particle size fraction of compacted Starch acetate powders, with and without model drug caffeine, on acoustic properties of ...
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Thursday, May 1st, 2008
Process analytical technology: application to particle sizing in spray drying.
The purpose of this research was to explore the possibility of employing PAT for particle sizing during spray drying with the use of an in-line and at-line laser diffraction system. Microspheres were made using maltodextrin and ...
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Thursday, May 1st, 2008
Comparative evaluation of flow for pharmaceutical powders and granules.
The objective of the present work was to carry out a systematic evaluation of flow of pharmaceutical powders and granules using compendial and non-compendial methods. Angle of repose, bulk density, tapped density, Carr\'s compressibility index, and Hausner ...
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Thursday, May 1st, 2008
The influence of sodium hyaluronate, L: -leucine and sodium taurocholate on the nebulization of aqueous betamethasone-17-valerate suspensions.
The purpose of this research was to evaluate the variables that are suggested to influence the adsorption of the hydrophilic hyaluronic acid (HA) onto the surface of the hydrophobic ...
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Thursday, May 1st, 2008
Formulation and Evaluation of Gastroretentive Dosage Forms of Clarithromycin.
The purpose of this research was to develop the hydrodynamically balanced delivery system of Clarithromycin (CLA) which, after oral administration should have the ability to prolong gastric residence time with the desired in vitro release profile for ...
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Thursday, May 1st, 2008
Design and development of gliclazide mucoadhesive microcapsules: in vitro and in vivo evaluation.
In this study an attempt was made to prepare mucoadhesive microcapsules of gliclazide using various mucoadhesive polymers designed for oral controlled release. Gliclazide microcapsules were prepared using sodium alginate and mucoadhesive polymer such ...
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Thursday, May 1st, 2008
Intracellular delivery of nanoparticles of an antiasthmatic drug.
The aim of the investigation was to prepare and characterize wheat germ agglutinin(WGA)-conjugated poly(D: ,L: -lactic-co-glycolic) acid nanoparticles encapsulating mometasone furoate (MF) as a model drug and assess changes in its fate in terms of cellular interactions. MF ...
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Thursday, May 1st, 2008
Influence of position and size of substituents on the mechanism of partitioning: a thermodynamic study on acetaminophens, hydroxybenzoic acids, and parabens.
The objective of the present investigation was to study the influence of size, nature, and topology of substituents on the thermodynamic characteristics of sublimation, fusion, ...
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Thursday, May 1st, 2008
Development and evaluation of buccoadhesive controlled release tablets of lercanidipine.
The purpose of this research was to develop and evaluate buccal mucoadhesive controlled release tablets of lercanidipine hydrochloride using polyethylene oxide and different viscosity grades of hydroxypropyl methylcellulose individually and in combination. Effect of polymer type, ...
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Thursday, May 1st, 2008
Formulation and Evaluation of a Salted-out Isoniazid-loaded Nanosystem.
The purpose of this study was to develop a drug-loaded nanosystem that has the ability to achieve flexible yet rate-controlled release of model drug isoniazid (INH) employing either an aqueous or emulsion-based salting-out approach. Formulation conditions were aimed ...
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Thursday, May 1st, 2008
Development of Lapachol Topical Formulation: Anti-inflammatory Study of a Selected Formulation.
This study aimed at developing a topical formulation of lapachol, a compound isolated from various Bignoniaceae species and at evaluating its topical anti-inflammatory activity. The influence of the pharmaceutical form and different types of emulsifiers ...
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Thursday, May 1st, 2008
Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation.
The purpose of this study was to prepare lipospheres containing aceclofenac intended for topical skin delivery with the aim of exploiting the favorable properties of this carrier system and developing a sustained ...
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Thursday, May 1st, 2008
Amorphization Alone Does Not Account for the Enhancement of Solubility of Drug Co-ground with Silicate: The Case of Indomethacin.
The solubility advantage of indomethacin amorphized by co-grinding with Neusilin US2 in various media was investigated. Physical mixtures of gamma-indomethacin and Neusilin US2 (in the ratios 1:1, ...
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Thursday, May 1st, 2008
Design and evaluation of microemulsions for improved parenteral delivery of propofol.
The objective of this investigation was to evaluate the potential of the microemulsions to improve the parenteral delivery of propofol. Pseudo-ternary phase diagrams were plotted to identify microemulsification region of propofol. The propofol microemulsions were ...
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Thursday, May 1st, 2008
Preparation, characterization and evaluation of marsupsin-phospholipid complex.
The aim of this research was to formulate Marsupsin-phospholipid complex (M-P Complex) in attempt to increase the bioavailability of marsupsin and to characterize this new formulation along with its evaluation. Marsupsin-phospholipid complex was formulated by mechanical dispersion method. In ...
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Thursday, May 1st, 2008
Formulation and evaluation of microemulsion based delivery system for amphotericin B.
The present studies were designed to develop a formulation of amphotericin B in a lipid-based preparation as a microemulsion and to compare its toxicity with the commercial formulation Fungizone(R). The final product developed is a ...
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Thursday, May 1st, 2008
Estimating the Number of Droplets and Drug Particles Emitted from MDIs.
The objective of this paper is to assess the number of drug particles or droplets contained in metered dose inhaler (MDI) aerosols. Equations were developed to estimate this. The number of drug particles was estimated ...
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