Archive for May, 2008
Thursday, May 1st, 2008
Improving Care for Urban Children with Asthma: Design and Methods of the School-Based Asthma Therapy (SBAT) Trial.
The School Based Asthma Therapy (SBAT) trial builds on a pilot study in which we found that school-based administration of preventive asthma medications for inner-city children reduced asthma symptoms. ...
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Thursday, May 1st, 2008
Normal Variation of Bronchial Reactivity in Nonasthmatics is Associated with the Level of Mite-Specific IgE.
Objective. To investigate association between non-specific bronchial reactivity (NBR) and level of mite specific IgE amongst mite-sensitized non-asthmatic subjects. Methods. Subjects attending occupational check-up were assessed for: respiratory symptoms, atopic status ...
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Thursday, May 1st, 2008
Early Bronchodilatory Effects of Budesonide/Formoterol pMDI Compared with Fluticasone/Salmeterol DPI and Albuterol pMDI: 2 Randomized Controlled Trials in Adults with Persistent Asthma Previously Treated with Inhaled Corticosteroids.
Two identically designed, randomized, multicenter, single-dose, crossover studies were conducted in patients aged >/=18 years with mild to moderate ...
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Thursday, May 1st, 2008
Asthma genetics: personalizing medicine.
Asthma is a chronic inflammatory lung disease that leads to significant morbidity, mortality, and economic burden. The clinical symptoms, which are a result of airway inflammation and reversible airway obstruction, have led to the mainstay of therapies for asthma: anti-inflammatory medications and ...
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Thursday, May 1st, 2008
Early maternal separation and chronic variable stress as adults differentially affect fos expression in the anterodorsal thalami nuclei.
The present study examined the participation of the anterodorsal thalamic nuclei (ADTN) in mediating the long-term effects of early maternal separation on the stress/hypothalamic-pituitary-adrenal axis response of adult ...
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Thursday, May 1st, 2008
Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites.
Results from several studies have shown that a series of chemically distinct insecticide compounds (picrotoxin, BIDN, TBPS, fipronil, lindane, EBOB, and alpha-endosulfan) affect GABA(A) receptor function. In this investigation, docking of this set of insecticides ...
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Thursday, May 1st, 2008
Effects of nestin-antisense treatment in mice on memory-related performance.
Nestin is a neuronal stem cell marker. It has been reported that newly generated adult neurons play a role in murine memory. The purpose of this study was to determine whether nestin itself plays a role in ...
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Thursday, May 1st, 2008
Reduced Energy Utilization in the Brain is a Feature of an Animal Model of Fatigue.
Recently, the authors established an animal model of fatigue. The fatigued animals showed reduced 2-[(18)F]fluoro-2-deoxy-D-glucose uptake in their brain, although their blood glucose level did not differ from that of the ...
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Thursday, May 1st, 2008
The effects of antidepressants in Parkinson\'s disease: a meta-analysis.
This study explored the therapeutic effect of antidepressants in Parkinson\'s disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin ...
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Thursday, May 1st, 2008
Near-infrared spectroscopy study of language activated hyper- and hypo-oxygenation in human prefrontal cortex.
Oxygenation changes in the left prefrontal cortex during language processing were assessed with near-infrared spectroscopy (NIRS). Oxyhemoglobin and deoxyhemoglobin concentrations at the Fp1 site during 5 min of resting with eyes closed (control), ...
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Thursday, May 1st, 2008
Increased Tunel Positive Cells in CA1, CA2, and CA3 Subfields of Rat Hippocampus Due to Copper and Ethanol Co-Exposure.
Copper (Cu) is an essential element for life. However, it is toxic at excessive doses, whereas exposure to ethanol (EtOH) has known to cause morphological changes, degeneration, ...
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Thursday, May 1st, 2008
Angiotensinogen gene polymorphism predicts hypertension, and iridological constitutional classification enhances the risk for hypertension in koreans.
This study investigated the relationship between iridological constitution and angiotensinogen (AGN) gene polymorphism in hypertensives. In addition to angiotensin converting enzyme gene, AGN genotype is also one of the most ...
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Thursday, May 1st, 2008
Spontaneous incomplete recovery of peroneal palsy after a sealbite.
Incomplete recovery of peroneal palsy, after a sealbite during swimming has not been reported. A 58-year-old woman was bitten into the right knee by a seal during swimming, resulting in incomplete division of the right profound branch ...
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Thursday, May 1st, 2008
Bilateral and Unilateral Hippocampal Inactivation Did not Differ in their Effect on Consolidation Processes in the Morris Water Maze.
Consolidation processes were studied in the rat by using functional inactivation techniques. Previous results showed that unilateral hippocampal inactivation alters consolidation. It is not clear if bilateral ...
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Thursday, May 1st, 2008
Analysis of altered mental status in Turkey.
The aim of this study was to determine the frequency and etiology of altered mental status in adults at an Emergency Department. Medical records of 790 patients with altered mental status were reviewed. Out of 790 patients, 414 (52.3%) ...
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Thursday, May 1st, 2008
Grammaticality judgements in adolescents with and without language impairment.
Background: Existing evidence suggests that young children with specific language impairment have unusual difficulty in detecting omissions of obligatory tense-marking morphemes, but little is known about adolescents\' sensitivity to such violations. Aims: The study investigated whether limitations ...
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Thursday, May 1st, 2008
Investigating factors related to the effects of time-out on stuttering in adults.
Background: Response-contingent time-out has been shown to be an effective technique for enhancing fluency in people who stutter. However, the factors that determine individual responsiveness to time-out are not well understood. Aims: The study ...
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Thursday, May 1st, 2008
Economic aspects of a therapy and support service for people with long-term stroke and aphasia.
Backgound: This paper considers some economic aspects of a therapy and support service for people with stroke and aphasia. This material was part of a broader evaluation of the service, which ...
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Thursday, May 1st, 2008
Development of Controlled Release Sildenafil Formulations for Vaginal Administration.
Sildenafil is an active substance that has already been approved by FDA for human use. It is known to be an active compound for the treatment of sexual dysfunction in men. Some encouraging results have been published ...
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Thursday, May 1st, 2008
Molecularly Imprinted Polymers for alpha-Tocopherol Delivery.
Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on alpha -tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for alpha ...
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Thursday, May 1st, 2008
Chitosan-N-acetyl cysteine conjugates: in vitro evaluation of permeation enhancing and p-glycoprotein inhibiting properties.
This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate ...
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Thursday, May 1st, 2008
The delivery of platinum drugs from thermosensitive hydrogels containing different ratios of chitosan.
New thermosensitive hydrogels of poly(N-isopropylacrylamide) (PNIPAAm) with chitosan (CPN) were prepared and evaluated for use in the delivery of the platinum drugs, cisplatin and carboplatin. The effects of polymers containing different ratios of ...
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Thursday, May 1st, 2008
Penetration-enhancing effect of ethanolic solution of menthol on transdermal permeation of ondansetron hydrochloride across rat epidermis.
The aim of this investigation was to study the effect of an ethanol-water solvent system and ehtanolic solution of menthol on the permeation of ondansetron hydrochloride across the rat epidermis ...
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Thursday, May 1st, 2008
Permeation Studies and Histological Examination of Sheep Nasal Mucosa Following Administration of Different Nasal Formulations with or without Absorption Enhancers.
This study was designed to investigate the possible histological effects of different intranasal (IN) formulations of indomethacin (IND) on nasal mucosa in sheep. For this purpose, ...
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Thursday, May 1st, 2008
Liposomal polyethyleneglycol and polyethyleneglycol-Peptide combinations for active targeting to liver in vivo.
This report describes the development and evaluation of a range of polyethyleneglycol and polyethyleneglycol-peptide liposome formulations that effectively target liver in vivo. A 19-amino-acid sequence from the N-terminal region of the circumsporozoite protein of ...
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