Archive for April, 2008
Saturday, April 12th, 2008
Synthesis and Biological Activity of Functionalized Indole-2-carboxylates, Triazino- and Pyridazino-indoles.
Condensation of aryl hydrazines with ethyl pyruvate gave the respective hydrazones 4-6; Fischer indolization led to substituted-1H-indole-2-carboxylic acid ethyl esters 7-9. The Mannich reaction of these compounds with formaldehyde and morpholine yielded ethyl 3-(morpholinomethyl)-substituted-1H-indole-2-carboxylates 10-12. The ...
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Saturday, April 12th, 2008
Stable Non-IPR C(60) and C(70) Fullerenes Containing a Uniform Distribution of Pyrenes and Adjacent Pentagons.
The most abundant fullerenes, C(60) and C(70), and all the pure carbon fullerenes larger than C(70), follow the isolated-pentagon rule (IPR). Non-IPR fullerenes containing adjacent pentagons (APs) have been stabilized experimentally ...
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Saturday, April 12th, 2008
Synthesis and Antiviral Evaluation of Novel 5- (N-Aryl-aminomethyl -1,3,4-oxadiazol -2-yl)hydrazines and Their Sugars, 1,2,4-Triazoles, Tetrazoles and Pyrazolyl Derivatives.
A number of new N-arylaminomethyl-1,3,4- oxadiazole derivatives 2, 3a,b, and 9-12a,b were prepared. Sugar (5-N-arylaminomethyl-1,3,4-oxadiazol-2-yl) hydrazones 4-6a,b were synthesized by the reaction of the hydrazino derivatives 3a,b with the corresponding monosaccharides. ...
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Saturday, April 12th, 2008
Spotlights on our sister journals: ChemPhysChem 6/2008.
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Saturday, April 12th, 2008
Preview: ChemPhysChem 7/2008.
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Saturday, April 12th, 2008
Competitive Activation of C--H and C--X Bonds in Reactions of Pt(+) with CH(3)X (X=F,Cl): Experiment and Theory.
The reactions of Pt(+) with CH(3)X (X=F, Cl) are studied experimentally by employing an inductively coupled plasma/selected-ion flow tube tandem mass spectrometer and theoretically by density functional theory. Dehydrogenation ...
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Saturday, April 12th, 2008
Tuning the expression level of recombinant proteins by modulating mRNA stability in a cell-free protein synthesis system.
In this work, it was discovered that the stability of mRNA in a cell-free extract could be controlled by using engineered T7 terminator sequences. Specifically, it was found that ...
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Saturday, April 12th, 2008
Quantification of power consumption and oxygen transfer characteristics of a stirred miniature bioreactor for predictive fermentation scale-up.
Miniature parallel bioreactors are becoming increasingly important as tools to facilitate rapid bioprocess design. Once the most promising strain and culture conditions have been identified a suitable scale-up basis ...
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Saturday, April 12th, 2008
Mechanistic kinetic model for symmetric carboligations using benzaldehyde lyase.
For reactions using thiamine diphosphate (ThDP)-dependent enzymes many empirically-derived kinetic models exist. However, there is a lack of mechanistic kinetic models. This is especially true for the synthesis of symmetric 2-hydroxy ketones from two identical aldehydes, with ...
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Saturday, April 12th, 2008
Color Change of Proteorhodopsin by a Single Amino Acid Replacement at a Distant Cytoplasmic Loop.
Yoshitsugu M, Shibata M, Ikeda D, Furutani Y, Kandori H.
Department of Materials Science and Engineering, Nagoya Institute of Technology, Showa-ku, Nagoya, Japan, Fax: (+81) 52-735-5207 http://www.ach.nitech.ac.jp/~physchem/kandori/
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Saturday, April 12th, 2008
Cholesterol seco-Sterol-Induced Aggregation of Methylated Amyloid-beta Peptides-Insights into Aldehyde-Initiated Fibrillization of Amyloid-beta.
Scheinost JC, Wang H, Boldt GE, Offer J, Wentworth P Jr.
The Scripps-Oxford Laboratory, Dept. of Biochemistry, University of Oxford, South Parks Rd., Oxford OX1 3QU, UK, Fax: (+44) 1865-285-329 http://www2.bioch.ox.ac.uk/wentworthlab.
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Saturday, April 12th, 2008
Azadipeptide Nitriles: Highly Potent and Proteolytically Stable Inhibitors of Papain-Like Cysteine Proteases.
Löser R, Frizler M, Schilling K, Gütschow M.
present address: Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, Brisbane Qld 4072, Australia.
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Saturday, April 12th, 2008
Kinetic Gate-Opening Process in a Flexible Porous Coordination Polymer.
Tanaka D, Nakagawa K, Higuchi M, Horike S, Kubota Y, Kobayashi TC, Takata M, Kitagawa S.
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan, Fax: ...
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Saturday, April 12th, 2008
Understanding the Supramolecular Self-Assembly of the Fullerene Derivative PCBM on Gold Surfaces.
We report a DFT study on the self-assembly of the fullerene derivative PCBM on the Au(111) surface. Recent STM experiments (Angew. Chem. 2007, 119, 8020-8023([1])) show a coverage-dependent transition of the adsorption and self-assembly ...
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Saturday, April 12th, 2008
Photocontrol of Single-Chain DNA Conformation in Cell-Mimicking Microcompartments.
Sollogoub M, Guieu S, Geoffroy M, Yamada A, Estévez-Torres A, Yoshikawa K, Baigl D.
Institut de Chimie Moléculaire (FR2769), Laboratoire de Chimie Organique (UMR CNRS 7611), UPMC Université Paris 06, 4, Place Jussieu, C. 181, 75005 ...
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Saturday, April 12th, 2008
Light-Regulated RNA-Small Molecule Interactions.
Young DD, Deiters A.
North Carolina State University, Department of Chemistry, Raleigh, NC 27695-8204, USA, Fax: (+1) 919-515-5079.
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Saturday, April 12th, 2008
Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic.
The biosynthetic gene cluster for tetronomycin (TMN), a polyether ionophoric antibiotic that contains four different types of ring, including the distinctive tetronic acid moiety, has been cloned from Streptomyces sp. NRRL11266. ...
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Saturday, April 12th, 2008
Synthesis of Diastereomers of Complestatin and Chloropeptin I: Substrate-Dependent Atropstereoselectivity of the Intramolecular Suzuki-Miyaura Reaction.
Jia Y, Bois-Choussy M, Zhu J.
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France, Fax: (+33) 1-6907-7247 http://www.icsn.cnrs-gif.fr/article.php3?id_article=122.
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Saturday, April 12th, 2008
An Expedient Strategy for the Synthesis of Tryptamines and Other Heterocycles.
Nicolaou KC, Krasovskiy A, Trépanier VE, Chen DY.
Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. ...
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Saturday, April 12th, 2008
Total Synthesis of Macbecin I.
Belardi JK, Micalizio GC.
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA, Fax: (+1) 203-432-6144.
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Saturday, April 12th, 2008
An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from beta-Heteroatom Amino Compounds and Vinyl Sulfonium Salts.
Yar M, McGarrigle EM, Aggarwal VK.
School of Chemistry, University of Bristol, Cantock\'s Close, Bristol, BS8 1TS, UK, Fax: (+44) 117-929-8611 http://www.chm.bris.ac.uk/org/aggarwal/about.html.
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Saturday, April 12th, 2008
Controlled Direct Synthesis of C-Mono- and C-Disubstituted Derivatives of [3,3\'-Co(1,2-C(2)B(9)H(11))(2)](-) with Organosilane Groups: Theoretical Calculations Compared with Experimental Results.
Mono- and dilithium salts of [3,3\'-Co(1,2-C(2)B(9)H(11))(2)](-), (1(-)), react with different chlorosilanes (Me(2)SiHCl, Me(2)SiCl(2), Me(3)SiCl and MeSiHCl(2)) with an accurate control of the temperature to give a set ...
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Saturday, April 12th, 2008
Tuning the Nucleophilicity in Cyclopropenylidenes.
Cyclopropenylidenes are Hückel aromatic pi systems in which one of the ring atoms is a carbene center. Quantum chemical calculations at the density functional level of theory, supplemented by coupled-cluster calculations, indicate that there is a sizeable energy separation between the ...
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Saturday, April 12th, 2008
Optically Active Mixed Phthalocyaninato-Porphyrinato Rare-Earth Double-Decker Complexes: Synthesis, Spectroscopy, and Solvent-Dependent Molecular Conformations.
Reaction between the optically active metal-free phthalocyanine with a pi system with noncentrosymmetrical C(2v) symmetry ((S)- and (R)-H(2){Pc(OBNP)(2)}; OBNP=binaphthylphthalocyanine) and half-sandwich complexes [M(III)(acac)(TClPP)] (M=Y, Eu; TClPP=meso-tetrakis(4-chlorophenyl)porphyrinate; acac=acetylacetonate), which were generated in situ from ...
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Saturday, April 12th, 2008
Oxidative Homolysis of a Nitrosylchromium Complex.
Metal(III)-polypyridine complexes [M(NN)(3)](3+) (M=Ru or Fe; NN=bipyridine (bpy), phenanthroline (phen), or 4,7-dimethylphenanthroline (Me(2)-phen)) oxidize the nitrosylpentaaquachromium(III) ion, [Cr(aq)NO](2+), with an overall 4:1 stoichiometry, 4 [Ru(bpy)(3)](3+)+[Cr(aq)NO](2+)+2 H(2)O-->4 [Ru(bpy)(3)](2+)+[Cr(aq)](3+)+NO(3) (-)+4 H(+). The kinetics follow a mixed second-order rate law, -d[[M(NN)(3)](3+)]/dt=nk[[M(NN)(3)](3+)][[Cr(aq)NO](2+)], in which ...
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