Archive for April, 2008
Saturday, April 12th, 2008
Term and role of tumor centres in oncology healthcare in Germany.
Breast cancer is the most common malignant disease among women in Germany. There are more than 50,000 new cases of breast cancer diagnosed each year in the country. As breast cancer is a complex disease ...
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Saturday, April 12th, 2008
Hibernoma: A benign lipomatous tumor mimicking liposarcoma.
Hibernoma is a rare, benign, slow-growing soft tissue tumor. It was named after its resemblance to the brown fat found in hibernating animals. Due to its rich vascularity and magnetic resonance appearance, this tumor may mimic a liposarcoma before ...
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Saturday, April 12th, 2008
Preoperative diagnosis of jejunal adenocarcinoma - a case report.
We report herein the case of a preoperatively diagnosed small bowel adenocarcinoma. A 57-year-old man was hospitalized twice for a month in the Gastroenterology Clinic due to complaints lasting a year before hospitalization and consisting of heaviness ...
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Saturday, April 12th, 2008
Fibrous tumor of the lung: diagnostic and therapeutic considerations apropos of two cases.
Solitary fibrous tumor (SFT) of the pleura and the lung is an uncommon spindle cell neoplasm arising from the visceral pleura in the majority of the cases. Current diagnostic and therapeutic considerations are ...
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Saturday, April 12th, 2008
A patient with diffuse large B-cell non-Hodgkin\'s lymphoma and AA type amyloidosis.
AA-type amyloidosis is a consequence of a long-standing systemic inflammation and is not associated with a monoclonal protein or clonal bone marrow plasma cells. Proinflammatory cytokines such as interleukin (IL)1, IL-6, and tumor necrosis ...
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Saturday, April 12th, 2008
A woman with synchronous cervical, vaginal and laryngeal squamous cell carcinomas and positive human papillomavirus type 16; case presentation with literature review.
During the last 25 years the development of cervical cancer and cancer of the anorectum has been related to human papillomavirus (HPV) infection. HPV ...
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Saturday, April 12th, 2008
Two-dimensional electrophoresis and immunohistochemical study of calreticulin in colorectal adenocarcinoma and mirror biopsies.
Purpose: The purpose of this study was to analyse the polypeptide patterns of colorectal adenocarcinomas and mirror biopsies and to investigate the expression of calreticulin and the relationship of this chaperon to colon ...
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Saturday, April 12th, 2008
The histological outcome of glandular dyskaryosis - AGUS - reported in Papanicolaou smears.
Purpose: The objective of this study was to investigate the prognostic significance of glandular dyskaryosis/ AGUS, reported in Papanicolaou (Pap) smears. Materials and methods: During a 4-year period 26,408 smears were assessed at ...
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Saturday, April 12th, 2008
Neuron specific enolase tissue expression as a prognostic factor in advanced non small cell lung cancer.
Purpose: To determine the frequency of neuron specific enolase (NSE) tissue expression and its possible influence on survival of patients treated for advanced non small cell lung cancer (NSCLC). Patients ...
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Saturday, April 12th, 2008
Nitric oxide and the collagenous protein biosynthesis of irradiated chick chorioallantoic membrane.
Purpose: To study the effect of irradiation doses (2 Gy and 5 Gy) on the rate of collagenous protein biosynthesis (CPB) of chick embryo chorioallantoic membrane (CAM) and to investigate the possible role of ...
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Saturday, April 12th, 2008
Comparison of the 3D-conformal, helical tomotherapy and multileaf collimators-based intensity modulated radiotherapy modalities using radiobiological measures.
Purpose: Intensity modulated radiotherapy (IMRT) using multileaf collimators (MLC) and helical tomotherapy (HT) have become increasingly popular over the past few years. However, their clinical efficacy and effectiveness continue to ...
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Saturday, April 12th, 2008
Association between bone scintigraphy and serum levels of procollagen (I) and PSA in the detection of bone disease in prostate cancer patients.
Purpose: To evaluate the clinical usefulness of serum procollagen I carboxyterminal propeptide (PICP) and prostate specific antigen (PSA) in relation to bone scan results ...
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Saturday, April 12th, 2008
Pressure dressing in breast surgery: is this the solution for seroma formation?
Purpose: Pressure dressing (PD) after modified radical mastectomy (MRM) for breast cancer is investigated here as an easy-to-apply method to reduce seroma formation and subsequent need for clinical care. Patients and methods: Two hundred ...
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Saturday, April 12th, 2008
Factor V 1691 G-A (Leiden) polymorphism and cancer-related venous thromboembolism: a meta-analysis of published studies.
Purpose: Although one of the most common genetic polymorphisms that predispose to venous thromboembolism (VTE) is factor V 1691 G-A (Factor V Leiden; FVL), the effect of this polymorphism on the ...
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Saturday, April 12th, 2008
Impact of body mass index on cancer development.
Purpose: To determine the impact of body mass index (BMI) on cancer in a hospital-based Turkish population. Patients and methods: The study group consisted of 2015 (1172 females: 423 pre- and 749 postmenopausal; and 843 males) patients with ...
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Saturday, April 12th, 2008
Clinical staging and histopathological findings after radical hysterectomy in FIGO stage IIB cervical cancer.
Purpose: Advanced cervical cancer still represents a major health care challenge in the developing world. According to standard protocols the treatment of choice for stage IIB cervical cancer is cisplatin-based chemoradiotherapy. However, ...
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Saturday, April 12th, 2008
Toxicity and feasibility analysis for cisplatin-based concomitant chemoradiotherapy in locally advanced nasopharyngeal carcinoma.
Purpose: To assess the side effects of cisplatin-based concurrent chemoradiotherapy (CRT) for locally advanced nasopharyngeal carcinoma (NPC). Patients and methods: From 2001 through 2007, 34 (27 males; 7 females) patients received a median ...
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Saturday, April 12th, 2008
Capecitabine as salvage treatment in relapsed nasopharyngeal carcinoma: a phase II study.
Purpose: To evaluate the efficacy of capecitabine (Xeloda (R)) as rescue treatment (2nd, 3rd and 4th line) in patients with relapsed nasopharyngeal carcinoma (NPC) in a phase II study. Patients and methods: Between 5/2002-11/2005, ...
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Saturday, April 12th, 2008
Chemotherapy and cerebrovascular disease.
Cerebrovascular disease is common in cancer patients. Some tumors are at high risk for cerebrovascular complications. The development of cerebrovascular disease may be provoked by cancer treatment. No well-planned prospective studies about other causes of thrombosis are available, although various case reports ...
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Saturday, April 12th, 2008
Risk factors and adjuvant chemotherapy in the treatment of endometrial cancer.
Endometrial carcinoma is the most common and potentially curable gynecologic malignant neoplasm. The staging of endometrial cancer, according to the International Federation of Gynecology and Obstetrics (FIGO), is surgical. Recent studies suggest a therapeutic benefit ...
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Saturday, April 12th, 2008
Cell signaling in cancer.
The pathways that control cell differentiation and growth are almost always compromised in cancer. Although in the last years there have been major advances in understanding these changes and how they contribute to tumor initiation and growth, the task is far from ...
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Saturday, April 12th, 2008
Erythropoietin in cancer: the new face of an old friend.
During the last decade, anemia, a very common situation in patients with malignant diseases, either associated with chemotherapy or not, is being treated with recombinant erythropoietin (rEPO). Recent experimental findings have elucidated the role of EPO ...
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Saturday, April 12th, 2008
Investigations Concerning the Correlation of COX-1 Inhibitory and Hydroxyl Radical Scavenging Activity.
The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical ...
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Saturday, April 12th, 2008
Synthesis and Anticancer Activity of New 1 -Substituted- 6H-pyrido [4,3-b]carbazole Derivatives.
This study examines the synthesis and cytostatic activity of new 5,6-dimethyl-1-substituted-6H-pyrido [4,3-b] carbazole derivatives. Their structures were confirmed by (1) H-NMR and elemental analysis. Seven of the new compounds were tested by the SRB method in vitro against human ...
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Saturday, April 12th, 2008
Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides.
A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in-vitro cytotoxicity against various human cancer cell lines and their protein-kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the ...
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