Archive for March, 2008
Saturday, March 29th, 2008
DISPOSITION OF LASOFOXIFENE, A NEXT GENERATION SELECTIVE ESTROGEN RECEPTOR MODULATOR, IN HEALTHY MALE SUBJECTS.
Disposition of lasofoxifene, a next generation selective estrogen receptor modulator, was investigated in male volunteers after oral administration of a single 20 mg dose of [(14)C]lasofoxifene. Approximately 72% of the administered dose ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
PROBING THE BINDING SITES AND MECHANISMS OF ACTION OF TWO hERG CHANNEL ACTIVATORS, NS1643 AND PD307243.
We studied the mechanisms and sites of activator actions of PD(307243) and NS(1643) on the hERG channel expressed in oocytes and COS-7 cells. PD and NS affected hERG in a ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse.
Crossing the Cyp1a1/1a2(-/-) double-knockout with the Cyp1b1(-/-) single-knockout, we generated the Cyp1a1/1a2/1b1(-/-) triple-knockout mouse. In this triple-knockout, statistically significant phenotypes (with incomplete penetrance) included slower weight gain and greater risk of: embryolethality before gestational day 11, hydrocephalus, hermaphroditism, and cystic ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariates.
A typical longitudinal study prospectively collects both repeated measures of a health status outcome as well as covariates that are used either as the primary predictor of interest or as important adjustment factors. In ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Estrogen Plus Progestin Therapy and Breast Cancer in Recently Postmenopausal Women.
The Women\'s Health Initiative trial found a modestly increased risk of invasive breast cancer with daily 0.625-mg conjugated equine estrogens plus 2.5-mg medroxyprogesterone acetate, with most evidence among women who had previously received postmenopausal hormone ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Dose-Response Effect of a {beta}3-Adrenergic Receptor Agonist, Solabegron, on Gastrointestinal Transit, Bowel Function and Somatostatin Levels in Health.
beta3-adrenoceptors (AR) are expressed by cholinergic myenteric neurons and beta3-AR agonists are effective in experimental models of diarrhea. Our aim was to explore the effects of a beta3-AR ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Selective expansion of the {beta}-cell compartment in the pancreas of keratinocyte growth factor transgenic mice.
Epithelial-mesenchymal interactions are essential for growth, differentiation and regeneration of exocrine and endocrine cells in the pancreas. The keratinocyte growth factor (KGF) is derived from mesenchyme and has been shown to ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose.
Glucose-dependent insulinotropic polypeptide (GIP) is an important incretin produced in the K cells of the intestine and secreted into the circulating blood following ingestion of carbohydrate ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Tumor Necrosis Factor-{alpha} Directly Stimulates the Overproduction of Hepatic Apolipoprotein B100-containing VLDL via Impairment of Hepatic Insulin Signaling.
Insulin resistant states are commonly associated with both increased circulating levels of tumor necrosis factor (TNF)-alpha and hepatic overproduction of very low density lipoproteins (VLDL). Here, we provide ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Effect of a quality improvement strategy on several haemodialysis outcomes.
Background. Intermediate outcomes are associated with the survival of long-term haemodialysis patients; however, outcome variability across centres may result in heterogeneous quality of care. The study aim was to evaluate a multifaceted quality improvement activity (QIA) ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Moderately decreased renal function negatively affects the health-related quality of life among the elderly Korean population: a population-based study.
Background. The incidence of chronic kidney disease (CKD) is increasing in Korea, especially in the aged population. The health-related quality of life (HRQOL) of patients with chronic ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD.
Background. Soy protein ameliorates rat polycystic kidney disease with concomitant renal enrichment of omega3-polyunsaturated fatty acids. A study was conducted to examine the effects of eicosapentaenoic acids (EPA) on renal volume and ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Effects of albuminuria and renal dysfunction on development of dyslipidaemia in type 2 diabetes--the Hong Kong Diabetes Registry.
Background. It is uncertain whether albuminuria precedes the future development of high total cholesterol (TC > 6.2 mmol/l) and high LDL-C (>4.1 mmol/l) while renal dysfunction precedes the ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Orosensory Detection of Fatty Acids by Obesity-Prone and Obesity-Resistant Rats: Strain and Sex Differences.
A series of brief-access (15s) behavioral assays following the formation of a conditioned taste aversion (CTA) to linoleic acid were performed in order to follow up on observations showing differences in the ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
The importance of a word: how to translate \'breakthrough\'.
Gonçalves JA.
Unidade de Cuidados Paliativos - Rede Instituto Português de Oncologia, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Does acupressure help reduce nausea and vomiting in palliative care patients? Pilot study.
Perkins P, Vowler SL.
Sue Ryder Care Leckhampton Court Hospice Church Road Leckhampton Cheltenham GL53 0QJ UK. E-mail: paul.perkins@suerydercare.org.
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Opioid withdrawal syndrome on switching from hydromorphone to alfentanil.
Opioid switching is increasingly practiced. This patient did not tolerate morphine, oxycodone or hydromorphone due to opioid toxicity. Finally switch to alfentanil was performed. The patient developed classical opioid withdrawal symptoms and signs from discontinuation of the ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Access to medications in the community by patients in a palliative setting. A systems analysis.
This study performed a systems analysis of the process by which patients under the care of a specialist palliative home care obtained medications, and highlighted factors that delay this process. Systems ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Patients\' experiences of carcinoma of unknown primary site: dealing with uncertainty.
It is generally acknowledged that patients may find it particularly hard to accept a cancer diagnosis if the primary origin cannot be identified. However, there is very little research exploring this. AIMS: This is an ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Death rattle: its impact on staff and volunteers in palliative care.
BACKGROUND: Hospice staff and volunteers frequently hear the sound of death rattle and offer explanations and reassurance to relatives and other patients. This paper describes our study into the impact of hearing the sound of ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Knowledge and information needs of informal caregivers in palliative care: a qualitative systematic review.
OBJECTIVES: To review current understanding of the knowledge and information needs of informal caregivers in palliative settings. Data sources: Seven electronic databases were searched for the period January 1994-November 2006: Medline, CINAHL, ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
The effect of the Liverpool Care Pathway for the dying: a multi-centre study.
We studied the effect of the Liverpool Care Pathway (LCP) on the documentation of care, symptom burden and communication in three health care settings. Between November 2003 and February 2005 (baseline period), the ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
How well do current instruments using bereaved relatives\' views evaluate care for dying patients?
BACKGROUND: Providing good quality of care for dying patients and their families has been highlighted as a national priority in the UK. Defining and measuring the quality of this care is therefore ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
Improving the effectiveness of interventions in palliative care: the potential role of qualitative research in enhancing evidence from randomized controlled trials.
Evaluating interventions in palliative care using randomized controlled trials (RCTs) has helped advance the specialty and create an evidence base for the delivery of care. ...
Posted in researches 3 | No Comments »
Saturday, March 29th, 2008
The Edmonton Symptom Assessment System: a 15-year retrospective review of validation studies (1991-2006).
INTRODUCTION: The purpose of this review was to identify and critique validation studies focusing on the Edmonton Symptom Assessment System (ESAS), a commonly used symptom assessment tool for advanced cancer and palliative patients. ...
Posted in researches 3 | No Comments »