Archive for March, 2008
Saturday, March 29th, 2008
Antiprion Prophylaxis by Gene Transfer of a Soluble Prion Antagonist.
Prion diseases are untreatable neurodegenerative disorders characterized by accumulation of PrP(Sc), an aggregated isoform of the normal prion protein PrP(C). Here, we delivered the soluble prion antagonist PrP-Fc2 to the brains of mice by lentiviral gene ...
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Saturday, March 29th, 2008
Molecular Characterization of Neisseria meningitidis Isolates Using a Resequencing DNA Microarray.
Neisseria meningitidis is a major cause of both meningitis and septicemia. Typically, isolates are characterized by using a combination of immunological phenotyping, using monoclonal and polyclonal antisera, and Sanger nucleotide sequencing of epitope-encoding variable regions, ...
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Saturday, March 29th, 2008
Death by Nondiagnosis: Why Emergent CT Angiography Should Not Be Done for Patients With Subarachnoid Hemorrhage.
Westerlaan HE, Eshghi S, Oudkerk M, Groen RJ, Metzemaekers JD, van Dijk JM, Mooij JJ.
Department of Radiology.
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Saturday, March 29th, 2008
Intra-Arterial Nimodipine for Severe Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Influence on Clinical Course and Cerebral Perfusion.
BACKGROUND AND PURPOSE: The efficacy of intra-arterial administration of nimodipine (IAN) in patients with severe vasospasm after aneurysmal subarachnoid hemorrhage (SAH) remains unproved. The goal of the present study ...
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Saturday, March 29th, 2008
Recurrent Intracranial Stenosis Induced by the Wingspan Stent: Comparison with Balloon Angioplasty Alone in a Single Patient.
SUMMARY: We present a case in which angioplasty alone and stent-assisted angioplasty were performed in the same patient to treat medically refractory intracranial stenoses. This elderly patient with presumed ...
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Saturday, March 29th, 2008
Cerebral Corticospinal Tract Injury Resulting from High-Voltage Electrical Shock.
SUMMARY: Electrical injuries are becoming more common and are increasingly imaged with advanced technologies, such as MR imaging. However, the MR imaging findings of such injuries remain largely unstudied. We report a high-voltage electrical injury to the ...
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Saturday, March 29th, 2008
Preoperative Onyx Embolization of Aggressive Vertebral Hemangiomas.
SUMMARY: We report the first use of Onyx in the embolization of spinal tumors in 2 cases of aggressive vertebral hemangioma. In both cases, Onyx embolization provided effective preoperative tumor devascularization after the initial prolonged particulate embolization with Embospheres ...
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Saturday, March 29th, 2008
Simultaneous Treatment with Intravenous Recombinant Tissue Plasminogen Activator and Endovascular Therapy for Acute Ischemic Stroke Within 3 Hours of Onset.
BACKGROUND AND PURPOSE: Because intravenous (IV) recombinant tissue plasminogen activator (rtPA) does not always lead to a good outcome in a considerable proportion of patients, combined ...
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Saturday, March 29th, 2008
Arterial Spin-Labeling in Routine Clinical Practice, Part 1: Technique and Artifacts.
SUMMARY: The routine use of arterial spin-labeling (ASL) in a clinical population has led to the depiction of diverse brain pathologic features. Unique challenges in the acquisition, postprocessing, and analysis of cerebral blood flow (CBF) ...
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Saturday, March 29th, 2008
Subtraction 3D CT Angiography with the Orbital Synchronized Helical Scan Technique for the Evaluation of Postoperative Cerebral Aneurysms Treated with Cobalt-Alloy Clips.
BACKGROUND AND PURPOSE: We investigated the clinical usefulness of subtraction CT angiography (CTA) by using the orbital synchronized helical scan technique (OSHST) for evaluating ...
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Saturday, March 29th, 2008
Reproducibility, Interrater Agreement, and Age-Related Changes of Fractional Anisotropy Measures at 3T in Healthy Subjects: Effect of the Applied b-Value.
BACKGROUND AND PURPOSE: There is no reproducibility study of fractional anisotropy (FA) measurements at 3T using regions of interest (ROIs). Our purpose was to establish the ...
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Saturday, March 29th, 2008
Trigeminocardiac Reflex in Embolization of Intracranial Dural Arteriovenous Fistula.
Schaller B, Prank K, Filis A, Buchfelder M; for the Trigemino-Cardiac-Reflex-Examination-Group.
Neurosurgical Department of University HospitalParis, France;Center of BiotechnologyBielefeld UniversityBielefeld, Germany.
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Saturday, March 29th, 2008
A Developmental Venous Anomaly Presenting Atypical Findings on Susceptibility-Weighted Imaging.
Fushimi Y, Miki Y, Togashi K, Kikuta K, Hashimoto N, Fukuyama H.
Department of Diagnostic Imaging and Nuclear MedicineKyoto University Graduate School of MedicineDepartment of Radiology, Hikone Municipal HospitalHikone, Japan.
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Saturday, March 29th, 2008
Attenuation of Cerebral Veins in Susceptibility-Weighted MR Imaging Performed with the Patient under General Anesthesia.
Kesavadas C, Thomas B, Misra S, Saini J.
Sree Chitra Tirunal Institutefor Medical Sciences and TechnologyTrivandrum, India.
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Saturday, March 29th, 2008
CT Angiography Is State-of-the-Art First Vascular Imaging for Subarachnoid Hemorrhage.
Fox AJ.
Sunnybrook Health Sciences CentreUniversity of TorontoDepartment of Medical ImagingDivison of NeuroradiologyToronto, Canada.
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Saturday, March 29th, 2008
Life at the End of the Tunnel: Why Emergent CT Angiography Should Be Done for Patients With Acute Subarachnoid Hemorrhage.
Agid R, Willinsky RA, Farb RI, Terbrugge KG.
Division of NeuroradiologyDepartment of Medical ImagingToronto Western HospitalUniversity of TorontoToronto, Canada.
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Saturday, March 29th, 2008
Regarding the Risk of Death from CT Angiography in Patient with Subarachnoid Hemorrhage.
Livingston RR.
TRA Medical ImagingTacoma, WA.
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Saturday, March 29th, 2008
Differences of Apparent Diffusion Coefficient Values in Patients with Creutzfeldt-Jakob Disease According to the Codon 129 Genotype.
Galanaud D, Dormont D, Chiras J, Haïk S, Brandel JP, Ranjeva JP.
Department of NeuroradiologyCNRS UPR 640 LENA.
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Saturday, March 29th, 2008
Stability and biological activities of heterodimeric and single-chain equine LH/chorionic gonadotropin variants.
Recombinant equine LH/chorionic gonadotropin (eLH/CG) was expressed in the baculovirus-Sf9 insect cell system either as a single-chain with the C-terminus of the beta-subunit fused to the N-terminus of the alpha-subunit or as non-covalently linked ...
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Saturday, March 29th, 2008
Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-{alpha} activity.
Phosphorylation of estrogen receptor-alpha (ERalpha) at specific residues in transcription activation function 1 (AF-1) can stimulate ERalpha activity in a ligand-independent manner. This has led to the proposal that AF-1 phosphorylation ...
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Saturday, March 29th, 2008
Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer.
Estrogen exposure is a risk factor for breast cancer. Given that HSD17B2 gene encodes an enzyme that catalyses estradiol inactivation, it appears ...
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Saturday, March 29th, 2008
RNAs as extracellular signaling molecules.
RNA is emerging as a major component of the regulatory circuitry that underpins the development and physiology of complex organisms. Here we review recent evidence that suggests that RNA may supplement endocrine and paracrine signaling by small molecules and proteins, and ...
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Saturday, March 29th, 2008
Traumatic Dislocation of the Hip in a High School Football Player.
Background: Although traumatic dislocation of the hip often occurs as a result of automobile accidents, dislocations have been reported to occur during sports activities. Objective: Using the experience in treating a 17-year-old high school football ...
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Saturday, March 29th, 2008
Osmotic regulation of a novel flavin-containing monooxygenase in primary cultured cells from rainbow trout (Oncorhynchus mykiss).
A cDNA encoding a hepatic isoform of flavin-containing monooxygenase (hFMO) , (EF063736) containing an open reading frame of 1792 bp and encoding 554 amino acids was cloned and sequenced from ...
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Saturday, March 29th, 2008
The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2.
Prasugrel is a novel thienopyridine prodrug with demonstrated inhibition of platelet aggregation and activation. The biotransformation of prasugrel to its active metabolite, R-138727, requires ester bond hydrolysis, forming the thiolactone R-95913, ...
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