Editorial.
Sunday, March 16th, 2008Editorial. Blieszner R.
Archive for the ‘researches 3’ Category
Physical Activity in Prefrail Older Adults: Confidence and Satisfaction Related to Physical Function
Sunday, March 16th, 2008Physical Activity in Prefrail Older Adults: Confidence and Satisfaction Related to Physical Function. We examined the hypothesis that physical activity will have favorable effects on measures of self-efficacy for a 400-m walk and satisfaction with physical functioning in older adults 70+ years of age who have ...
Within-group differences in depression among older hispanics living in the United States.
Sunday, March 16th, 2008Within-group differences in depression among older hispanics living in the United States. Using the Health and Retirement Study, we examine the prevalence of depression in different groups of Hispanic older adults. Respondents (n = 759) were aged 59 and older and identified themselves as Mexican American ...
Age differences in memory for arousing and nonarousing emotional words.
Sunday, March 16th, 2008Age differences in memory for arousing and nonarousing emotional words. Older adults sometimes demonstrate a mnemonic \"positivity effect,\" remembering more positive than negative information. The present study examined whether this effect would occur for arousing words (elation vs slaughter) or for nonarousing ones (serenity vs sorrow). ...
Racial and Ethnic Variations in Caregiver Service Use.
Sunday, March 16th, 2008Racial and Ethnic Variations in Caregiver Service Use. OBJECTIVE: This article examines whether race and ethnicity contribute to the differential use of caregiver support services, when controlling for caregiver and care recipient characteristics, as represented by predisposing, enabling, and need factors included in the Behavioral Model ...
Life Course Socioeconomic Disadvantage and Cognitive Function Among the Elderly Population of Seven
Sunday, March 16th, 2008Life Course Socioeconomic Disadvantage and Cognitive Function Among the Elderly Population of Seven Capitals in Latin America and the Caribbean. OBJECTIVE: To examine the influence of life course socioeconomic disadvantages (SED) on cognitive function in later life. METHOD: Data originate from a survey of people 60 ...
Effects of Own and Spousal Disability on Loneliness Among Older Adults.
Sunday, March 16th, 2008Effects of Own and Spousal Disability on Loneliness Among Older Adults. OBJECTIVES: This study examines the effects of own and spousal disability on social and emotional loneliness among married adults aged 65 and older. METHOD: Data from 710 men and 379 women of a Dutch community ...
Education and Psychological Distress Among Older Chinese.
Sunday, March 16th, 2008Education and Psychological Distress Among Older Chinese. OBJECTIVE: The goal of this research is to see if more highly educated older Chinese have lower levels of distress than do their poorly educated counterparts and whether engaging in cognitively stimulating activities such as reading and playing mahjong ...
Fixing DNA breaks during class switch recombination.
Sunday, March 16th, 2008Fixing DNA breaks during class switch recombination. Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining ...
Going Outdoors Daily Predicts Long-Term Functional and Health Benefits Among Ambulatory Older People
Sunday, March 16th, 2008Going Outdoors Daily Predicts Long-Term Functional and Health Benefits Among Ambulatory Older People. OBJECTIVE: This article examines the association between frequency of going out of the house and health and functional status among older people. METHOD: A randomly chosen cohort of ambulatory participants born in 1920 ...
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.
Sunday, March 16th, 2008CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2 natural killer (NK) receptor family is a central innate mechanism by which NK cells monitor the expression of other HLA ...
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent
Sunday, March 16th, 2008IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. Therapeutic vaccination is a potentially powerful strategy to establish immune control and eradicate persistent viral infections. Large and multifunctional antiviral T cell responses are associated with control of viral persistence; however, ...
Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infect
Sunday, March 16th, 2008Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. Therapeutic vaccination is a potentially promising strategy to enhance T cell immunity and viral control in chronically infected individuals. However, therapeutic vaccination approaches have fallen short of expectations, and effective boosting of antiviral T cell ...
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired
Sunday, March 16th, 2008Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. A diverse T cell repertoire is essential for a vigorous immune response to new infections, and decreasing repertoire diversity has been implicated in the age-associated decline in ...
A gammaherpesvirus-secreted activator of V{beta}4+ CD8+ T cells regulates chronic infection and immu
Sunday, March 16th, 2008A gammaherpesvirus-secreted activator of V{beta}4+ CD8+ T cells regulates chronic infection and immunopathology. Little is known about herpesvirus modulation of T cell activation in latently infected individuals or the implications of such for chronic immune disorders. Murine gammaherpesvirus 68 (MHV68) elicits persistent activation of CD8(+) T ...
Emergence of Serratia marcescens, Klebsiella pneumoniae and Escherichia coli possessing the plasmid-
Sunday, March 16th, 2008Emergence of Serratia marcescens, Klebsiella pneumoniae and Escherichia coli possessing the plasmid-mediated carbapenem-hydrolyzing {beta}-lactamase KPC-2 in intensive care units from a Chinese hospital. Twenty-one Serratia marcescens, ten Klebsiella pneumoniae and one Escherichia coli isolates with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care ...
“Keepin’ My Mind Right”: Identity Maintenance and Religious Social Support in the Prison Context.
Sunday, March 16th, 2008\"Keepin\' My Mind Right\": Identity Maintenance and Religious Social Support in the Prison Context. It is not uncommon for inmates to experience religious conversions in prison. These conversions allow inmates to portray themselves in a prosocial light and help them to establish a sense of control ...
Efficacies of Ceftobiprole Medocaril and Comparators in a Rabbit Model of Methicillin-Resistant Stap
Sunday, March 16th, 2008Efficacies of Ceftobiprole Medocaril and Comparators in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Osteomyelitis. The pharmacokinetics and distribution into bone tissue of ceftobiprole in uninfected New Zealand white rabbits were determined after subcutaneous administration of prodrug ceftobiprole medocaril. Serum exposure (Cmax, Ctrough, AUC) to ceftobiprole ...
Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell - mediated HIV transfer.
Sunday, March 16th, 2008Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell - mediated HIV transfer. Without an effective vaccine against HIV infection, topical microbicide development has become a priority. The sulfonated polyanion PRO 2000, a candidate topical microbicide now in Phase II/III clinical trials, blocks HIV ...
Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, against Extracel
Sunday, March 16th, 2008Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, against Extracellular and Intracellular Staphylococcus aureus and its Stable Small Colony Variant (SCV) in Human Monocyte-derived Macrophages and in Broth. We investigated the antistaphylococcal activities of daptomycin, gentamicin, and rifampin against two Staphylococcus aureus strains and ...
Buthionine sulfoximine has anti-T.cruzi activity in a murine model of acute Chagas’ disease and enh
Sunday, March 16th, 2008Buthionine sulfoximine has anti-T.cruzi activity in a murine model of acute Chagas\' disease and enhances the efficacy of nifurtimox. L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/Kg/day showed an anti-T. cruzi effect in mice, increasing the survival rate and decreasing the parasitemias and parasite burden ...
Mouse beta-defensin-14 (mBD-14/defb14): An antimicrobial ortholog of human beta-defensin-3 (hBD-3/DE
Sunday, March 16th, 2008Mouse beta-defensin-14 (mBD-14/defb14): An antimicrobial ortholog of human beta-defensin-3 (hBD-3/DEFB103A). Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with IFN-gamma or TGF-alpha increased ...
Efficacy of Benzoxazinorifamycins in the Mouse Model of Chlamydia pneumoniae Lung Infection.
Sunday, March 16th, 2008Efficacy of Benzoxazinorifamycins in the Mouse Model of Chlamydia pneumoniae Lung Infection. The efficacy of rifalazil and other benzoxazinorifamycins was tested in a mouse model of lung infection against Chlamydia pneumoniae. Rifalazil and 6 related new chemical entities all showed efficacy after one dose per day ...
Pharmacodynamic Analysis and Clinical Trial of Amoxicillin Sprinkle QD for 7 Days Compared to Penici
Sunday, March 16th, 2008Pharmacodynamic Analysis and Clinical Trial of Amoxicillin Sprinkle QD for 7 Days Compared to Penicillin VK QID for 10 Days in the Treatment of Tonsillopharyngitis due to Streptococcus Pyogenes in Children. An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the minimum inhibitory concentration ...