Archive for the ‘researches 3’ Category
Sunday, March 16th, 2008
Stem cells on the brain.
Knoepfler PS.
Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Sacramento, CA 95817. knoepfler@ucdavis.edu.
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Sunday, March 16th, 2008
The HapMap: Charting a Course for Genetic Discovery in Neurological Diseases.
Whole-genome association analyses have begun to yield confirmed findings for genetic risk variants for complex disease. As the first reports of its application to neurological disease are described, we review this progress, explain the principles ...
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Sunday, March 16th, 2008
Correction: editorial board news.
Rosenberg RN.
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390. archneurol@jama-archives.org.
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Sunday, March 16th, 2008
Neuromics.
Rosenberg RN.
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9108. archneurol@jama-archives.org.
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Sunday, March 16th, 2008
Neuromics and neurological disease.
Rosenberg RN.
Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75236-3239. archneurol@jama-archives.org.
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Sunday, March 16th, 2008
Safety of Antiplatelet Therapy Prior to Intravenous Thrombolysis in Acute Ischemic Stroke.
BACKGROUND: There is some uncertainty whether prior use of antiplatelet (AP) drugs increases the risk of symptomatic intracerebral hemorrhage (SICH) and influences functional outcome in patients with ischemic stroke treated with intravenous thrombolysis. OBJECTIVE: ...
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Sunday, March 16th, 2008
The Effect of Maternal Body Condition Score Before and During Pregnancy on the Glucose Tolerance of Adult Sheep Offspring.
This study investigates the effects of diet-induced changes in maternal body condition on glucose tolerance in sheep.Welsh Mountain ewes were established, by dietary manipulation, at a body ...
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Sunday, March 16th, 2008
Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT1R antagonism.
Montelukast (MLK) is a cysteinyl leukotriene receptor-1 (cysLT1R) antagonist with inhibitory effects on eosinophils, key proinflammatory cells in asthma. We assessed the effect of MLK on resting and ...
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Sunday, March 16th, 2008
Expression of Fox Head Protein 1 in Human Eutopic Endometrium and Endometriosis.
The objective of this study is to examine the localization and expression of FOXP1 in human endometrium during the menstrual cycle and in endometriotic lesions and endometrial adenocarcinoma. FOXP1 protein expression was analyzed by ...
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Sunday, March 16th, 2008
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.
CD14+ peripheral blood monocytes can differentiate into fibroblast-like cells called fibrocytes, which are associated with and are at least partially responsible for wound healing and fibrosis in multiple organ systems. Signals regulating fibrocyte differentiation are ...
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Sunday, March 16th, 2008
Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.
Antica M, Sain LC, Kapitanovic S, Matulic M, Dzebro S, Dominis M.
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Sunday, March 16th, 2008
Eliminating the complete response penalty from myeloma response assessment.
Lonial S, Gertz MA.
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Sunday, March 16th, 2008
Bovine protein disulfide isomerase-enhanced tissue factor coagulant function: is phospholipid contaminant in it the real culprit?
Kothari H, Sen P, Pendurthi UR, Rao LV.
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Sunday, March 16th, 2008
Multiple myeloma.
Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The ...
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Sunday, March 16th, 2008
PDGF, TGF-b and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSC into adipogenic, chondrogenic and ostoegenic lineages.
We compared the transcriptomes of marrow derived MSCs with differentiated adipocytes, ...
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Sunday, March 16th, 2008
Unprecedented diversity of genotypic revertants in lymphocytes of a patient with the Wiskott-Aldrich Syndrome.
Spontaneous somatic reversions of inherited mutations are poorly understood phenomena that are thought to occur uncommonly in a variety of genetic disorders. When molecularly characterized, revertant cells have rarely exhibited more than ...
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Sunday, March 16th, 2008
Meristem identity gene expression during curd proliferation and flower initiation in Brassica oleracea.
The regulation of reproductive development in cauliflower (Brassica oleracea var. botrytis DC) and broccoli (B. oleracea L. var. italica Plenck) is unusual in that most enlargement occurs while development is arrested at a ...
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Sunday, March 16th, 2008
Nitric oxide, stomatal closure, and abiotic stress.
Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO, usually in ...
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Sunday, March 16th, 2008
Hexoses as phloem transport sugars: the end of a dogma?
According to most textbooks, only non-reducing carbohydrate species such as sucrose, sugar alcohols, and raffinose-family sugars function as phloem translocates. Occasional abundance of reducing sugar species (such as hexoses) in sieve-tube sap has been discarded as ...
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Sunday, March 16th, 2008
Why are literature data for H2O2 contents so variable? A discussion of potential difficulties in the quantitative assay of leaf extracts.
Leaf metabolism produces H2O2 at high rates, but current concepts suggest that the potent signalling effects of this oxidant require that concentrations be controlled by ...
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Sunday, March 16th, 2008
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage.
Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1 integrin and mediates phosphorylation of protein kinase B (PKB)/Akt, which in turn ...
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Sunday, March 16th, 2008
Myoblasts and macrophages share molecular components that contribute to cell-cell fusion.
Cell-cell fusion is critical to the normal development of certain tissues, yet the nature and degree of conservation of the underlying molecular components remains largely unknown. Here we show that the two guanine-nucleotide exchange factors ...
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Sunday, March 16th, 2008
Important role of matrix metalloproteinase 9 in epileptogenesis.
Temporal lobe epilepsy (TLE) is a devastating disease in which aberrant synaptic plasticity plays a major role. We identify matrix metalloproteinase (MMP) 9 as a novel synaptic enzyme and a key pathogenic factor in two animal models of ...
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Sunday, March 16th, 2008
Inhibition of \"self\" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells.
Phagocytosis of foreign cells or particles by macrophages is a rapid process that is inefficient when faced with \"self\" cells that display CD47-although signaling mechanisms in self-recognition have remained largely unknown. ...
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Sunday, March 16th, 2008
Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development.
Mutations in the extracellular signal-regulated kinase (ERK) pathway, particularly in the mitogen-activated protein kinase/ERK kinase (MEK) activator B-Raf, are associated with human tumorigenesis and genetic disorders. Hence, B-Raf is a prime ...
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