Archive for the ‘researches 3’ Category
Saturday, March 29th, 2008
Pituitary tumor apoplexy: a review.
Laws ER.
Department of Neurosurgery, Stanford University Medical Center, Advanced Medicine Center, 875 Blake Wilbur Dr Room CC-2330, MC 5821, Stanford, California. erlaws@stanford.edu.
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Saturday, March 29th, 2008
Experience in the management of eighty-two newborns with congenital diaphragmatic hernia treated with high-frequency oscillatory ventilation and delayed surgery without the use of extracorporeal membrane oxygenation.
The aim of this study is to analyze neonatal outcome of isolated congenital diaphragmatic hernia and to identify prenatal and ...
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Saturday, March 29th, 2008
Transfusion-related acute lung injury.
Transfusion-related acute lung injury (TRALI) refers to a clinical syndrome of acute lung injury that occurs in a temporal relationship with the transfusion of blood products. Because of the difficulty in making its diagnosis, TRALI is often underreported. Three not necessarily mutually ...
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Saturday, March 29th, 2008
Analytic review: pituitary tumor apoplexy: a review.
Pituitary tumor apoplexy is an uncommon syndrome resulting often spontaneously from hemorrhage or infarction of a pre-existing pituitary adenoma. As the primary event involves the adenoma, the syndrome should be referred to as pituitary tumor apoplexy and not as ...
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Saturday, March 29th, 2008
Medication-related complications in the trauma patient.
Trauma patients are twice as likely to have adverse reactions to medication as nontrauma patients. The need for medication in trauma patients is high. Surgery is often necessary, and immunosuppression and hypercoagulability may be present. Adverse drug events can be ...
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Saturday, March 29th, 2008
Endocrine-related resources from the national institutes of health.
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Saturday, March 29th, 2008
ASC-2 IS AN ESSENTIAL ADAPTOR TO RECRUIT HISTONE H3 LYSINE 4 METHYLTRANSFERASES MLL3 AND MLL4 TO THE LIVER X RECEPTORS.
ASC-2, a coactivator of multiple nuclear receptors and transcription factors, including the liver X receptors (LXRs), is associated with histone H3 lysine 4 methyltransferase (H3K4MT) MLL3 ...
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Saturday, March 29th, 2008
CNS-Specific Knockout of Steroidogenic Factor 1 Results in Increased Anxiety-Like Behavior.
Steroidogenic factor 1 (SF-1) plays key roles in adrenal and gonadal development, expression of pituitary gonadotropins, and development of the ventromedial hypothalamic nucleus (VMH). If kept alive by adrenal transplants, global knockout (KO) mice lacking ...
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Saturday, March 29th, 2008
Insights into the Structural Basis of Endogenous Agonist Activation of Family B G Protein-Coupled Receptors.
Agonist drugs targeting the glucagon-like peptide-1 (GLP1) receptor represent important additions to the clinical management of patients with diabetes mellitus. In the current report, we have explored whether the recently described ...
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Saturday, March 29th, 2008
PKC{alpha}-induced Derepression of the Human LH Receptor Gene Transcription through ERK-mediated Release of HDAC1/Sin3A Corepressor Complex from Sp1 Sites.
LHR gene transcription is subject to repression/derepression through various modes and multiple effectors. Epigenetic silencing and activation of the LHR is achieved through coordinated regulation at both ...
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Saturday, March 29th, 2008
Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide.
Ceramide is recognized as an antiproliferative and proapoptotic sphingolipid metabolite; however, the role of ceramide in inflammation is not well understood. To determine the role of C6-ceramide in regulating inflammatory responses, human corneal epithelial cells ...
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Saturday, March 29th, 2008
Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow.
Galectin-1 (Gal-1) is a beta-galactoside-binding protein endowed with anti-inflammatory properties. The purpose of this study was to investigate the effects of endogenous and exogenous Gal-1 on neutrophil recruitment onto TNF-treated endothelium. The effect ...
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Saturday, March 29th, 2008
S-phase entry leads to cell death in circulating T cells from HIV-infected persons.
Central memory T cells are thought to play a critical role in memory T cell homoestasis by undergoing self-renewal and by maturating into effector T cells that mediate immunity at tissue sites. Circulating ...
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Saturday, March 29th, 2008
Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes.
Neutrophils play an important role in immune complex (IC)-mediated diseases, but the mechanisms underlying their recruitment to sites of IC deposition remain largely undefined. Furthermore, neutrophils encounter cytokines that prime their effector ...
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Saturday, March 29th, 2008
Gr-1+CD11b+ cells as an accelerator of sepsis stemming from Pseudomonas aeruginosa wound infection in thermally injured mice.
Using a mouse model of thermal injury, we studied why antimicrobial peptides are not produced at the burn-site tissues and how this defect contributes to the increased susceptibility to ...
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Saturday, March 29th, 2008
Elevation in Intracellular Long Chain Acyl-CoAs Leads to Reduced {beta}-cell Excitability via Activation of KATP Channels.
Closure of pancreatic beta-cell ATP-sensitive potassium (KATP) channels links glucose metabolism to electrical activity and insulin secretion. It is now known that saturated, but not polyunsaturated, long chain acyl-CoA esters ...
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Saturday, March 29th, 2008
Moraxella catarrhalis-dependent tonsillar B cell activation does not lead to apoptosis but to vigorous proliferation resulting in nonspecific IgM production.
The respiratory pathogen Moraxella catarrhalis has a high affinity for human IgD and is mitogenic for peripheral blood B lymphocytes. Moraxella IgD-binding protein, which is a ...
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Saturday, March 29th, 2008
Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction.
Rats subjected to early postnatal food restriction (FR) show persistent changes in energy balance. The hypothalamus plays a major role in the regulation of energy balance. Therefore, we hypothesized that early postnatal food ...
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Saturday, March 29th, 2008
The Muscle Transcription Factor MyoD Promotes Osteoblast Differentiation by Stimulation of the Osterix Promoter.
Transcription factors regulate tissue specific differentiation of pluripotent mesenchyme to osteoblast (OB), myoblast (MB) and other lineages. Osterix (Osx) is an essential transcription factor for bone development as knock-out results in lack ...
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Saturday, March 29th, 2008
GnRH-1 neuronal activity is independent of HCN channels but is sensitive to PKA-dependent phosphorylation.
Pulsatile release of gonadotropin-releasing hormone-1 (GnRH-1) stimulates the anterior pituitary and induces secretion of gonadotropin hormones. GnRH-1 release is modulated by many neurotransmitters that act via G protein-coupled membrane receptors. cAMP is ...
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Saturday, March 29th, 2008
Small-conductance calcium-activated potassium (SK) channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons.
The cellular mechanisms determining the firing patterns of gonadotropin-releasing hormone (GnRH) neurons are presently under intense investigation. In this study, we used GnRH-green fluorescent protein transgenic mice and perforated-patch electrophysiology to ...
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Saturday, March 29th, 2008
Efficacy of Ghrelin as a therapeutic approach for age-related physiologic changes.
Aging is associated with decreases in food intake and GH secretion, termed the \'anorexia of aging\' and \'somatopause\', respectively. The mechanisms underlying these phenomena are not fully understood. While many approaches have attempted to improve ...
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Saturday, March 29th, 2008
Energetic Responses Are Triggered by Caudal Brainstem Melanocortin Receptor Stimulation and Mediated by Local Sympathetic Effector Circuits.
The central melanocortin system is a critical contributor to energy balance control. Melanocortin receptors (MC-Rs) are widely distributed throughout forebrain and caudal brainstem nuclei. In order to assess the ...
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Saturday, March 29th, 2008
Prokineticin-1 - a novel mediator of the inflammatory response in third trimester human placenta.
Prokineticin-1 (PK1) is a recently described protein with a wide range of functions, including tissue specific angiogenesis, modulation of inflammatory responses and regulation of haemopoiesis. The aim of this study was to ...
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Saturday, March 29th, 2008
Loss of glucocorticoid receptor function in the pituitary results in early postnatal lethality.
Glucocorticoid action in the brain is mediated by the glucocorticoid receptor (GR) and the mineralocorticoid receptor, thereby affecting physiological processes such as neurogenesis, synaptic plasticity and neuroendocrine control. To examine GR function in ...
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