Archive for the ‘researches 3’ Category
Saturday, March 29th, 2008
Spindle Pole Regulation by a Discrete Eg5-Interacting Domain in TPX2.
Targeting protein for Xklp2 (TPX2) activates the Ser/Thr kinase Aurora A in mitosis and targets it to the mitotic spindle [1, 2]. These effects on Aurora A are mediated by the N-terminal domain of TPX2, whereas ...
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Saturday, March 29th, 2008
The innervation of muscle and the neuron theory.
Swash M.
Department of Neurology, The Royal London Hospital, London, Queen Mary School of Medicine, Queen Mary University of London, Whitechapel, London E1 4NL, USA.
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Saturday, March 29th, 2008
PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold.
We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has been replaced by potential bioisosteric replacements. Several mono- or di-charged compounds (8a, ...
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Saturday, March 29th, 2008
Effects of sewage sludge application on heavy metal leaching from mine tailings impoundments.
Column experiments were conducted to investigate the removal of heavy metals from two mine tailings (El Arteal and JaravÃas) using sewage sludge as a reactive material. When sewage sludge is used as a ...
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Saturday, March 29th, 2008
Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits.
Sargahydroquinoic acid (2), a major active constituent of Sargassum micracanthum collected from the coast of the East Sea in Korea, showed a selective vasodilatation effect on the basilar ...
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Saturday, March 29th, 2008
Performance of CaO and MgO for the hot gas clean up in gasification of a chlorine-containing (RDF) feedstock.
Calcined limestone (CaO) and calcined dolomite (CaO.MgO) were tested at bench scale to study their usefulness in cleaning hot raw gas from a fluidized bed gasifier of a ...
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Saturday, March 29th, 2008
Biochemical and computational insights into the anti-aromatase activity of natural catechol estrogens.
High levels of endogenous estrogens are associated with increased risks of breast cancer. Estrogen levels are mainly increased by the activity of the aromatase enzyme and reduced by oxidative/conjugative metabolic pathways. In this paper, ...
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Saturday, March 29th, 2008
High strength sewage treatment in a UASB reactor and an integrated UASB-digester system.
The treatment of high strength sewage was investigated in a one-stage upflow anaerobic sludge blanket (UASB) reactor and a UASB-digester system. The one-stage UASB reactor was operated in Palestine at a hydraulic retention ...
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Saturday, March 29th, 2008
The challenge of conducting pharmacoeconomic evaluations in oncology using crossover trials: The example of sunitinib for gastrointestinal stromal tumour.
This paper examines the challenge of conducting economic evaluations to support patient access to cancer therapies when the cost-effectiveness estimation is hampered by crossover trial design. To ...
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Saturday, March 29th, 2008
Epigenetic regulation of heterochromatic DNA stability.
In this review we summarize recent studies that demonstrate the importance of epigenetic mechanisms for maintaining genome integrity, specifically with respect to repeated DNAs within heterochromatin. Potential problems that arise during replication, recombination, and repair of repeated sequences are counteracted ...
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Saturday, March 29th, 2008
Mechanical properties of concrete containing a high volume of tire-rubber particles.
Due to the increasingly serious environmental problems presented by waste tires, the feasibility of using elastic and flexible tire-rubber particles as aggregate in concrete is investigated in this study. Tire-rubber particles composed of tire chips, ...
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Saturday, March 29th, 2008
Splicing, transcription, and chromatin: a ménage à trois.
Alternative splicing allows for one gene to encode multiple proteins. This mechanism is regulated by dedicated splicing factors. However, recent data have shown that these factors contact the RNA polymerase II as well as transcription factors and chromatin ...
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Saturday, March 29th, 2008
Molecular and clinical characterization in Japanese and Korean patients with Hailey-Hailey disease: Six new mutations in the ATP2C1 gene.
BACKGROUND: The autosomal dominant disorder Hailey-Hailey disease (HHD) results from mutations in the ATP2C1 gene, which encodes the human secretory pathway Ca(2+)/Mn(2+)-ATPase protein 1. To date, over ...
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Saturday, March 29th, 2008
Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall).
Abnormalities in GABA levels in the central nucleus of the inferior colliculus (CNIC) of the epilepsy-prone hamster (GPG/Vall) were evaluated by using immunohistochemistry, densitometry and high performance liquid chromatography (HPLC). These findings demonstrate ...
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Saturday, March 29th, 2008
Effects of an extra X chromosome on language lateralization: An fMRI study with Klinefelter men (47,XXY).
De novo occurring genetic variations provide an opportunity to study the effects of genes on structure and function of the brain. The presence of an extra X chromosome in men ...
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Saturday, March 29th, 2008
Post operative hiccups.
Dhanrajani PJ.
Oral surgery, Sydney, Australia.
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Saturday, March 29th, 2008
Ossification of vascular pedicle in fibular free flaps: A report of four cases.
The fibular free flap is the most widely used flap for jaw reconstruction. Flap contouring requires removal of bone excess in the proximal segment by a subperiosteal dissection, preserving vascular connections between the ...
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Saturday, March 29th, 2008
Subgemmal neurogenous plaque associated with burning tongue: report of two cases and review of the literature.
Subgemmal neurogenous plaques, biphasic structures with a neurofibroma and neuroma patterns, are observed in tongue biopsies involving subepithelial areas, being characterized as aggregates of nerve plexus and ganglion cells. Oral ...
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Saturday, March 29th, 2008
Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3\'K and ERK1/2 MAPK signal transduction pathways.
Oncostatin M (OSM) is an IL-6/LIF cytokine family member whose role has been identified in a range of biological activities in vitro, including upregulation of inflammatory gene expression and ...
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Saturday, March 29th, 2008
An overview of behavioral strategies for reducing hand-related stereotypies of persons with severe to profound intellectual and multiple disabilities: 1995-2007.
This paper provides an overview of behavioral strategies used for reducing hand-related stereotypies (i.e., hand/finger mouthing, eye poking, self-slapping, and other hand-to-head/body responses) of persons with ...
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Saturday, March 29th, 2008
Discussion.
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Saturday, March 29th, 2008
[How the drug allergy risk in the intensive care software is considered? About a comparative study.]
The aim of this study was to evaluate the way the drug allergy risk was considered in five intensive care software available for the French market. It is an observational ...
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Saturday, March 29th, 2008
Pharmacologic risk factor management in peripheral arterial disease: A vade mecum for vascular surgeons.
There is broad and compelling evidence for risk factor reduction to limit cardiovascular morbidity and mortality in patients with peripheral arterial disease. Indeed, vascular surgeons have placed a call to arms to ...
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Saturday, March 29th, 2008
Effect of prolonged treatment with compression stockings to prevent post-thrombotic sequelae: A randomized controlled trial.
OBJECTIVE: Compression stockings are widely applied after acute proximal deep vein thrombosis, but their efficacy in preventing the post-thrombotic syndrome remains controversial. This study assessed the effect of prolonged compression therapy ...
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Saturday, March 29th, 2008
Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm.
BACKGROUND: Increased biomechanical stresses within the abdominal aortic aneurysm (AAA) wall contribute to its rupture. Calcification and intraluminal thrombus can be commonly found in AAAs, but the relationship between calcification/intraluminal thrombus ...
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