Archive for the ‘researches 3’ Category
Saturday, March 29th, 2008
Mechanisms of glucocorticoid-induced myopathy.
Glucocorticoid-induced muscle atrophy is characterized by fast-twitch or type II muscle fiber atrophy illustrated by decreased fiber cross-sectional area and reduced myofibrillar protein content. Muscle proteolysis, in particular through the ubiquitin- proteasome system (UPS), is considered to play a major role in ...
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Saturday, March 29th, 2008
HCV infection in haemodialysed patients: A role for serum IL-10 and TGF-beta(1) in liver damage?
BACKGROUND: Hepatitis C virus (HCV) infection is often clinically silent in haemodialysed (HD) patients and their immune response may modulate liver damage in HCV infection. IL-10 and TGF-beta(1) could play a ...
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Saturday, March 29th, 2008
Characterizing the BMP pathway in a wild type mouse model of distraction osteogenesis.
Distraction osteogenesis (DO) is a well established surgical technique for limb lengthening and replacement of bone loss due to trauma, infection or malignancies. Although the technique is widely used, one of its limitations ...
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Saturday, March 29th, 2008
Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry.
This work describes the determination of N3-methyladenine, N7-methylguanine and O(6)-methylguanine adducts in dimethyl sulphate-treated salmon-testes DNA employing reversed-phase high performance liquid chromatography (RP-HPLC) with UV-vis detection, followed ...
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Saturday, March 29th, 2008
Scanning electrochemical microscopy study of laccase within a sol-gel processed silicate film.
The enzyme p-diphenol:dioxygen oxidoreductase (laccase, EC 1.10.3.2) was isolated from Cerrena unicolor fungus and embedded in a sol-gel film obtained by acidic condensation of TMOS. The gel was cast to thin films on glass. ...
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Saturday, March 29th, 2008
Genotype determination in Moroccan hepatitis B chronic carriers.
BACKGROUND: In Morocco, chronic liver disease related to hepatitis B virus (HBV) is a public health burden. Treatment of chronic hepatitis B is often complicated by the appearance of escape mutants after treatment with nucleoside analogs, especially with ...
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Saturday, March 29th, 2008
Role of spoligotyping and IS6110-RFLP in assessing genetic diversity of Mycobacterium tuberculosis in India.
In the present study, genetic diversity analysis of Mycobacterium tuberculosis isolated from patients attending a tertiary care hospital, North India, has been attempted. Eighty three isolates of M. tuberculosis were subjected to ...
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Saturday, March 29th, 2008
Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats.
Our previous studies in heterozygous Ren-2 transgenic rats (TGR) have shown that early treatment with selective endothelin (ET)(A) receptor blockade is superior to nonselective ET(A/B) receptor blockade. The aim of this study was to evaluate the ...
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Saturday, March 29th, 2008
Effects of high frequency exercise in patients before and after elective percutaneous coronary intervention.
BACKGROUND: The aim of this study was to evaluate the effects of high frequency exercise for patients before and after an elective percutaneous coronary intervention (PCI), with special reference to maximal aerobic ...
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Saturday, March 29th, 2008
Clinical presentation of fibroids.
Uterine fibroids, the most common tumours in women of reproductive age, are asymptomatic in at least 50% of afflicted women. However, in other women, they cause significant morbidity and affect quality of life. Clinically, they present with a variety of symptoms: menstrual ...
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Saturday, March 29th, 2008
Challenges of beta blocker therapy in chronic heart failure: The story continues.
Beta blockers are underused and underprescribed in patients with chronic heart failure. This may be due to poor patient knowledge about their condition, pharmacological treatment and self-care management in case of deterioration. Nurse specialist ...
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Saturday, March 29th, 2008
Feedback: An essential element of student learning in clinical practice.
Clinical practice is an essential component of the nursing curriculum. In order for the student to benefit fully from the experience regular performance feedback is required. Feedback should provide the student with information on current practice ...
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Saturday, March 29th, 2008
Impact of bone marrow on respiratory disease.
The bone marrow is not only a site of haematopoiesis but also serves as an important reservoir for mature granulocytes and stem cells, including haematopoietic stem cells, mesenchymal stem cells and fibrocytes. In respiratory diseases, such as asthma and ...
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Saturday, March 29th, 2008
Exploiting dendritic cells and natural killer T cells in immunotherapy against malignancies.
A primary focus of tumor immunotherapy research is to change the immune system so that it becomes immunized and not tolerized to the presentation of antigens by or from tumor cells. Dendritic cells (DCs) ...
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Saturday, March 29th, 2008
The role of endocrine therapies in reducing risk of recurrence in postmenopausal women with hormone receptor-positive breast cancer.
Hormone receptor-positive breast cancer is increasingly considered a chronic disease, as there remains an ongoing risk of local and distant relapse for years after diagnosis. While early recurrence ...
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Saturday, March 29th, 2008
Long-term deficits of preterm birth: Evidence for arousal and attentional disturbances.
OBJECTIVE: Quantitative measures of pre-attentional, attentional and frontal lobe processes were compared to evaluate quantitative measures of these deficits in Ex-Preterm vs. Ex-Term adolescents. METHODS: We compared 43 Ex-Preterm with 26 Ex-Term adolescents using the ...
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Saturday, March 29th, 2008
Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells.
The genus Piper belongs to the Piperaceae family, and includes species of commercial and medicinal importance. Chemical studies on Piper species resulted in the isolation of several biologically active ...
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Saturday, March 29th, 2008
EPR as an analytical tool in assessing the mineral nutrients and irradiated food products-vegetables.
EPR spectral investigations of some commonly available vegetables in south India, which are of global importance like Daucus carota (carrot), Cyamopsis tetragonoloba (cluster beans), Coccinia indica (little gourd) and Beta vulgaris (beet ...
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Saturday, March 29th, 2008
Regulation of type II fatty acid synthase in Gram-positive bacteria.
Bacterial cells stringently regulate the synthesis of their membrane phospholipids but the responsible mechanisms are incompletely understood. Recent biochemical, genetic and structural analyses have greatly expanded the knowledge of lipid metabolism in Gram-positive bacteria, revealing that ...
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Saturday, March 29th, 2008
p53-Mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.
The tumor suppressor protein p53 triggers many of the cellular responses to DNA damage by regulating the transcription of a series of downstream target genes. p53 acts on the promoter of the target genes by interacting ...
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Saturday, March 29th, 2008
Plant pathogenic bacterial type III effectors subdue host responses.
Like animals, plants sense bacterial pathogens through surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding leucine-rich repeat proteins (NB-LRR) and trigger defense responses. Many plant-pathogenic bacteria secrete a large repertoire of effector proteins into host cells to ...
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Saturday, March 29th, 2008
Acute immune-mediated thrombocytopenic purpura related to Toxoplasma gondii infection.
Tuon FF, Higashino HR, Amato VS, Nicodemo AC.
Department of Infectious and Parasitic Diseases, Medical School, University of São Paulo, São Paulo, SP, Brazil.
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Saturday, March 29th, 2008
Pharmacokinetics and toxicity of zonisamide in cats.
With the eventual goal of making zonisamide (ZNS), a relatively new antiepileptic drug, available for the treatment of epilepsy in cats, the pharmacokinetics after a single oral administration at 10mg/kg and the toxicity after 9-week daily administration of 20mg/kg/day ...
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Saturday, March 29th, 2008
Molecular characterization and expression analysis of regucalcin in disk abalone (Haliotis discus discus): Intramuscular calcium administration stimulates the regucalcin mRNA expression.
Regucalcin is a novel calcium (Ca(2+)) binding protein and it has been demonstrated to play a multifunctional role in many organisms. Here, we report the ...
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Saturday, March 29th, 2008
Alleviation of feedback inhibition in Saccharomyces cerevisiae aromatic amino acid biosynthesis: Quantification of metabolic impact.
A quantitative analysis of the impact of feedback inhibition on aromatic amino acid biosynthesis was performed in chemostat cultures of Saccharomyces cerevisiae. Introduction of a tyrosine-insensitive allele of ARO4 (encoding 3-deoxy-d-arabino-heptulosonate-7-phosphate ...
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