Archive for the ‘researches 6’ Category
Sunday, March 23rd, 2008
Is Mammography Adequate for Screening Women with Inherited BRCA Mutations and Low Breast Density?
BACKGROUND: Several observational studies have shown that magnetic resonance imaging (MRI) is significantly more sensitive than mammography for screening women over age 25 at high risk for hereditary breast cancer; however, MRI ...
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Sunday, March 23rd, 2008
Gilbert\'s Syndrome and Irinotecan Toxicity: Combination with UDP-Glucuronosyltransferase 1A7 Variants Increases Risk.
BACKGROUND: Gilbert\'s syndrome is characterized by a functional promoter single nucleotide polymorphism (SNP) of the UDP-glucuronosyltransferase (UGT) 1A1 gene and represents a pharmacogenetic risk factor for irinotecan toxicity, but study data remain controversial. The ...
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Sunday, March 23rd, 2008
Nonsteroidal Anti-inflammatory Drug Use and Serum Total Estradiol in Postmenopausal Women.
Laboratory and epidemiologic evidence suggest that nonsteroidal anti-inflammatory drug (NSAID) use may be inversely related to the risk of breast cancer; however, the mechanism by which NSAIDs may protect against the development of this disease ...
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Sunday, March 23rd, 2008
Association between Tortilla Consumption and Human Urinary Fumonisin B1 Levels in a Mexican Population.
Fumonisins are mycotoxins produced by Fusarium spp. and commonly contaminate maize and maize products worldwide. Fumonisins are rodent carcinogens and have been associated with human esophageal cancer. However, the lack of a ...
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Sunday, March 23rd, 2008
Comparative Bioavailability of Sulindac in Capsule and Tablet Formulations.
The cyclooxygenase (COX)-2 enzyme appears to be an important target for cancer chemoprevention. Given the recent emergence of potentially serious cardiovascular toxicity associated with selective COX-2 inhibitors, nonsteroidal antiinflammatory drugs (NSAIDs), which inhibit both COX-1 and COX-2, ...
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Sunday, March 23rd, 2008
NAT2*7 Allele Is a Potential Risk Factor for Adult Brain Tumors in Taiwanese Population.
Arylamine N-acetyltransferase-2 (NAT2) displays extensive genetic polymorphisms that affect the rates of acetylation of drugs and toxic compounds such as amine carcinogens. The association of NAT2 polymorphisms with adult brain tumors has ...
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Sunday, March 23rd, 2008
Effect of tissue shipping on plasma cell isolation, viability, and RNA integrity in the context of a centralized good laboratory practice-certified tissue banking facility.
The Multiple Myeloma Research Consortium has established a tissue bank for the deposition of bone marrow samples from patients with multiple myeloma ...
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Sunday, March 23rd, 2008
Postmenopausal Hormone Therapy and Lung Cancer Risk in the Cancer Prevention Study II Nutrition Cohort.
BACKGROUND: Studies of postmenopausal hormone therapy and lung cancer incidence have reported positive, negative, and null associations. Most of these studies, however, have had limited ability to control rigorously for cigarette ...
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Sunday, March 23rd, 2008
Use of the Prostate-Specific Antigen Test among U.S. Men: Findings from the 2005 National Health Interview Survey.
BACKGROUND: Although evidence that prostate cancer deaths are reduced by screening for elevated prostate-specific antigen (PSA) concentration coupled with early diagnosis and treatment is insufficient to advocate routine screening ...
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Sunday, March 23rd, 2008
DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.
We used MethyLight assays to analyze DNA methylation status of 27 genes on 49 paired cancerous and noncancerous tissue samples from non-small cell lung cancer (NSCLC) patients who underwent surgical resection. Seven ...
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Sunday, March 23rd, 2008
Glycemic status and risk of prostate cancer.
BACKGROUND: To examine the risk of prostate cancer and glucose tolerance in a large, racially diverse cohort. METHODS: We conducted a cohort study of 47,209 male members of Kaiser Permanente Northern California who had completed at least one Multiphasic ...
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Sunday, March 23rd, 2008
Multiple Diagnostic X-rays for Spine Deformities and Risk of Breast Cancer.
BACKGROUND: Ionizing radiation is a well-established human mammary carcinogen. Women historically monitored by radiography at young ages for abnormal spinal curvature are an exposed population suitable for investigating radiation-related risk and its variation by modifying ...
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Sunday, March 23rd, 2008
Does Breast Size Modify the Association between Mammographic Density and Breast Cancer Risk?
BACKGROUND: Both the absolute and the percent of mammographic density are strong and independent risk factors for breast cancer. Previously, we showed that the association between mammographic density and breast cancer risk tended ...
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Sunday, March 23rd, 2008
A Prospective Study of Risk-Reducing Salpingo-oophorectomy and Longitudinal CA-125 Screening among Women at Increased Genetic Risk of Ovarian Cancer: Design and Baseline Characteristics: A Gynecologic Oncology Group Study.
BACKGROUND: Women who are genetically predisposed to ovarian cancer are at very high risk of developing this disease. ...
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Sunday, March 23rd, 2008
Progestin Treatment Induces Apoptosis and Modulates Transforming Growth Factor-{beta} in the Uterine Endometrium.
BACKGROUND: Epidemiologic, animal, and human data suggest that progestins are potent endometrial cancer preventive agents. In the ovarian surface epithelium, progestins have been hypothesized to confer a cancer preventive effect via apoptosis and ...
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Sunday, March 23rd, 2008
Cyclin e overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.
BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled ...
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Sunday, March 23rd, 2008
Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma.
The aim of this study was to determine the role of prostate-specific membrane antigen (PSMA) as a prognostic marker in endometrial adenocarcinoma (EAC) and to explore whether its down-regulation could be due to epigenetic ...
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Sunday, March 23rd, 2008
Flavonoid intake and risk of pancreatic cancer in male smokers (Finland).
Extending research on the protective effect of flavonoids in cell culture and animal studies, we examined the association between consumption of flavonoids and flavonoid-rich foods and development of exocrine pancreatic cancer within the alpha-Tocopherol, beta-Carotene ...
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Sunday, March 23rd, 2008
UGT1A1 Genetic Polymorphisms, Endogenous Estrogen Exposure, Soy Food Intake, and Endometrial Cancer Risk.
Estrogen exposures play a critical role in the development of endometrial cancer. Genetic variation in the estrogen metabolism UGT1A1 gene may modify the effect of estrogenic exposures on endometrial cancer risk. We tested ...
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Sunday, March 23rd, 2008
Meta-analysis of Colorectal Cancer Gene Expression Profiling Studies Identifies Consistently Reported Candidate Biomarkers.
PURPOSE: Elucidation of candidate colorectal cancer biomarkers often begins by comparing the expression profiles of cancerous and normal tissue by performing gene expression profiling. Although many such studies have been done, the resulting ...
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Sunday, March 23rd, 2008
Urinary 8-oxo-7,8-dihydro-2\'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis.
Parasite infection of Opisthorchis viverrini is a major risk factor for cholangiocarcinoma. Our previous immunohistochemical studies showed that O. viverrini infection induced oxidative DNA lesions in the bile duct epithelium ...
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Sunday, March 23rd, 2008
Decreased Expression of UK114 Is Related to the Differentiation Status of Human Hepatocellular Carcinoma.
Previous studies have identified that the expression of UK114 is tissue specific and the protein has been found to be most abundant in liver and kidney. However, the expression of UK114 in ...
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Sunday, March 23rd, 2008
DNA Repair Gene XPD Polymorphisms and Cancer Risk: A Meta-analysis Based on 56 Case-Control Studies.
Genetic variations in the XPD gene may increase cancer susceptibility by affecting the capacity for DNA repair. Several studies have investigated this possibility; however, the conclusions remain controversial. Therefore, we did ...
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Sunday, March 23rd, 2008
Issues of diagnostic review in brain tumor studies: from the brain tumor epidemiology consortium.
Epidemiologists routinely conduct centralized single pathology reviews to minimize interobserver diagnostic variability, but this practice does not facilitate the combination of studies across geographic regions and institutions where diagnostic practices differ. A ...
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Sunday, March 23rd, 2008
Genetic polymorphisms and head and neck cancer outcomes: a review.
Head and neck cancer (HNC) patients have variable prognoses even within the same clinical stage and while receiving similar treatments. The number of studies of genetic polymorphisms as prognostic factors of HNC outcomes is growing. Candidate ...
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