Archive for the ‘researches 6’ Category
Thursday, July 3rd, 2008
Correlates of late and very late thrombosis of drug eluting stents.
BACKGROUND: Late and very late thrombosis of coronary drug-eluting stents (DES) has received much attention but essentially remains unpredictable. We sought to identify correlates of stent thrombosis (ST) developing >30 days after DES implantation. METHODS: ...
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Thursday, July 3rd, 2008
One-year clinical outcome after abciximab bolus-only compared with abciximab bolus and 12-hour infusion in the Randomized EArly Discharge after Transradial Stenting of CoronarY Arteries (EASY) Study.
BACKGROUND: Long-term clinical follow-up has shown a significant benefit after percutaneous coronary intervention (PCI) for abciximab bolus followed by 12-hour ...
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Thursday, July 3rd, 2008
Safety and effectiveness of drug-eluting stents among diabetic patients: a propensity analysis.
BACKGROUND: Diabetic patients frequently receive drug-eluting stents (DES) during percutaneous coronary interventions (PCI), but recent data have raised concerns as to whether DES are associated with increased risk of myocardial infarction or death. Accordingly, ...
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Thursday, July 3rd, 2008
Thrombocytopenia at baseline is a predictor of inhospital mortality in patients undergoing percutaneous coronary intervention.
BACKGROUND: Thrombocytopenia (TP) is a common baseline abnormality in patients undergoing percutaneous coronary intervention (PCI). Whether TP has any influence on the outcome of PCI patients is unknown. Our aim was ...
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Thursday, July 3rd, 2008
Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004.
BACKGROUND: Despite improvements in low-density lipoprotein cholesterol (LDL-C) levels, recent national data are limited regarding the proportion of adults at recommended ...
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Thursday, July 3rd, 2008
An assessment of the joint associations of aspirin and statin use with C-reactive protein concentration.
BACKGROUND: The use of aspirin alone and statins alone has been shown to reduce markers of inflammation, including C-reactive protein (CRP); however, their combination has been poorly studied. METHODS: In a ...
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Thursday, July 3rd, 2008
Exercise capacity and biventricular function in adult patients with repaired tetralogy of Fallot.
BACKGROUND: Adult patients with repaired tetralogy of Fallot (rTOF) often have diminished exercise capacity. The primary objective of this study was to examine whether abnormalities of biventricular function play a role in exercise ...
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Thursday, July 3rd, 2008
Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy.
BACKGROUND: Growing evidence suggests participation of autoimmune mechanisms in the pathogenesis of dilated cardiomyopathy (DCM). METHODS: Patients with heart failure (left ventricular ejection fraction < or =50%) due to DCM (n = 98) ...
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Thursday, July 3rd, 2008
Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy.
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is defined by the presence of unexplained left ventricular hypertrophy, myocyte disarray, and interstitial fibrosis. An increase in extracellular matrix produces interstitial fibrosis, by raised amounts of collagen type I/III. Regions of myocardial late ...
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Thursday, July 3rd, 2008
Impact of do-not-resuscitation orders on quality of care performance measures in patients hospitalized with acute heart failure.
BACKGROUND: Heart failure (HF) is one of the leading causes of morbidity and mortality among Americans. Despite increased interest in end-of-life care, the implications of do-not-resuscitate (DNR) orders in ...
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Thursday, July 3rd, 2008
N-terminal pro-brain natriuretic peptide testing in the emergency department: beneficial effects on hospitalization, costs, and outcome.
BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) is an established biomarker for heart failure. Assessment of this biomarker in patients with acute dyspnea presenting to the emergency department (ED) may aid ...
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Thursday, July 3rd, 2008
Atorvastatin prevents atrial fibrillation in patients with bradyarrhythmias and implantation of an atrial-based or dual-chamber pacemaker: a prospective randomized trial.
BACKGROUND: Increasing evidence suggests that atrial fibrillation (AF) is an inflammatory disease. Statins is an anti-inflammatory agent. The present study was conducted to test the efficacy ...
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Thursday, July 3rd, 2008
Chronic atrial fibrillation: Incidence, prevalence, and prediction of stroke using the Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack (CHADS2) risk stratification scheme.
BACKGROUND: The aim of the study is to estimate the incidence and prevalence of chronic AF ...
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Thursday, July 3rd, 2008
The Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial: study design and rationale.
BACKGROUND: Advances in coronary angioplasty and adjunct pharmacology have improved patient outcomes after primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI). However, several areas for improvement remain. ...
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Thursday, July 3rd, 2008
Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas\' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).
BACKGROUND: Benznidazole is effective for treating acute and chronic (recently acquired) Trypanosoma cruzi infection (Chagas\' disease). Recent data indicate that parasite persistence ...
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Thursday, July 3rd, 2008
Rationale and design of the Post-MI FREEE trial: a randomized evaluation of first-dollar drug coverage for post-myocardial infarction secondary preventive therapies.
BACKGROUND: Medication nonadherence is a major public health problem, especially for patients with coronary artery disease. The cost of prescription drugs is a central reason ...
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Thursday, July 3rd, 2008
Challenges in meta-analysis of randomized clinical trials for rare harmful cardiovascular events: the case of rosiglitazone.
Rare cardiovascular events of commonly used drugs are important to document and investigate, but single trials are notoriously underpowered to provide conclusive evidence. Recently, meta-analyses have been used to improve ...
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Thursday, July 3rd, 2008
Body mass index and mortality in heart failure: a meta-analysis.
BACKGROUND: In patients with chronic heart failure (CHF), previous studies have reported reduced mortality rates in patients with increased body mass index (BMI). The potentially protective effect of increased BMI in CHF has been termed the ...
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Thursday, July 3rd, 2008
Decreased H(2)O(2) in exhaled breath condensate during pregnancy-Feasible effect of 17beta-estradiol.
Since pregnancy is known to favor systemic generation of reactive oxygen species, this study was designed to assess the levels of exhaled hydrogen peroxide (eH(2)O(2)), serum progesterone (PG), 17beta-estradiol (E2) and systemic oxidative parameters in ...
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Thursday, July 3rd, 2008
Role of mechanical stress in regulating airway surface hydration and mucus clearance rates.
Effective clearance of mucus is a critical innate airway defense mechanism, and under appropriate conditions, can be stimulated to enhance clearance of inhaled pathogens. It has become increasingly clear that extracellular nucleotides (ATP ...
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Thursday, July 3rd, 2008
Use of the quasi-experimental sequential cohort design in the Study of Patient-Nurse Effectiveness with Assisted Communication Strategies (SPEACS).
This paper describes a quasi-experimental three-phase sequential cohort design used in the Study of Patient-Nurse Effectiveness with Assisted Communication Strategies (SPEACS) to test two interventions to improve nurse-patient ...
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Thursday, July 3rd, 2008
beta-Adrenoceptor-mediated vasodilation of retinal blood vessels is reduced in streptozotocin-induced diabetic rats.
We investigated the effects of epinephrine and dopamine on retinal blood vessels in streptozotocin (STZ, 80 mg/kg, i.p.)-treated rats and age-matched control rats to determine whether diabetes mellitus alters the retinal vascular responses to ...
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Thursday, July 3rd, 2008
Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide.
Laboratory studies were conducted to determine the effects of carbamate fungicide TATTU (mixture of propamocarb and mancozeb, 0.091 mg L(-1)) on biochemical markers of exposure in ...
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Thursday, July 3rd, 2008
Choriogenin and vitellogenin in red lip mullet (Chelon haematocheilus):Purification, characterization, and evaluation as potential biomarkers for detecting estrogenic activity.
Two vitelline envelope precursors (choriogenin H: Chg H; choriogenin L: Chg L) and an egg yolk precursor (vitellogenin B: VgB) were purified from red lip mullet. The ...
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Thursday, July 3rd, 2008
A Mu-class glutathione S-transferase (GSTM) from the rock shell Thais clavigera.
The rock shell (Thais clavigera) has attracted interest due to high frequency of imposex induced by endocrine disrupting chemicals (EDCs) in its natural populations. Oxidative stress is one of the mechanisms of action of EDCs. ...
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