Archive for the ‘researches 6’ Category
Thursday, July 3rd, 2008
Dietary restriction started after spinal cord injury improves functional recovery.
Spinal cord injury typically results in limited functional recovery. Here we investigated whether therapeutic dietary restriction, a multi-faceted, safe, and clinically-feasible treatment, can improve outcome from cervical spinal cord injury. The well-established notion that dietary restriction ...
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Thursday, July 3rd, 2008
Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion.
Latent transforming growth factor (TGF)-beta binding proteins are extracellular matrix (ECM) proteins involved in the regulation of TGF-beta sequestration and activation. In this study, we have identified binding domains ...
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Thursday, July 3rd, 2008
The alpha-galactosyl derivatives of ganglioside GD(1b) are essential for the organization of lipid rafts in RBL-2H3 mast cells.
Gangliosides are complex glycosphingolipids that are important in many biological processes. The present study investigated the role of gangliosides in the organization of lipid rafts in RBL-2H3 mast ...
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Thursday, July 3rd, 2008
Nuclear and nucleolar localization signals and their targeting function in phosphatidylinositol 4-kinase PI4K230.
PI4K230, an isoform of phosphatidylinositol 4-kinase, known primarily as a cytoplasmic membrane-bound enzyme, was detected recently also in the nucleolus of several cells. Here we provide mechanistic insight on the targeting function of ...
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Thursday, July 3rd, 2008
Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin.
Kalirin is a GDP/GTP exchange factor (GEF) for Rho proteins that modulates the actin cytoskeleton in neurons. Alternative splicing generates Delta-isoforms, which encode the RhoGEF domain, but lack the N-terminal Sec14p domain and first 4 spectrin-like repeats of ...
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Thursday, July 3rd, 2008
On the mechanism of antidepressant-like action of berberine chloride.
Berberine, an alkaloid isolated from Berberis aristata Linn. has been used in the Indian system of medicines as a stomachic, bitter tonic, antiamoebic and also in the treatment of oriental sores. Evidences have demonstrated that berberine possesses ...
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Thursday, July 3rd, 2008
Dual role of hydrogen sulfide in mechanical inflammatory hypernociception.
Hydrogen sulfide (H(2)S) is an endogenous gas involved in several biological functions, including modulation of nociception. However, the mechanisms involved in such modulation are not fully elucidated. The present study demonstrated that the pretreatment of mice with ...
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Thursday, July 3rd, 2008
Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia.
The influence of various statins on low-density-lipoprotein (LDL)-particle phenotype has been reportedly trivial or moderate. We assessed the effect ...
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Thursday, July 3rd, 2008
Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.
Although the formation and maintenance of epithelial tubes are essential for the viability of multicellular organisms, our understanding of the molecular and cellular events coordinating tubulogenesis is relatively limited. Here, we focus on the activities ...
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Thursday, July 3rd, 2008
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.
Developmental signaling pathways hold the keys to unlocking the promise of adult tissue regeneration, and to inhibiting carcinogenesis. Patients with mutations in the Adenomatous Polyposis Coli (APC) gene are at increased risk ...
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Thursday, July 3rd, 2008
Sensory-specific amnesia and hypoemotionality in humans and monkeys: Gateway for developing a hodology of memory.
Amnesia is a dramatic clinical syndrome caused by diverse pathologies and lesion localizations. Although amnesia is typically screened for by clinicians using verbal stimuli, amnestic syndromes have been described that do ...
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Thursday, July 3rd, 2008
Medial temporal and prefrontal function: Recent behavioural disconnection studies in the macaque monkey.
In the macaque monkey, disconnection syndromes can be produced experimentally either by selective section of axonal pathways or by crossed unilateral asymmetrical ablations. Behavioural investigation of the effects of these disconnections gives information ...
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Thursday, July 3rd, 2008
The disconnection apraxias.
Limb apraxia is the loss of the ability to perform voluntary skilled movements, when this loss cannot be attributed to elemental sensorimotor deficits. Successful manual interactions with the objects in the environment require the storage of information about movement parameters. This information is ...
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Thursday, July 3rd, 2008
Cortical processes underlying sound-induced flash fusion.
When two brief flashes presented in rapid succession (<100 ms apart) are paired with a single auditory stimulus, subjects often report perceiving only a single flash [Andersen, T.S., Tiippana, K., Sams, M., 2004. Factors influencing audiovisual fission and fusion illusions. ...
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Thursday, July 3rd, 2008
Correlation of axon size and myelin occupancy in rats prenatally exposed to methamphetamine.
The abuse of methamphetamine (MA) and other psychostimulants is a social and medical problem. In particular, the use of these drugs by pregnant women results in an increased number of children exposed prenatally ...
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Thursday, July 3rd, 2008
Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.
Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer\'s disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant ...
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Thursday, July 3rd, 2008
The different stages of visual recognition need different attentional binding strategies.
Many think that visual attention needs an executive to allocate resources. Although the cortex exhibits substantial plasticity, dynamic allocation of neurons seems outside its capability. Suppose instead that the visual processing architecture is fixed, but ...
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Thursday, July 3rd, 2008
A morphometric study on the longitudinal and lateral symmetry of the sural nerve in mature and aging female rats.
Aging affects peripheral nerve function and regeneration in experimental models but few literature reports deal with animals aged more than one year. We investigated morphological and morphometric ...
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Thursday, July 3rd, 2008
Pre-weaning undernutrition alters the expression levels of reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain.
It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be ...
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Thursday, July 3rd, 2008
Vision and touch: Independent or integrated systems for the perception of texture?
In the following review, we discuss the evidence for the role of vision and touch in the perception of texture with the particular aim of evaluating whether these systems contribute information to texture perception ...
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Thursday, July 3rd, 2008
Environmental enrichment during adolescence regulates gene expression in the striatum of mice.
We have previously shown that environmental enrichment decreases the activating and rewarding effects of the psychostimulant cocaine and increases resistance to the neurotoxic effect of the Parkinson-inducing drug MPTP. These effects were accompanied by ...
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Thursday, July 3rd, 2008
Pitch accent and lexical tone processing in Chinese discourse comprehension: An ERP study.
In the present study, event-related brain potentials (ERP) were recorded to investigate the role of pitch accent and lexical tone in spoken discourse comprehension. Chinese was used as material to explore the potential ...
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Thursday, July 3rd, 2008
Unveiling the mystery of visual information processing in human brain.
It is generally accepted that human vision is an extremely powerful information processing system that facilitates our interaction with the surrounding world. However, despite extended and extensive research efforts, which encompass many exploration fields, the underlying ...
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Thursday, July 3rd, 2008
Disruption of agonist and ligand activity in an AMPA glutamate receptor splice-variable domain deletion mutant.
The mechanisms by which agonists and other ligands bind ligand-gated ion channels are important determinants of function in neurotransmitter receptors. The partial agonist, kainic acid (KA) activates a less desensitized, and ...
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Thursday, July 3rd, 2008
Is lexical access autonomous? Evidence from combining overlapping tasks with recording event-related brain potentials.
In order to test the frequent assumption that lexical access in visual word recognition would proceed independent of central attention, the overlapping task paradigm has recently been employed with somewhat contradictory results. ...
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