Archive for the ‘researches 5’ Category
Sunday, June 29th, 2008
In good times and bad: p73 in cancer.
It is widely accepted in cancer biology that p53 has a tumor suppressive activity, which is lost during tumorigenesis most frequently by mutations in the p53 gene. The discovery of p73 as the first homologue of p53 raised ...
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Sunday, June 29th, 2008
Serum and urinary biomarker signatures for rapid preclinical in vivo assessment of CDK inhibition as a therapeutic approach for PKD.
Recent advances in understanding the molecular pathogenesis of polycystic kidney diseases (PKD) are being translated into promising treatments. Currently, a response to therapy in preclinical animal ...
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Sunday, June 29th, 2008
Leptin and mTOR: Partners in metabolism and inflammation.
Leptin is both a hormone/cytokine that plays a major role in the regulation of feeding and energy expenditure. Beyond its central role in the hypothalamus, leptin modulates peripheral tissues\' responses to growth and storage based on nutrient availability, ...
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Sunday, June 29th, 2008
Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle.
Cyclin-dependent kinases are highly conserved among all eukaryotes, and have essential roles in the cell cycle. However, these roles are still only poorly understood at a molecular level, partly due ...
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Sunday, June 29th, 2008
New roles for the major human 3\'-5\' exonuclease TREX1 in human disease.
Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE), Familial Chilblain Lupus (FCL) and Retinal Vasculopathy and Cerebral Leukodystrophy (RVCL) {a new term encompassing three independently described conditions with a common etiology-Cerebroretinal Vasculopathy (CRV), Hereditary Vascular ...
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Sunday, June 29th, 2008
p14(ARF) interacts with DAXX: Effects on HDM2 and p53.
The p14(ARF) (ARF) tumour suppressor plays an important role in the cellular response to oncogene activation. In this report, we demonstrate an interaction between ARF and DAXX, a highly conserved protein with identified roles in the regulation ...
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Sunday, June 29th, 2008
Lineage-specific reprogramming as a strategy for cell therapy.
Embryonic stem (ES) cells are endowed with extensive ability for self renewal and differentiation. These features make them a promising candidate for cell therapy. However, despite the enthusiasm and hype surrounding the potential therapeutic use of human ES ...
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Sunday, June 29th, 2008
eIF3-f function in skeletal muscles: To stand at the crossroads of atrophy and hypertrophy.
The control of muscle cell size is a physiological process balanced by a fine tuning between protein synthesis and protein degradation. MAFbx/Atrogin-1 is a muscle specific E3 ubiquitin ligase upregulated during disuse, ...
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Sunday, June 29th, 2008
Novel anticancer compounds induce apoptosis in melanoma cells.
We previously described the identification of a nucleoside analog transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-Dribofuranosyl-7H-Pyrrolo[2,3-d]-pyrimidine-5-carboxamide) and FoxM1 inhibitor, thiazole antibiotic Siomycin A that were able to induce apoptosis in cancer cell lines of different origin. Here, we report the characterization ...
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Sunday, June 29th, 2008
An old HAT in human p300/CBP and yeast Rtt109.
The crystal structure of the human p300 histone acetyltransferase (HAT) domain reveals a familiar alpha + beta fold with unique structural elaborations(1) that merit its classification as a third divergent HAT branch alongside the GCN5-related N-acetyltransferase (GNAT) ...
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Sunday, June 29th, 2008
Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.
CDC5 proteins are components of the pre-mRNA splicing complex and essential for cell cycle progression in yeast, plants and mammals. Human CDC5 is phosphorylated in a mitogen-dependent manner, and its association with the spliceosome is ATP-dependent. Examination ...
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Sunday, June 29th, 2008
Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function.
The mouse hair follicle is an easily accessible source of actively growing, pluripotent adult stem cells. C57BL transgenic mice, labeled with the fluorescent protein GFP, afforded follicle stem cells whose ...
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Sunday, June 29th, 2008
Mesothelioma and asbestos-related pleural diseases.
At present, the use of asbestos is not regulated at a worldwide scale. Moreover, there is a latency period between asbestos exposure and the manifestations of asbestos-related diseases. Consequently, pulmonologists are still dealing with consequences of asbestos exposure, which mainly occur ...
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Sunday, June 29th, 2008
Hydroxysafflor Yellow A Inhibits Rat Brain Mitochondrial Permeability Transition Pores by a Free Radical Scavenging Action.
Hydroxysafflor yellow A (HSYA), the major and most active antioxidant from Carthamus tinctorius L., has been clinically prescribed in China to treat patients with cerebral ischemia, but the detailed mechanism ...
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Sunday, June 29th, 2008
PAF, rather than Histamine, Participates in Mouse Anaphylactic Hypotension.
We determined the roles of platelet-activating factor (PAF) and histamine in anaphylactic hypotension in ovalbumin-sensitized anesthetized BALB/c mice. The effects of PAF and histamine on hemodynamic variables were studied by measuring the systemic arterial (Psa), portal venous ...
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Sunday, June 29th, 2008
Cervical Partial Hydatidiform Molar Pregnancy.
Background: Cervical hydatidiform molar pregnancy is an exceedingly rare occurrence that has been reported only twice before. Case: We report a 25-year-old, G4P1D&C2 woman with a positive pregnancy test and vaginal bleeding. A cervical pregnancy with hydatidiform mole was detected on ...
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Sunday, June 29th, 2008
The Fine Line between Harm Reduction and Harm Production - Development of a Clinical Policy on Femoral (Groin) Injecting.
Background/Aims: The femoral region (\'groin\') appears to be increasingly commonly used by injecting drug users in the UK. With the advent of Britain\'s first supervised prescribed injectable ...
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Sunday, June 29th, 2008
Office-Based Treatment in Opioid Dependence: A Critical Survey of Prescription Practices for Opioid Maintenance Medications and Concomitant Benzodiazepines in Vienna, Austria.
Background: The success of maintenance treatment for opioid dependence in office-based settings is influenced by the extent of treatment coverage, the availability of effective medications ...
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Sunday, June 29th, 2008
From the Office to the Pub: The Role of Smoking-Relevant Contexts and Cue-Elicited Urge to Smoke.
The present study investigates how environmental contexts can affect cue-elicited urge to smoke. A total of 33 smokers were repeatedly presented with a cue predicting smoking and a cue predicting ...
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Sunday, June 29th, 2008
How to Screen for Problematic Cannabis Use in Population Surveys. An Evaluation of the Cannabis Use Disorders Identification Test (CUDIT) in a Swiss Sample of Adolescents and Young Adults.
Background/Aims: Cannabis use is a growing challenge for public health, calling for adequate instruments to identify problematic ...
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Sunday, June 29th, 2008
Efficacy of a Polyethylene Glycol Marker System in Urine Drug Screening in an Opiate Substitution Program.
Aims: Screening for concomitant drug consumption is necessary in opiate substitution therapy of opiate-dependent patients. Adulteration of samples is a common problem in this setting. A recently developed polyethylene glycol ...
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Sunday, June 29th, 2008
Post-Treatment Outcomes of Buprenorphine Detoxification in Community Settings: A Systematic Review.
A systematic review was undertaken to examine studies of buprenorphine detoxification that has included post-treatment outcomes as well as more immediate aspects of progress. Studies were required to report details of buprenorphine withdrawal regime and ...
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Sunday, June 29th, 2008
Disseminated Giant Molluscum Contagiosum in a Patient with Idiopathic CD4+ Lymphocytopenia. Successful Eradication with Systemic Interferon.
Idiopathic CD4+ lymphocytopenia is a rare disease without HIV infection or any other underlying immunodeficiency. Patients with this condition are predisposed to various opportunistic infections. We describe a 31-year-old woman ...
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Sunday, June 29th, 2008
A Randomized Double-Blind Study to Investigate the Clinical Efficacy of Adding a Non-Migrating Antimicrobial to a Special Silk Fabric in the Treatment of Atopic Dermatitis.
Background: A randomized, double-blind study designed to compare the efficacy of DermaSilk(R) versus a sleeve of similar structure but minus the ...
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Sunday, June 29th, 2008
High Tofu Intake Is Associated with Worse Memory in Elderly Indonesian Men and Women.
Background/Aims: Cell culture studies suggest that phytoestrogens, abundant in soy products such as tempe and tofu, could protect against cognitive decline. Paradoxically, the Honolulu Asia Aging Study reported an increased risk for ...
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