Archive for the ‘researches 5’ Category
Sunday, June 29th, 2008
Transcriptional regulation and function of the Neurospora clock gene white collar 2 and its isoforms.
FREQUENCY (FRQ) and the White Collar Complex (WCC), consisting of WC1 and WC2 subunits, are crucial components of positive and negative feedback loops of the circadian clock of Neurospora. In the ...
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Sunday, June 29th, 2008
The nature and character of the transition state for the ADP-ribosyltransferase reaction.
Exotoxin A (ExoA) from Pseudomonas aeruginosa is an important virulence factor that belongs to a class of exotoxins that are secreted by pathogenic bacteria which cause human diseases such as cholera, diphtheria, pneumonia and ...
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Sunday, June 29th, 2008
Prevalence, Causes, and Consequences of Masked Hypertension: A Meta-analysis.
BackgroundMasked hypertension (MH) is a relatively newly detected condition of which little is known. More information about MH may help to improve overall antihypertensive health care. We aimed to investigate the prevalence, potential causes, and associated consequences ...
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Sunday, June 29th, 2008
Prostasin: A Possible Candidate Gene for Human Hypertension.
BackgroundProstasin, a serine protease, is suggested to be a novel mechanism regulating the epithelial sodium channel (ENaC) expressed in the distal nephron. This study aimed to evaluate whether the human prostasin gene is a novel candidate gene underlying ...
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Sunday, June 29th, 2008
Plasma Aldosterone and Its Relationships With Left Ventricular Mass in Essential Hypertensive Patients With the Metabolic Syndrome.
BackgroundThe association of aldosterone with the metabolic syndrome (MetS) has not been fully elucidated. The aim of our study was to evaluate the relationships of plasma aldosterone concentration (PAC) ...
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Sunday, June 29th, 2008
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide have published over 1,000 genetic association studies with largely inconsistent results. To facilitate the interpretation of these findings, ...
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Sunday, June 29th, 2008
Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.
LIM-homeodomain (LIM-HD) transcription factors form a combinatorial \'LIM code\' that contributes to the specification of cell types. In the ventral spinal cord, the binary LIM homeobox protein 3 (Lhx3)/LIM domain-binding protein 1 ...
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Sunday, June 29th, 2008
Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme.
CCA-adding enzyme builds the 3\'-end CCA of tRNA without a nucleic acid template. The mechanism for the maintenance of fidelity during the CCA-adding reaction remains elusive. Here, we present almost a dozen ...
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Sunday, June 29th, 2008
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of ...
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Sunday, June 29th, 2008
Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress.
The transcription factor NF-kappaB has critical functions in biologic responses to genotoxic stimuli. Activation of NF-kappaB in response to DNA double strand break (DSB) inducers can be mediated by ATM ...
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Sunday, June 29th, 2008
Delayed onset and diminished magnitude of rotavirus activity --- United States, november 2007--may 2008.
Rotavirus is the leading cause of severe acute gastroenteritis among infants and young children, accounting for an estimated 527,000 deaths among children aged <5 years worldwide in 2004. In the United States, ...
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Sunday, June 29th, 2008
Influenza activity --- United States and worldwide, 2007--08 season.
During the 2007--08 influenza season, influenza activity peaked in mid-February in the United States and was associated with greater mortality and higher rates of hospitalization of children aged 0--4 years, compared with each of the previous three ...
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Sunday, June 29th, 2008
Elevated serum aluminum levels in hemodialysis patients associated with use of electric pumps --- wyoming, 2007.
Aluminum toxicity can cause osteomalacia, anemia, and dementia in hemodialysis patients and has historically been associated with exposure to contaminated water or dialysate preparations or ingestion of aluminum-containing phosphate binders. ...
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Sunday, June 29th, 2008
Cigarette use among high school students --- United States, 1991--2007.
Cigarette use is the leading preventable cause of death in the United States. A national health objective for 2010 is to reduce the prevalence of current cigarette use among high school students to 16% or less ...
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Sunday, June 29th, 2008
Trends in HIV/AIDS Diagnoses Among Men Who Have Sex with Men --- 33 States, 2001--2006.
In 2008, CDC conducted an analysis of trends in diagnoses of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) among men who have sex with men (MSM) in the 33 states that have ...
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Sunday, June 29th, 2008
[The multifunctionality of CHIP protein in the protein quality-control system]
Selective protein degradation depends on their quality being controlled by the cellular system, which includes chaperones involved in protein folding and two degradation systems, the proteasomal and lysosomal. CHIP (carboxyl terminus of Hsp70-interacting protein), an E3 ...
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Sunday, June 29th, 2008
[The chemical structure of Helicobacter pylori lipopolysaccharide and innate immune response]
H. pylori is a causative agent of chronic gastritis. Gastrointestinal disorders are associated with a bacterial mechanism of adaptation to the stomach\'s environment and the immune responses of gastric epithelial cells. The efficacy of H. ...
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Sunday, June 29th, 2008
Early histological evaluation of bone defect healing with and without guided bone regeneration techniques: experimental animal studies.
INTRODUCTIONS: To obtain osseous tissue regeneration, treatment methods referred to as guided bone regeneration are used which utilize the mechanical, chemical, and biological properties of materials. MATERIAL/METHODS: Eighteen white ...
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Sunday, June 29th, 2008
Side effects during interferon-alpha therapy of hepatitis C with special consideration of thyroid dysfunction.
Hepatitis C virus infection is a worldwide problem and its natural, unfavorable course is still a challenge for the hepatologist. The standard of treatment is combined therapy with interferon-alpha and ribavirin. This ...
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Sunday, June 29th, 2008
Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis.
Our recent studies have shown that MEK1/2 is a critical regulator of microtubule organization and spindle formation during oocyte meiosis. In the present study, we found that Plk1 colocalized with p-MEK1/2 at various ...
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Sunday, June 29th, 2008
Cytoplasmic sumoylation by PIAS-type Siz1-SUMO ligase.
SUMO (small ubiquitin-related modifier), a 12 kDa protein with distant similarity to ubiquitin, covalently binds to many proteins in eukaryotic cells. In contrast to ubiquitination, which mainly regulates proteasome-dependent degradation and protein sorting, sumoylation is known to regulate assembly and ...
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Sunday, June 29th, 2008
Coordination of mitochondrial bioenergetics with G(1) phase cell cycle progression.
Relatively little is known regarding how energetic demand during cell proliferation is sensed or coordinated with mitochondrial metabolism. Here we demonstrate that cell cycle progression through G(1) is associated with a significant increase in mitochondrial membrane ...
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Sunday, June 29th, 2008
Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype.
Roles of cyclin dependent kinase inhibitors, p21/Cip1 (p21) and p27/Kip1 (p27) in prostate cancer (PCa) progression is still not clear. Lower p27 protein expression in PCa tissues is often associated with poor prognosis, ...
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Sunday, June 29th, 2008
A new function of microtubule-associated protein tau: Involvement in chromosome stability.
Tau is a microtubule-associated protein that promotes assembly and stabilization of cytoskeleton microtubules. It is mostly expressed in neuronal and glial cells but it is also present in non-neural cells such as fibroblasts and lymphocytes. ...
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Sunday, June 29th, 2008
E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression.
To better understand the role of E2F1 in tumor formation, we analyzed spontaneous tumorigenesis in p53(-/-)E2F1(+/+) and p53(-/-)E2F1(-/-) mice. We show that the combined loss of p53 and E2F1 leads to an increased incidence ...
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