Archive for the ‘researches 5’ Category
Sunday, June 29th, 2008
Sepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation.
The gene expression pattern specified by an animal regulatory sequence is generally viewed as arising from the particular arrangement of transcription factor binding sites it contains. However, we demonstrate here that regulatory sequences ...
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Sunday, June 29th, 2008
Low Levels of DNA Polymerase Alpha Induce Mitotic and Meiotic Instability in the Ribosomal DNA Gene Cluster of Saccharomyces cerevisiae.
The ribosomal DNA (rDNA) genes of Saccharomyces cerevisiae are located in a tandem array of about 150 repeats. Using a diploid with markers flanking and within ...
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Sunday, June 29th, 2008
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair.
Characterizing the functional overlap and mutagenic potential of different pathways of chromosomal double-strand break (DSB) repair is important to understand how mutations arise during cancer development and treatment. To this end, we have compared the ...
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Sunday, June 29th, 2008
Temperature, Viral Genetics, and the Transmission of West Nile Virus by Culex pipiens Mosquitoes.
The distribution and intensity of transmission of vector-borne pathogens can be strongly influenced by the competence of vectors. Vector competence, in turn, can be influenced by temperature and viral genetics. West Nile ...
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Sunday, June 29th, 2008
HpaC Controls Substrate Specificity of the Xanthomonas Type III Secretion System.
The Gram-negative bacterial plant pathogen Xanthomonas campestris pv. vesicatoria employs a type III secretion (T3S) system to inject bacterial effector proteins into the host cell cytoplasm. One essential pathogenicity factor is HrpB2, which is secreted ...
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Sunday, June 29th, 2008
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to ...
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Sunday, June 29th, 2008
Evidence-based Dentistry: Managing Information for Better Practice.
Evidence-Based Dentistry (2008) 9, 61. doi:10.1038/sj.ebd.6400588.
Toy A.
1Dental Practitioner, Loughborough, UK.
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Sunday, June 29th, 2008
Sequential analysis applied to clinical trials in dentistry: a systematic review.
Clinical trials employ sequential analysis for the ethical and economic benefits it brings. In dentistry, as in other fields, resources are scarce and efforts are made to ensure that patients are treated ethically. The objective ...
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Sunday, June 29th, 2008
Gastro-oesophageal reflux and dental erosion.
Data sourcesRelevant studies were sourced using Medline and the Cochrane Controlled Trials Register, along with reference lists from identified papers and reviews.Study selectionFull papers were selected that assessed the prevalence of dental erosion in individuals who had gastro-oesophageal reflux (GERD), or ...
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Sunday, June 29th, 2008
Ultrasonic preparation improves outcome in apical surgery.
DesignThis was a randomised controlled trial (RCT).InterventionRoot-end resection and preparation with a round dental bur was compared with the use of ultrasonic diamond coated retro-tips.Outcome measureTreatment was considered a success when the radiological and clinical criteria listed (Table 1) ...
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Sunday, June 29th, 2008
Growing body of evidence on survival rates of implant-supported fixed prostheses.
Data sourcesMedline and manual searches were made of the bibliographies of all full-text articles and related reviews selected from the electronic search and the following journals: American Journal of Dentistry, Australian Dental Journal, British Journal ...
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Sunday, June 29th, 2008
No difference between failure rates of early and conventionally loaded implants.
Data sourcesThe Cochrane Oral Health Group\'s Trials Register, Cochrane Central Register of Controlled Trials, Medline and Embase were searched. Handsearching included several dental journals. Authors of all identified trials, an internet discussion group and 55 ...
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Sunday, June 29th, 2008
No good evidence to link toothbrushing trauma to gingival recession.
Data sourcesMedline, Embase, Web of Knowledge, the Cochrane Central Register of Controlled Trials, Current Contents Connect and the Google Scholar databases were searched. Searches by hand were also made of the Journal of Clinical Periodontology, Journal ...
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Sunday, June 29th, 2008
Periodontal disease and adverse pregnancy outcomes.
DesignThis was a prospective cohort study.Cohort selectionThe initial sample comprised 1404 pregnant women seeking prenatal care at the University Hospital of Lleida (Spain) between March 2003 and January 2005.Data collection and analysisPeriodontal data [full-mouth data, pocket probing depths (PPD) and ...
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Sunday, June 29th, 2008
Studies suggest an association between maternal periodontal disease and pre-eclampsia.
In this systematic review, several types of infections are identified and investigated: urinary tract infection, periodontal disease, Chlamydia pneumoniae infection, HIV infection, malaria and other persistent bacterial and viral infections. Separate analyses were conducted for each ...
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Sunday, June 29th, 2008
The Hall technique is an effective treatment option for carious primary molar teeth.
DesignThis was a general dental practice (GDP)-based, split-mouth, randomised controlled trial (RCT).InterventionThe Hall technique, where a preformed metal crown (PMC) is cemented with no local anaesthesia, caries removal or tooth preparation, was compared ...
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Sunday, June 29th, 2008
A systematic review of the efficacy and safety of fluoridation.
Scope and purposeThe systematic review was commissioned by the Australian National Health and Medical Research Council (NHMRC) to evaluate the scientific literature relating to the health effects of fluoride and fluoridation. The systematic review\'s research questions ...
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Sunday, June 29th, 2008
ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice.
Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer variant, accounting for 1-2% of all cases, but 33% of deaths, ...
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Sunday, June 29th, 2008
Verteporfin therapy in occult with no classic CNV due to AMD: results of the Photodynamic Therapy in Occult-Only Lesions study.
PurposeTo provide further information on verteporfin photodynamic therapy in occult with no classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).MethodsVerteporfin therapy was administered at ...
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Sunday, June 29th, 2008
Confirmation of the presence of lens epithelial cells in the anterior chamber after phacoemulsification.
AimsTo detect the presence of lens epithelial cells in the anterior chamber of the eye at the end of phacoemulsification.MethodsA prospective observational study was carried out on 50 patients undergoing phacoemulsification. Fluid ...
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Sunday, June 29th, 2008
Effect of room temperature and cooled intraocular irrigating solution on the cornea and anterior segment inflammation after phacoemulsification: a randomized clinical trial.
PurposeTo compare the effects of cooled and room temperature BSS Plus solution on the central corneal thickness (CCT), anterior segment inflammation, and corneal endothelium ...
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Sunday, June 29th, 2008
Neogenin regulates neuronal survival through DAP kinase.
The repulsive guidance molecule (RGM) is a membrane-bound protein that has diverse functions in the developing central nervous system. Identification of neogenin as a receptor for RGM provided evidence of its cell death-inducing activity in the absence of RGM. ...
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Sunday, June 29th, 2008
The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein.
Postmitotic neurons need to keep their cell cycle under control to survive and maintain a differentiated state. This study aims to test the hypothesis that the chemokine CXCL12 regulates neuronal survival and differentiation by ...
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Sunday, June 29th, 2008
Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor.
Although nuclear factor-kappaB (NF-kappaB) usually exerts anti-apoptotic activity, upon activation by interleukin-1 (IL-1) it enhances ultraviolet-B radiation (UVB)-induced apoptosis. This paradoxical effect is associated ...
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Sunday, June 29th, 2008
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is ...
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